Details for: POLD3

Gene ID: 10714

Symbol: POLD3

Ensembl ID: ENSG00000077514

Description: DNA polymerase delta 3, accessory subunit

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.12
    Marker Score: 3,702
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.88
    Marker Score: 1,728
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.45
    Marker Score: 3,415
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.33
    Marker Score: 5,140
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.33
    Marker Score: 12,597
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.31
    Marker Score: 80,555
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.27
    Marker Score: 10,881
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.26
    Marker Score: 1,943
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.17
    Marker Score: 933
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.15
    Marker Score: 10,826
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.1
    Marker Score: 40,397
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.08
    Marker Score: 2,947
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.08
    Marker Score: 11,149
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.06
    Marker Score: 333
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.04
    Marker Score: 4,331
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.03
    Marker Score: 333
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.02
    Marker Score: 16,018
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.01
    Marker Score: 1,449
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,732
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,956
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.99
    Marker Score: 3,407
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,396
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.96
    Marker Score: 1,199
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,402
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.94
    Marker Score: 704
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.94
    Marker Score: 3,879
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 482
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.93
    Marker Score: 1,894
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 437
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.92
    Marker Score: 13,802
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5,251
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.92
    Marker Score: 3,542
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.91
    Marker Score: 7,942
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.91
    Marker Score: 34,558
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,713
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.87
    Marker Score: 17,391
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,295
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.87
    Marker Score: 3,556
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.83
    Marker Score: 17,647
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.81
    Marker Score: 1,545
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.79
    Marker Score: 747
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,264
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 592
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.77
    Marker Score: 563
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.77
    Marker Score: 4,605
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.77
    Marker Score: 307
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.76
    Marker Score: 5,790
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.73
    Marker Score: 457
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.73
    Marker Score: 3,045
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.72
    Marker Score: 246
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 374
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.71
    Marker Score: 336
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.7
    Marker Score: 206
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.7
    Marker Score: 694
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.69
    Marker Score: 199
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.69
    Marker Score: 253
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.68
    Marker Score: 1,548
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.68
    Marker Score: 618
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.67
    Marker Score: 332
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.67
    Marker Score: 719
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.67
    Marker Score: 533
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.66
    Marker Score: 664
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.65
    Marker Score: 270
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.64
    Marker Score: 695
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.64
    Marker Score: 2,288
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.64
    Marker Score: 1,835
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.64
    Marker Score: 679
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.64
    Marker Score: 359
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.64
    Marker Score: 383
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.62
    Marker Score: 689
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.62
    Marker Score: 15,971
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.62
    Marker Score: 1,050
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.62
    Marker Score: 535
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.61
    Marker Score: 409
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.61
    Marker Score: 813
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.61
    Marker Score: 631
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6
    Marker Score: 20,778
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.6
    Marker Score: 167
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.59
    Marker Score: 1,240
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.59
    Marker Score: 280
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.58
    Marker Score: 1,389
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.58
    Marker Score: 1,574
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.58
    Marker Score: 1,710
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.58
    Marker Score: 2,264
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.57
    Marker Score: 740
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.57
    Marker Score: 148
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.57
    Marker Score: 171
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.56
    Marker Score: 255
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.56
    Marker Score: 642
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.55
    Marker Score: 1,309
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.54
    Marker Score: 250
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 433
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.54
    Marker Score: 143
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.53
    Marker Score: 197
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.53
    Marker Score: 847
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.53
    Marker Score: 339
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.53
    Marker Score: 1,300
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.53
    Marker Score: 106

