Details for: NRG3
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 61.26rCSI 73.17%PRS 98.55
-
CSI 58.4rCSI 79.91%PRS 98.91
-
CSI 57.78rCSI 71.88%PRS 98.32
-
CSI 56.29rCSI 72.56%PRS 98.85
-
CSI 47.02rCSI 77.01%PRS 98.91
-
CSI 46.96rCSI 87.95%PRS 98.63
-
CSI 44.86rCSI 91.03%PRS 96.84
-
CSI 44.55rCSI 71.65%PRS 98.41
-
CSI 43.32rCSI 100%PRS 98.66
-
CSI 40.53rCSI 71.58%PRS 98.58
-
CSI 40.33rCSI 67.7%PRS 98.66
-
CSI 40.06rCSI 85.36%PRS 97.82
-
CSI 39.69rCSI 71.31%PRS 99.08
-
CSI 38.11rCSI 69.25%PRS 98.96
-
CSI 37.53rCSI 65.79%PRS 99.27
-
CSI 37.19rCSI 95.61%PRS 99.25
-
CSI 36.37rCSI 100%PRS 98.7
-
CSI 35.94rCSI 80.57%PRS 98.69
-
CSI 35.09rCSI 77.22%PRS 96.98
-
CSI 33.67rCSI 73.05%PRS 97.7
-
CSI 33.21rCSI 53.45%PRS 98.39
-
CSI 32.91rCSI 38.01%PRS 98.99
-
CSI 31.34rCSI 50%PRS 98.89
-
CSI 30.59rCSI 52.91%PRS 99.1
-
CSI 30.34rCSI 79.05%PRS 98.55
-
CSI 29.5rCSI 59.22%PRS 99.15
-
CSI 29.49rCSI 78.54%PRS 97.52
-
CSI 29.09rCSI 40.41%PRS 99.72
-
CSI 27.59rCSI 65.99%PRS 98.04
-
CSI 26.81rCSI 65.15%PRS 97.95
-
CSI 26.36rCSI 54.16%PRS 97.2
-
CSI 25.95rCSI 33.3%PRS 99.32
-
CSI 25.51rCSI 36.16%PRS 99.42
-
CSI 25.33rCSI 55.96%PRS 98.53
-
CSI 25.21rCSI 67.36%PRS 99.27
-
CSI 24.43rCSI 55.76%PRS 98.9
-
CSI 23.71rCSI 18.74%PRS 99.55
-
CSI 23.53rCSI 57.46%PRS 98.47
-
CSI 22.48rCSI 70.3%PRS 98.68
-
CSI 21.63rCSI 31.8%PRS 98.86
-
CSI 21.54rCSI 67.32%PRS 98.53
-
CSI 20.73rCSI 77.65%PRS 99.46
-
CSI 20.32rCSI 76.67%PRS 97.66
-
CSI 20.15rCSI 25.88%PRS 98.87
-
CSI 19.92rCSI 81.16%PRS 98.55
-
CSI 19.86rCSI 41.2%PRS 99.59
-
CSI 19.45rCSI 86.89%PRS 97.09
-
CSI 19.35rCSI 38.36%PRS 99.63
-
CSI 18.79rCSI 79.86%PRS 99.46
-
CSI 18.75rCSI 62.83%PRS 96.99
-
CSI 18.36rCSI 66.08%PRS 98.24
-
CSI 18.13rCSI 68.52%PRS 98.21
-
CSI 17.92rCSI 85.79%PRS 99.34
-
CSI 17.78rCSI 58.43%PRS 97.76
-
CSI 17.46rCSI 59.8%PRS 97.85
-
CSI 16.97rCSI 33.69%PRS 99.1
-
CSI 16.05rCSI 44.24%PRS 99.69
-
CSI 16.01rCSI 75.34%PRS 97.79
-
CSI 15.83rCSI 21.63%PRS 99.85
-
CSI 15.56rCSI 11.53%PRS 99.31
-
CSI 14.95rCSI 84.5%PRS 98.17
-
CSI 14.71rCSI 77.36%PRS 97.65
-
CSI 13.74rCSI 21.94%PRS 99.8
-
CSI 13.45rCSI 59.11%PRS 99.08
-
CSI 13.45rCSI 54.13%PRS 99.23
-
CSI 12.43rCSI 55.22%PRS 99.54
-
CSI 12.3rCSI 100%PRS 99.2
-
CSI 12.15rCSI 21.42%PRS 98.72
-
CSI 12.13rCSI 71.64%PRS 98.03
-
CSI 11.2rCSI 65.93%PRS 98.33
-
