POLD3 | ENSG00000077514 | NCBI 10714

Details for: POLD3

Gene ID: 10714

Symbol: POLD3

Ensembl ID: ENSG00000077514

Description: DNA polymerase delta 3, accessory subunit

Associated with

Base excision repair
(R-HSA-73884)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Chromosome maintenance
(R-HSA-73886)
Dna damage bypass
(R-HSA-73893)
Dna double-strand break repair
(R-HSA-5693532)
Dna repair
(R-HSA-73894)
Dna replication
(R-HSA-69306)
Dna strand elongation
(R-HSA-69190)
Dual incision in gg-ner
(R-HSA-5696400)
Dual incision in tc-ner
(R-HSA-6782135)
Extension of telomeres
(R-HSA-180786)
Gap-filling dna repair synthesis and ligation in gg-ner
(R-HSA-5696397)
Gap-filling dna repair synthesis and ligation in tc-ner
(R-HSA-6782210)
Global genome nucleotide excision repair (gg-ner)
(R-HSA-5696399)
Hdr through homologous recombination (hrr)
(R-HSA-5685942)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-HSA-5693567)
Homology directed repair
(R-HSA-5693538)
Lagging strand synthesis
(R-HSA-69186)
Leading strand synthesis
(R-HSA-69109)
Mismatch repair (mmr) directed by msh2:msh3 (mutsbeta)
(R-HSA-5358606)
Mismatch repair (mmr) directed by msh2:msh6 (mutsalpha)
(R-HSA-5358565)
Nucleotide excision repair
(R-HSA-5696398)
Pcna-dependent long patch base excision repair
(R-HSA-5651801)
Polymerase switching
(R-HSA-69091)
Polymerase switching on the c-strand of the telomere
(R-HSA-174411)
Processive synthesis on the c-strand of the telomere
(R-HSA-174414)
Processive synthesis on the lagging strand
(R-HSA-69183)
Recognition of dna damage by pcna-containing replication complex
(R-HSA-110314)
Removal of the flap intermediate
(R-HSA-69166)
Removal of the flap intermediate from the c-strand
(R-HSA-174437)
Resolution of abasic sites (ap sites)
(R-HSA-73933)
Resolution of ap sites via the multiple-nucleotide patch replacement pathway
(R-HSA-110373)
S phase
(R-HSA-69242)
Synthesis of dna
(R-HSA-69239)
Telomere c-strand (lagging strand) synthesis
(R-HSA-174417)
Telomere maintenance
(R-HSA-157579)
Termination of translesion dna synthesis
(R-HSA-5656169)
Transcription-coupled nucleotide excision repair (tc-ner)
(R-HSA-6781827)
Translesion synthesis by y family dna polymerases bypasses lesions on dna template
(R-HSA-110313)
Cytoplasm
(GO:0005737)
Delta dna polymerase complex
(GO:0043625)
Dna-directed dna polymerase activity
(GO:0003887)
Dna-templated dna replication
(GO:0006261)
Dna biosynthetic process
(GO:0071897)
Dna strand elongation involved in dna replication
(GO:0006271)
Dna synthesis involved in dna repair
(GO:0000731)
Dna synthesis involved in uv-damage excision repair
(GO:1904161)
Error-prone translesion synthesis
(GO:0042276)
Mismatch repair
(GO:0006298)
Nucleoplasm
(GO:0005654)
Nucleotide-excision repair, dna gap filling
(GO:0006297)
Protein-macromolecule adaptor activity
(GO:0030674)
Protein binding
(GO:0005515)
Zeta dna polymerase complex
(GO:0016035)

Other Information

Proteins

DNA polymerase delta subunit 3

Genular Protein ID: 3090508855

Symbol: DPOD3_HUMAN

Name: DNA polymerase delta subunit 3

UniProtKB Accession Codes:

Q15054 B7ZAI6 Q32MZ9 Q32N00

Database IDs:

Citations:

PubMed ID: 7584026

Title: Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1.

PubMed ID: 7584026

DOI: 10.1093/dnares/1.1.27

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10219083

Title: Isolation and identification of the third subunit of mammalian DNA polymerase delta by PCNA-affinity chromatography of mouse FM3A cell extracts.

