Details for: CETN3

Gene ID: 1070

Symbol: CETN3

Ensembl ID: ENSG00000153140

Description: centrin 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 137.4841
    Cell Significance Index: -21.3900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 95.1533
    Cell Significance Index: -24.1400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 62.7992
    Cell Significance Index: -25.8700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 54.1529
    Cell Significance Index: -22.0000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 23.1162
    Cell Significance Index: -22.0700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 21.4363
    Cell Significance Index: -26.4300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.4145
    Cell Significance Index: -25.2200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.0146
    Cell Significance Index: -27.6800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.6227
    Cell Significance Index: -17.2700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.4263
    Cell Significance Index: 231.9800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1391
    Cell Significance Index: 1028.4800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.1338
    Cell Significance Index: 132.1400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.1117
    Cell Significance Index: 70.0700
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.0113
    Cell Significance Index: 10.7500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.9945
    Cell Significance Index: 7.9400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.7996
    Cell Significance Index: 10.9100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.7996
    Cell Significance Index: 102.5000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7993
    Cell Significance Index: 47.9900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7618
    Cell Significance Index: 34.5300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.7609
    Cell Significance Index: 26.4400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.6834
    Cell Significance Index: 17.9700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6765
    Cell Significance Index: 35.1400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5066
    Cell Significance Index: 100.5400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4515
    Cell Significance Index: 62.0100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4335
    Cell Significance Index: 236.7600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4290
    Cell Significance Index: 11.6800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3722
    Cell Significance Index: 36.8200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3616
    Cell Significance Index: 65.1800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3456
    Cell Significance Index: 42.4900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.3155
    Cell Significance Index: 2.6500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2991
    Cell Significance Index: 6.2600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2870
    Cell Significance Index: 54.6100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2559
    Cell Significance Index: 51.3400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2548
    Cell Significance Index: 30.0500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2512
    Cell Significance Index: 111.0500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2390
    Cell Significance Index: 12.5500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2063
    Cell Significance Index: 142.7100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.2022
    Cell Significance Index: 2.4100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1975
    Cell Significance Index: 5.6900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1947
    Cell Significance Index: 13.7700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1911
    Cell Significance Index: 4.1400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1821
    Cell Significance Index: 12.5900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1812
    Cell Significance Index: 8.4500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1477
    Cell Significance Index: 52.9800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1476
    Cell Significance Index: 7.6900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0826
    Cell Significance Index: 1.7600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0128
    Cell Significance Index: 0.2100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0074
    Cell Significance Index: 0.2600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0030
    Cell Significance Index: 0.0800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0025
    Cell Significance Index: 1.9000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0012
    Cell Significance Index: -2.2600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0044
    Cell Significance Index: -0.2000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0056
    Cell Significance Index: -4.0900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0128
    Cell Significance Index: -23.5400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0143
    Cell Significance Index: -21.9700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0168
    Cell Significance Index: -22.8300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0186
    Cell Significance Index: -0.5200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0247
    Cell Significance Index: -15.6700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0331
    Cell Significance Index: -24.5300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0395
    Cell Significance Index: -17.9400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0415
    Cell Significance Index: -0.8600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0416
    Cell Significance Index: -23.4600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0452
    Cell Significance Index: -2.7800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0464
    Cell Significance Index: -4.7400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0476
    Cell Significance Index: -3.6600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0499
    Cell Significance Index: -31.1700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0643
    Cell Significance Index: -18.5000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0875
    Cell Significance Index: -14.9400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0901
    Cell Significance Index: -5.0600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0915
    Cell Significance Index: -6.8200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0946
    Cell Significance Index: -13.7500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1012
    Cell Significance Index: -13.0800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1306
    Cell Significance Index: -3.2700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1480
    Cell Significance Index: -31.1700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1564
    Cell Significance Index: -17.9200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2253
    Cell Significance Index: -17.8400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2288
    Cell Significance Index: -14.7600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2332
    Cell Significance Index: -7.4700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2337
    Cell Significance Index: -5.9700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2580
    Cell Significance Index: -26.8600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2584
    Cell Significance Index: -5.9700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2694
    Cell Significance Index: -3.0600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2750
    Cell Significance Index: -16.8600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2787
    Cell Significance Index: -2.8900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2954
    Cell Significance Index: -19.8700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.3091
    Cell Significance Index: -3.3600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3381
    Cell Significance Index: -8.6900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.3839
    Cell Significance Index: -6.0900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3879
    Cell Significance Index: -5.8500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4240
    Cell Significance Index: -11.3600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4268
    Cell Significance Index: -12.5700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.4482
    Cell Significance Index: -5.7400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4545
    Cell Significance Index: -6.7100
  • Cell Name: theca cell (CL0000503)
    Fold Change: -0.4545
    Cell Significance Index: -2.6700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4576
    Cell Significance Index: -20.2400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4791
    Cell Significance Index: -14.0700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4857
    Cell Significance Index: -9.4800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4909
    Cell Significance Index: -18.0200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4931
    Cell Significance Index: -8.4500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5266
    Cell Significance Index: -19.9400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CETN3 is a small, conserved protein that belongs to the centrin family, which is characterized by the presence of a globular domain and a coiled-coil region. The protein is highly expressed in various cell types, including germ cells, epithelial cells, and immune cells. CETN3 exhibits a high degree of conservation across species, suggesting its essential role in fundamental cellular processes. The protein's ability to bind to microtubules, calcium ions, and G-protein beta/gamma-subunit complexes underscores its multifunctional nature. **Pathways and Functions:** CETN3 is implicated in several key cellular pathways, including: 1. **Cell Division:** CETN3 plays a crucial role in the regulation of microtubule dynamics, which is essential for proper cell division. The protein's ability to bind to microtubules and regulate their stability ensures accurate chromosome segregation and cell cycle progression. 2. **Calcium Ion Binding:** CETN3's capacity to bind to calcium ions suggests its involvement in calcium-dependent signaling pathways, which regulate various cellular processes, including muscle contraction, neurotransmission, and cell proliferation. 3. **Microtubule Organizing Center (MTOC):** CETN3 is a key component of the MTOC, a complex organelle that regulates microtubule dynamics and organization. The protein's presence in the MTOC ensures proper microtubule function and stability. 4. **Nuclear Transport:** CETN3 is involved in the regulation of nuclear transport, which is essential for the proper transport of proteins and RNAs between the nucleus and cytoplasm. **Clinical Significance:** Dysregulation of CETN3 has been implicated in various diseases, including: 1. **Cancer:** Alterations in CETN3 expression have been observed in various types of cancer, including breast, lung, and colon cancer. The protein's role in regulating cell division and microtubule dynamics suggests its potential as a therapeutic target in cancer treatment. 2. **Neurological Disorders:** CETN3's involvement in calcium-dependent signaling pathways suggests its potential role in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Immune System Dysregulation:** CETN3's expression in immune cells suggests its potential role in immune system dysregulation, including autoimmune diseases and immunodeficiency disorders. In conclusion, CETN3 is a multifunctional protein that plays a crucial role in various cellular processes, including cell division, microtubule organization, and calcium ion binding. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the protein's mechanisms of action and potential therapeutic applications.

