Details for: ADCY1

Gene ID: 107

Symbol: ADCY1

Ensembl ID: ENSG00000164742

Description: adenylate cyclase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 187.2124
    Cell Significance Index: -29.1200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 114.9646
    Cell Significance Index: -29.1600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 6.7885
    Cell Significance Index: 148.6500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 4.8647
    Cell Significance Index: 306.6100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 4.5813
    Cell Significance Index: 73.5000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 2.8977
    Cell Significance Index: 194.8500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.6236
    Cell Significance Index: 526.3000
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 2.4844
    Cell Significance Index: 25.8800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.8724
    Cell Significance Index: 82.8200
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: 1.7463
    Cell Significance Index: 14.1000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.6935
    Cell Significance Index: 64.1300
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 1.5353
    Cell Significance Index: 20.4800
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: 1.4964
    Cell Significance Index: 16.5100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.2808
    Cell Significance Index: 36.5500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 1.2420
    Cell Significance Index: 21.2900
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.0910
    Cell Significance Index: 9.0100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.0679
    Cell Significance Index: 65.6400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0151
    Cell Significance Index: 364.1100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.8591
    Cell Significance Index: 594.2100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5677
    Cell Significance Index: 31.8600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.5411
    Cell Significance Index: 9.1200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.5045
    Cell Significance Index: 12.1000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4532
    Cell Significance Index: 44.8300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4109
    Cell Significance Index: 371.0500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3762
    Cell Significance Index: 19.7500
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.3547
    Cell Significance Index: 4.6000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2375
    Cell Significance Index: 38.6300
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.2155
    Cell Significance Index: 2.0500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1777
    Cell Significance Index: 33.8100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1430
    Cell Significance Index: 25.7800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1211
    Cell Significance Index: 13.1800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0890
    Cell Significance Index: 55.5700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.0622
    Cell Significance Index: 1.3200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0563
    Cell Significance Index: 1.9800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0554
    Cell Significance Index: 0.6600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0553
    Cell Significance Index: 10.9700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.0492
    Cell Significance Index: 1.6100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0441
    Cell Significance Index: 82.9600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.0398
    Cell Significance Index: 0.2700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0227
    Cell Significance Index: 10.2800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.0211
    Cell Significance Index: 0.2300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.0048
    Cell Significance Index: 0.0600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0030
    Cell Significance Index: 1.8900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0033
    Cell Significance Index: -6.0000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0035
    Cell Significance Index: -0.5900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0044
    Cell Significance Index: -3.2300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0059
    Cell Significance Index: -9.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0099
    Cell Significance Index: -13.4800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0139
    Cell Significance Index: -0.8500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0224
    Cell Significance Index: -12.6400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0239
    Cell Significance Index: -0.7600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0363
    Cell Significance Index: -26.6500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0375
    Cell Significance Index: -1.0800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0419
    Cell Significance Index: -5.7600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0426
    Cell Significance Index: -32.2400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0442
    Cell Significance Index: -6.4200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0446
    Cell Significance Index: -19.7300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0447
    Cell Significance Index: -24.4100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0666
    Cell Significance Index: -14.0300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0802
    Cell Significance Index: -23.0800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0926
    Cell Significance Index: -4.2000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0929
    Cell Significance Index: -5.5800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0941
    Cell Significance Index: -9.8000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0962
    Cell Significance Index: -1.4200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1019
