Details for: ADCY1

Gene ID: 107

Symbol: ADCY1

Ensembl ID: ENSG00000164742

Description: adenylate cyclase 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 4.79
    Marker Score: 161834
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 2.52
    Marker Score: 3137
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.46
    Marker Score: 11363
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.43
    Marker Score: 10089
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.32
    Marker Score: 85431
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 2.13
    Marker Score: 675
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.11
    Marker Score: 811
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 2.06
    Marker Score: 2901
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.91
    Marker Score: 18169
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.91
    Marker Score: 117407
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.84
    Marker Score: 15783
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.81
    Marker Score: 17040
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.8
    Marker Score: 938.5
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.75
    Marker Score: 7141
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.75
    Marker Score: 26149
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1.71
    Marker Score: 8993
  • Cell Name: granule cell (CL0000120)
    Fold Change: 1.64
    Marker Score: 12344
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.63
    Marker Score: 2517
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.62
    Marker Score: 680
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 1.62
    Marker Score: 8702
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1164
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 1.58
    Marker Score: 479
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.54
    Marker Score: 30675
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.52
    Marker Score: 454
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168910
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.47
    Marker Score: 5686
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.45
    Marker Score: 4123
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.42
    Marker Score: 10914
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.4
    Marker Score: 14413
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 865
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.33
    Marker Score: 7135
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.31
    Marker Score: 8435
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.31
    Marker Score: 49644
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.29
    Marker Score: 5568
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.28
    Marker Score: 2605
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.27
    Marker Score: 2139
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.27
    Marker Score: 401
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 850
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.23
    Marker Score: 335
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.22
    Marker Score: 4093
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.21
    Marker Score: 680
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.15
    Marker Score: 668
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4805
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.1
    Marker Score: 2521
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.1
    Marker Score: 17136
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.07
    Marker Score: 1227
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.05
    Marker Score: 330
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.05
    Marker Score: 470
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.02
    Marker Score: 536
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71810
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48035
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 506
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 460
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.96
    Marker Score: 400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.95
    Marker Score: 568
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.93
    Marker Score: 9475
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.93
    Marker Score: 5597
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 372
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5218
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.89
    Marker Score: 3858
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.88
    Marker Score: 420
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.88
    Marker Score: 3657
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.87
    Marker Score: 1080
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5286
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.87
    Marker Score: 1911.5
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.87
    Marker Score: 2482
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.87
    Marker Score: 418
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.83
    Marker Score: 632
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.82
    Marker Score: 803
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.8
    Marker Score: 604
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1260
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.78
    Marker Score: 3000
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.74
    Marker Score: 299
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.73
    Marker Score: 779.5
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.7
    Marker Score: 1426.5
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.68
    Marker Score: 337
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.66
    Marker Score: 1548
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.62
    Marker Score: 2611
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.61
    Marker Score: 737
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.59
    Marker Score: 390
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.59
    Marker Score: 559
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.59
    Marker Score: 379
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.58
    Marker Score: 257
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.56
    Marker Score: 142
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.55
    Marker Score: 11795
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.55
    Marker Score: 191
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.54
    Marker Score: 201
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.53
    Marker Score: 199
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.52
    Marker Score: 642
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.52
    Marker Score: 5804
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.46
    Marker Score: 306

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Other Information

**Key characteristics:** * The ADCY1 gene is located on chromosome 15q21.1. * It is a member of the adenylate cyclase family of enzymes. * The protein is a transmembrane protein that is expressed in the plasma membrane. * It is a key regulator of water and electrolyte balance in the body. **Pathways and functions:** * ADCY1 is involved in the regulation of aquaporin-mediated transport. * It is also involved in the regulation of Dag and ip3 signaling. * It is involved in disease, glucagon signaling in metabolic regulation, and Gpcr downstream signaling. * It is involved in the Hedgehog 'off' state. * It is involved in infectious disease. * It is involved in the integration of energy metabolism. * It is involved in intracellular signaling by second messengers. * It is involved in metabolism. * It is involved in neuronal system, neurotransmitter receptors and postsynaptic signal transmission. * It is involved in parasitic infection pathways. * It is involved in the Pka activation. * It is involved in signaling by gpcr. * It is involved in signaling by hedgehog. * It is involved in signal transduction. * It is involved in transmission across chemical synapses. * It is involved in the transport of small molecules. **Clinical significance:** * Mutations in the ADCY1 gene have been linked to a number of human diseases, including nephropathies, diabetes, and heart failure. * ADCY1 is a potential therapeutic target for these diseases.

Genular Protein ID: 2970730296

Symbol: ADCY1_HUMAN

Name: Adenylate cyclase type 1

UniProtKB Accession Codes:

Q08828 A4D2L8 Q75MI1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 ChEBI 17 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 6 DrugCentral 1 EC 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 28 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 14 RefSeq 1 Rhea 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 4 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 8314585

Title: Cloning, chromosomal mapping, and expression of human fetal brain type I adenylyl cyclase.

