Details for: CETN1

Gene ID: 1068

Symbol: CETN1

Ensembl ID: ENSG00000177143

Description: centrin 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 19.9893
    Cell Significance Index: 509.2900
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 11.4276
    Cell Significance Index: 185.0800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 7.7473
    Cell Significance Index: 132.4300
  • Cell Name: mast cell (CL0000097)
    Fold Change: 7.7286
    Cell Significance Index: 101.7100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 4.3255
    Cell Significance Index: 55.9700
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 3.4176
    Cell Significance Index: 36.3100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.4609
    Cell Significance Index: 6.6900
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.1637
    Cell Significance Index: 2.1500
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.1355
    Cell Significance Index: 1.6200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0255
    Cell Significance Index: 0.3600
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.0073
    Cell Significance Index: 0.1000
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0066
    Cell Significance Index: -0.0800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0102
    Cell Significance Index: -0.1400
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0118
    Cell Significance Index: -0.2400
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0140
    Cell Significance Index: -0.1600
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0142
    Cell Significance Index: -0.1900
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0411
    Cell Significance Index: -0.4700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0509
    Cell Significance Index: -1.3600
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0561
    Cell Significance Index: -0.6600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0598
    Cell Significance Index: -0.7800
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0601
    Cell Significance Index: -0.7100
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0642
    Cell Significance Index: -0.7700
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0652
    Cell Significance Index: -0.8700
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0721
    Cell Significance Index: -0.7800
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0738
    Cell Significance Index: -0.9400
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0765
    Cell Significance Index: -0.9300
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0816
    Cell Significance Index: -0.8100
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0826
    Cell Significance Index: -0.4900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0833
    Cell Significance Index: -0.7900
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0846
    Cell Significance Index: -0.8500
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0850
    Cell Significance Index: -0.8600
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0875
    Cell Significance Index: -1.0300
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0888
    Cell Significance Index: -0.9500
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0937
    Cell Significance Index: -1.1200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0945
    Cell Significance Index: -2.0700
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0991
    Cell Significance Index: -0.8800
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1009
    Cell Significance Index: -0.8700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1050
    Cell Significance Index: -4.3000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1080
    Cell Significance Index: -2.8400
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1081
    Cell Significance Index: -1.1400
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.1219
    Cell Significance Index: -1.6200
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1225
    Cell Significance Index: -1.3800
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.1225
    Cell Significance Index: -1.0400
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.1253
    Cell Significance Index: -1.1900
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.1257
    Cell Significance Index: -1.3400
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.1275
    Cell Significance Index: -1.7800
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.1287
    Cell Significance Index: -0.9900
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1365
    Cell Significance Index: -1.6400
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.1417
    Cell Significance Index: -1.8400
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.1513
    Cell Significance Index: -1.6200
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.1598
    Cell Significance Index: -1.4300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1703
    Cell Significance Index: -2.8500
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1712
    Cell Significance Index: -2.1000
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.1742
    Cell Significance Index: -1.1300
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.1760
    Cell Significance Index: -1.6000
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.1855
    Cell Significance Index: -1.1600
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.1936
    Cell Significance Index: -2.2200
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1963
    Cell Significance Index: -2.3200
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.2008
    Cell Significance Index: -1.0800
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: -0.2072
    Cell Significance Index: -1.9500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.2140
    Cell Significance Index: -2.7000
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.2157
    Cell Significance Index: -2.4500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2157
    Cell Significance Index: -2.3500
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.2193
    Cell Significance Index: -1.4000
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.2237
    Cell Significance Index: -1.3900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2291
    Cell Significance Index: -4.4800
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.2302
    Cell Significance Index: -2.3500
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.2368
    Cell Significance Index: -2.8200
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.2524
    Cell Significance Index: -2.3700
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.2545
    Cell Significance Index: -2.8300
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.3119
    Cell Significance Index: -2.3600
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.3586
    Cell Significance Index: -4.4800
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.3731
    Cell Significance Index: -4.5000
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.3911
    Cell Significance Index: -4.5000
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.4045
    Cell Significance Index: -4.4800
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.4109
    Cell Significance Index: -2.8500
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.4302
    Cell Significance Index: -4.5300
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.4682
    Cell Significance Index: -4.5000
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.5043
    Cell Significance Index: -6.1300
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.6077
    Cell Significance Index: -6.3700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.6144
    Cell Significance Index: -6.3600
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.6205
    Cell Significance Index: -6.3400
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.6220
    Cell Significance Index: -5.4400
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -1.0128
    Cell Significance Index: -6.3400
  • Cell Name: glial cell (CL0000125)
    Fold Change: -1.0813
    Cell Significance Index: -11.8500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CETN1 is a member of the centrin family, which is characterized by its ability to bind microtubules and participate in the regulation of cell division. CETN1 is also a calcium-binding protein, which suggests its involvement in calcium-dependent signaling pathways. Its expression in various cell types and its ability to interact with multiple proteins highlight its versatility and importance in maintaining cellular functions. **Pathways and Functions:** CETN1 is implicated in several cellular processes, including: 1. **Autophagy:** CETN1 is involved in the regulation of autophagy, a process by which cells recycle damaged or dysfunctional components. CETN1 interacts with autophagy-related proteins, such as LC3 and Atg7, to regulate the formation and fusion of autophagosomes. 2. **Cell Division:** CETN1 plays a crucial role in the regulation of cell division, particularly in the formation of centrosomes and the separation of chromosomes. CETN1 interacts with centrin-related proteins to regulate microtubule dynamics and the formation of the mitotic spindle. 3. **Calcium Signaling:** CETN1 is a calcium-binding protein that regulates calcium-dependent signaling pathways. CETN1 interacts with calcium channels and pumps to regulate calcium flux and maintain cellular homeostasis. 4. **Microtubule Dynamics:** CETN1 interacts with microtubule-associated proteins to regulate microtubule dynamics and the formation of microtubule-based structures, such as cilia and centrioles. **Clinical Significance:** CETN1 dysregulation has been implicated in various diseases, including: 1. **Neurodegenerative Disorders:** CETN1 mutations have been associated with neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. 2. **Cancer:** CETN1 is overexpressed in various types of cancer, including breast cancer and leukemia. 3. **Autophagy-Related Disorders:** CETN1 dysregulation has been implicated in autophagy-related disorders, such as Ataxia-Telangiectasia and Fanconi Anemia. In conclusion, CETN1 is a multifunctional protein that plays a crucial role in various cellular processes, including autophagy, cell division, and calcium signaling. Its dysregulation has been implicated in various diseases, highlighting the importance of CETN1 in maintaining cellular homeostasis and regulating cellular functions. Further research is necessary to fully elucidate the functions of CETN1 and its role in human disease.

