GNB5 | ENSG00000069966 | NCBI 10681

Details for: GNB5

Gene ID: 10681

Symbol: GNB5

Ensembl ID: ENSG00000069966

Description: G protein subunit beta 5

Associated with

Activation of gabab receptors
(R-HSA-991365)
Activation of g protein gated potassium channels
(R-HSA-1296041)
Activation of kainate receptors upon glutamate binding
(R-HSA-451326)
Adora2b mediated anti-inflammatory cytokines production
(R-HSA-9660821)
Adp signalling through p2y purinoceptor 1
(R-HSA-418592)
Adp signalling through p2y purinoceptor 12
(R-HSA-392170)
Adrenaline,noradrenaline inhibits insulin secretion
(R-HSA-400042)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Aquaporin-mediated transport
(R-HSA-445717)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
Ca2+ pathway
(R-HSA-4086398)
Chaperonin-mediated protein folding
(R-HSA-390466)
Class b/2 (secretin family receptors)
(R-HSA-373080)
Cooperation of pdcl (phlp1) and tric/cct in g-protein beta folding
(R-HSA-6814122)
Disease
(R-HSA-1643685)
Esr-mediated signaling
(R-HSA-8939211)
Extra-nuclear estrogen signaling
(R-HSA-9009391)
G-protein activation
(R-HSA-202040)
G-protein beta:gamma signalling
(R-HSA-397795)
Gaba b receptor activation
(R-HSA-977444)
Gaba receptor activation
(R-HSA-977443)
G alpha (12/13) signalling events
(R-HSA-416482)
G alpha (i) signalling events
(R-HSA-418594)
G alpha (q) signalling events
(R-HSA-416476)
G alpha (s) signalling events
(R-HSA-418555)
G alpha (z) signalling events
(R-HSA-418597)
G beta:gamma signalling through btk
(R-HSA-8964315)
G beta:gamma signalling through cdc42
(R-HSA-8964616)
G beta:gamma signalling through pi3kgamma
(R-HSA-392451)
G beta:gamma signalling through plc beta
(R-HSA-418217)
Glucagon-like peptide-1 (glp1) regulates insulin secretion
(R-HSA-381676)
Glucagon-type ligand receptors
(R-HSA-420092)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Gper1 signaling
(R-HSA-9634597)
G protein gated potassium channels
(R-HSA-1296059)
Hemostasis
(R-HSA-109582)
Inactivation, recovery and regulation of the phototransduction cascade
(R-HSA-2514859)
Infectious disease
(R-HSA-5663205)
Inhibition of voltage gated ca2+ channels via gbeta/gamma subunits
(R-HSA-997272)
Integration of energy metabolism
(R-HSA-163685)
Inwardly rectifying k+ channels
(R-HSA-1296065)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Metabolism
(R-HSA-1430728)
Metabolism of proteins
(R-HSA-392499)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Opioid signalling
(R-HSA-111885)
Parasitic infection pathways
(R-HSA-9824443)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Platelet homeostasis
(R-HSA-418346)
Potassium channels
(R-HSA-1296071)
Presynaptic function of kainate receptors
(R-HSA-500657)
Prostacyclin signalling through prostacyclin receptor
(R-HSA-392851)
Protein folding
(R-HSA-391251)
Regulation of insulin secretion
(R-HSA-422356)
Sensory perception
(R-HSA-9709957)
Signal amplification
(R-HSA-392518)
Signaling by gpcr
(R-HSA-372790)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by wnt
(R-HSA-195721)
The phototransduction cascade
(R-HSA-2514856)
Thrombin signalling through proteinase activated receptors (pars)
(R-HSA-456926)
Thromboxane signalling through tp receptor
(R-HSA-428930)
Transmission across chemical synapses
(R-HSA-112315)
Transport of small molecules
(R-HSA-382551)
Vasopressin regulates renal water homeostasis via aquaporins
(R-HSA-432040)
Visual phototransduction
(R-HSA-2187338)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dark adaptation
(GO:1990603)
Dopamine receptor signaling pathway
(GO:0007212)
G-protein gamma-subunit binding
(GO:0031682)
G protein-coupled receptor signaling pathway
(GO:0007186)
Gtpase activator activity
(GO:0005096)
Gtpase activator complex
(GO:1902773)
Gtpase activity
(GO:0003924)
Heterotrimeric g-protein complex
(GO:0005834)
Light adaption
(GO:0036367)
Negative regulation of voltage-gated calcium channel activity
(GO:1901386)
Nucleus
(GO:0005634)
Positive regulation of gtpase activity
(GO:0043547)
Presynapse
(GO:0098793)
Protein-folding chaperone binding
(GO:0051087)
Protein binding
(GO:0005515)
Signaling receptor complex adaptor activity
(GO:0030159)
Signal transduction
(GO:0007165)

