Details for: CCT8

Gene ID: 10694

Symbol: CCT8

Ensembl ID: ENSG00000156261

Description: chaperonin containing TCP1 subunit 8

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 3.62
    Marker Score: 3,778
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 3.42
    Marker Score: 7,219
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.77
    Marker Score: 36,584
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.64
    Marker Score: 3,731
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.56
    Marker Score: 10,460
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.5
    Marker Score: 5,227
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.43
    Marker Score: 84,023
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.42
    Marker Score: 1,522
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.41
    Marker Score: 2,906
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.39
    Marker Score: 81,203
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 2.38
    Marker Score: 2,806
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.36
    Marker Score: 2,520
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 2.36
    Marker Score: 2,375
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.36
    Marker Score: 5,755
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.35
    Marker Score: 2,511
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.33
    Marker Score: 3,342
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.31
    Marker Score: 26,896
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.31
    Marker Score: 3,924
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.29
    Marker Score: 4,058
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.26
    Marker Score: 14,721
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 2.26
    Marker Score: 832
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.24
    Marker Score: 6,099
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.23
    Marker Score: 2,102
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.21
    Marker Score: 1,472
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.2
    Marker Score: 1,256
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.19
    Marker Score: 3,815
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.18
    Marker Score: 22,064
  • Cell Name: Unknown (CL0002371)
    Fold Change: 2.17
    Marker Score: 2,308
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.15
    Marker Score: 6,385
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.15
    Marker Score: 2,408
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 2.13
    Marker Score: 2,248
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.12
    Marker Score: 4,996
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.12
    Marker Score: 9,135
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.1
    Marker Score: 8,255
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 2.06
    Marker Score: 1,495
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.05
    Marker Score: 10,063
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 2.05
    Marker Score: 967
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.04
    Marker Score: 4,145
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 2.04
    Marker Score: 1,210
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.03
    Marker Score: 3,127
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.02
    Marker Score: 12,921
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.02
    Marker Score: 7,480
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.01
    Marker Score: 1,006
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 2
    Marker Score: 978
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 2
    Marker Score: 1,214
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.98
    Marker Score: 17,072
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.98
    Marker Score: 5,372
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.97
    Marker Score: 19,872
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.97
    Marker Score: 663
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.96
    Marker Score: 4,477
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.96
    Marker Score: 1,894
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.95
    Marker Score: 3,488
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.95
    Marker Score: 2,872
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.93
    Marker Score: 2,571
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.91
    Marker Score: 48,878
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.91
    Marker Score: 1,495
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.91
    Marker Score: 549
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.9
    Marker Score: 1,387
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.88
    Marker Score: 4,462
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.87
    Marker Score: 600
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.86
    Marker Score: 884
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.86
    Marker Score: 3,055
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.86
    Marker Score: 917
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.86
    Marker Score: 444
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.85
    Marker Score: 659
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.84
    Marker Score: 1,540
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.84
    Marker Score: 979
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.83
    Marker Score: 1,388
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.83
    Marker Score: 1,628
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.82
    Marker Score: 636
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.81
    Marker Score: 953
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.81
    Marker Score: 1,949
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 1.8
    Marker Score: 576
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.79
    Marker Score: 443
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.78
    Marker Score: 2,837
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.78
    Marker Score: 3,351
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.77
    Marker Score: 6,838
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.77
    Marker Score: 17,488
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.76
    Marker Score: 19,817
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.75
    Marker Score: 2,264
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.75
    Marker Score: 1,253
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.74
    Marker Score: 960
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.74
    Marker Score: 725
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.74
    Marker Score: 1,639
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.73
    Marker Score: 2,084
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.72
    Marker Score: 2,858
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.72
    Marker Score: 23,154
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 1.72
    Marker Score: 475
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.72
    Marker Score: 404
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.72
    Marker Score: 1,167
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.7
    Marker Score: 14,810
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.7
    Marker Score: 1,644
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.7
    Marker Score: 1,786
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.7
    Marker Score: 1,598
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.69
    Marker Score: 371
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.69
    Marker Score: 2,120
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.69
    Marker Score: 1,836
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.68
    Marker Score: 13,151
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.68
    Marker Score: 3,297
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 1.68
    Marker Score: 1,267

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key characteristics** CCT8 is a highly conserved gene with high sequence similarity to other subunits of the tric/cct complex. The gene's expression is widespread, with significant levels detected in hematopoietic cells, epithelial cells, and immune cells. CCT8 is involved in various cellular processes, including protein folding, cell signaling, and immune response. The gene's structure and function are characterized by its ability to bind to unfolded proteins and facilitate their proper folding. CCT8 is also involved in the assembly and disassembly of the tric/cct complex, which is essential for regulating protein folding and cell signaling. **Pathways and functions** CCT8 plays a critical role in various cellular pathways, including: 1. **Protein folding**: CCT8 is involved in the proper folding of proteins, including actin, tubulin, and actin-binding proteins. It binds to unfolded proteins and facilitates their folding, ensuring the proper assembly of protein complexes. 2. **Cell signaling**: CCT8 is involved in cell signaling pathways, including those regulated by G-proteins and telomerase. It regulates the localization of telomerase RNA to Cajal bodies and maintains telomere length. 3. **Immune response**: CCT8 is involved in the regulation of immune responses, including neutrophil degranulation and the formation of azurophil granules. 4. **Cargo trafficking**: CCT8 is involved in the trafficking of cargo proteins to the periciliary membrane and cilium, regulating the assembly and disassembly of cilia. **Clinical significance** The CCT8 gene's involvement in protein folding and cell signaling has significant implications for understanding its role in human diseases. Mutations in the CCT8 gene have been associated with various diseases, including: 1. **Neurodegenerative diseases**: CCT8 mutations have been linked to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 2. **Immune disorders**: CCT8 mutations have been associated with immune disorders, including neutropenia and immunodeficiency. 3. **Cancer**: CCT8 is involved in the regulation of telomerase activity, which is often dysregulated in cancer cells. 4. **Telomere maintenance**: CCT8 plays a critical role in maintaining telomere length, which is essential for preventing telomere shortening and cancer. In conclusion, the CCT8 gene plays a crucial role in protein folding, cell signaling, and immune response. Its involvement in various cellular pathways and its association with human diseases make it an important target for therapeutic strategies. Further research is needed to fully understand the CCT8 gene's role in human health and disease.

