Details for: NRG3

Gene ID: 10718

Symbol: NRG3

Ensembl ID: ENSG00000185737

Description: neuregulin 3

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granule cell (CL0000120)
    Fold Change: 9.94
    Marker Score: 74,974
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 9.25
    Marker Score: 48,525
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 8.78
    Marker Score: 28,780
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 8.3
    Marker Score: 19,070
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 7.71
    Marker Score: 5,074
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 7.46
    Marker Score: 40,056
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 6
    Marker Score: 202,812
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 5.13
    Marker Score: 17,208
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 4.93
    Marker Score: 22,791
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 4.64
    Marker Score: 3,274
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 3.77
    Marker Score: 3,265
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.74
    Marker Score: 6,806
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 3.74
    Marker Score: 2,094
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 3.64
    Marker Score: 1,104
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 3.42
    Marker Score: 1,986
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 3.28
    Marker Score: 69,905
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 3.27
    Marker Score: 1,037
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 3.21
    Marker Score: 2,777
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 3.2
    Marker Score: 9,131
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 3.18
    Marker Score: 5,336
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 3.17
    Marker Score: 13,261
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 3.03
    Marker Score: 1,164
  • Cell Name: glial cell (CL0000125)
    Fold Change: 3.02
    Marker Score: 3,326
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.92
    Marker Score: 58,147
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.88
    Marker Score: 22,081
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.86
    Marker Score: 42,820
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.75
    Marker Score: 104,400
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 2.72
    Marker Score: 1,309
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.68
    Marker Score: 784
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.62
    Marker Score: 10,864
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.61
    Marker Score: 1,092
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.54
    Marker Score: 2,928
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 2.46
    Marker Score: 838
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.46
    Marker Score: 90,695
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 2.41
    Marker Score: 2,975
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.38
    Marker Score: 1,418
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.36
    Marker Score: 9,143
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.2
    Marker Score: 20,664
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2.1
    Marker Score: 21,643
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 2.09
    Marker Score: 759
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.08
    Marker Score: 127,983
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 2.07
    Marker Score: 2,578
  • Cell Name: neuron (CL0000540)
    Fold Change: 2.05
    Marker Score: 8,341
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.95
    Marker Score: 532
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.94
    Marker Score: 1,462
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.93
    Marker Score: 18,320
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.88
    Marker Score: 16,155
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.78
    Marker Score: 3,626
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.75
    Marker Score: 7,314
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.75
    Marker Score: 708
  • Cell Name: bipolar neuron (CL0000103)
    Fold Change: 1.68
    Marker Score: 565
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.66
    Marker Score: 2,557
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 1.63
    Marker Score: 481
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.61
    Marker Score: 967
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.6
    Marker Score: 996
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.54
    Marker Score: 3,374
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.54
    Marker Score: 1,657
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.5
    Marker Score: 1,378
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.46
    Marker Score: 824
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.44
    Marker Score: 164,981
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.37
    Marker Score: 937
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 868
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.36
    Marker Score: 493
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.34
    Marker Score: 3,155
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.32
    Marker Score: 1,862
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.26
    Marker Score: 394
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.19
    Marker Score: 18,547
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.16
    Marker Score: 6,986
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.16
    Marker Score: 1,401
  • Cell Name: dermis microvascular lymphatic vessel endothelial cell (CL2000041)
    Fold Change: 1.12
    Marker Score: 363
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.12
    Marker Score: 2,683
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.09
    Marker Score: 446
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.06
    Marker Score: 336
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 794
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,761
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,986
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.98
    Marker Score: 2,801
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.98
    Marker Score: 2,494
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,404
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.98
    Marker Score: 362
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.97
    Marker Score: 478
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,305
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.92
    Marker Score: 239
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.92
    Marker Score: 438
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.92
    Marker Score: 1,330
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,738
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.9
    Marker Score: 1,210
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.89
    Marker Score: 1,687
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.88
    Marker Score: 516
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,296
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.84
    Marker Score: 1,094
  • Cell Name: visceromotor neuron (CL0005025)
    Fold Change: 0.84
    Marker Score: 245
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.84
    Marker Score: 382
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.79
    Marker Score: 223
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,260
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.77
    Marker Score: 691
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 702
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.73
    Marker Score: 485
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.72
    Marker Score: 378

