Details for: CERS1

Gene ID: 10715

Symbol: CERS1

Ensembl ID: ENSG00000223802

Description: ceramide synthase 1

Associated with

Other Information

Genular Protein ID: 3878381393

Symbol: CERS1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2034669

Title: Expression of growth/differentiation factor 1 in the nervous system: conservation of a bicistronic structure.

PubMed ID: 2034669

DOI: 10.1073/pnas.88.10.4250

PubMed ID: 9872981

Title: Homologs of the yeast longevity gene LAG1 in Caenorhabditis elegans and human.

PubMed ID: 9872981

DOI: 10.1101/gr.8.12.1259

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17977534

Title: Kinetic characterization of mammalian ceramide synthases: determination of K(m) values towards sphinganine.

PubMed ID: 17977534

DOI: 10.1016/j.febslet.2007.10.018

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22922758

Title: Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy.

PubMed ID: 22922758

DOI: 10.1038/nchembio.1059

PubMed ID: 23530041

Title: Myristate-derived d16:0 sphingolipids constitute a cardiac sphingolipid pool with distinct synthetic routes and functional properties.

PubMed ID: 23530041

DOI: 10.1074/jbc.m112.428185

PubMed ID: 24782409

Title: Impairment of ceramide synthesis causes a novel progressive myoclonus epilepsy.

PubMed ID: 24782409

DOI: 10.1002/ana.24170

PubMed ID: 26887952

Title: Enzyme activities of the ceramide synthases CERS2-6 are regulated by phosphorylation in the C-terminal region.

PubMed ID: 26887952

DOI: 10.1074/jbc.m115.695858

PubMed ID: 31916624

Title: Biosynthesis of the anti-lipid-microdomain sphingoid base 4,14-sphingadiene by the ceramide desaturase FADS3.

PubMed ID: 31916624

DOI: 10.1096/fj.201902645r

PubMed ID: 33798445

Title: Progressive myoclonus epilepsies-Residual unsolved cases have marked genetic heterogeneity including dolichol-dependent protein glycosylation pathway genes.

PubMed ID: 33798445

DOI: 10.1016/j.ajhg.2021.03.013

Sequence Information:

  • Length: 350
  • Mass: 39536
  • Checksum: F102C12C47DB4162
  • Sequence:
  • MAAAGPAAGP TGPEPMPSYA QLVQRGWGSA LAAARGCTDC GWGLARRGLA EHAHLAPPEL 
    LLLALGALGW TALRSAATAR LFRPLAKRCC LQPRDAAKMP ESAWKFLFYL GSWSYSAYLL 
    FGTDYPFFHD PPSVFYDWTP GMAVPRDIAA AYLLQGSFYG HSIYATLYMD TWRKDSVVML 
    LHHVVTLILI VSSYAFRYHN VGILVLFLHD ISDVQLEFTK LNIYFKSRGG SYHRLHALAA 
    DLGCLSFGFS WFWFRLYWFP LKVLYATSHC SLRTVPDIPF YFFFNALLLL LTLMNLYWFL 
    YIVAFAAKVL TGQVHELKDL REYDTAEAQS LKPSKAEKPL RNGLVKDKRF

Genular Protein ID: 3417555665

Symbol: Q5XG75_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

Sequence Information:

  • Length: 239
  • Mass: 27902
  • Checksum: F6E9DE576D57E657
  • Sequence:
  • MPESAWKFLF YLGSWSYSAY LLFGTDYPFF HDPPSVFYDW TPGMAVPRDI AAAYLLQGSF 
    YGHSIYATLY MDTWRKDSVV MLLHHVVTLI LIVSSYAFRY HNVGILVLFL HDISDVQLEF 
    TKLNIYFKSR GGSYHRLHAL AADLGCLSFG FSWFWFRLYW FPLKVLYATS HCSLRTVPDI 
    PFYFFFNALL LLLTLMNLYW FLYIVAFAAK VLTGQVHELK DLREYDTAEA QSLKPSKAE

Genular Protein ID: 2516263714

Symbol: B4DE47_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 239
  • Mass: 27842
  • Checksum: B7476E16C786ED57
  • Sequence:
  • MPESAWKFLF YLGSWSYSAY LLFGTDCPFF HDPPSVFYDW TPGMAVPRDI AAAYLLQGSF 
    YGHSIYATLY MDTWRKDSVV MLLHHVVTLI LIVSSYAFRY HNVGILVLFL HDISDVQLEF 
    TKLNIYFKSR GGSYHRLHAL AADLGCLSFG FSWFWFRLYW FPLKVLYATS HCSLRTVPDI 
    PFYFFFNALL LLLTLMNLYW FLYIVAFAAK VLTGQVHELK DLREYDTAEA QSLKPSKAE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.