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Accessory subunit**: POLD3 is a non-catalytic subunit of DNA polymerase delta, which is responsible for the processive synthesis of DNA on the lagging strand. 2. **DNA replication**: POLD3 is essential for the replication of DNA, particularly during the lagging strand synthesis, where it facilitates the processive elongation of DNA. 3. **Error-prone translesion synthesis**: POLD3 is involved in error-prone translesion synthesis, a mechanism that allows DNA polymerase delta to bypass DNA lesions and maintain genome integrity. 4. **DNA damage repair**: POLD3 plays a role in the repair of DNA damage, including base excision repair, nucleotide excision repair, and homologous recombination. **Pathways and Functions:** 1. **DNA replication**: POLD3 is involved in the replication of DNA, particularly on the lagging strand, where it facilitates processive synthesis. 2. **Error-prone translesion synthesis**: POLD3 is responsible for error-prone translesion synthesis, allowing DNA polymerase delta to bypass DNA lesions and maintain genome integrity. 3. **DNA damage repair**: POLD3 plays a role in the repair of DNA damage, including base excision repair, nucleotide excision repair, and homologous recombination. 4. **Telomere maintenance**: POLD3 is involved in the maintenance of telomeres, particularly on the lagging strand, where it facilitates processive synthesis. 5. **Chromatin maintenance**: POLD3 is involved in the maintenance of chromatin structure and function, particularly during the replication of DNA. **Clinical Significance:** 1. **Cancer**: Dysregulation of POLD3 has been implicated in various cancers, including breast, lung, and colon cancer, where it contributes to genome instability and tumorigenesis. 2. **Genetic disorders**: Mutations in POLD3 have been associated with genetic disorders, such as Fanconi anemia, a rare genetic disorder characterized by bone marrow failure and increased risk of cancer. 3. **Neurological disorders**: POLD3 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it contributes to genome instability and neurodegeneration. 4. **Aging**: POLD3 is involved in the aging process, where it contributes to telomere shortening and genome instability, leading to aging-related diseases. In conclusion, POLD3 is a crucial accessory subunit of DNA polymerase delta, playing a pivotal role in DNA replication, repair, and maintenance. Its dysregulation has been implicated in various human diseases, including cancer, genetic disorders, and neurological disorders. Further research is needed to fully elucidate the mechanisms by which POLD3 contributes to human diseases and to develop therapeutic strategies targeting this enzyme. **Recommendations:** 1. **Further research**: Conduct further research to elucidate the mechanisms by which POLD3 contributes to human diseases. 2. **Therapeutic strategies**: Develop therapeutic strategies targeting POLD3, such as small molecule inhibitors or RNA interference, to prevent or treat diseases associated with POLD3 dysregulation. 3. **Cancer therapy**: Investigate the use of POLD3 inhibitors as a potential therapeutic strategy for cancer treatment. 4. **Genetic disorders**: Investigate the use of POLD3 inhibitors as a potential therapeutic strategy for genetic disorders associated with POLD3 mutations.

Genular Protein ID: 3090508855

Symbol: DPOD3_HUMAN

Name: DNA polymerase delta subunit 3

UniProtKB Accession Codes:

Q15054 B7ZAI6 Q32MZ9 Q32N00

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 8 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 8 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 17 RefSeq 1 SAM 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7584026

Title: Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1.

PubMed ID: 7584026

DOI: 10.1093/dnares/1.1.27

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10219083

Title: Isolation and identification of the third subunit of mammalian DNA polymerase delta by PCNA-affinity chromatography of mouse FM3A cell extracts.

PubMed ID: 10219083

DOI: 10.1093/nar/27.10.2108

PubMed ID: 10852724

Title: Evidence that DNA polymerase delta isolated by immunoaffinity chromatography exhibits high-molecular weight characteristics and is associated with the KIAA0039 protein and RPA.

PubMed ID: 10852724

DOI: 10.1021/bi0000871

PubMed ID: 11328591

Title: The human homologue of fission Yeast cdc27, p66, is a component of active human DNA polymerase delta.

PubMed ID: 11328591

DOI: 10.1093/oxfordjournals.jbchem.a002909

PubMed ID: 11595739

Title: Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like PCNA-binding motif present in the third subunit of human DNA polymerase delta.

PubMed ID: 11595739

DOI: 10.1074/jbc.m106990200

PubMed ID: 12403614

Title: Reconstitution and characterization of the human DNA polymerase delta four-subunit holoenzyme.

PubMed ID: 12403614

DOI: 10.1021/bi0262707

PubMed ID: 12522211

Title: Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen.

PubMed ID: 12522211

DOI: 10.1074/jbc.m208694200

PubMed ID: 16934752

Title: The p66 and p12 subunits of DNA polymerase delta are modified by ubiquitin and ubiquitin-like proteins.

PubMed ID: 16934752

DOI: 10.1016/j.bbrc.2006.08.049

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16510448

Title: Functional roles of p12, the fourth subunit of human DNA polymerase delta.