Genular Protein ID: 1514510399

Symbol: CETN3_HUMAN

Name: Centrin-3

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9256449

Title: Identification of a new mammalian centrin gene, more closely related to Saccharomyces cerevisiae CDC31 gene.

PubMed ID: 9256449

DOI: 10.1073/pnas.94.17.9141

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 22307388

Title: Functional and structural characterization of the mammalian TREX-2 complex that links transcription with nuclear messenger RNA export.

PubMed ID: 22307388

DOI: 10.1093/nar/gks059

PubMed ID: 23591820

Title: The human TREX-2 complex is stably associated with the nuclear pore basket.

PubMed ID: 23591820

DOI: 10.1242/jcs.118000

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 26337392

Title: MDM1 is a microtubule-binding protein that negatively regulates centriole duplication.

PubMed ID: 26337392

DOI: 10.1091/mbc.e15-04-0235

PubMed ID: 36702832

Title: USP49 deubiquitinase regulates the mitotic spindle checkpoint and prevents aneuploidy.

PubMed ID: 36702832

DOI: 10.1038/s41419-023-05600-x

Sequence Information:

  • Length: 167
  • Mass: 19550
  • Checksum: EF67724B2D6C2680
  • Sequence:
  • MSLALRSELV VDKTKRKKRR ELSEEQKQEI KDAFELFDTD KDEAIDYHEL KVAMRALGFD 
    VKKADVLKIL KDYDREATGK ITFEDFNEVV TDWILERDPH EEILKAFKLF DDDDSGKISL 
    RNLRRVAREL GENMSDEELR AMIEEFDKDG DGEINQEEFI AIMTGDI

Genular Protein ID: 2013313772

Symbol: E5RFM2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 153
  • Mass: 18048
  • Checksum: 7B596A83029E26D2
  • Sequence:
  • MSLALRSELV VDKTKRKKRR ELSEEQKQEI KDAFELFDTD KDEAIDYHEL KVAMRALGFD 
    VKKADVLKIL KDYDREATGK ITFEDFNEVV TDWILERDPH EEILKAFKLF DDDDSVLKNI 
    LLLPIWSRCL SLNREFFSEV NQEEFIAIMT GDI

Genular Protein ID: 2424398455

Symbol: E5RJF8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 191
  • Mass: 22423
  • Checksum: EB933F556116239A
  • Sequence:
  • MSLALRSELV VDKTKRKKRR ELSEEQKQEI KDAFELFDTD KDEAIDYHEL KVAMRALGFD 
    VKKADVLKIL KDYDREATGK ITFEDFNEVV TDWILERDPH EEILKAFKLF DDDDSGKISL 
    RNLRRVAREL GENMSDEELR AMIEEFDKDG DGEILKNILL LPIWSRCLSL NREFFSEVNQ 
    EEFIAIMTGD I

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.