Details for: GMEB1

Gene ID: 10691

Symbol: GMEB1

Ensembl ID: ENSG00000162419

Description: glucocorticoid modulatory element binding protein 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,244
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.45
    Marker Score: 1,335
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.24
    Marker Score: 2,162
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1
    Marker Score: 3,545
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,713
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,937
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,394
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.97
    Marker Score: 21,616
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,397
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 478
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 432
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,705
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,281
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 306
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.85
    Marker Score: 4,838
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.85
    Marker Score: 1,306
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.81
    Marker Score: 645
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.79
    Marker Score: 48,777
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.79
    Marker Score: 284
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,272
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.77
    Marker Score: 12,104
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.77
    Marker Score: 3,135
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.77
    Marker Score: 309
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.76
    Marker Score: 1,609
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.76
    Marker Score: 7,188
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 576
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.73
    Marker Score: 6,295
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 371
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.7
    Marker Score: 691
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.69
    Marker Score: 6,501
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2,882
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.68
    Marker Score: 7,066
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.68
    Marker Score: 1,844
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 607
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.65
    Marker Score: 225
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.64
    Marker Score: 409
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.64
    Marker Score: 388
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.63
    Marker Score: 431
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.63
    Marker Score: 541
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.63
    Marker Score: 1,475
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.62
    Marker Score: 2,595
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.62
    Marker Score: 746
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.62
    Marker Score: 772
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.61
    Marker Score: 899
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.6
    Marker Score: 363
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.6
    Marker Score: 22,185
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.6
    Marker Score: 395
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.6
    Marker Score: 372
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6
    Marker Score: 6,035
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.59
    Marker Score: 674
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.58
    Marker Score: 703
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.58
    Marker Score: 584
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.57
    Marker Score: 764
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.57
    Marker Score: 418
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.57
    Marker Score: 6,637
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.57
    Marker Score: 282
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.56
    Marker Score: 2,162
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.56
    Marker Score: 161
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.55
    Marker Score: 223
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.54
    Marker Score: 162
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 430
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.54
    Marker Score: 3,225
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.53
    Marker Score: 172
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.53
    Marker Score: 2,791
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.53
    Marker Score: 188
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.53
    Marker Score: 2,210
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.53
    Marker Score: 529
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.53
    Marker Score: 756
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.52
    Marker Score: 125
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.52
    Marker Score: 564
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.52
    Marker Score: 3,999
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.52
    Marker Score: 128
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.52
    Marker Score: 10,355
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.52
    Marker Score: 1,001
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.52
    Marker Score: 584
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.52
    Marker Score: 511
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.52
    Marker Score: 19,648
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.51
    Marker Score: 250
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.51
    Marker Score: 115
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.51
    Marker Score: 377
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.51
    Marker Score: 1,261
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.51
    Marker Score: 188
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.51
    Marker Score: 228
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.51
    Marker Score: 488
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.5
    Marker Score: 232
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5
    Marker Score: 1,493
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.5
    Marker Score: 357
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.5
    Marker Score: 2,074
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.5
    Marker Score: 340
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.5
    Marker Score: 109
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.49
    Marker Score: 131
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.49
    Marker Score: 105
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.49
    Marker Score: 519
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.49
    Marker Score: 520
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.49
    Marker Score: 212
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.49
    Marker Score: 199
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.49
    Marker Score: 111
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.49
    Marker Score: 436
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.49
    Marker Score: 106

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key characteristics:** GMEB1 is a member of the glucocorticoid modulatory element-binding protein family, which is characterized by its ability to bind to glucocorticoid response elements (GRE) in the genome. This binding activity is crucial for regulating gene expression in response to glucocorticoid hormones, such as cortisol. GMEB1 is a transcriptional activator that regulates the expression of target genes by interacting with RNA polymerase II, a key enzyme in gene transcription. The gene is highly expressed in cells of the nervous system, including GABAergic interneurons and radial glial cells, suggesting its involvement in neural development and function. **Pathways and functions:** GMEB1 is involved in several signaling pathways that regulate gene expression, including: 1. **Glucocorticoid signaling pathway**: GMEB1 binds to GRE in the genome, regulating the expression of target genes in response to glucocorticoid hormones. 2. **RNA polymerase II-mediated transcription**: GMEB1 interacts with RNA polymerase II, influencing the transcriptional activity of target genes. 3. **Chromatin remodeling**: GMEB1 interacts with chromatin-modifying enzymes, regulating chromatin structure and gene expression. 4. **Neurotransmitter signaling**: GMEB1 is expressed in GABAergic interneurons and radial glial cells, suggesting its involvement in neurotransmitter signaling and neural development. **Clinical significance:** Dysregulation of GMEB1 has been implicated in various diseases, including: 1. **Neurological disorders**: GMEB1 has been linked to neurological disorders, such as epilepsy, schizophrenia, and autism spectrum disorder. 2. **Cancer**: GMEB1 has been found to be overexpressed in certain types of cancer, including breast cancer and lung cancer. 3. **Immune system disorders**: GMEB1 has been implicated in immune system disorders, such as multiple sclerosis and rheumatoid arthritis. In conclusion, GMEB1 is a critical regulator of gene expression that plays a significant role in various biological processes, including glucocorticoid signaling, RNA polymerase II-mediated transcription, and chromatin remodeling. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms of GMEB1 and its role in human disease.

Genular Protein ID: 1198125473

Symbol: GMEB1_HUMAN

Name: Glucocorticoid modulatory element-binding protein 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10386584

Title: Cloning and characterization of hGMEB1, a novel glucocorticoid modulatory element binding protein.