CSI 11.16rCSI 45.02%PRS 99.8
-
CSI 10.48rCSI 26.58%PRS 99.23
-
CSI 10.15rCSI 69.1%PRS 97.99
-
CSI 9.97rCSI 37.95%PRS 98.46
-
CSI 9.96rCSI 71.2%PRS 97.84
-
CSI 9.76rCSI 15.53%PRS 98.78
-
CSI 9.49rCSI 51.86%PRS 98.67
-
CSI 9.33rCSI 70.13%PRS 97.71
-
CSI 9.32rCSI 24.08%PRS 99.51
-
CSI 9.15rCSI 23.23%PRS 99.58
-
CSI 9.05rCSI 60.09%PRS 98.18
-
CSI 8.71rCSI 73.34%PRS 97.5
-
CSI 8.7rCSI 54.5%PRS 95.91
-
CSI 8.44rCSI 65.34%PRS 98
-
CSI 8.36rCSI 61.42%PRS 98.77
-
CSI 7.85rCSI 67.65%PRS 98.64
-
CSI 7.6rCSI 43.84%PRS 99.2
-
CSI 7.2rCSI 50.96%PRS 99.34
-
CSI 7.14rCSI 10.25%PRS 98.56
-
CSI 6.76rCSI 69.98%PRS 98.98
-
CSI 5.99rCSI 26.36%PRS 96.8
-
CSI 5.65rCSI 64.68%PRS 96.87
-
CSI 5.46rCSI 57.85%PRS 99.17
-
CSI 5.42rCSI 22.11%PRS 99.94
-
CSI 5.08rCSI 12.1%PRS 99.58
-
CSI 4.31rCSI 61.11%PRS 98.56
-
CSI 4.1rCSI 37.94%PRS 98.91
-
CSI 3.99rCSI 19.68%PRS 99.66
-
CSI 3.49rCSI 10.75%PRS 99.72
-
CSI 3.21rCSI 4.89%PRS 99.42
-
CSI 1.6rCSI 7.9%PRS 98.9%
-
CSI 2.0rCSI 13.0%PRS 98.7%
-
CSI 2.5rCSI 20.5%PRS 99.7%
-
CSI 2.7rCSI 65.1%PRS 97.5%
-
CSI 2.7rCSI 65.3%PRS 97.5%
-
CSI 3.2rCSI 64.5%PRS 98.4%
-
CSI 3.2rCSI 64.5%PRS 98.5%
-
CSI 3.2rCSI 4.9%PRS 99.4%
-
CSI 3.5rCSI 10.8%PRS 99.7%
-
CSI 4.0rCSI 19.7%PRS 99.7%
-
CSI 4.1rCSI 37.9%PRS 98.9%
-
CSI 4.3rCSI 61.1%PRS 98.6%
-
CSI 5.1rCSI 12.1%PRS 99.6%
-
CSI 5.4rCSI 22.1%PRS 99.9%
-
CSI 5.5rCSI 57.9%PRS 99.2%
-
CSI 5.7rCSI 64.7%PRS 96.9%
-
CSI 6.0rCSI 26.4%PRS 96.8%
-
CSI 6.8rCSI 70.0%PRS 99.0%
-
CSI 7.1rCSI 10.3%PRS 98.6%
-
CSI 7.2rCSI 51.0%PRS 99.3%
-
CSI 7.6rCSI 43.8%PRS 99.2%
-
CSI 7.9rCSI 67.7%PRS 98.6%
-
CSI 8.4rCSI 61.4%PRS 98.8%
-
CSI 8.4rCSI 65.3%PRS 98.0%
-
CSI 8.7rCSI 54.5%PRS 95.9%
-
CSI 8.7rCSI 73.3%PRS 97.5%
-
CSI 9.1rCSI 60.1%PRS 98.2%
-
CSI 9.2rCSI 23.2%PRS 99.6%
-
CSI 9.3rCSI 24.1%PRS 99.5%
-
CSI 9.3rCSI 70.1%PRS 97.7%
-
CSI 9.5rCSI 51.9%PRS 98.7%
-
CSI 9.8rCSI 15.5%PRS 98.8%
-
CSI 10.0rCSI 71.2%PRS 97.8%
-
CSI 10.0rCSI 38.0%PRS 98.5%
-
CSI 10.2rCSI 69.1%PRS 98.0%
-
CSI 10.5rCSI 26.6%PRS 99.2%
-
CSI 11.2rCSI 45.0%PRS 99.8%
-
CSI 11.2rCSI 65.9%PRS 98.3%
-
CSI 12.1rCSI 71.6%PRS 98.0%
-
CSI 12.2rCSI 21.4%PRS 98.7%
-
CSI 12.3rCSI 100.0%PRS 99.2%
-
CSI 12.4rCSI 55.2%PRS 99.5%
-
CSI 13.5rCSI 54.1%PRS 99.2%
-
CSI 13.5rCSI 59.1%PRS 99.1%
-
CSI 13.7rCSI 21.9%PRS 99.8%
-
CSI 14.7rCSI 77.4%PRS 97.7%
-
CSI 15.0rCSI 84.5%PRS 98.2%
-