Genular Protein ID: 1545842351

Symbol: CETN1_HUMAN

Name: Caltractin isoform 2

UniProtKB Accession Codes:

Q12798 B2R536

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 10 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8175926

Title: Cloning of a cDNA encoding human centrin, an EF-hand protein of centrosomes and mitotic spindle poles.

PubMed ID: 8175926

DOI: 10.1242/jcs.107.1.9

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20643351

Title: Pitchfork regulates primary cilia disassembly and left-right asymmetry.

PubMed ID: 20643351

DOI: 10.1016/j.devcel.2010.06.005

PubMed ID: 36702832

Title: USP49 deubiquitinase regulates the mitotic spindle checkpoint and prevents aneuploidy.

PubMed ID: 36702832

DOI: 10.1038/s41419-023-05600-x

Sequence Information:

  • Length: 172
  • Mass: 19570
  • Checksum: 9ED8193F26F18881
  • Sequence:
    • MASGFKKPSA ASTGQKRKVA PKPELTEDQK QEVREAFDLF DVDGSGTIDA KELKVAMRAL 
GFEPRKEEMK KMISEVDREG TGKISFNDFL AVMTQKMSEK DTKEEILKAF RLFDDDETGK 
ISFKNLKRVA NELGENLTDE ELQEMIDEAD RDGDGEVNEE EFLRIMKKTS LY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.