Details for: FUT9

Gene ID: 10690

Symbol: FUT9

Ensembl ID: ENSG00000172461

Description: fucosyltransferase 9

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 11.14
    Marker Score: 6,173
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 6.19
    Marker Score: 8,537
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 4.08
    Marker Score: 2,151
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 3.81
    Marker Score: 2,508
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 3.38
    Marker Score: 2,933
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 3.31
    Marker Score: 17,387
  • Cell Name: granule cell (CL0000120)
    Fold Change: 3.25
    Marker Score: 24,490
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 3.2
    Marker Score: 17,186
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 3.15
    Marker Score: 67,321
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 2.7
    Marker Score: 6,209
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.61
    Marker Score: 12,073
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.59
    Marker Score: 87,399
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.58
    Marker Score: 2,595
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 2.56
    Marker Score: 8,589
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.56
    Marker Score: 38,268
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.55
    Marker Score: 10,589
  • Cell Name: neuron (CL0000540)
    Fold Change: 2.48
    Marker Score: 10,088
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 2.42
    Marker Score: 1,405
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.4
    Marker Score: 91,213
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.35
    Marker Score: 17,981
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.32
    Marker Score: 46,078
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.27
    Marker Score: 8,762
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 2.19
    Marker Score: 5,239
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.18
    Marker Score: 20,531
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.11
    Marker Score: 77,825
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 2.09
    Marker Score: 872
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.05
    Marker Score: 126,137
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2.01
    Marker Score: 20,726
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.91
    Marker Score: 18,190
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.91
    Marker Score: 1,317
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.89
    Marker Score: 728
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.88
    Marker Score: 16,115
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.82
    Marker Score: 4,130
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.73
    Marker Score: 969
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.72
    Marker Score: 2,123
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.65
    Marker Score: 2,546
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 1.6
    Marker Score: 4,580
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 1.55
    Marker Score: 1,027
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.55
    Marker Score: 743
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.49
    Marker Score: 5,770
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.45
    Marker Score: 2,744
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 871
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.33
    Marker Score: 2,235
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.26
    Marker Score: 2,570
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.24
    Marker Score: 518
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.19
    Marker Score: 1,332
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.16
    Marker Score: 2,120
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.13
    Marker Score: 681
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.11
    Marker Score: 3,156
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.1
    Marker Score: 579
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.07
    Marker Score: 1,157
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 1.05
    Marker Score: 347
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,795
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,020
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1
    Marker Score: 2,532
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,406
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.96
    Marker Score: 440
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,349
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.92
    Marker Score: 703
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,741
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.87
    Marker Score: 1,809
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,283
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.86
    Marker Score: 8,761
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.86
    Marker Score: 1,067
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.79
    Marker Score: 241
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.79
    Marker Score: 330
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.78
    Marker Score: 3,259
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,265
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 704
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.74
    Marker Score: 642
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.74
    Marker Score: 11,577
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.65
    Marker Score: 263
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.63
    Marker Score: 727
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.62
    Marker Score: 357
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.61
    Marker Score: 272
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.58
    Marker Score: 1,376
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.57
    Marker Score: 2,379
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.57
    Marker Score: 339
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 446
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.55
    Marker Score: 262
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.54
    Marker Score: 510
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.53
    Marker Score: 366
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.51
    Marker Score: 561
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.51
    Marker Score: 3,022
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 477
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.49
    Marker Score: 139
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.48
    Marker Score: 318
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.46
    Marker Score: 125
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.43
    Marker Score: 137
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.41
    Marker Score: 568
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.39
    Marker Score: 221
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.38
    Marker Score: 557
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 373
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.36
    Marker Score: 2,398
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.35
    Marker Score: 157
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.34
    Marker Score: 201
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.34
    Marker Score: 315

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FUT9 is a type II transmembrane glycosyltransferase that catalyzes the transfer of fucose moieties to specific carbohydrate structures. It has a broad substrate specificity, recognizing various glycosphingolipids, glycoproteins, and glycolipids. FUT9 is highly expressed in erythrocytes, hematopoietic stem cells, and neurons, suggesting its importance in maintaining cellular homeostasis and immune function. The enzyme's activity is regulated by various signaling pathways, including the Notch and Wnt signaling pathways, which are crucial for cellular differentiation and proliferation. **Pathways and Functions:** FUT9 is involved in several key pathways, including: 1. **Glycosylation**: FUT9 catalyzes the transfer of fucose moieties to glycoproteins, glycolipids, and glycosphingolipids, which is essential for maintaining cellular homeostasis and immune function. 2. **Blood Group Systems**: FUT9 is involved in the biosynthesis of Lewis blood group antigens, which play a crucial role in determining an individual's blood group. 3. **Immune Regulation**: FUT9 modulates immune responses by regulating the expression of adhesion molecules, such as CD44 and ICAM-1, which are involved in leukocyte tethering and rolling. 4. **Cellular Differentiation**: FUT9 is involved in the regulation of neuronal development and differentiation, as well as the maintenance of hematopoietic stem cells. **Clinical Significance:** Dysregulation of FUT9 has been implicated in various diseases, including: 1. **Cancer**: FUT9 overexpression has been observed in several types of cancer, including leukemia and lymphoma, suggesting its potential as a diagnostic biomarker. 2. **Autoimmune Disorders**: FUT9 deficiency has been linked to autoimmune disorders, such as rheumatoid arthritis and lupus, highlighting its role in immune regulation. 3. **Neurodegenerative Conditions**: FUT9 dysregulation has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's, suggesting its potential as a therapeutic target. 4. **Glycosylation Disorders**: FUT9 deficiency can lead to glycosylation disorders, such as congenital dysgalactosylsulfatide storage disease, highlighting its importance in maintaining glycosylation patterns. In conclusion, FUT9 is a multifunctional enzyme that plays a critical role in regulating immune responses, cellular differentiation, and homeostasis. Its dysregulation has been implicated in various diseases, highlighting the need for further research into its mechanisms and potential therapeutic applications.