CSI 15.6rCSI 11.5%PRS 99.3%
-
CSI 15.8rCSI 21.6%PRS 99.9%
-
CSI 16.0rCSI 75.3%PRS 97.8%
-
CSI 16.1rCSI 44.2%PRS 99.7%
-
CSI 17.0rCSI 33.7%PRS 99.1%
-
CSI 17.5rCSI 59.8%PRS 97.9%
-
CSI 17.8rCSI 58.4%PRS 97.8%
-
CSI 17.9rCSI 85.8%PRS 99.3%
-
CSI 18.1rCSI 68.5%PRS 98.2%
-
CSI 18.4rCSI 66.1%PRS 98.2%
-
CSI 18.8rCSI 62.8%PRS 97.0%
-
CSI 18.8rCSI 79.9%PRS 99.5%
-
CSI 19.4rCSI 38.4%PRS 99.6%
-
CSI 19.5rCSI 86.9%PRS 97.1%
-
CSI 19.9rCSI 41.2%PRS 99.6%
-
CSI 19.9rCSI 81.2%PRS 98.6%
-
CSI 20.2rCSI 25.9%PRS 98.9%
-
CSI 20.3rCSI 76.7%PRS 97.7%
-
CSI 20.7rCSI 77.7%PRS 99.5%
-
CSI 21.5rCSI 67.3%PRS 98.5%
-
CSI 21.6rCSI 31.8%PRS 98.9%
-
CSI 22.5rCSI 70.3%PRS 98.7%
-
CSI 23.5rCSI 57.5%PRS 98.5%
-
CSI 23.7rCSI 18.7%PRS 99.6%
-
CSI 24.4rCSI 55.8%PRS 98.9%
-
CSI 25.2rCSI 67.4%PRS 99.3%
-
CSI 25.3rCSI 56.0%PRS 98.5%
-
CSI 25.5rCSI 36.2%PRS 99.4%
-
CSI 26.0rCSI 33.3%PRS 99.3%
-
CSI 26.4rCSI 54.2%PRS 97.2%
-
CSI 26.8rCSI 65.2%PRS 98.0%
-
CSI 27.6rCSI 66.0%PRS 98.0%
-
CSI 29.1rCSI 40.4%PRS 99.7%
-
CSI 29.5rCSI 78.5%PRS 97.5%
-
CSI 29.5rCSI 59.2%PRS 99.2%
-
CSI 30.3rCSI 79.1%PRS 98.6%
-
CSI 30.6rCSI 52.9%PRS 99.1%
-
CSI 31.3rCSI 50.0%PRS 98.9%
-
CSI 32.9rCSI 38.0%PRS 99.0%
-
CSI 33.2rCSI 53.5%PRS 98.4%
-
CSI 33.7rCSI 73.1%PRS 97.7%
-
CSI 35.1rCSI 77.2%PRS 97.0%
-
CSI 35.9rCSI 80.6%PRS 98.7%
-
CSI 36.4rCSI 100.0%PRS 98.7%
-
CSI 37.2rCSI 95.6%PRS 99.3%
-
CSI 37.5rCSI 65.8%PRS 99.3%
-
CSI 38.1rCSI 69.3%PRS 99.0%
-
CSI 39.7rCSI 71.3%PRS 99.1%
-
CSI 40.1rCSI 85.4%PRS 97.8%
-
CSI 40.3rCSI 67.7%PRS 98.7%
-
CSI 40.5rCSI 71.6%PRS 98.6%
-
CSI 43.3rCSI 100.0%PRS 98.7%
-
CSI 44.6rCSI 71.7%PRS 98.4%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3462348598
Symbol: NRG3_HUMAN
Name: Pro-neuregulin-3, membrane-bound isoform
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9275162
Title: Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4.
PubMed ID: 9275162
PubMed ID: 16478787
Title: Characterization of a neural-specific splicing form of the human neuregulin 3 gene involved in oligodendrocyte survival.
PubMed ID: 16478787
DOI: 10.1242/jcs.02799
PubMed ID: 15164054
Title: The DNA sequence and comparative analysis of human chromosome 10.
PubMed ID: 15164054
DOI: 10.1038/nature02462
PubMed ID: 10867024
Title: Ligand discrimination in signaling through an ErbB4 receptor homodimer.