    Cell Significance Index: -7.0500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1055
    Cell Significance Index: -2.2600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1177
    Cell Significance Index: -2.5500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1230
    Cell Significance Index: -15.1300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1334
    Cell Significance Index: -1.9100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1542
    Cell Significance Index: -15.7500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1586
    Cell Significance Index: -8.2400
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1759
    Cell Significance Index: -2.2200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1913
    Cell Significance Index: -14.6800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1955
    Cell Significance Index: -25.0600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1990
    Cell Significance Index: -22.8000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2101
    Cell Significance Index: -6.7300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2136
    Cell Significance Index: -5.9700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2146
    Cell Significance Index: -24.5000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2166
    Cell Significance Index: -27.9800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2179
    Cell Significance Index: -25.3900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2382
    Cell Significance Index: -4.7100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2473
    Cell Significance Index: -29.1600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.2892
    Cell Significance Index: -3.6500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2961
    Cell Significance Index: -6.1800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3228
    Cell Significance Index: -6.4800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3236
    Cell Significance Index: -8.0700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3256
    Cell Significance Index: -23.0300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3282
    Cell Significance Index: -24.4600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3453
    Cell Significance Index: -27.3500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3468
    Cell Significance Index: -8.6500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3518
    Cell Significance Index: -7.6000
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.3621
    Cell Significance Index: -5.2000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3914
    Cell Significance Index: -13.7100
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.4109
    Cell Significance Index: -5.1300
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.4148
    Cell Significance Index: -4.9600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4342
    Cell Significance Index: -28.0100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4373
    Cell Significance Index: -22.7800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.4459
    Cell Significance Index: -5.5300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.4600
    Cell Significance Index: -4.3600
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.4607
    Cell Significance Index: -5.3800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Function**: Adenylate cyclase 1 is an enzyme that catalyzes the conversion of ATP to cAMP, a key second messenger molecule that regulates various cellular processes. 2. **Expression**: The ADCY1 gene is expressed in multiple cell types, including Purkinje cells, retinal ganglion cells, inhibitory interneurons, and chromaffin cells. 3. **Pathways**: ADCY1 is involved in various signaling pathways, including the activation of GABA receptors, NMDA receptors, and the adenylate cyclase-activating G protein-coupled receptor signaling pathway. 4. **Regulation**: The activity of ADCY1 is regulated by various factors, including calcium ions, calmodulin, and protein kinase A (PKA). **Pathways and Functions** The ADCY1 gene is involved in various signaling pathways, including: 1. **GABA receptor activation**: ADCY1 is involved in the regulation of GABA receptor-mediated neurotransmission, which is crucial for inhibitory synaptic transmission. 2. **NMDA receptor activation**: ADCY1 is also involved in the regulation of NMDA receptor-mediated neurotransmission, which is crucial for excitatory synaptic transmission. 3. **Adenylate cyclase-activating G protein-coupled receptor signaling pathway**: ADCY1 is involved in the regulation of this signaling pathway, which is crucial for various physiological processes, including metabolism and immune response. 4. **Ca-dependent events**: ADCY1 is involved in the regulation of calcium-dependent events, which are crucial for various physiological processes, including neurotransmission and muscle contraction. **Clinical Significance** Dysregulation of the ADCY1 gene has been implicated in various neurological and psychiatric disorders, including: 1. **Parkinson's disease**: ADCY1 mutations have been identified in patients with Parkinson's disease, a neurodegenerative disorder characterized by motor symptoms and cognitive impairment. 2. **Schizophrenia**: ADCY1 has been implicated in the pathophysiology of schizophrenia, a psychiatric disorder characterized by hallucinations, delusions, and cognitive impairment. 3. **Alzheimer's disease**: ADCY1 has been implicated in the pathophysiology of Alzheimer's disease, a neurodegenerative disorder characterized by cognitive impairment and memory loss. 4. **Leishmania parasite infection**: ADCY1 has been implicated in the regulation of Leishmania parasite growth and survival, which is crucial for the development of leishmaniasis, a parasitic disease characterized by skin lesions and visceral organ involvement. In conclusion, the ADCY1 gene plays a crucial role in various physiological processes, including neurotransmission, metabolism, and immune response. Dysregulation of the ADCY1 gene has been implicated in various neurological and psychiatric disorders, highlighting the importance of this gene in human health and disease.