Other Information

Proteins

Guanine nucleotide-binding protein subunit beta-5

Genular Protein ID: 2413689733

Symbol: GNB5_HUMAN

Name: Guanine nucleotide-binding protein subunit beta-5

UniProtKB Accession Codes:

O14775 B2RBR5 Q9HAU9 Q9UFT3

Database IDs:

Citations:

PubMed ID: 9606987

Title: Cloning and tissue distribution of the human G protein beta 5 cDNA.

PubMed ID: 9606987

DOI: 10.1016/s0167-4889(98)00017-2

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10521509

Title: Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways.

PubMed ID: 10521509

DOI: 10.1074/jbc.274.43.31087

PubMed ID: 10339615

Title: Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11.

PubMed ID: 10339615

DOI: 10.1073/pnas.96.11.6489

PubMed ID: 27523599

Title: GNB5 mutations cause an autosomal-recessive multisystem syndrome with sinus bradycardia and cognitive disability.

PubMed ID: 27523599

DOI: 10.1016/j.ajhg.2016.06.025

PubMed ID: 27677260

Title: GNB5 mutation causes a novel neuropsychiatric disorder featuring attention deficit hyperactivity disorder, severely impaired language development and normal cognition.

PubMed ID: 27677260

DOI: 10.1186/s13059-016-1061-6

PubMed ID: 34815401

Title: Structure of the class C orphan GPCR GPR158 in complex with RGS7-Gbeta5.

PubMed ID: 34815401

DOI: 10.1038/s41467-021-27147-1

Sequence Information:

Length: 395
Mass: 43566
Checksum: E001B07FCFA587AD
Sequence:

MCDQTFLVNV FGSCDKCFKQ RALRPVFKKS QQLSYCSTCA EIMATEGLHE NETLASLKSE 
AESLKGKLEE ERAKLHDVEL HQVAERVEAL GQFVMKTRRT LKGHGNKVLC MDWCKDKRRI 
VSSSQDGKVI VWDSFTTNKE HAVTMPCTWV MACAYAPSGC AIACGGLDNK CSVYPLTFDK 
NENMAAKKKS VAMHTNYLSA CSFTNSDMQI LTASGDGTCA LWDVESGQLL QSFHGHGADV 
LCLDLAPSET GNTFVSGGCD KKAMVWDMRS GQCVQAFETH ESDINSVRYY PSGDAFASGS 
DDATCRLYDL RADREVAIYS KESIIFGASS VDFSLSGRLL FAGYNDYTIN VWDVLKGSRV 
SILFGHENRV STLRVSPDGT AFCSGSWDHT LRVWA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: GNB5

Associated with

Other Information

Cloning and tissue distribution of the human G protein beta 5 cDNA. PubMed ID: 9606987

Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. PubMed ID: 11230166

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways. PubMed ID: 10521509

Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11. PubMed ID: 10339615

GNB5 mutations cause an autosomal-recessive multisystem syndrome with sinus bradycardia and cognitive disability. PubMed ID: 27523599

GNB5 mutation causes a novel neuropsychiatric disorder featuring attention deficit hyperactivity disorder, severely impaired language development and normal cognition. PubMed ID: 27677260

Structure of the class C orphan GPCR GPR158 in complex with RGS7-Gbeta5. PubMed ID: 34815401