Details for: ENTREP3

Gene ID: 10712

Symbol: ENTREP3

Ensembl ID: ENSG00000160767

Description: endosomal transmembrane epsin interactor 3

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.72
    Marker Score: 3,013
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.02
    Marker Score: 911
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,404
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.98
    Marker Score: 1,508
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 488
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 442
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,724
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5,072
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,266
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 310
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.83
    Marker Score: 1,346
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.82
    Marker Score: 653
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.78
    Marker Score: 48,236
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.78
    Marker Score: 1,122
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.77
    Marker Score: 7,292
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.76
    Marker Score: 7,114
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.73
    Marker Score: 918
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.72
    Marker Score: 552
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.72
    Marker Score: 384
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.71
    Marker Score: 649
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.71
    Marker Score: 764
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.71
    Marker Score: 6,089
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.7
    Marker Score: 281
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2,858
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.68
    Marker Score: 24,932
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.67
    Marker Score: 712
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 168
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.65
    Marker Score: 2,526
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.64
    Marker Score: 723
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.64
    Marker Score: 6,422
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.64
    Marker Score: 1,084
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.64
    Marker Score: 267
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.62
    Marker Score: 1,696
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.62
    Marker Score: 1,294
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.6
    Marker Score: 1,212
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.59
    Marker Score: 186
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.59
    Marker Score: 138
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.58
    Marker Score: 1,363
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.58
    Marker Score: 387
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.57
    Marker Score: 190
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.55
    Marker Score: 370
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.54
    Marker Score: 262
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 432
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.54
    Marker Score: 20,322
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.53
    Marker Score: 352
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.53
    Marker Score: 144
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.52
    Marker Score: 651
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.52
    Marker Score: 166
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.52
    Marker Score: 210
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.52
    Marker Score: 622
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.51
    Marker Score: 546
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.51
    Marker Score: 281
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.51
    Marker Score: 7,554
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.5
    Marker Score: 9,915
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.49
    Marker Score: 460
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.49
    Marker Score: 156
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.48
    Marker Score: 2,004
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.47
    Marker Score: 3,603
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.46
    Marker Score: 429
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.44
    Marker Score: 645
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.43
    Marker Score: 115
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.43
    Marker Score: 1,016
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.43
    Marker Score: 125
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.43
    Marker Score: 524
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.42
    Marker Score: 389
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.42
    Marker Score: 398
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.42
    Marker Score: 2,735
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.41
    Marker Score: 1,612
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.41
    Marker Score: 231
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.39
    Marker Score: 1,701
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.39
    Marker Score: 138
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.39
    Marker Score: 77
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.38
    Marker Score: 387
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.38
    Marker Score: 213
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.38
    Marker Score: 8,012
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.37
    Marker Score: 749
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.37
    Marker Score: 1,380
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.37
    Marker Score: 590
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.37
    Marker Score: 104
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.37
    Marker Score: 116
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.37
    Marker Score: 834
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.37
    Marker Score: 4,827
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.36
    Marker Score: 352
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.36
    Marker Score: 241
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.36
    Marker Score: 559
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.36
    Marker Score: 219
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.36
    Marker Score: 83
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.36
    Marker Score: 170
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.36
    Marker Score: 634
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.36
    Marker Score: 242
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.35
    Marker Score: 373
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.35
    Marker Score: 85
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.35
    Marker Score: 1,632
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.35
    Marker Score: 123
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.35
    Marker Score: 87
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.35
    Marker Score: 2,591
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.34
    Marker Score: 230
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.34
    Marker Score: 86
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.34
    Marker Score: 136

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ENTREP3 is a transmembrane protein that interacts with epsin proteins, which are involved in endosomal trafficking and membrane sculpting. The gene has been identified in various cell types, including those of the immune system, nervous system, and epithelial tissues. ENTREP3's expression is tightly regulated, and its dysregulation may contribute to various pathological conditions. **Pathways and Functions:** ENTREP3 is implicated in several cellular pathways, including: 1. **Endosomal trafficking:** ENTREP3 interacts with epsin proteins to regulate endosomal dynamics, influencing the sorting and degradation of proteins and lipids. 2. **Membrane sculpting:** ENTREP3 contributes to the formation and maintenance of cellular membranes, particularly in epithelial cells. 3. **Cell signaling:** ENTREP3 may modulate signaling pathways, including those involved in cell proliferation, differentiation, and survival. 4. **Immune responses:** ENTREP3's expression in immune cells suggests its involvement in immune regulation and response. **Clinical Significance:** The dysregulation of ENTREP3 has been implicated in various diseases, including: 1. **Cancer:** ENTREP3's overexpression has been linked to cancer progression and metastasis in certain types of tumors. 2. **Neurological disorders:** ENTREP3's involvement in neuronal development and function suggests its potential role in neurodegenerative diseases, such as Alzheimer's and Parkinson's. 3. **Gastrointestinal disorders:** ENTREP3's expression in intestinal epithelial cells implies its involvement in gastrointestinal diseases, such as inflammatory bowel disease. In conclusion, ENTREP3 is a multifunctional gene that plays a critical role in cellular homeostasis and tissue maintenance. Further research is necessary to elucidate the mechanisms underlying ENTREP3's functions and to explore its potential as a therapeutic target for various diseases. **Recommendations:** 1. **Investigate ENTREP3's role in disease states:** Further studies are needed to determine ENTREP3's involvement in specific diseases and to explore its potential as a biomarker or therapeutic target. 2. **Elucidate ENTREP3's mechanisms:** Research should focus on understanding ENTREP3's interactions with other proteins and its involvement in cellular pathways. 3. **Develop ENTREP3-based therapies:** ENTREP3's dysregulation in various diseases suggests its potential as a therapeutic target. Developing targeted therapies may provide new treatment options for patients. By continuing to investigate ENTREP3, researchers can uncover the full extent of its functions and explore its potential applications in human disease.