Genular Protein ID: 2970730296

Symbol: ADCY1_HUMAN

Name: Adenylate cyclase type 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 8314585

Title: Cloning, chromosomal mapping, and expression of human fetal brain type I adenylyl cyclase.

PubMed ID: 8314585

DOI: 10.1006/geno.1993.1213

PubMed ID: 11549699

Title: Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland.

PubMed ID: 11549699

DOI: 10.1210/jcem.86.9.7837

PubMed ID: 24482543

Title: Adenylate cyclase 1 (ADCY1) mutations cause recessive hearing impairment in humans and defects in hair cell function and hearing in zebrafish.

PubMed ID: 24482543

DOI: 10.1093/hmg/ddu042

Sequence Information:

  • Length: 1119
  • Mass: 123440
  • Checksum: E8DDC8FCB58743D7
  • Sequence:
  • MAGAPRGGGG GGGGAGEPGG AERAAGTSRR RGLRACDEEF ACPELEALFR GYTLRLEQAA 
    TLKALAVLSL LAGALALAEL LGAPGPAPGL AKGSHPVHCV LFLALLVVTN VRSLQVPQLQ 
    QVGQLALLFS LTFALLCCPF ALGGPARGSA GAAGGPATAE QGVWQLLLVT FVSYALLPVR 
    SLLAIGFGLV VAASHLLVTA TLVPAKRPRL WRTLGANALL FVGVNMYGVF VRILTERSQR 
    KAFLQARSCI EDRLRLEDEN EKQERLLMSL LPRNVAMEMK EDFLKPPERI FHKIYIQRHD 
    NVSILFADIV GFTGLASQCT AQELVKLLNE LFGKFDELAT ENHCRRIKIL GDCYYCVSGL 
    TQPKTDHAHC CVEMGLDMID TITSVAEATE VDLNMRVGLH TGRVLCGVLG LRKWQYDVWS 
    NDVTLANVME AAGLPGKVHI TKTTLACLNG DYEVEPGYGH ERNSFLKTHN IETFFIVPSH 
    RRKIFPGLIL SDIKPAKRMK FKTVCYLLVQ LMHCRKMFKA EIPFSNVMTC EDDDKRRALR 
    TASEKLRNRS SFSTNVVYTT PGTRVNRYIS RLLEARQTEL EMADLNFFTL KYKHVEREQK 
    YHQLQDEYFT SAVVLTLILA ALFGLVYLLI FPQSVVVLLL LVFCICFLVA CVLYLHITRV 
    QCFPGCLTIQ IRTVLCIFIV VLIYSVAQGC VVGCLPWAWS SKPNSSLVVL SSGGQRTALP 
    TLPCESTHHA LLCCLVGTLP LAIFFRVSSL PKMILLSGLT TSYILVLELS GYTRTGGGAV 
    SGRSYEPIVA ILLFSCALAL HARQVDIRLR LDYLWAAQAE EEREDMEKVK LDNRRILFNL 
    LPAHVAQHFL MSNPRNMDLY YQSYSQVGVM FASIPNFNDF YIELDGNNMG VECLRLLNEI 
    IADFDELMEK DFYKDIEKIK TIGSTYMAAV GLAPTSGTKA KKSISSHLST LADFAIEMFD 
    VLDEINYQSY NDFVLRVGIN VGPVVAGVIG ARRPQYDIWG NTVNVASRMD STGVQGRIQV 
    TEEVHRLLRR CPYHFVCRGK VSVKGKGEML TYFLEGRTDG NGSQIRSLGL DRKMCPFGRA 
    GLQGRRPPVC PMPGVSVRAG LPPHSPGQYL PSAAAGKEA

Genular Protein ID: 3067350381

Symbol: C9J1J0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 338
  • Mass: 38688
  • Checksum: F268F27185D9AECB
  • Sequence:
  • MYGVFVRILT ERSQRKAFLQ ARSCIEDRLR LEDENEKQER LLMSLLPRNV AMEMKEDFLK 
    PPERIFHKIY IQRHDNVSIL FADIVGFTGL ASQCTAQELV KLLNELFGKF DELATENHCR 
    RIKILGDCYY CVSGLTQPKT DHAHCCVEMG LDMIDTITSV AEATEVDLNM RVGLHTGRVL 
    CGVLGLRKWQ YDVWSNDVTL ANVMEAAGLP GKVHITKTTL ACLNGDYEVE PGYGHERNSF 
    LKTHNIETFF IVPSHRRKIF PGLILSDIKP AKRMKFKTVC YLLVQLMHCR KMFKAEIPFS 
    NVMTCEDDDK VQIHPSLSGL DVLLGFWSPT LQRGRLCT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.