Details for: CETN3

Gene ID: 1070

Symbol: CETN3

Ensembl ID: ENSG00000153140

Description: centrin 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.67
    Marker Score: 4666
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.59
    Marker Score: 2292
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.51
    Marker Score: 2097
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.39
    Marker Score: 2909
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.38
    Marker Score: 5432
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.29
    Marker Score: 2185
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.23
    Marker Score: 821
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.17
    Marker Score: 4326
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 1.15
    Marker Score: 1418
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.14
    Marker Score: 1894
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.12
    Marker Score: 9651.5
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.12
    Marker Score: 9722
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1.12
    Marker Score: 1166
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.09
    Marker Score: 1153
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.08
    Marker Score: 1659
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.05
    Marker Score: 576
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.04
    Marker Score: 244
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.03
    Marker Score: 4438
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71723.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47948
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30396
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.97
    Marker Score: 2777.5
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2399
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 481
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 436
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.92
    Marker Score: 2511.5
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.92
    Marker Score: 867
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.92
    Marker Score: 982
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.92
    Marker Score: 14359
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.91
    Marker Score: 271
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2703
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.88
    Marker Score: 595
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5293
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.87
    Marker Score: 171
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.87
    Marker Score: 2355.5
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.85
    Marker Score: 1257
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 306
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.85
    Marker Score: 403.5
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.85
    Marker Score: 4842
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.84
    Marker Score: 1059
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.84
    Marker Score: 700
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.83
    Marker Score: 1335
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.81
    Marker Score: 878
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.81
    Marker Score: 5294
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.8
    Marker Score: 505
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.8
    Marker Score: 1523
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.8
    Marker Score: 424
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.79
    Marker Score: 2002
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.79
    Marker Score: 27352
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.79
    Marker Score: 227
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1266
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 312
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.78
    Marker Score: 198
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 591
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.76
    Marker Score: 378
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.76
    Marker Score: 3986
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.75
    Marker Score: 472
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.75
    Marker Score: 4454
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.75
    Marker Score: 2002
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.74
    Marker Score: 1216
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.73
    Marker Score: 9690
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.73
    Marker Score: 335
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.73
    Marker Score: 1131
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.73
    Marker Score: 545
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.72
    Marker Score: 270
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 463
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 373
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.72
    Marker Score: 658.5
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.72
    Marker Score: 7213
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.71
    Marker Score: 289
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.71
    Marker Score: 212.5
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.7
    Marker Score: 162
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.7
    Marker Score: 708
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.7
    Marker Score: 291
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.69
    Marker Score: 736
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.69
    Marker Score: 222
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.69
    Marker Score: 414
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.69
    Marker Score: 1394
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.69
    Marker Score: 1795
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.68
    Marker Score: 693
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2850
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.68
    Marker Score: 2627
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.68
    Marker Score: 758
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 616
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.67
    Marker Score: 4358
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.67
    Marker Score: 6877
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.66
    Marker Score: 299
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.66
    Marker Score: 347
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.66
    Marker Score: 730.5
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.66
    Marker Score: 2755
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.66
    Marker Score: 471
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.65
    Marker Score: 1552
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.65
    Marker Score: 184
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.65
    Marker Score: 681
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.65
    Marker Score: 6128.5
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.64
    Marker Score: 1022
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.64
    Marker Score: 317
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.64
    Marker Score: 500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.64
    Marker Score: 5482

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** - The CETN3 gene is located on chromosome 17q21.1. - It is a large gene with a complex structure that includes multiple exons and intron regions. - The protein encoded by CETN3 is a microtubule-associated protein that is essential for the stability and integrity of the centrosome. - It is involved in cell division, centrosome assembly, and the maintenance of cell shape and structure. **Pathways and functions:** - The CETN3 gene is involved in multiple cellular pathways, including those involved in cell division, centrosome function, and cytoskeletal organization. - It is a key regulator of cell cycle progression and is essential for the completion of mitosis and meiosis. - Mutations in the CETN3 gene have been linked to several human cancers, including breast cancer, ovarian cancer, and colon cancer. **Clinical significance:** - Dysregulation of CETN3 has been implicated in the pathogenesis of various human diseases, including cancer and developmental disorders. - Targeting CETN3 has emerged as a potential therapeutic strategy for these diseases. - Small molecule inhibitors of CETN3 have been shown to inhibit cancer cell growth in vitro and in vivo.

Genular Protein ID: 1514510399

Symbol: CETN3_HUMAN

Name: Centrin-3

UniProtKB Accession Codes:

O15182 Q53YD2 Q9BS23

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 5 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 EMBL 6 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9256449

Title: Identification of a new mammalian centrin gene, more closely related to Saccharomyces cerevisiae CDC31 gene.

PubMed ID: 9256449

DOI: 10.1073/pnas.94.17.9141

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 22307388

Title: Functional and structural characterization of the mammalian TREX-2 complex that links transcription with nuclear messenger RNA export.

PubMed ID: 22307388

DOI: 10.1093/nar/gks059

PubMed ID: 23591820

Title: The human TREX-2 complex is stably associated with the nuclear pore basket.

PubMed ID: 23591820

DOI: 10.1242/jcs.118000

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 26337392

Title: MDM1 is a microtubule-binding protein that negatively regulates centriole duplication.

PubMed ID: 26337392

DOI: 10.1091/mbc.e15-04-0235

Sequence Information:

  • Length: 167
  • Mass: 19550
  • Checksum: EF67724B2D6C2680
  • Sequence:
    • MSLALRSELV VDKTKRKKRR ELSEEQKQEI KDAFELFDTD KDEAIDYHEL KVAMRALGFD 
VKKADVLKIL KDYDREATGK ITFEDFNEVV TDWILERDPH EEILKAFKLF DDDDSGKISL 
RNLRRVAREL GENMSDEELR AMIEEFDKDG DGEINQEEFI AIMTGDI

Genular Protein ID: 2424398455

Symbol: E5RJF8_HUMAN

Name: N/A

UniProtKB Accession Codes:

E5RJF8

Database IDs:

ARBA 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 EPD 2 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 2 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PaxDb 1 PeptideAtlas 1 Pfam 1 PhylomeDB 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 191
  • Mass: 22423
  • Checksum: EB933F556116239A
  • Sequence:
    • MSLALRSELV VDKTKRKKRR ELSEEQKQEI KDAFELFDTD KDEAIDYHEL KVAMRALGFD 
VKKADVLKIL KDYDREATGK ITFEDFNEVV TDWILERDPH EEILKAFKLF DDDDSGKISL 
RNLRRVAREL GENMSDEELR AMIEEFDKDG DGEILKNILL LPIWSRCLSL NREFFSEVNQ 
EEFIAIMTGD I

Genular Protein ID: 2013313772

Symbol: E5RFM2_HUMAN

Name: N/A

UniProtKB Accession Codes:

E5RFM2

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 2 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

Sequence Information:

  • Length: 153
  • Mass: 18048
  • Checksum: 7B596A83029E26D2
  • Sequence:
    • MSLALRSELV VDKTKRKKRR ELSEEQKQEI KDAFELFDTD KDEAIDYHEL KVAMRALGFD 
VKKADVLKIL KDYDREATGK ITFEDFNEVV TDWILERDPH EEILKAFKLF DDDDSVLKNI 
LLLPIWSRCL SLNREFFSEV NQEEFIAIMT GDI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.