PubMed ID: 16510448

DOI: 10.1074/jbc.m600322200

PubMed ID: 17317665

Title: A novel DNA damage response: rapid degradation of the p12 subunit of dna polymerase delta.

PubMed ID: 17317665

DOI: 10.1074/jbc.m610356200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19074196

Title: DNA damage alters DNA polymerase delta to a form that exhibits increased discrimination against modified template bases and mismatched primers.

PubMed ID: 19074196

DOI: 10.1093/nar/gkn1000

PubMed ID: 20334433

Title: The p12 subunit of human polymerase delta modulates the rate and fidelity of DNA synthesis.

PubMed ID: 20334433

DOI: 10.1021/bi100042b

PubMed ID: 20227374

Title: Three DNA polymerases, recruited by different mechanisms, carry out NER repair synthesis in human cells.

PubMed ID: 20227374

DOI: 10.1016/j.molcel.2010.02.009

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22148433

Title: Phosphorylation of the p68 subunit of Pol delta acts as a molecular switch to regulate its interaction with PCNA.

PubMed ID: 22148433

DOI: 10.1021/bi201638e

PubMed ID: 22801543

Title: Spatiotemporal recruitment of human DNA polymerase delta to sites of UV damage.

PubMed ID: 22801543

DOI: 10.4161/cc.21280

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 24035200

Title: Dynamics of enzymatic interactions during short flap human Okazaki fragment processing by two forms of human DNA polymerase delta.

PubMed ID: 24035200

DOI: 10.1016/j.dnarep.2013.08.008

PubMed ID: 23913683

Title: A novel function of CRL4(Cdt2): regulation of the subunit structure of DNA polymerase delta in response to DNA damage and during the S phase.

PubMed ID: 23913683

DOI: 10.1074/jbc.m113.490466

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 24449906

Title: Human Pol zeta purified with accessory subunits is active in translesion DNA synthesis and complements Pol eta in cisplatin bypass.

PubMed ID: 24449906

DOI: 10.1073/pnas.1324001111

PubMed ID: 24310611

Title: Break-induced replication repair of damaged forks induces genomic duplications in human cells.

PubMed ID: 24310611

DOI: 10.1126/science.1243211

PubMed ID: 25628356

Title: The POLD3 subunit of DNA polymerase delta can promote translesion synthesis independently of DNA polymerase zeta.

PubMed ID: 25628356

DOI: 10.1093/nar/gkv023

PubMed ID: 27185888

Title: In vivo evidence for translesion synthesis by the replicative DNA polymerase delta.

PubMed ID: 27185888

DOI: 10.1093/nar/gkw439

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 18818516

Title: X-ray structure of the complex of regulatory subunits of human DNA polymerase delta.

PubMed ID: 18818516

DOI: 10.4161/cc.7.19.6720

PubMed ID: 21248752

Title: Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.

PubMed ID: 21248752

DOI: 10.1038/nature09639

Sequence Information:

  • Length: 466
  • Mass: 51400
  • Checksum: E9625E0188725F45
  • Sequence:
    • MADQLYLENI DEFVTDQNKI VTYKWLSYTL GVHVNQAKQM LYDYVERKRK ENSGAQLHVT 
YLVSGSLIQN GHSCHKVAVV REDKLEAVKS KLAVTASIHV YSIQKAMLKD SGPLFNTDYD 
ILKSNLQNCS KFSAIQCAAA VPRAPAESSS SSKKFEQSHL HMSSETQANN ELTTNGHGPP 
ASKQVSQQPK GIMGMFASKA AAKTQETNKE TKTEAKEVTN ASAAGNKAPG KGNMMSNFFG 
KAAMNKFKVN LDSEQAVKEE KIVEQPTVSV TEPKLATPAG LKKSSKKAEP VKVLQKEKKR 
GKRVALSDDE TKETENMRKK RRRIKLPESD SSEDEVFPDS PGAYEAESPS PPPPPSPPLE 
PVPKTEPEPP SVKSSSGENK RKRKRVLKSK TYLDGEGCIV TEKVYESESC TDSEEELNMK 
TSSVHRPPAM TVKKEPREER KGPKKGTAAL GKANRQVSIT GFFQRK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.