PubMed ID: 10219083

DOI: 10.1093/nar/27.10.2108

PubMed ID: 10852724

Title: Evidence that DNA polymerase delta isolated by immunoaffinity chromatography exhibits high-molecular weight characteristics and is associated with the KIAA0039 protein and RPA.

PubMed ID: 10852724

DOI: 10.1021/bi0000871

PubMed ID: 11328591

Title: The human homologue of fission Yeast cdc27, p66, is a component of active human DNA polymerase delta.

PubMed ID: 11328591

DOI: 10.1093/oxfordjournals.jbchem.a002909

PubMed ID: 11595739

Title: Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like PCNA-binding motif present in the third subunit of human DNA polymerase delta.

PubMed ID: 11595739

DOI: 10.1074/jbc.m106990200

PubMed ID: 12403614

Title: Reconstitution and characterization of the human DNA polymerase delta four-subunit holoenzyme.

PubMed ID: 12403614

DOI: 10.1021/bi0262707

PubMed ID: 12522211

Title: Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen.

PubMed ID: 12522211

DOI: 10.1074/jbc.m208694200

PubMed ID: 16934752

Title: The p66 and p12 subunits of DNA polymerase delta are modified by ubiquitin and ubiquitin-like proteins.

PubMed ID: 16934752

DOI: 10.1016/j.bbrc.2006.08.049

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16510448

Title: Functional roles of p12, the fourth subunit of human DNA polymerase delta.

PubMed ID: 16510448

DOI: 10.1074/jbc.m600322200

PubMed ID: 17317665

Title: A novel DNA damage response: rapid degradation of the p12 subunit of dna polymerase delta.

PubMed ID: 17317665

DOI: 10.1074/jbc.m610356200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19074196

Title: DNA damage alters DNA polymerase delta to a form that exhibits increased discrimination against modified template bases and mismatched primers.

PubMed ID: 19074196

DOI: 10.1093/nar/gkn1000

PubMed ID: 20334433

Title: The p12 subunit of human polymerase delta modulates the rate and fidelity of DNA synthesis.

PubMed ID: 20334433

DOI: 10.1021/bi100042b

PubMed ID: 20227374

Title: Three DNA polymerases, recruited by different mechanisms, carry out NER repair synthesis in human cells.

PubMed ID: 20227374

DOI: 10.1016/j.molcel.2010.02.009

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22148433

Title: Phosphorylation of the p68 subunit of Pol delta acts as a molecular switch to regulate its interaction with PCNA.

PubMed ID: 22148433

DOI: 10.1021/bi201638e

PubMed ID: 22801543

Title: Spatiotemporal recruitment of human DNA polymerase delta to sites of UV damage.

PubMed ID: 22801543

DOI: 10.4161/cc.21280

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 24035200

Title: Dynamics of enzymatic interactions during short flap human Okazaki fragment processing by two forms of human DNA polymerase delta.

PubMed ID: 24035200

DOI: 10.1016/j.dnarep.2013.08.008

PubMed ID: 23913683

Title: A novel function of CRL4(Cdt2): regulation of the subunit structure of DNA polymerase delta in response to DNA damage and during the S phase.

PubMed ID: 23913683

DOI: 10.1074/jbc.m113.490466

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 24449906

Title: Human Pol zeta purified with accessory subunits is active in translesion DNA synthesis and complements Pol eta in cisplatin bypass.

PubMed ID: 24449906

DOI: 10.1073/pnas.1324001111

PubMed ID: 24310611

Title: Break-induced replication repair of damaged forks induces genomic duplications in human cells.

PubMed ID: 24310611

DOI: 10.1126/science.1243211

PubMed ID: 25628356

Title: The POLD3 subunit of DNA polymerase delta can promote translesion synthesis independently of DNA polymerase zeta.

PubMed ID: 25628356

DOI: 10.1093/nar/gkv023

PubMed ID: 27185888

Title: In vivo evidence for translesion synthesis by the replicative DNA polymerase delta.

PubMed ID: 27185888

DOI: 10.1093/nar/gkw439

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 18818516

Title: X-ray structure of the complex of regulatory subunits of human DNA polymerase delta.

PubMed ID: 18818516

DOI: 10.4161/cc.7.19.6720

PubMed ID: 21248752

Title: Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.