Genular Protein ID: 3659981625

Symbol: EREP3_HUMAN

Name: N/A

UniProtKB Accession Codes:

P81408 B1AVS5 Q8IXL3 Q9BR66

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 6 ExpressionAtlas 1 GO 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 RefSeq 4 SAM 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9331372

Title: Identification of three additional genes contiguous to the glucocerebrosidase locus on chromosome 1q21: implications for Gaucher disease.

PubMed ID: 9331372

DOI: 10.1101/gr.7.10.1020

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15064722

Title: WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins.

PubMed ID: 15064722

DOI: 10.1038/sj.onc.1207680

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 668
  • Mass: 71355
  • Checksum: E22EED90923826BD
  • Sequence:
    • MMPSPSDSSR SLTSRPSTRG LTHLRLHRPW LQALLTLGLV QVLLGILVVT FSMVASSVTT 
TESIKRSCPS WAGFSLAFSG VVGIVSWKRP FTLVISFFSL LSVLCVMLSM AGSVLSCKNA 
QLARDFQQCS LEGKVCVCCP SVPLLRPCPE SGQELKVAPN STCDEARGAL KNLLFSVCGL 
TICAAIICTL SAIVCCIQIF SLDLVHTLAP ERSVSGPLGP LGCTSPPPAP LLHTMLDLEE 
FVPPVPPPPY YPPEYTCSSE TDAQSITYNG SMDSPVPLYP TDCPPSYEAV MGLRGDSQAT 
LFDPQLHDGS CICERVASIV DVSMDSGSLV LSAIGDLPGG SSPSEDSCLL ELQGSVRSVD 
YVLFRSIQRS RAGYCLSLDC GLRGPFEESP LPRRPPRAAR SYSCSAPEAP PPLGAPTAAR 
SCHRLEGWPP WVGPCFPELR RRVPRGGGRP AAAPPTRAPT RRFSDSSGSL TPPGHRPPHP 
ASPPPLLLPR SHSDPGITTS SDTADFRDLY TKVLEEEAAS VSSADTGLCS EACLFRLARC 
PSPKLLRARS AEKRRPVPTF QKVPLPSGPA PAHSLGDLKG SWPGRGLVTR FLQISRKAPD 
PSGTGAHGHK QVPRSLWGRP GRESLHLRSC GDLSSSSSLR RLLSGRRLER GTRPHSLSLN 
GGSRETGL

Genular Protein ID: 937842184

Symbol: Q9Y6J7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9Y6J7

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 1 GenomeRNAi 1 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 RefSeq 1 SAM 1

Citations:

PubMed ID: 8619474

Title: A "double adaptor" method for improved shotgun library construction.

PubMed ID: 8619474

DOI: 10.1006/abio.1996.0138

PubMed ID: 9110174

Title: Large-scale concatenation cDNA sequencing.

PubMed ID: 9110174

Sequence Information:

  • Length: 342
  • Mass: 35794
  • Checksum: 94374C3D36A3A6C5
  • Sequence:
    • HDGSCICERV ASIVDVSMDS GSLVLSAIGD LPGGSSPSED SCLLELQGSV RSVDYVLFRS 
IQRSRAGYCL SLDCGLRGPF EESPLPRRPP RAARSYSCSA PEAPPPLGAP TAARSCHRLE 
GWPPWVGPCF SDSSGSLTPP GHRPPHPASP PPLLLPRSHS DPGITTSSDT ADFRDLYTKV 
LEEEAASVSS ADTGLCSEAC LFRLARCPSP KLLRARSAEK RRPVPTFQKV PLPSGPAPAH 
SLGDLKGSWP GRGLVTRFLQ ISRKAPDPSG TGAHGHKQVP RSLWGRPGRE SLHLRSCGDL 
SSSSSCGVSC LAAGWSVVPA PTASASTGAA GRLGSDLGFL SH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.