Details for: CNPY3

Gene ID: 10695

Symbol: CNPY3

Ensembl ID: ENSG00000137161

Description: canopy FGF signaling regulator 3

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.21
    Marker Score: 179,730
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.79
    Marker Score: 5,435
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.79
    Marker Score: 32,392
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.47
    Marker Score: 6,150
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 2.25
    Marker Score: 2,117
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.21
    Marker Score: 3,852
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 2.2
    Marker Score: 900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.03
    Marker Score: 1,119
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.98
    Marker Score: 2,265
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.96
    Marker Score: 1,178
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.95
    Marker Score: 7,986
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.91
    Marker Score: 1,382
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.89
    Marker Score: 1,892
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.84
    Marker Score: 1,395
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.82
    Marker Score: 1,069
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.82
    Marker Score: 18,396
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.8
    Marker Score: 1,816
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.79
    Marker Score: 45,954
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.74
    Marker Score: 1,554
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.69
    Marker Score: 600
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.69
    Marker Score: 2,035
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.66
    Marker Score: 2,344
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.64
    Marker Score: 1,669
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.62
    Marker Score: 3,919
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.62
    Marker Score: 4,191
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.59
    Marker Score: 10,374
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.58
    Marker Score: 9,601
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.55
    Marker Score: 2,061
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.55
    Marker Score: 758
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.54
    Marker Score: 1,489
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.53
    Marker Score: 4,167
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.53
    Marker Score: 15,401
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.52
    Marker Score: 487
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.52
    Marker Score: 531
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.51
    Marker Score: 1,610
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.5
    Marker Score: 14,897
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.5
    Marker Score: 3,169
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.47
    Marker Score: 4,639
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 1.45
    Marker Score: 719
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.45
    Marker Score: 1,057
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 1.44
    Marker Score: 624
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.44
    Marker Score: 2,626
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.43
    Marker Score: 953
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.43
    Marker Score: 2,551
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.43
    Marker Score: 3,881
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.42
    Marker Score: 981
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.42
    Marker Score: 1,396
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.41
    Marker Score: 2,770
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.39
    Marker Score: 319
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.38
    Marker Score: 3,367
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.38
    Marker Score: 1,484
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.37
    Marker Score: 1,722
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.37
    Marker Score: 5,882
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.37
    Marker Score: 18,407
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.37
    Marker Score: 569
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.36
    Marker Score: 927
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.36
    Marker Score: 71,675
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.35
    Marker Score: 4,005
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.35
    Marker Score: 3,786
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.35
    Marker Score: 3,718
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 1.33
    Marker Score: 884
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.32
    Marker Score: 1,243
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 1.31
    Marker Score: 457
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.31
    Marker Score: 925
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.29
    Marker Score: 446
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.29
    Marker Score: 1,212
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.27
    Marker Score: 2,648
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.27
    Marker Score: 618
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.25
    Marker Score: 300
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.25
    Marker Score: 623
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.25
    Marker Score: 1,834
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.25
    Marker Score: 16,427
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.24
    Marker Score: 2,599
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.23
    Marker Score: 1,453
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 1.22
    Marker Score: 322
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.22
    Marker Score: 1,072
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.22
    Marker Score: 772
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.21
    Marker Score: 638
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 1.21
    Marker Score: 812
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 1.2
    Marker Score: 1,070
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.2
    Marker Score: 659
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.2
    Marker Score: 2,033
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.19
    Marker Score: 977
  • Cell Name: macrophage (CL0000235)
    Fold Change: 1.19
    Marker Score: 1,321
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 1.19
    Marker Score: 314
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.18
    Marker Score: 4,920
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 1.18
    Marker Score: 407
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.17
    Marker Score: 1,250
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.17
    Marker Score: 1,128
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.16
    Marker Score: 1,034
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.16
    Marker Score: 823
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.15
    Marker Score: 1,700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.14
    Marker Score: 4,485
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 1.14
    Marker Score: 694
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 1.14
    Marker Score: 302
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.14
    Marker Score: 300
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 1.14
    Marker Score: 250
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.13
    Marker Score: 248
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 1.13
    Marker Score: 829
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.13
    Marker Score: 753

