CFL1 | ENSG00000172757 | NCBI 1072

Details for: CFL1

Gene ID: 1072

Symbol: CFL1

Ensembl ID: ENSG00000172757

Description: cofilin 1

Associated with

Axon guidance
(R-HSA-422475)
Cytokine signaling in immune system
(R-HSA-1280215)
Developmental biology
(R-HSA-1266738)
Eph-ephrin signaling
(R-HSA-2682334)
Ephb-mediated forward signaling
(R-HSA-3928662)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Gene and protein expression by jak-stat signaling after interleukin-12 stimulation
(R-HSA-8950505)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Interleukin-12 family signaling
(R-HSA-447115)
Interleukin-12 signaling
(R-HSA-9020591)
Nervous system development
(R-HSA-9675108)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Platelet degranulation
(R-HSA-114608)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Response to elevated platelet cytosolic ca2+
(R-HSA-76005)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate rocks
(R-HSA-5627117)
Sema3a pak dependent axon repulsion
(R-HSA-399954)
Semaphorin interactions
(R-HSA-373755)
Signaling by interleukins
(R-HSA-449147)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
Actin cytoskeleton
(GO:0015629)
Actin cytoskeleton organization
(GO:0030036)
Actin filament binding
(GO:0051015)
Actin filament depolymerization
(GO:0030042)
Actin filament fragmentation
(GO:0030043)
Actin filament severing
(GO:0051014)
Cytoplasm
(GO:0005737)
Cytoskeleton organization
(GO:0007010)
Cytosol
(GO:0005829)
Establishment of spindle localization
(GO:0051293)
Extracellular exosome
(GO:0070062)
Extracellular space
(GO:0005615)
Focal adhesion
(GO:0005925)
Growth cone
(GO:0030426)
Lamellipodium
(GO:0030027)
Lamellipodium membrane
(GO:0031258)
Membrane
(GO:0016020)
Mitotic cytokinesis
(GO:0000281)
Negative regulation of apoptotic process
(GO:0043066)
Nuclear matrix
(GO:0016363)
Nucleus
(GO:0005634)
Positive regulation by host of viral process
(GO:0044794)
Positive regulation of embryonic development
(GO:0040019)
Protein binding
(GO:0005515)
Regulation of cell morphogenesis
(GO:0022604)
Regulation of dendritic spine morphogenesis
(GO:0061001)
Response to virus
(GO:0009615)
Rho protein signal transduction
(GO:0007266)
Ruffle membrane
(GO:0032587)
Vesicle
(GO:0031982)

Other Information

Proteins

Cofilin-1

Genular Protein ID: 3225620032

Symbol: COF1_HUMAN

Name: Cofilin-1

UniProtKB Accession Codes:

P23528 B3KUQ1 Q53Y87 Q9UCA2

Database IDs:

Citations:

PubMed ID: 2263493

Title: Coding sequence of human placenta cofilin cDNA.

PubMed ID: 2263493

DOI: 10.1093/nar/18.23.7169

PubMed ID: 7552146

Title: A provisional transcript map of the spinal muscular atrophy (SMA) critical region.

PubMed ID: 7552146

DOI: 10.1159/000472281

PubMed ID: 8800436

Title: Mapping of human non-muscle type cofilin (CFL1) to chromosome 11q13 and muscle-type cofilin (CFL2) to chromosome 14.

PubMed ID: 8800436

DOI: 10.1111/j.1469-1809.1996.tb00423.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 8037689

Title: Dephosphorylation of cofilin in stimulated platelets: roles for a GTP-binding protein and Ca2+.

PubMed ID: 8037689

DOI: 10.1042/bj3010041

PubMed ID: 11812157

Title: Determining the differences in actin binding by human ADF and cofilin.

PubMed ID: 11812157

DOI: 10.1006/jmbi.2001.5280

PubMed ID: 12837278

Title: Cofilin phosphorylation and actin polymerization by NRK/NESK, a member of the germinal center kinase family.

PubMed ID: 12837278

DOI: 10.1016/s0014-4827(03)00136-8

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 15580268

Title: Chronophin, a novel HAD-type serine protein phosphatase, regulates cofilin-dependent actin dynamics.

PubMed ID: 15580268

DOI: 10.1038/ncb1201

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16548883

Title: Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection.

PubMed ID: 16548883

DOI: 10.1111/j.1462-5822.2005.00644.x

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21834987

Title: Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration.

PubMed ID: 21834987

DOI: 10.1186/1741-7007-9-54

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23633677

Title: Beta-arrestin-dependent activation of the cofilin pathway is required for the scavenging activity of the atypical chemokine receptor D6.

PubMed ID: 23633677

DOI: 10.1126/scisignal.2003627

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 25556234

Title: New host factors important for respiratory syncytial virus (RSV) replication revealed by a novel microfluidics screen for interactors of matrix (M) protein.

PubMed ID: 25556234

DOI: 10.1074/mcp.m114.044107

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 30550596

Title: A quantitative proteomic analysis of cofilin phosphorylation in myeloid cells and its modulation using the LIM kinase inhibitor Pyr1.

PubMed ID: 30550596

DOI: 10.1371/journal.pone.0208979

PubMed ID: 14627701

Title: Solution structure of human cofilin: actin binding, pH sensitivity, and relationship to actin-depolymerizing factor.

PubMed ID: 14627701

DOI: 10.1074/jbc.m310148200

Sequence Information:

Length: 166
Mass: 18502
Checksum: 589EF8FC1EC13719
Sequence:

MASGVAVSDG VIKVFNDMKV RKSSTPEEVK KRKKAVLFCL SEDKKNIILE EGKEILVGDV 
GQTVDDPYAT FVKMLPDKDC RYALYDATYE TKESKKEDLV FIFWAPESAP LKSKMIYASS 
KDAIKKKLTG IKHELQANCY EEVKDRCTLA EKLGGSAVIS LEGKPL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CFL1

Associated with

Other Information

Coding sequence of human placenta cofilin cDNA. PubMed ID: 2263493

A provisional transcript map of the spinal muscular atrophy (SMA) critical region. PubMed ID: 7552146

Mapping of human non-muscle type cofilin (CFL1) to chromosome 11q13 and muscle-type cofilin (CFL2) to chromosome 14. PubMed ID: 8800436

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. PubMed ID: 12665801

Dephosphorylation of cofilin in stimulated platelets: roles for a GTP-binding protein and Ca2+. PubMed ID: 8037689

Determining the differences in actin binding by human ADF and cofilin. PubMed ID: 11812157

Cofilin phosphorylation and actin polymerization by NRK/NESK, a member of the germinal center kinase family. PubMed ID: 12837278

Proteomic characterization of the human centrosome by protein correlation profiling. PubMed ID: 14654843

Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. PubMed ID: 15592455

Chronophin, a novel HAD-type serine protein phosphatase, regulates cofilin-dependent actin dynamics. PubMed ID: 15580268

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection. PubMed ID: 16548883

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration. PubMed ID: 21834987

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Beta-arrestin-dependent activation of the cofilin pathway is required for the scavenging activity of the atypical chemokine receptor D6. PubMed ID: 23633677

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

New host factors important for respiratory syncytial virus (RSV) replication revealed by a novel microfluidics screen for interactors of matrix (M) protein. PubMed ID: 25556234

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

A quantitative proteomic analysis of cofilin phosphorylation in myeloid cells and its modulation using the LIM kinase inhibitor Pyr1. PubMed ID: 30550596

Solution structure of human cofilin: actin binding, pH sensitivity, and relationship to actin-depolymerizing factor. PubMed ID: 14627701