Genular Protein ID: 4077575930

Symbol: TCPQ_HUMAN

Name: T-complex protein 1 subunit theta

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7584026

Title: Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1.

PubMed ID: 7584026

DOI: 10.1093/dnares/1.1.27

PubMed ID: 8590283

Title: Nucleotide sequence surrounding the locus marker D21S246 on human chromosome 21.

PubMed ID: 8590283

DOI: 10.1093/dnares/2.4.187

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7890169

Title: The eighth Cct gene, Cctq, encoding the theta subunit of the cytosolic chaperonin containing TCP-1.

PubMed ID: 7890169

DOI: 10.1016/0378-1119(94)00880-2

PubMed ID: 10508479

Title: Antigens recognized by autologous antibody in patients with renal-cell carcinoma.

PubMed ID: 10508479

DOI: 10.1002/(sici)1097-0215(19991112)83:4<456::aid-ijc4>3.0.co;2-5

PubMed ID: 14532270

Title: A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death.

PubMed ID: 14532270

DOI: 10.1074/jbc.m309655200

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20080638

Title: BBS6, BBS10, and BBS12 form a complex with CCT/TRiC family chaperonins and mediate BBSome assembly.

PubMed ID: 20080638

DOI: 10.1073/pnas.0910268107

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25467444

Title: Proteostatic control of telomerase function through TRiC-mediated folding of TCAB1.

PubMed ID: 25467444

DOI: 10.1016/j.cell.2014.10.059

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 548
  • Mass: 59621
  • Checksum: 566A6622BC2D15E9
  • Sequence:
  • MALHVPKAPG FAQMLKEGAK HFSGLEEAVY RNIQACKELA QTTRTAYGPN GMNKMVINHL 
    EKLFVTNDAA TILRELEVQH PAAKMIVMAS HMQEQEVGDG TNFVLVFAGA LLELAEELLR 
    IGLSVSEVIE GYEIACRKAH EILPNLVCCS AKNLRDIDEV SSLLRTSIMS KQYGNEVFLA 
    KLIAQACVSI FPDSGHFNVD NIRVCKILGS GISSSSVLHG MVFKKETEGD VTSVKDAKIA 
    VYSCPFDGMI TETKGTVLIK TAEELMNFSK GEENLMDAQV KAIADTGANV VVTGGKVADM 
    ALHYANKYNI MLVRLNSKWD LRRLCKTVGA TALPRLTPPV LEEMGHCDSV YLSEVGDTQV 
    VVFKHEKEDG AISTIVLRGS TDNLMDDIER AVDDGVNTFK VLTRDKRLVP GGGATEIELA 
    KQITSYGETC PGLEQYAIKK FAEAFEAIPR ALAENSGVKA NEVISKLYAV HQEGNKNVGL 
    DIEAEVPAVK DMLEAGILDT YLGKYWAIKL ATNAAVTVLR VDQIIMAKPA GGPKPPSGKK 
    DWDDDQND

Genular Protein ID: 119156907

Symbol: Q7Z759_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 497
  • Mass: 54106
  • Checksum: 67A4ED7066DB3882
  • Sequence:
  • MNKMVINHLE KLFVTNDAAT ILRELEVQHP AAKMIVMASH MQEQEVGDGT NFVLVFAGAL 
    LELAEELLRI GLSVSEVIEG YEIACRKAHE ILPNLVCCSA KNLRDIDEVS SLLRTSIMSK 
    QYGNEVFLAK LIAQACVSIF PDSGHFNVDN IRVCKILGSG ISSSSVLHGM VFKKETEGDV 
    TSVKDAKIAV YSCPFDGMIT ETKGTVLIKT AEELMNFSKG EENLMDAQVK AIADTGANVV 
    VTGGKVADMA LHYANKYNIM LVRLNSKWDL RRLCKTVGAT ALPRLTPPVL EEMGHCDSVY 
    LSEVGDTQVV VFKHEKEDGA ISTIVLRGST DNLMDDIERA VDDGVNTFKV LTRDKRLVPG 
    GGATEIELAK QITSYGETCP GLEQYAIKKF AEAFEAIPRA LAENSGVKAN EVISKLYAVH 
    QEGNKNVGLD IEAEVPAVKD MLEAGILDTY LGKYWAIKLA TNAAVTVLRV DQIIMAKPAG 
    GPKPPSGKKD WDDDQND

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.