PubMed ID: 10386584

DOI: 10.1016/s0014-5793(99)00634-1

PubMed ID: 10523663

Title: Two new members of the emerging KDWK family of combinatorial transcription modulators bind as a heterodimer to flexibly spaced PuCGPy half-sites.

PubMed ID: 10523663

DOI: 10.1128/mcb.19.11.7741

PubMed ID: 10894151

Title: Properties of the glucocorticoid modulatory element binding proteins GMEB-1 and -2: potential new modifiers of glucocorticoid receptor transactivation and members of the family of KDWK proteins.

PubMed ID: 10894151

DOI: 10.1210/mend.14.7.0494

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 12702733

Title: Crystal structure and nuclear magnetic resonance analyses of the SAND domain from glucocorticoid modulatory element binding protein-1 reveals deoxyribonucleic acid and zinc binding regions.

PubMed ID: 12702733

DOI: 10.1210/me.2002-0409

Sequence Information:

  • Length: 573
  • Mass: 62591
  • Checksum: 8175B0730F1550B8
  • Sequence:
  • MANAEVSVPV GDVVVVPTEG NEGENPEDTK TQVILQLQPV QQGLFIDGHF YNRIYEAGSE 
    NNTAVVAVET HTIHKIEEGI DTGTIEANED MEIAYPITCG ESKAILLWKK FVCPGINVKC 
    VKFNDQLISP KHFVHLAGKS TLKDWKRAIR LGGIMLRKMM DSGQIDFYQH DKVCSNTCRS 
    TKFDLLISSA RAPVPGQQTS VVQTPTSADG SITQIAISEE SMEEAGLEWN SALTAAVTMA 
    TEEGVKKDSE EISEDTLMFW KGIADVGLME EVVCNIQKEI EELLRGVQQR LIQAPFQVTD 
    AAVLNNVAHT FGLMDTVKKV LDNRRNQVEQ GEEQFLYTLT DLERQLEEQK KQGQDHRLKS 
    QTVQNVVLMP VSTPKPPKRP RLQRPASTTV LSPSPPVQQP QFTVISPITI TPVGQSFSMG 
    NIPVATLSQG SSPVTVHTLP SGPQLFRYAT VVSSAKSSSP DTVTIHPSSS LALLSSTAMQ 
    DGSTLGNMTT MVSPVELVAM ESGLTSAIQA VESTSEDGQT IIEIDPAPDP EAEDTEGKAV 
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Genular Protein ID: 676880870

Symbol: B1AT47_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 563
  • Mass: 61327
  • Checksum: DFDF1EA16BAFB055
  • Sequence:
  • MANAEVSVPV GDVVVVPTEG NEGENPEDTK TQVILQLQPV QQGIYEAGSE NNTAVVAVET 
    HTIHKIEEGI DTGTIEANED MEIAYPITCG ESKAILLWKK FVCPGINVKC VKFNDQLISP 
    KHFVHLAGKS TLKDWKRAIR LGGIMLRKMM DSGQIDFYQH DKVCSNTCRS TKFDLLISSA 
    RAPVPGQQTS VVQTPTSADG SITQIAISEE SMEEAGLEWN SALTAAVTMA TEEGVKKDSE 
    EISEDTLMFW KGIADVGLME EVVCNIQKEI EELLRGVQQR LIQAPFQVTD AAVLNNVAHT 
    FGLMDTVKKV LDNRRNQVEQ GEEQFLYTLT DLERQLEEQK KQGQDHRLKS QTVQNVVLMP 
    VSTPKPPKRP RLQRPASTTV LSPSPPVQQP QFTVISPITI TPVGQSFSMG NIPVATLSQG 
    SSPVTVHTLP SGPQLFRYAT VVSSAKSSSP DTVTIHPSSS LALLSSTAMQ DGSTLGNMTT 
    MVSPVELVAM ESGLTSAIQA VESTSEDGQT IIEIDPAPDP EAEDTEGKAV ILETELRTEE 
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Genular Protein ID: 3795055052

Symbol: B2RCN8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 573
  • Mass: 62672
  • Checksum: 36DB29DA992D2662
  • Sequence:
  • MANAEVSVPV GDVVVVPTEG NEGENPEDTK TQVILQLQPV QQGLFIDGHF YNRIYEAGSE 
    NNTAVVAVET HTIHKIEEGI DTGTIEANED MEIAYPITCG ESKAILLWKK FVCPGINVKC 
    VKFNDQLISP KHFVHLAGKS TLKDWKRAIR LGGIMLRKMM DSGQIDFYQH DKVCSNTCRS 
    TKFDLLISSA RAPVPGQQTS VVQTPTSADG SITQIAISEE SMEEAGLEWN SALTAAVTMA 
    TEEGVKKDSE EISEDTLMFW KGIADVGLME EVVRNIQKEI EELLRGVQQR LIQAPFQVTD 
    AAVLNNVAHT FGLMDTVKKV LDNRRNQVEQ GEEQFLYTLT DLERQLEERK KQGQDHRLKS 
    QTVQNVVLMP VSTPKPPKRP RLQRPASTTV LSPSPPVQQP QFTVISPITI TPVGQSFSMG 
    NIPVATLSQG SSPVTVHTLP SGPQLFRYAT VVSSAKSSSP DTVTIHPSSS LALLSSTAMQ 
    DGSTLGNMTT MVSPVELVAM ESGLTSAIQA VESTSEDGQT IIEIDPAPDP EAEDTEGKAV 
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Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.