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CNPY3 is a protein-coding gene that belongs to the CANPY family of genes, which are characterized by their role in regulating FGF signaling pathways. The gene is expressed in specific immune cells, including monocytes, macrophages, and B cells, and is involved in the regulation of innate immune responses. Key characteristics of CNPY3 include: * High expression levels in immune cells, particularly in monocytes and macrophages * Specific expression in CD14-positive and CD16-positive monocytes * Involvement in the regulation of FGF signaling pathways * Expression in other cell types, including lung macrophages and Hofbauer cells **Pathways and Functions** CNPY3 is involved in the regulation of FGF signaling pathways, which are essential for various cellular processes, including: * Cell growth and differentiation * Survival and apoptosis * Angiogenesis and wound healing * Immune response and inflammation The gene's expression is specifically regulated by the FGF signaling pathway, and its dysregulation has been implicated in various diseases, including cancer and inflammatory disorders. CNPY3's role in regulating FGF signaling pathways involves the interaction with FGF receptors and other signaling molecules, which modulate the downstream effects of FGF signaling. **Clinical Significance** CNPY3's dysregulation has been implicated in various diseases, including: * Cancer: CNPY3's role in regulating FGF signaling pathways has been implicated in the development and progression of various cancers, including breast, lung, and colon cancer. * Inflammatory disorders: CNPY3's expression in immune cells has been linked to the regulation of innate immune responses, and its dysregulation has been implicated in the development of inflammatory disorders, including rheumatoid arthritis and atherosclerosis. * Neurological disorders: CNPY3's expression in certain cell types has been linked to the regulation of neuroinflammation, and its dysregulation has been implicated in the development of neurological disorders, including multiple sclerosis and Alzheimer's disease. In conclusion, CNPY3 is a gene that plays a crucial role in regulating FGF signaling pathways, which are essential for various cellular processes, including cell growth, differentiation, and survival. Its expression is specifically regulated in immune cells, and its dysregulation has been implicated in various diseases, including cancer, inflammatory disorders, and neurological disorders. Further research is needed to fully understand the role of CNPY3 in human disease and to develop therapeutic strategies to target its dysregulation.

Genular Protein ID: 1900695806

Symbol: CNPY3_HUMAN

Name: Protein canopy homolog 3

UniProtKB Accession Codes:

Q9BT09 O15412 Q0P6I2 Q8NF54 Q8WTU8 Q9P0F2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 3 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9225980

Title: cDNAs with long CAG trinucleotide repeats from human brain.

PubMed ID: 9225980

DOI: 10.1007/s004390050476

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 20865800

Title: Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone.

PubMed ID: 20865800

DOI: 10.1038/ncomms1070

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29394991

Title: Biallelic Variants in CNPY3, Encoding an Endoplasmic Reticulum Chaperone, Cause Early-Onset Epileptic Encephalopathy.

PubMed ID: 29394991

DOI: 10.1016/j.ajhg.2018.01.004

Sequence Information:

  • Length: 278
  • Mass: 30748
  • Checksum: 07587320D316E0CE
  • Sequence:
    • MDSMPEPASR CLLLLPLLLL LLLLLPAPEL GPSQAGAEEN DWVRLPSKCE VCKYVAVELK 
SAFEETGKTK EVIGTGYGIL DQKASGVKYT KSDLRLIEVT ETICKRLLDY SLHKERTGSN 
RFAKGMSETF ETLHNLVHKG VKVVMDIPYE LWNETSAEVA DLKKQCDVLV EEFEEVIEDW 
YRNHQEEDLT EFLCANHVLK GKDTSCLAEQ WSGKKGDTAA LGGKKSKKKS SRAKAAGGRS 
SSSKQRKELG GLEGDPSPEE DEGIQKASPL THSPPDEL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.