Genular Protein ID: 2213916176

Symbol: FUT9_HUMAN

Name: Galactoside 3-L-fucosyltransferase

UniProtKB Accession Codes:

Q9Y231 Q5T0W4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 1 CTD 1 ChEBI 54 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 4 Ensembl 1 GO 24 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 8 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 5 Rhea 16 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10386598

Title: Alpha-1,3-fucosyltransferase IX (Fuc-TIX) is very highly conserved between human and mouse; molecular cloning, characterization and tissue distribution of human Fuc-TIX.

PubMed ID: 10386598

DOI: 10.1016/s0014-5793(99)00640-7

PubMed ID: 10929005

Title: FUT4 and FUT9 genes are expressed early in human embryogenesis.

PubMed ID: 10929005

DOI: 10.1093/glycob/10.8.789

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10622713

Title: Alpha1,3-fucosyltransferase 9 (FUT9; Fuc-TIX) preferentially fucosylates the distal GlcNAc residue of polylactosamine chain while the other four alpha1,3FUT members preferentially fucosylate the inner GlcNAc residue.

PubMed ID: 10622713

DOI: 10.1016/s0014-5793(99)01549-5

PubMed ID: 11278338

Title: CD15 expression in mature granulocytes is determined by alpha 1,3-fucosyltransferase IX, but in promyelocytes and monocytes by alpha 1,3-fucosyltransferase IV.

PubMed ID: 11278338

DOI: 10.1074/jbc.m007272200

PubMed ID: 12107078

Title: Fuc-TIX: a versatile alpha1,3-fucosyltransferase with a distinct acceptor- and site-specificity profile.

PubMed ID: 12107078

DOI: 10.1093/glycob/12.6.361

PubMed ID: 16282604

Title: CEACAM1, an adhesion molecule of human granulocytes, is fucosylated by fucosyltransferase IX and interacts with DC-SIGN of dendritic cells via Lewis x residues.

PubMed ID: 16282604

DOI: 10.1093/glycob/cwj057

PubMed ID: 17335083

Title: Increased levels of fucosyltransferase IX and carbohydrate Lewis(x) adhesion determinant in human NT2N neurons.

PubMed ID: 17335083

DOI: 10.1002/jnr.21230

PubMed ID: 18395013

Title: Human fucosyltransferase IX: specificity towards N-linked glycoproteins and relevance of the cytoplasmic domain in intra-Golgi localization.

PubMed ID: 18395013

DOI: 10.1016/j.biochi.2008.03.002

PubMed ID: 23000574

Title: Expression of glycogenes in differentiating human NT2N neurons. Downregulation of fucosyltransferase 9 leads to decreased Lewis(x) levels and impaired neurite outgrowth.

PubMed ID: 23000574

DOI: 10.1016/j.bbagen.2012.09.004

PubMed ID: 23263199

Title: N-glycosylations of human alpha1,3-fucosyltransferase IX are required for full enzyme activity.

PubMed ID: 23263199

DOI: 10.1093/glycob/cws219

PubMed ID: 23192350

Title: Silencing alpha1,3-fucosyltransferases in human leukocytes reveals a role for FUT9 enzyme during E-selectin-mediated cell adhesion.

PubMed ID: 23192350

DOI: 10.1074/jbc.m112.400929

PubMed ID: 29593094

Title: Distinct human alpha(1,3)-fucosyltransferases drive Lewis-X/sialyl Lewis-X assembly in human cells.

PubMed ID: 29593094

DOI: 10.1074/jbc.ra117.000775

PubMed ID: 37202521

Title: Structural basis for Lewis antigen synthesis by the alpha1,3-fucosyltransferase FUT9.

PubMed ID: 37202521

DOI: 10.1038/s41589-023-01345-y

Sequence Information:

  • Length: 359
  • Mass: 42071
  • Checksum: D57CFCB039B644D9
  • Sequence:
    • MTSTSKGILR PFLIVCIILG CFMACLLIYI KPTNSWIFSP MESASSVLKM KNFFSTKTDY 
FNETTILVWV WPFGQTFDLT SCQAMFNIQG CHLTTDRSLY NKSHAVLIHH RDISWDLTNL 
PQQARPPFQK WIWMNLESPT HTPQKSGIEH LFNLTLTYRR DSDIQVPYGF LTVSTNPFVF 
EVPSKEKLVC WVVSNWNPEH ARVKYYNELS KSIEIHTYGQ AFGEYVNDKN LIPTISTCKF 
YLSFENSIHK DYITEKLYNA FLAGSVPVVL GPSRENYENY IPADSFIHVE DYNSPSELAK 
YLKEVDKNNK LYLSYFNWRK DFTVNLPRFW ESHACLACDH VKRHQEYKSV GNLEKWFWN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.