Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 185.0909
Cell Significance Index: -28.7900 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 110.8643
Cell Significance Index: -28.1200 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 75.5193
Cell Significance Index: -31.1100 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 73.5084
Cell Significance Index: -34.7100 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 68.7496
Cell Significance Index: -27.9300 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 61.4714
Cell Significance Index: -31.6200 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 51.9655
Cell Significance Index: -34.8700 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 29.1859
Cell Significance Index: -27.8700 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 26.8055
Cell Significance Index: -33.0500 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 11.2921
Cell Significance Index: -30.2500 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 8.7125
Cell Significance Index: -34.3800 - Cell Name: kidney cell (CL1000497)
Fold Change: 5.4670
Cell Significance Index: 43.6500 - Cell Name: cell in vitro (CL0001034)
Fold Change: 2.3772
Cell Significance Index: 1298.2500 - Cell Name: peg cell (CL4033014)
Fold Change: 2.2096
Cell Significance Index: 51.0500 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 1.6721
Cell Significance Index: 35.0000 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 1.6604
Cell Significance Index: 15.2900 - Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 1.5440
Cell Significance Index: 15.2900 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.3565
Cell Significance Index: 186.2900 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.3244
Cell Significance Index: 79.5100 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.3188
Cell Significance Index: 98.2900 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 1.2492
Cell Significance Index: 43.4100 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.2368
Cell Significance Index: 33.6700 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.2353
Cell Significance Index: 1115.4200 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.0540
Cell Significance Index: 129.6000 - Cell Name: granulosa cell (CL0000501)
Fold Change: 1.0268
Cell Significance Index: 27.0000 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.9304
Cell Significance Index: 48.3300 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.8897
Cell Significance Index: 114.0500 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.8754
Cell Significance Index: 142.3800 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.7876
Cell Significance Index: 141.9800 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.6157
Cell Significance Index: 272.2100 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.5666
Cell Significance Index: 39.1800 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.5534
Cell Significance Index: 25.8000 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.5180
Cell Significance Index: 32.6500 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.5141
Cell Significance Index: 5.8400 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.4735
Cell Significance Index: 33.4900 - Cell Name: glioblast (CL0000030)
Fold Change: 0.4379
Cell Significance Index: 2.7500 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.4372
Cell Significance Index: 56.4800 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.4287
Cell Significance Index: 4.6600 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.4251
Cell Significance Index: 22.3200 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.3291
Cell Significance Index: 4.4900 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2580
Cell Significance Index: 49.0900 - Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 0.1230
Cell Significance Index: 1.1300 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.1190
Cell Significance Index: 20.3200 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.1037
Cell Significance Index: 4.7000 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0939
Cell Significance Index: 18.8400 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.0769
Cell Significance Index: 56.9300 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0733
Cell Significance Index: 55.5200 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.0600
Cell Significance Index: 3.8700 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0549
Cell Significance Index: 1.9300 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0311
Cell Significance Index: 6.1700 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0294
Cell Significance Index: 21.5400 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0045
Cell Significance Index: 1.6100 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0084
Cell Significance Index: -0.2700 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0106
Cell Significance Index: -19.9200 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0109
Cell Significance Index: -6.7900 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0164
Cell Significance Index: -0.8300 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0196
Cell Significance Index: -36.1900 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0236
Cell Significance Index: -36.3400 - Cell Name: colon goblet cell (CL0009039)
Fold Change: -0.0271
Cell Significance Index: -2.6800 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0304
Cell Significance Index: -41.3700 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0409
Cell Significance Index: -1.6800 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0417
Cell Significance Index: -26.4600 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0418
Cell Significance Index: -23.6000 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0432
Cell Significance Index: -4.4100 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0624
Cell Significance Index: -13.1400 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0671
Cell Significance Index: -30.4600 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0715
Cell Significance Index: -3.3600 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0849
Cell Significance Index: -10.0100 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0929
Cell Significance Index: -10.6400 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.0951
Cell Significance Index: -10.8600 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0977
Cell Significance Index: -11.3900 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.1165
Cell Significance Index: -3.1100 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1280
Cell Significance Index: -3.2700 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1281
Cell Significance Index: -3.5800 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1353
Cell Significance Index: -7.0500 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1576
Cell Significance Index: -12.4800 - Cell Name: lung ciliated cell (CL1000271)
Fold Change: -0.1605
Cell Significance Index: -1.5700 - Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: -0.1745
Cell Significance Index: -1.6600 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.1924
Cell Significance Index: -3.2200 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2018
Cell Significance Index: -29.3400 - Cell Name: theca cell (CL0000503)
Fold Change: -0.2417
Cell Significance Index: -1.4200 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.2518
Cell Significance Index: -5.4600 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3316
Cell Significance Index: -34.5300 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.3395
Cell Significance Index: -19.0500 - Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: -0.3452
Cell Significance Index: -4.7900 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.3970
Cell Significance Index: -4.1100 - Cell Name: germ cell (CL0000586)
Fold Change: -0.4291
Cell Significance Index: -3.2400 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.4363
Cell Significance Index: -26.7500 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.4556
Cell Significance Index: -13.4200 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.4823
Cell Significance Index: -37.0100 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.5184
Cell Significance Index: -11.0400 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.5537
Cell Significance Index: -6.6000 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.5720
Cell Significance Index: -7.3300 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.6171
Cell Significance Index: -15.4300 - Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.6224
Cell Significance Index: -8.7300 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: -0.6467
Cell Significance Index: -3.9800 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.6493
Cell Significance Index: -16.6900 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.6548
Cell Significance Index: -5.5000 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.6576
Cell Significance Index: -24.1400 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.6999
Cell Significance Index: -30.9600
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3782472839
Symbol: CETN2_HUMAN
Name: Centrin-2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8248209
Title: Molecular cloning and centrosomal localization of human caltractin.