PubMed ID: 8314585

DOI: 10.1006/geno.1993.1213

PubMed ID: 11549699

Title: Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland.

PubMed ID: 11549699

DOI: 10.1210/jcem.86.9.7837

PubMed ID: 24482543

Title: Adenylate cyclase 1 (ADCY1) mutations cause recessive hearing impairment in humans and defects in hair cell function and hearing in zebrafish.

PubMed ID: 24482543

DOI: 10.1093/hmg/ddu042

Sequence Information:

  • Length: 1119
  • Mass: 123440
  • Checksum: E8DDC8FCB58743D7
  • Sequence:
    • MAGAPRGGGG GGGGAGEPGG AERAAGTSRR RGLRACDEEF ACPELEALFR GYTLRLEQAA 
TLKALAVLSL LAGALALAEL LGAPGPAPGL AKGSHPVHCV LFLALLVVTN VRSLQVPQLQ 
QVGQLALLFS LTFALLCCPF ALGGPARGSA GAAGGPATAE QGVWQLLLVT FVSYALLPVR 
SLLAIGFGLV VAASHLLVTA TLVPAKRPRL WRTLGANALL FVGVNMYGVF VRILTERSQR 
KAFLQARSCI EDRLRLEDEN EKQERLLMSL LPRNVAMEMK EDFLKPPERI FHKIYIQRHD 
NVSILFADIV GFTGLASQCT AQELVKLLNE LFGKFDELAT ENHCRRIKIL GDCYYCVSGL 
TQPKTDHAHC CVEMGLDMID TITSVAEATE VDLNMRVGLH TGRVLCGVLG LRKWQYDVWS 
NDVTLANVME AAGLPGKVHI TKTTLACLNG DYEVEPGYGH ERNSFLKTHN IETFFIVPSH 
RRKIFPGLIL SDIKPAKRMK FKTVCYLLVQ LMHCRKMFKA EIPFSNVMTC EDDDKRRALR 
TASEKLRNRS SFSTNVVYTT PGTRVNRYIS RLLEARQTEL EMADLNFFTL KYKHVEREQK 
YHQLQDEYFT SAVVLTLILA ALFGLVYLLI FPQSVVVLLL LVFCICFLVA CVLYLHITRV 
QCFPGCLTIQ IRTVLCIFIV VLIYSVAQGC VVGCLPWAWS SKPNSSLVVL SSGGQRTALP 
TLPCESTHHA LLCCLVGTLP LAIFFRVSSL PKMILLSGLT TSYILVLELS GYTRTGGGAV 
SGRSYEPIVA ILLFSCALAL HARQVDIRLR LDYLWAAQAE EEREDMEKVK LDNRRILFNL 
LPAHVAQHFL MSNPRNMDLY YQSYSQVGVM FASIPNFNDF YIELDGNNMG VECLRLLNEI 
IADFDELMEK DFYKDIEKIK TIGSTYMAAV GLAPTSGTKA KKSISSHLST LADFAIEMFD 
VLDEINYQSY NDFVLRVGIN VGPVVAGVIG ARRPQYDIWG NTVNVASRMD STGVQGRIQV 
TEEVHRLLRR CPYHFVCRGK VSVKGKGEML TYFLEGRTDG NGSQIRSLGL DRKMCPFGRA 
GLQGRRPPVC PMPGVSVRAG LPPHSPGQYL PSAAAGKEA

Genular Protein ID: 3067350381

Symbol: C9J1J0_HUMAN

Name: N/A

UniProtKB Accession Codes:

C9J1J0

Database IDs:

ARBA 10 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 ChEBI 5 ChiTaRS 1 DNASU 1 EC 1 EMBL 4 Ensembl 3 GO 6 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 4 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 2 RefSeq 1 Rhea 1 RuleBase 1 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

Sequence Information:

  • Length: 338
  • Mass: 38688
  • Checksum: F268F27185D9AECB
  • Sequence:
    • MYGVFVRILT ERSQRKAFLQ ARSCIEDRLR LEDENEKQER LLMSLLPRNV AMEMKEDFLK 
PPERIFHKIY IQRHDNVSIL FADIVGFTGL ASQCTAQELV KLLNELFGKF DELATENHCR 
RIKILGDCYY CVSGLTQPKT DHAHCCVEMG LDMIDTITSV AEATEVDLNM RVGLHTGRVL 
CGVLGLRKWQ YDVWSNDVTL ANVMEAAGLP GKVHITKTTL ACLNGDYEVE PGYGHERNSF 
LKTHNIETFF IVPSHRRKIF PGLILSDIKP AKRMKFKTVC YLLVQLMHCR KMFKAEIPFS 
NVMTCEDDDK VQIHPSLSGL DVLLGFWSPT LQRGRLCT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.