Details for: CETN2

Gene ID: 1069

Symbol: CETN2

Ensembl ID: ENSG00000147400

Description: centrin 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 185.0909
    Cell Significance Index: -28.7900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 110.8643
    Cell Significance Index: -28.1200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 75.5193
    Cell Significance Index: -31.1100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 73.5084
    Cell Significance Index: -34.7100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 68.7496
    Cell Significance Index: -27.9300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 61.4714
    Cell Significance Index: -31.6200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 51.9655
    Cell Significance Index: -34.8700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 29.1859
    Cell Significance Index: -27.8700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.8055
    Cell Significance Index: -33.0500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.2921
    Cell Significance Index: -30.2500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.7125
    Cell Significance Index: -34.3800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 5.4670
    Cell Significance Index: 43.6500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.3772
    Cell Significance Index: 1298.2500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.2096
    Cell Significance Index: 51.0500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.6721
    Cell Significance Index: 35.0000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.6604
    Cell Significance Index: 15.2900
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 1.5440
    Cell Significance Index: 15.2900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.3565
    Cell Significance Index: 186.2900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.3244
    Cell Significance Index: 79.5100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.3188
    Cell Significance Index: 98.2900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.2492
    Cell Significance Index: 43.4100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.2368
    Cell Significance Index: 33.6700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2353
    Cell Significance Index: 1115.4200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.0540
    Cell Significance Index: 129.6000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.0268
    Cell Significance Index: 27.0000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9304
    Cell Significance Index: 48.3300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.8897
    Cell Significance Index: 114.0500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8754
    Cell Significance Index: 142.3800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7876
    Cell Significance Index: 141.9800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6157
    Cell Significance Index: 272.2100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5666
    Cell Significance Index: 39.1800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5534
    Cell Significance Index: 25.8000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5180
    Cell Significance Index: 32.6500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.5141
    Cell Significance Index: 5.8400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4735
    Cell Significance Index: 33.4900
  • Cell Name: glioblast (CL0000030)
    Fold Change: 0.4379
    Cell Significance Index: 2.7500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4372
    Cell Significance Index: 56.4800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.4287
    Cell Significance Index: 4.6600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4251
    Cell Significance Index: 22.3200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3291
    Cell Significance Index: 4.4900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2580
    Cell Significance Index: 49.0900
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.1230
    Cell Significance Index: 1.1300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1190
    Cell Significance Index: 20.3200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1037
    Cell Significance Index: 4.7000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0939
    Cell Significance Index: 18.8400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0769
    Cell Significance Index: 56.9300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0733
    Cell Significance Index: 55.5200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0600
    Cell Significance Index: 3.8700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0549
    Cell Significance Index: 1.9300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0311
    Cell Significance Index: 6.1700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0294
    Cell Significance Index: 21.5400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0045
    Cell Significance Index: 1.6100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0084
    Cell Significance Index: -0.2700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0106
    Cell Significance Index: -19.9200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0109
    Cell Significance Index: -6.7900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0164
    Cell Significance Index: -0.8300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0196
    Cell Significance Index: -36.1900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0236
    Cell Significance Index: -36.3400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0271
    Cell Significance Index: -2.6800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0304
    Cell Significance Index: -41.3700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0409
    Cell Significance Index: -1.6800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0417
    Cell Significance Index: -26.4600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0418
    Cell Significance Index: -23.6000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0432
    Cell Significance Index: -4.4100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0624
    Cell Significance Index: -13.1400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0671
    Cell Significance Index: -30.4600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0715
    Cell Significance Index: -3.3600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0849
    Cell Significance Index: -10.0100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0929
    Cell Significance Index: -10.6400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0951
    Cell Significance Index: -10.8600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0977
    Cell Significance Index: -11.3900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1165
    Cell Significance Index: -3.1100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1280
    Cell Significance Index: -3.2700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1281
    Cell Significance Index: -3.5800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1353
    Cell Significance Index: -7.0500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1576
    Cell Significance Index: -12.4800
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.1605
    Cell Significance Index: -1.5700
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.1745
    Cell Significance Index: -1.6600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1924
    Cell Significance Index: -3.2200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2018
    Cell Significance Index: -29.3400
  • Cell Name: theca cell (CL0000503)
    Fold Change: -0.2417
    Cell Significance Index: -1.4200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2518
    Cell Significance Index: -5.4600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3316
    Cell Significance Index: -34.5300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3395
    Cell Significance Index: -19.0500
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.3452
    Cell Significance Index: -4.7900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3970
    Cell Significance Index: -4.1100
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.4291
    Cell Significance Index: -3.2400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4363
    Cell Significance Index: -26.7500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4556
    Cell Significance Index: -13.4200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4823
    Cell Significance Index: -37.0100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5184
    Cell Significance Index: -11.0400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.5537
    Cell Significance Index: -6.6000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.5720
    Cell Significance Index: -7.3300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.6171
    Cell Significance Index: -15.4300
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.6224
    Cell Significance Index: -8.7300
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.6467
    Cell Significance Index: -3.9800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6493
    Cell Significance Index: -16.6900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.6548
    Cell Significance Index: -5.5000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6576
    Cell Significance Index: -24.1400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6999
    Cell Significance Index: -30.9600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** Centrin 2 is a small, acidic protein with a molecular weight of approximately 45 kDa. It is highly conserved across species, with a high degree of sequence similarity to other centrin proteins. The protein contains a characteristic centrin domain, which is involved in its interaction with microtubules and other cellular components. Centrin 2 has been shown to bind to microtubules and regulate their dynamics, which is essential for maintaining cellular structure and function. **Pathways and Functions** Centrin 2 is involved in various cellular processes, including: 1. **Cell cycle regulation**: Centrin 2 regulates the cell cycle by interacting with microtubules and modulating the activity of cyclin-dependent kinases (CDKs). 2. **DNA damage response**: Centrin 2 is involved in the recognition and repair of DNA damage through its interaction with proteins involved in the nucleotide excision repair pathway. 3. **Protein modification**: Centrin 2 has been shown to regulate the sumoylation of proteins, which is an important post-translational modification that affects protein function and localization. 4. **Ciliary function**: Centrin 2 is involved in the assembly and maintenance of cilia, which are essential for maintaining cellular homeostasis and function. 5. **Mitotic regulation**: Centrin 2 regulates the mitotic process by interacting with microtubules and modulating the activity of kinases involved in mitosis. **Clinical Significance** Dysregulation of centrin 2 has been implicated in various diseases, including: 1. **Ciliary dyskinesia**: Mutations in the CETN2 gene have been associated with ciliary dyskinesia, a condition characterized by defective ciliary function and respiratory problems. 2. **Cancer**: Centrin 2 has been shown to be overexpressed in certain types of cancer, including breast and lung cancer, suggesting its potential role in tumorigenesis. 3. **Neurological disorders**: Centrin 2 has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, centrin 2 is a critical protein that plays a key role in regulating various cellular processes, including cell cycle progression, DNA damage response, and protein modification. Its dysregulation has been implicated in various diseases, highlighting its importance in maintaining cellular homeostasis and function. Further research is needed to fully elucidate the role of centrin 2 in human disease and to develop therapeutic strategies to target this protein.