PubMed ID: 21248752

DOI: 10.1038/nature09639

Sequence Information:

Length: 466
Mass: 51400
Checksum: E9625E0188725F45
Sequence:

MADQLYLENI DEFVTDQNKI VTYKWLSYTL GVHVNQAKQM LYDYVERKRK ENSGAQLHVT 
YLVSGSLIQN GHSCHKVAVV REDKLEAVKS KLAVTASIHV YSIQKAMLKD SGPLFNTDYD 
ILKSNLQNCS KFSAIQCAAA VPRAPAESSS SSKKFEQSHL HMSSETQANN ELTTNGHGPP 
ASKQVSQQPK GIMGMFASKA AAKTQETNKE TKTEAKEVTN ASAAGNKAPG KGNMMSNFFG 
KAAMNKFKVN LDSEQAVKEE KIVEQPTVSV TEPKLATPAG LKKSSKKAEP VKVLQKEKKR 
GKRVALSDDE TKETENMRKK RRRIKLPESD SSEDEVFPDS PGAYEAESPS PPPPPSPPLE 
PVPKTEPEPP SVKSSSGENK RKRKRVLKSK TYLDGEGCIV TEKVYESESC TDSEEELNMK 
TSSVHRPPAM TVKKEPREER KGPKKGTAAL GKANRQVSIT GFFQRK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: POLD3

Associated with

Other Information

Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. PubMed ID: 7584026

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Human chromosome 11 DNA sequence and analysis including novel gene identification. PubMed ID: 16554811

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Isolation and identification of the third subunit of mammalian DNA polymerase delta by PCNA-affinity chromatography of mouse FM3A cell extracts. PubMed ID: 10219083

Evidence that DNA polymerase delta isolated by immunoaffinity chromatography exhibits high-molecular weight characteristics and is associated with the KIAA0039 protein and RPA. PubMed ID: 10852724

The human homologue of fission Yeast cdc27, p66, is a component of active human DNA polymerase delta. PubMed ID: 11328591

Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like PCNA-binding motif present in the third subunit of human DNA polymerase delta. PubMed ID: 11595739

Reconstitution and characterization of the human DNA polymerase delta four-subunit holoenzyme. PubMed ID: 12403614

Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen. PubMed ID: 12522211

The p66 and p12 subunits of DNA polymerase delta are modified by ubiquitin and ubiquitin-like proteins. PubMed ID: 16934752

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

Functional roles of p12, the fourth subunit of human DNA polymerase delta. PubMed ID: 16510448

A novel DNA damage response: rapid degradation of the p12 subunit of dna polymerase delta. PubMed ID: 17317665

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

DNA damage alters DNA polymerase delta to a form that exhibits increased discrimination against modified template bases and mismatched primers. PubMed ID: 19074196

The p12 subunit of human polymerase delta modulates the rate and fidelity of DNA synthesis. PubMed ID: 20334433

Three DNA polymerases, recruited by different mechanisms, carry out NER repair synthesis in human cells. PubMed ID: 20227374

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Phosphorylation of the p68 subunit of Pol delta acts as a molecular switch to regulate its interaction with PCNA. PubMed ID: 22148433

Spatiotemporal recruitment of human DNA polymerase delta to sites of UV damage. PubMed ID: 22801543

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

Dynamics of enzymatic interactions during short flap human Okazaki fragment processing by two forms of human DNA polymerase delta. PubMed ID: 24035200

A novel function of CRL4(Cdt2): regulation of the subunit structure of DNA polymerase delta in response to DNA damage and during the S phase. PubMed ID: 23913683

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Uncovering global SUMOylation signaling networks in a site-specific manner. PubMed ID: 25218447

Human Pol zeta purified with accessory subunits is active in translesion DNA synthesis and complements Pol eta in cisplatin bypass. PubMed ID: 24449906

Break-induced replication repair of damaged forks induces genomic duplications in human cells. PubMed ID: 24310611

The POLD3 subunit of DNA polymerase delta can promote translesion synthesis independently of DNA polymerase zeta. PubMed ID: 25628356

In vivo evidence for translesion synthesis by the replicative DNA polymerase delta. PubMed ID: 27185888

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

X-ray structure of the complex of regulatory subunits of human DNA polymerase delta. PubMed ID: 18818516

Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. PubMed ID: 21248752