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Membrane-bound isoform:** NRG3 exists primarily as a membrane-bound isoform, which enables it to interact with cell surface receptors and modulate signaling pathways. 2. **Receptor tyrosine kinase (RTK) activator:** NRG3 acts as an activator of RTKs, including ErbB2, ErbB4, and others, which are involved in various signaling cascades. 3. **Diverse expression patterns:** NRG3 is expressed in a range of cell types, including granule cells, neurons, hepatoblasts, macroglial cells, and others, suggesting its broad functional implications. **Pathways and Functions:** 1. **Signaling by ErbB2 and ErbB4:** NRG3 interacts with ErbB2 and ErbB4, activating downstream signaling pathways, including PI3K/AKT, MAPK, and others. 2. **Regulation of cell growth and differentiation:** NRG3 modulates cell growth, differentiation, and survival by influencing the PI3K/AKT and MAPK signaling pathways. 3. **Inhibition of neuron migration:** NRG3 negatively regulates neuron migration, which is essential for proper neural development and function. 4. **Cancer-related functions:** NRG3 is involved in cancer progression, including the regulation of cell growth, survival, and metastasis, as well as the modulation of the PI3K/AKT signaling pathway. **Clinical Significance:** 1. **Immune-related disorders:** NRG3 may play a role in immune-related disorders, such as autoimmune diseases and cancer immunotherapy resistance. 2. **Cancer progression:** NRG3 is a potential therapeutic target for cancer treatment, particularly in cancers expressing ErbB2 and ErbB4. 3. **Neurological disorders:** NRG3 may contribute to neurological disorders, such as Alzheimer's disease and Parkinson's disease, by modulating neuronal signaling and migration. 4. **Neurodevelopmental disorders:** NRG3's role in neuronal development and migration suggests its potential involvement in neurodevelopmental disorders, such as autism and schizophrenia. In conclusion, NRG3 is a multifaceted protein with a wide range of biological activities, including immune regulation, cancer progression, and neural development. Further research is needed to fully elucidate its role in human diseases and to explore its potential as a therapeutic target.

Genular Protein ID: 3462348598

Symbol: NRG3_HUMAN

Name: Pro-neuregulin-3, membrane-bound isoform

UniProtKB Accession Codes:

P56975 A4D7U1 Q0PEH2 Q5VYH3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 3 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 17 RefSeq 3 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9275162

Title: Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4.

PubMed ID: 9275162

DOI: 10.1073/pnas.94.18.9562

PubMed ID: 16478787

Title: Characterization of a neural-specific splicing form of the human neuregulin 3 gene involved in oligodendrocyte survival.

PubMed ID: 16478787

DOI: 10.1242/jcs.02799

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 10867024

Title: Ligand discrimination in signaling through an ErbB4 receptor homodimer.

PubMed ID: 10867024

DOI: 10.1074/jbc.c901015199

Sequence Information:

  • Length: 720
  • Mass: 77901
  • Checksum: A4D6F10DDB95A693
  • Sequence:
    • MSEGAAAASP PGAASAAAAS AEEGTAAAAA AAAAGGGPDG GGEGAAEPPR ELRCSDCIVW 
NRQQTWLCVV PLFIGFIGLG LSLMLLKWIV VGSVKEYVPT DLVDSKGMGQ DPFFLSKPSS 
FPKAMETTTT TTSTTSPATP SAGGAASSRT PNRISTRLTT ITRAPTRFPG HRVPIRASPR 
STTARNTAAP ATVPSTTAPF FSSSTLGSRP PVPGTPSTQA MPSWPTAAYA TSSYLHDSTP 
SWTLSPFQDA ASSSSSSSSS ATTTTPETST SPKFHTTTYS TERSEHFKPC RDKDLAYCLN 
DGECFVIETL TGSHKHCRCK EGYQGVRCDQ FLPKTDSILS DPTDHLGIEF MESEEVYQRQ 
VLSISCIIFG IVIVGMFCAA FYFKSKKQAK QIQEQLKVPQ NGKSYSLKAS STMAKSENLV 
KSHVQLQNYS KVERHPVTAL EKMMESSFVG PQSFPEVPSP DRGSQSVKHH RSLSSCCSPG 
QRSGMLHRNA FRRTPPSPRS RLGGIVGPAY QQLEESRIPD QDTIPCQGIE VRKTISHLPI 
QLWCVERPLD LKYSSSGLKT QRNTSINMQL PSRETNPYFN SLEQKDLVGY SSTRASSVPI 
IPSVGLEETC LQMPGISEVK SIKWCKNSYS ADVVNVSIPV SDCLIAEQQE VKILLETVQE 
QIRILTDARR SEDYELASVE TEDSASENTA FLPLSPTAKS EREAQFVLRN EIQRDSALTK