PubMed ID: 8248209
PubMed ID: 10854409
Title: Comparative genome sequence analysis of the Bpa/Str region in mouse and man.
PubMed ID: 10854409
DOI: 10.1101/gr.10.6.758
PubMed ID: 15772651
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11279143
Title: Centrosome protein centrin 2/caltractin 1 is part of the xeroderma pigmentosum group C complex that initiates global genome nucleotide excision repair.
PubMed ID: 11279143
PubMed ID: 12176356
Title: Centrin-2 is required for centriole duplication in mammalian cells.
PubMed ID: 12176356
PubMed ID: 14654843
Title: Proteomic characterization of the human centrosome by protein correlation profiling.
PubMed ID: 14654843
DOI: 10.1038/nature02166
PubMed ID: 15356003
Title: Calcium-dependent self-assembly of human centrin 2.
PubMed ID: 15356003
PubMed ID: 15964821
Title: Centrin 2 stimulates nucleotide excision repair by interacting with xeroderma pigmentosum group C protein.
PubMed ID: 15964821
PubMed ID: 17154534
Title: Biochemical and structural domain analysis of xeroderma pigmentosum complementation group C protein.
PubMed ID: 17154534
DOI: 10.1021/bi061370o
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 16956364
Title: Binding of human centrin 2 to the centrosomal protein hSfi1.
PubMed ID: 16956364
PubMed ID: 16760425
Title: CP110 cooperates with two calcium-binding proteins to regulate cytokinesis and genome stability.
PubMed ID: 16760425
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22307388
Title: Functional and structural characterization of the mammalian TREX-2 complex that links transcription with nuclear messenger RNA export.
PubMed ID: 22307388
DOI: 10.1093/nar/gks059
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23591820
Title: The human TREX-2 complex is stably associated with the nuclear pore basket.
PubMed ID: 23591820
DOI: 10.1242/jcs.118000
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 36702832
Title: USP49 deubiquitinase regulates the mitotic spindle checkpoint and prevents aneuploidy.
PubMed ID: 36702832
PubMed ID: 12578356
Title: C-terminal half of human centrin 2 behaves like a regulatory EF-hand domain.
PubMed ID: 12578356
DOI: 10.1021/bi0269714
PubMed ID: 16411764
Title: The N-terminal domain of human centrin 2 has a closed structure, binds calcium with a very low affinity, and plays a role in the protein self-assembly.
PubMed ID: 16411764
DOI: 10.1021/bi051397s
PubMed ID: 16533048
Title: Flexibility and plasticity of human centrin 2 binding to the xeroderma pigmentosum group C protein (XPC) from nuclear excision repair.
PubMed ID: 16533048
DOI: 10.1021/bi0524868
PubMed ID: 16627479
Title: The structure of the human centrin 2-xeroderma pigmentosum group C protein complex.
PubMed ID: 16627479
Sequence Information:
- Length: 172
- Mass: 19738
- Checksum: 59CFD706AD7011B5
- Sequence:
MASNFKKANM ASSSQRKRMS PKPELTEEQK QEIREAFDLF DADGTGTIDV KELKVAMRAL GFEPKKEEIK KMISEIDKEG TGKMNFGDFL TVMTQKMSEK DTKEEILKAF KLFDDDETGK ISFKNLKRVA KELGENLTDE ELQEMIDEAD RDGDGEVSEQ EFLRIMKKTS LY
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.