Details for: CCT6B

Gene ID: 10693

Symbol: CCT6B

Ensembl ID: ENSG00000132141

Description: chaperonin containing TCP1 subunit 6B

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.66
    Marker Score: 3,150
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.51
    Marker Score: 2,631
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.22
    Marker Score: 1,753
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.04
    Marker Score: 2,117
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,812
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,037
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,407
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.98
    Marker Score: 15,284
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 500
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 454
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,411
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.91
    Marker Score: 366
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,735
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5,189
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 318
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,280
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.87
    Marker Score: 587
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.82
    Marker Score: 757
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,252
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 691
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 388
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.73
    Marker Score: 4,397
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.72
    Marker Score: 552
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2,969
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.71
    Marker Score: 424
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.66
    Marker Score: 1,559
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.58
    Marker Score: 188
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.58
    Marker Score: 182
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.56
    Marker Score: 267
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.55
    Marker Score: 742
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.53
    Marker Score: 2,216
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.5
    Marker Score: 293
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5
    Marker Score: 317
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.48
    Marker Score: 581
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.48
    Marker Score: 315
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.47
    Marker Score: 149
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.45
    Marker Score: 131
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.45
    Marker Score: 262
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.44
    Marker Score: 3,820
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.42
    Marker Score: 459
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.41
    Marker Score: 119
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.4
    Marker Score: 8,515
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.39
    Marker Score: 1,357
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.39
    Marker Score: 171
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.35
    Marker Score: 537
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.34
    Marker Score: 108
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.34
    Marker Score: 330
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.33
    Marker Score: 20,409
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.32
    Marker Score: 135
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.31
    Marker Score: 154
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.31
    Marker Score: 205
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.31
    Marker Score: 267
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.3
    Marker Score: 3,136
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.29
    Marker Score: 290
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.29
    Marker Score: 74
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.28
    Marker Score: 330
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.28
    Marker Score: 69
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.28
    Marker Score: 527
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.27
    Marker Score: 2,568
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.27
    Marker Score: 130
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.27
    Marker Score: 2,294
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.26
    Marker Score: 148
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.26
    Marker Score: 90
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.26
    Marker Score: 499
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.25
    Marker Score: 575
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.24
    Marker Score: 8,923
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.24
    Marker Score: 66
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.24
    Marker Score: 259
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.24
    Marker Score: 252
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.24
    Marker Score: 99
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.24
    Marker Score: 92
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.23
    Marker Score: 67
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.22
    Marker Score: 269
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.22
    Marker Score: 92
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.22
    Marker Score: 148
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.22
    Marker Score: 459
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.22
    Marker Score: 882
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.22
    Marker Score: 278
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.21
    Marker Score: 102
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.21
    Marker Score: 1,599
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.21
    Marker Score: 510
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.21
    Marker Score: 1,369
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.21
    Marker Score: 56
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.21
    Marker Score: 72
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.21
    Marker Score: 86
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.21
    Marker Score: 56
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.21
    Marker Score: 385
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.21
    Marker Score: 62
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.21
    Marker Score: 310
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.21
    Marker Score: 514
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.2
    Marker Score: 93
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.2
    Marker Score: 74
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.2
    Marker Score: 63
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.2
    Marker Score: 93
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2
    Marker Score: 767
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.2
    Marker Score: 90
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.19
    Marker Score: 115

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Protein folding**: CCT6B is integral to the CCT complex, which facilitates the folding of actin, tubulin, and G-protein beta subunits during biosynthesis. 2. **Cellular localization**: CCT6B is expressed in various cell types, including cardiac endothelial cells, germ cells, and cerebral cortex GABAergic interneurons. 3. **Subcellular localization**: CCT6B is predominantly found in the cytosol, where it interacts with other chaperone proteins to regulate protein folding. 4. **Protein-protein interactions**: CCT6B interacts with other subunits of the CCT complex, as well as with other chaperone proteins, such as prefoldin and PDCL, to regulate protein folding. **Pathways and Functions:** 1. **Association of tric/cct with target proteins during biosynthesis**: CCT6B, as a subunit of the CCT complex, facilitates the association of tric/cct with target proteins during biosynthesis, ensuring proper protein folding. 2. **Atp-dependent protein folding chaperone**: CCT6B contributes to the ATP-dependent protein folding chaperone activity, utilizing ATP hydrolysis to drive protein folding. 3. **Cooperation of pdcl (phlp1) and tric/cct in g-protein beta folding**: CCT6B interacts with PDCL and tric/cct to facilitate the folding of G-protein beta subunits. 4. **Cooperation of prefoldin and tric/cct in actin and tubulin folding**: CCT6B collaborates with prefoldin and tric/cct to regulate the folding of actin and tubulin. **Clinical Significance:** CCT6B's involvement in protein folding and immune function highlights its potential role in various diseases, including: 1. **Neurodegenerative disorders**: CCT6B's role in G-protein beta folding and actin/tubulin folding may contribute to the pathogenesis of neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. 2. **Immune system disorders**: CCT6B's involvement in immune function may contribute to the development of immune system disorders, such as autoimmune diseases and immunodeficiency disorders. 3. **Cancer**: CCT6B's role in protein folding and immune function may also contribute to cancer development and progression. In conclusion, CCT6B is a crucial component of the molecular chaperone complex, CCT, which plays a vital role in protein folding and immune function. Further research is needed to elucidate the mechanisms by which CCT6B contributes to disease development and progression, as well as to explore its potential as a therapeutic target.

Genular Protein ID: 3795350060

Symbol: TCPW_HUMAN

Name: T-complex protein 1 subunit zeta-2

UniProtKB Accession Codes:

Q92526 B4DX20 B4DYB0 Q8TC34

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 8 Gene3D 3 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 2 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 5 RefSeq 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8812458

Title: Isolation of three testis-specific genes (TSA303, TSA806, TSA903) by a differential mRNA display method.

PubMed ID: 8812458

DOI: 10.1006/geno.1996.0467

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 530
  • Mass: 57821
  • Checksum: AE28A28E3826C196
  • Sequence:
    • MAAIKAVNSK AEVARARAAL AVNICAARGL QDVLRTNLGP KGTMKMLVSG AGDIKLTKDG 
NVLLDEMQIQ HPTASLIAKV ATAQDDVTGD GTTSNVLIIG ELLKQADLYI SEGLHPRIIA 
EGFEAAKIKA LEVLEEVKVT KEMKRKILLD VARTSLQTKV HAELADVLTE VVVDSVLAVR 
RPGYPIDLFM VEIMEMKHKL GTDTKLIQGL VLDHGARHPD MKKRVEDAFI LICNVSLEYE 
KTEVNSGFFY KTAEEKEKLV KAERKFIEDR VQKIIDLKDK VCAQSNKGFV VINQKGIDPF 
SLDSLAKHGI VALRRAKRRN MERLSLACGG MAVNSFEDLT VDCLGHAGLV YEYTLGEEKF 
TFIEECVNPC SVTLLVKGPN KHTLTQVKDA IRDGLRAIKN AIEDGCMVPG AGAIEVAMAE 
ALVTYKNSIK GRARLGVQAF ADALLIIPKV LAQNAGYDPQ ETLVKVQAEH VESKQLVGVD 
LNTGEPMVAA DAGVWDNYCV KKQLLHSCTV IATNILLVDE IMRAGMSSLK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.