Details for: CETN1

Gene ID: 1068

Symbol: CETN1

Ensembl ID: ENSG00000177143

Description: centrin 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Unknown (CL0000003)
    Fold Change: 33.43
    Marker Score: 103331
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 15.95
    Marker Score: 161658
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 11.01
    Marker Score: 6102
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.62
    Marker Score: 8192
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 4.99
    Marker Score: 32157
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 4.84
    Marker Score: 2750
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 4.49
    Marker Score: 6194
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 3.97
    Marker Score: 2091
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.71
    Marker Score: 6758
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.15
    Marker Score: 3168
  • Cell Name: mast cell (CL0000097)
    Fold Change: 2.53
    Marker Score: 1464
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 2.44
    Marker Score: 1019
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 2.25
    Marker Score: 584
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.61
    Marker Score: 10723
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 1.51
    Marker Score: 999
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.42
    Marker Score: 444
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.42
    Marker Score: 408
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.39
    Marker Score: 441.5
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.37
    Marker Score: 442
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.24
    Marker Score: 7488
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.22
    Marker Score: 444
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.21
    Marker Score: 3633
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.05
    Marker Score: 32396.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 0.99
    Marker Score: 71406
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47649.5
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2405
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5306
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.86
    Marker Score: 379
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.84
    Marker Score: 488
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 743
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.81
    Marker Score: 426
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.79
    Marker Score: 407
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.78
    Marker Score: 370
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.74
    Marker Score: 1498
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.71
    Marker Score: 443
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.64
    Marker Score: 345
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.62
    Marker Score: 1176
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.6
    Marker Score: 396
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.57
    Marker Score: 437.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.49
    Marker Score: 295
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.49
    Marker Score: 438
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.48
    Marker Score: 286
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.46
    Marker Score: 440
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.43
    Marker Score: 441
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.43
    Marker Score: 2559
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.43
    Marker Score: 444
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4
    Marker Score: 6270
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.4
    Marker Score: 444
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.39
    Marker Score: 417.5
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.36
    Marker Score: 425
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.34
    Marker Score: 444
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.32
    Marker Score: 245
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.31
    Marker Score: 390
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.26
    Marker Score: 444
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.23
    Marker Score: 329
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.18
    Marker Score: 380
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.18
    Marker Score: 421
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.17
    Marker Score: 444
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.15
    Marker Score: 408.5
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.14
    Marker Score: 242
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.13
    Marker Score: 464
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.12
    Marker Score: 442
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.11
    Marker Score: 432
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.09
    Marker Score: 160
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.04
    Marker Score: 443

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Other Information

**Key characteristics:** * **Function:** Centrin 1 is a microtubule-associated protein that plays a crucial role in cell division, centrosome assembly, and other cellular processes. * **Location:** It is expressed in the nucleus, cytoplasm, and cell membrane. * **Protein structure:** It is a large protein composed of multiple repeating units. * **Isoform:** There is one known isoform of CETN1, which is expressed in humans. **Pathways and functions:** * **Aggrephagy:** Centrin 1 is involved in the early stages of aggrephagy, a process where cells fuse together to form larger ones. * **Autophagy:** It is essential for the initiation and execution of autophagy, a cellular process responsible for the removal of damaged or unnecessary components from the cell. * **Calcium ion binding:** Centrin 1 plays a role in calcium ion signaling pathways, which are crucial for various cellular processes, including cell division and migration. * **Cell division:** It is a key component of the centrosome, an organelle responsible for organizing the spindle fibers during cell division. * **Centriole replication:** Centrin 1 is involved in the replication of the centrosome, ensuring accurate segregation of genetic material during cell division. * **Centrosome:** It is a major component of the centrosome, which is responsible for organizing the mitotic spindle fibers and the nuclear envelope. * **Chaperone mediated autophagy:** Centrin 1 is a chaperone that assists in the initiation and execution of autophagy. * **G-protein beta/gamma-subunit complex binding:** It interacts with the G-protein beta/gamma-subunit complex, which is involved in various cellular processes, including cell migration and signaling. * **Late endosomal microautophagy:** Centrin 1 is a component of the late endosomal microautophagy pathway, a process involved in the degradation of damaged or misfolded proteins. * **Macroautophagy:** It is involved in macroautophagy, a process where entire organelles or large cytoplasmic structures are degraded by lysosomes. * **Microtubule binding:** Centrin 1 is a cytoskeletal protein that interacts with microtubules, which are essential for various cellular processes, including cell division and organelle transport. * **Nucleotide-excision repair:** It is involved in nucleotide-excision repair mechanisms, which are crucial for maintaining genomic integrity. * **Protein binding:** Centrin 1 interacts with various proteins involved in cell signaling, cytoskeletal organization, and other cellular processes. **Clinical significance:** Mutations in the CETN1 gene have been linked to several human diseases, including autism spectrum disorder, intellectual disability, and cancer. These mutations can disrupt the proper function of centrin 1, leading to cellular abnormalities and diseases.

Genular Protein ID: 1545842351

Symbol: CETN1_HUMAN

Name: Caltractin isoform 2

UniProtKB Accession Codes:

Q12798 B2R536

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 10 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8175926

Title: Cloning of a cDNA encoding human centrin, an EF-hand protein of centrosomes and mitotic spindle poles.

PubMed ID: 8175926

DOI: 10.1242/jcs.107.1.9

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20643351

Title: Pitchfork regulates primary cilia disassembly and left-right asymmetry.

PubMed ID: 20643351

DOI: 10.1016/j.devcel.2010.06.005

Sequence Information:

  • Length: 172
  • Mass: 19570
  • Checksum: 9ED8193F26F18881
  • Sequence:
    • MASGFKKPSA ASTGQKRKVA PKPELTEDQK QEVREAFDLF DVDGSGTIDA KELKVAMRAL 
GFEPRKEEMK KMISEVDREG TGKISFNDFL AVMTQKMSEK DTKEEILKAF RLFDDDETGK 
ISFKNLKRVA NELGENLTDE ELQEMIDEAD RDGDGEVNEE EFLRIMKKTS LY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.