Genular Protein ID: 2714766757

Symbol: B3KVG8_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KVG8

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 3 Genevisible 1 GenomeRNAi 1 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 PharmGKB 1 RefSeq 2 SAM 2

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 346
  • Mass: 38532
  • Checksum: 01D60CD0909BA391
  • Sequence:
    • MESEEVYQRQ VLSISCIIFG IVIVGMFCAA FYFKSKKQAK QIQEQLKVPQ NGKSYSLKAS 
STMAKSENLV KSHVQLQNYS KVERHPVTAL EKMIESSFVG PQSFPEVPSP DRGSQSVKHH 
RSLSSCCSPG QRSGMLHRNA FRRTPPSPRS RLGGIVGPAY QQLEESRIPN QDTIPCQGYS 
SSGLKTQRNT SINMQLPSRE TNPYFNSLEQ KDLVGYSSTR ASSVPIIPSV GLEETCLQMP 
GISEVKSIKW CKNSYSADVV NVSIPVSDCL IAEQQEVKIL LETVQEQIRI LTDARRSEDY 
ELASVETEDS ASENTAFLPL SPTAKSEREA QFVLRNEIQR DSALTK

Genular Protein ID: 880156629

Symbol: B9EGV5_HUMAN

Name: N/A

UniProtKB Accession Codes:

B9EGV5

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 4 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 PharmGKB 1 RefSeq 2 SAM 2 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 695
  • Mass: 74929
  • Checksum: D8BF4DBC39D8B801
  • Sequence:
    • MSEGAAAASP PGAASAAAAS AEEGTAAAAA AAAAGGGPDG GGEGAAEPPR ELRCSDCIVW 
NRQQTWLCVV PLFIGFIGLG LSLMLLKWIV VGSVKEYVPT DLVDSKGMGQ DPFFLSKPSS 
FPKAMETTTT TTSTTSPATP SAGGAASSRT PNRISTRLTT ITRAPTRFPG HRVPIRASPR 
STTARNTAAP ATVPSTTAPF FSSSTLGSRP PVPGTPSTQA MPSWPTAAYA TSSYLHDSTP 
SWTLSPFQDA ASSSSSSSSS ATTTTPETST SPKFHTTTYS TERSEHFKPC RDKDLAYCLN 
DGECFVIETL TGSHKHCRCK EGYQGVRCDQ FLPKTDSILS DPNHLGIEFM ESEEVYQRQV 
LSISCIIFGI VIVGMFCAAF YFKSKKQAKQ IQEQLKVPQN GKSYSLKASS TMAKSENLVK 
SHVQLQNYSK VERHPVTALE KMMESSFVGP QSFPEVPSPD RGSQSVKHHR SLSSCCSPGQ 
RSGMLHRNAF RRTPPSPRSR LGGIVGPAYQ QLEESRIPDQ DTIPCQGYSS SGLKTQRNTS 
INMQLPSRET NPYFNSLEQK DLVGYSSTRA SSVPIIPSVG LEETCLQMPG ISEVKSIKWC 
KNSYSADVVN VSIPVSDCLI AEQQEVKILL ETVQEQIRIL TDARRSEDYE LASVETEDSA 
SENTAFLPLS PTAKSEREAQ FVLRNEIQRD SALTK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.