Details for: RRH

Gene ID: 10692

Symbol: RRH

Ensembl ID: ENSG00000180245

Description: retinal pigment epithelium-derived rhodopsin homolog

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.2
    Marker Score: 1,516
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1,174
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 873
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 858
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 490
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4,820
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1
    Marker Score: 506
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 799
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,831
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,056
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 512
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 465
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 377
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,343
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,743
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 328
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,289
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,264
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 464
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.67
    Marker Score: 441
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.66
    Marker Score: 382
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.64
    Marker Score: 986
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.61
    Marker Score: 487
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.59
    Marker Score: 546
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.58
    Marker Score: 2,367
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.57
    Marker Score: 792
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 150
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 175
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.54
    Marker Score: 3,612
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.51
    Marker Score: 4,799
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.5
    Marker Score: 210
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.47
    Marker Score: 28,821
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.46
    Marker Score: 4,393
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.46
    Marker Score: 3,970
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.44
    Marker Score: 250
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.43
    Marker Score: 418
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.42
    Marker Score: 15,454
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 375
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.34
    Marker Score: 157
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.33
    Marker Score: 1,262
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.32
    Marker Score: 3,262
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.29
    Marker Score: 5,835
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.29
    Marker Score: 605
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.28
    Marker Score: 1,175
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.27
    Marker Score: 10,189
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.25
    Marker Score: 3,727
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.24
    Marker Score: 1,817
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.23
    Marker Score: 69
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.23
    Marker Score: 95
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.22
    Marker Score: 838
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.22
    Marker Score: 266
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.21
    Marker Score: 183
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.21
    Marker Score: 127
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.21
    Marker Score: 220
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.21
    Marker Score: 391
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.18
    Marker Score: 3,941
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.17
    Marker Score: 104
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.17
    Marker Score: 60
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.16
    Marker Score: 319
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.16
    Marker Score: 107
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.16
    Marker Score: 374
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.16
    Marker Score: 70
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.15
    Marker Score: 162
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.13
    Marker Score: 536
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.12
    Marker Score: 349
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.12
    Marker Score: 45
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.12
    Marker Score: 1,864
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.12
    Marker Score: 70
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.11
    Marker Score: 31
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.11
    Marker Score: 190
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.11
    Marker Score: 46
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.11
    Marker Score: 98
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.11
    Marker Score: 633
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1
    Marker Score: 31
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.1
    Marker Score: 107
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.1
    Marker Score: 180
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.1
    Marker Score: 157
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.1
    Marker Score: 135
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.09
    Marker Score: 237
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.09
    Marker Score: 170
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.09
    Marker Score: 218
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.08
    Marker Score: 48
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.08
    Marker Score: 48
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.08
    Marker Score: 381
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.08
    Marker Score: 187
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.08
    Marker Score: 48
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.08
    Marker Score: 31
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.08
    Marker Score: 44
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.07
    Marker Score: 54
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.07
    Marker Score: 24

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The RRH gene shares a high degree of homology with the rhodopsin gene, a key component in photoreception. This similarity suggests that RRH may play a similar role in the regulation of light-dependent cellular processes. The gene's expression in immune cells, such as conventional dendritic cells and granulocyte-monocyte progenitor cells, underscores its potential involvement in immune system regulation. Additionally, the RRH gene's presence in neurons, including GABAergic interneurons and radial glial cells, highlights its role in neural function and development. **Pathways and Functions:** The RRH gene is involved in several key signaling pathways, including: 1. **Cellular response to light stimulus:** RRH is crucial in the detection of visible light, which is essential for phototransduction and visual perception. 2. **G-protein coupled receptor (GPCR) signaling:** RRH is a member of the GPCR family, which plays a vital role in transmitting signals from ligand binding to downstream effectors. 3. **Visual perception:** As a homolog of the rhodopsin gene, RRH is likely involved in the regulation of light-dependent visual processes. 4. **Immune system regulation:** RRH expression in immune cells suggests its involvement in modulating immune responses to environmental stimuli. **Clinical Significance:** The RRH gene's involvement in immune and visual processes has significant implications for various diseases and disorders. For instance: 1. **Visual impairments:** Mutations in the RRH gene may contribute to visual impairments, such as photoreceptor degeneration or disorders of visual perception. 2. **Immune system dysregulation:** RRH expression in immune cells may influence the development of autoimmune diseases or immune system disorders. 3. **Neurological disorders:** RRH's presence in neurons may contribute to the pathogenesis of neurological disorders, such as autism spectrum disorder or schizophrenia. In conclusion, the RRH gene is a complex and multifaceted component of the human genome, with significant implications for our understanding of immune and visual processes. Further research is necessary to fully elucidate the role of RRH in these processes and to explore its potential applications in the treatment of related diseases and disorders.

Genular Protein ID: 416845429

Symbol: OPSX_HUMAN

Name: Visual pigment-like receptor peropsin

UniProtKB Accession Codes:

O14718 A1A4V2 Q7RTS4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 9275222

Title: Peropsin, a novel visual pigment-like protein located in the apical microvilli of the retinal pigment epithelium.

PubMed ID: 9275222

DOI: 10.1073/pnas.94.18.9893

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12542842

Title: In silico characterisation and chromosomal localisation of human RRH (peropsin) -- implications for opsin evolution.

PubMed ID: 12542842

DOI: 10.1186/1471-2164-4-3

Sequence Information:

  • Length: 337
  • Mass: 37423
  • Checksum: 9DFD8847F07A28EA
  • Sequence:
    • MLRNNLGNSS DSKNEDGSVF SQTEHNIVAT YLIMAGMISI ISNIIVLGIF IKYKELRTPT 
NAIIINLAVT DIGVSSIGYP MSAASDLYGS WKFGYAGCQV YAGLNIFFGM ASIGLLTVVA 
VDRYLTICLP DVGRRMTTNT YIGLILGAWI NGLFWALMPI IGWASYAPDP TGATCTINWR 
KNDRSFVSYT MTVIAINFIV PLTVMFYCYY HVTLSIKHHT TSDCTESLNR DWSDQIDVTK 
MSVIMICMFL VAWSPYSIVC LWASFGDPKK IPPPMAIIAP LFAKSSTFYN PCIYVVANKK 
FRRAMLAMFK CQTHQTMPVT SILPMDVSQN PLASGRI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.