PubMed ID: 10867024
Sequence Information:
- Length: 720
- Mass: 77901
- Checksum: A4D6F10DDB95A693
- Sequence:
MSEGAAAASP PGAASAAAAS AEEGTAAAAA AAAAGGGPDG GGEGAAEPPR ELRCSDCIVW NRQQTWLCVV PLFIGFIGLG LSLMLLKWIV VGSVKEYVPT DLVDSKGMGQ DPFFLSKPSS FPKAMETTTT TTSTTSPATP SAGGAASSRT PNRISTRLTT ITRAPTRFPG HRVPIRASPR STTARNTAAP ATVPSTTAPF FSSSTLGSRP PVPGTPSTQA MPSWPTAAYA TSSYLHDSTP SWTLSPFQDA ASSSSSSSSS ATTTTPETST SPKFHTTTYS TERSEHFKPC RDKDLAYCLN DGECFVIETL TGSHKHCRCK EGYQGVRCDQ FLPKTDSILS DPTDHLGIEF MESEEVYQRQ VLSISCIIFG IVIVGMFCAA FYFKSKKQAK QIQEQLKVPQ NGKSYSLKAS STMAKSENLV KSHVQLQNYS KVERHPVTAL EKMMESSFVG PQSFPEVPSP DRGSQSVKHH RSLSSCCSPG QRSGMLHRNA FRRTPPSPRS RLGGIVGPAY QQLEESRIPD QDTIPCQGIE VRKTISHLPI QLWCVERPLD LKYSSSGLKT QRNTSINMQL PSRETNPYFN SLEQKDLVGY SSTRASSVPI IPSVGLEETC LQMPGISEVK SIKWCKNSYS ADVVNVSIPV SDCLIAEQQE VKILLETVQE QIRILTDARR SEDYELASVE TEDSASENTA FLPLSPTAKS EREAQFVLRN EIQRDSALTK
Genular Protein ID: 880156629
Symbol: B9EGV5_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
Sequence Information:
- Length: 695
- Mass: 74929
- Checksum: D8BF4DBC39D8B801
- Sequence:
MSEGAAAASP PGAASAAAAS AEEGTAAAAA AAAAGGGPDG GGEGAAEPPR ELRCSDCIVW NRQQTWLCVV PLFIGFIGLG LSLMLLKWIV VGSVKEYVPT DLVDSKGMGQ DPFFLSKPSS FPKAMETTTT TTSTTSPATP SAGGAASSRT PNRISTRLTT ITRAPTRFPG HRVPIRASPR STTARNTAAP ATVPSTTAPF FSSSTLGSRP PVPGTPSTQA MPSWPTAAYA TSSYLHDSTP SWTLSPFQDA ASSSSSSSSS ATTTTPETST SPKFHTTTYS TERSEHFKPC RDKDLAYCLN DGECFVIETL TGSHKHCRCK EGYQGVRCDQ FLPKTDSILS DPNHLGIEFM ESEEVYQRQV LSISCIIFGI VIVGMFCAAF YFKSKKQAKQ IQEQLKVPQN GKSYSLKASS TMAKSENLVK SHVQLQNYSK VERHPVTALE KMMESSFVGP QSFPEVPSPD RGSQSVKHHR SLSSCCSPGQ RSGMLHRNAF RRTPPSPRSR LGGIVGPAYQ QLEESRIPDQ DTIPCQGYSS SGLKTQRNTS INMQLPSRET NPYFNSLEQK DLVGYSSTRA SSVPIIPSVG LEETCLQMPG ISEVKSIKWC KNSYSADVVN VSIPVSDCLI AEQQEVKILL ETVQEQIRIL TDARRSEDYE LASVETEDSA SENTAFLPLS PTAKSEREAQ FVLRNEIQRD SALTK
Genular Protein ID: 2714766757
Symbol: B3KVG8_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
Sequence Information:
- Length: 346
- Mass: 38532
- Checksum: 01D60CD0909BA391
- Sequence:
MESEEVYQRQ VLSISCIIFG IVIVGMFCAA FYFKSKKQAK QIQEQLKVPQ NGKSYSLKAS STMAKSENLV KSHVQLQNYS KVERHPVTAL EKMIESSFVG PQSFPEVPSP DRGSQSVKHH RSLSSCCSPG QRSGMLHRNA FRRTPPSPRS RLGGIVGPAY QQLEESRIPN QDTIPCQGYS SSGLKTQRNT SINMQLPSRE TNPYFNSLEQ KDLVGYSSTR ASSVPIIPSV GLEETCLQMP GISEVKSIKW CKNSYSADVV NVSIPVSDCL IAEQQEVKIL LETVQEQIRI LTDARRSEDY ELASVETEDS ASENTAFLPL SPTAKSEREA QFVLRNEIQR DSALTK