Genular Protein ID: 3782472839

Symbol: CETN2_HUMAN

Name: Centrin-2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8248209

Title: Molecular cloning and centrosomal localization of human caltractin.

PubMed ID: 8248209

DOI: 10.1073/pnas.90.23.11039

PubMed ID: 10854409

Title: Comparative genome sequence analysis of the Bpa/Str region in mouse and man.

PubMed ID: 10854409

DOI: 10.1101/gr.10.6.758

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11279143

Title: Centrosome protein centrin 2/caltractin 1 is part of the xeroderma pigmentosum group C complex that initiates global genome nucleotide excision repair.

PubMed ID: 11279143

DOI: 10.1074/jbc.m100855200

PubMed ID: 12176356

Title: Centrin-2 is required for centriole duplication in mammalian cells.

PubMed ID: 12176356

DOI: 10.1016/s0960-9822(02)01019-9

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15356003

Title: Calcium-dependent self-assembly of human centrin 2.

PubMed ID: 15356003

DOI: 10.1074/jbc.m404996200

PubMed ID: 15964821

Title: Centrin 2 stimulates nucleotide excision repair by interacting with xeroderma pigmentosum group C protein.

PubMed ID: 15964821

DOI: 10.1128/mcb.25.13.5664-5674.2005

PubMed ID: 17154534

Title: Biochemical and structural domain analysis of xeroderma pigmentosum complementation group C protein.

PubMed ID: 17154534

DOI: 10.1021/bi061370o

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16956364

Title: Binding of human centrin 2 to the centrosomal protein hSfi1.

PubMed ID: 16956364

DOI: 10.1111/j.1742-4658.2006.05456.x

PubMed ID: 16760425

Title: CP110 cooperates with two calcium-binding proteins to regulate cytokinesis and genome stability.

PubMed ID: 16760425

DOI: 10.1091/mbc.e06-04-0371

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22307388

Title: Functional and structural characterization of the mammalian TREX-2 complex that links transcription with nuclear messenger RNA export.

PubMed ID: 22307388

DOI: 10.1093/nar/gks059

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23591820

Title: The human TREX-2 complex is stably associated with the nuclear pore basket.

PubMed ID: 23591820

DOI: 10.1242/jcs.118000

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 36702832

Title: USP49 deubiquitinase regulates the mitotic spindle checkpoint and prevents aneuploidy.

PubMed ID: 36702832

DOI: 10.1038/s41419-023-05600-x

PubMed ID: 12578356

Title: C-terminal half of human centrin 2 behaves like a regulatory EF-hand domain.

PubMed ID: 12578356

DOI: 10.1021/bi0269714

PubMed ID: 16411764

Title: The N-terminal domain of human centrin 2 has a closed structure, binds calcium with a very low affinity, and plays a role in the protein self-assembly.

PubMed ID: 16411764

DOI: 10.1021/bi051397s

PubMed ID: 16533048

Title: Flexibility and plasticity of human centrin 2 binding to the xeroderma pigmentosum group C protein (XPC) from nuclear excision repair.

PubMed ID: 16533048

DOI: 10.1021/bi0524868

PubMed ID: 16627479

Title: The structure of the human centrin 2-xeroderma pigmentosum group C protein complex.

PubMed ID: 16627479

DOI: 10.1074/jbc.m513667200

Sequence Information:

  • Length: 172
  • Mass: 19738
  • Checksum: 59CFD706AD7011B5
  • Sequence:
  • MASNFKKANM ASSSQRKRMS PKPELTEEQK QEIREAFDLF DADGTGTIDV KELKVAMRAL 
    GFEPKKEEIK KMISEIDKEG TGKMNFGDFL TVMTQKMSEK DTKEEILKAF KLFDDDETGK 
    ISFKNLKRVA KELGENLTDE ELQEMIDEAD RDGDGEVSEQ EFLRIMKKTS LY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.