Details for: CFL1

Gene ID: 1072

Symbol: CFL1

Ensembl ID: ENSG00000172757

Description: cofilin 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 1116.9099
    Cell Significance Index: -173.7300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 648.5878
    Cell Significance Index: -164.5100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 518.6096
    Cell Significance Index: -213.6400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 437.9688
    Cell Significance Index: -206.7800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 407.3503
    Cell Significance Index: -209.5400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 309.2372
    Cell Significance Index: -207.5100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 162.6011
    Cell Significance Index: -200.4800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 53.3762
    Cell Significance Index: -210.6300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 46.8768
    Cell Significance Index: -143.9800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.5706
    Cell Significance Index: -33.6800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 9.6068
    Cell Significance Index: 177.5600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 8.1317
    Cell Significance Index: 238.8200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 7.1550
    Cell Significance Index: 843.7900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 7.1259
    Cell Significance Index: 334.9100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 6.3143
    Cell Significance Index: 166.0400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 6.0769
    Cell Significance Index: 127.2000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 5.8199
    Cell Significance Index: 305.5700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 5.3900
    Cell Significance Index: 401.7100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 5.3841
    Cell Significance Index: 187.1000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 5.1196
    Cell Significance Index: 90.4700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 4.9039
    Cell Significance Index: 55.7100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 4.8474
    Cell Significance Index: 596.0400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 4.4838
    Cell Significance Index: 289.2800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 4.3401
    Cell Significance Index: 560.7200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 4.1940
    Cell Significance Index: 756.0500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 4.1862
    Cell Significance Index: 2286.1600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 3.6675
    Cell Significance Index: 1621.4700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.5830
    Cell Significance Index: 33.0000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.5319
    Cell Significance Index: 485.0300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 3.3133
    Cell Significance Index: 36.0200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.2867
    Cell Significance Index: 89.4600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.8611
    Cell Significance Index: 366.7700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.4149
    Cell Significance Index: 170.7900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.6092
    Cell Significance Index: 75.0300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.3205
    Cell Significance Index: 35.2600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0774
    Cell Significance Index: 106.5800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8159
    Cell Significance Index: 163.6700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.5664
    Cell Significance Index: 428.7100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4552
    Cell Significance Index: 23.6500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4498
    Cell Significance Index: 85.6100
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.4395
    Cell Significance Index: 2.7100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4190
    Cell Significance Index: 83.1600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.3441
    Cell Significance Index: 39.2800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2580
    Cell Significance Index: 232.9300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2125
    Cell Significance Index: 36.2900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1824
    Cell Significance Index: 65.4400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0926
    Cell Significance Index: 1.5500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0377
    Cell Significance Index: 1.0800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0079
    Cell Significance Index: 5.7900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0248
    Cell Significance Index: -2.5300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0782
    Cell Significance Index: -147.3100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0809
    Cell Significance Index: -59.8900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1067
    Cell Significance Index: -66.6000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1329
    Cell Significance Index: -245.0800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1610
    Cell Significance Index: -247.8900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1830
    Cell Significance Index: -248.8200
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.2630
    Cell Significance Index: -2.2600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2759
    Cell Significance Index: -155.5700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.2893
    Cell Significance Index: -183.7100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2993
    Cell Significance Index: -6.9200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.3952
    Cell Significance Index: -64.2700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.4315
    Cell Significance Index: -195.8300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.4636
    Cell Significance Index: -97.6400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.6473
    Cell Significance Index: -186.2500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.8216
    Cell Significance Index: -20.9900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.8995
    Cell Significance Index: -11.5200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.9206
    Cell Significance Index: -41.7300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.9878
    Cell Significance Index: -113.1700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.1042
    Cell Significance Index: -67.8700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -1.2003
    Cell Significance Index: -139.8800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.3455
    Cell Significance Index: -195.5900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.3719
    Cell Significance Index: -38.3400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.4194
    Cell Significance Index: -30.7500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.5467
    Cell Significance Index: -49.5400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -1.5787
    Cell Significance Index: -12.6100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.5837
    Cell Significance Index: -23.7300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.7097
    Cell Significance Index: -95.9400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.9087
    Cell Significance Index: -151.1700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.9644
    Cell Significance Index: -123.8100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -2.0329
    Cell Significance Index: -211.6800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -2.1245
    Cell Significance Index: -142.8500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -2.1882
    Cell Significance Index: -37.5000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -2.3114
    Cell Significance Index: -61.8300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -2.7587
    Cell Significance Index: -211.7000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -2.7827
    Cell Significance Index: -47.9700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -2.8270
    Cell Significance Index: -17.0800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -2.8623
    Cell Significance Index: -71.5500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -3.1407
    Cell Significance Index: -42.8500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -3.3807
    Cell Significance Index: -207.2700
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -3.6714
    Cell Significance Index: -51.4600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -3.8830
    Cell Significance Index: -114.3700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -4.5155
    Cell Significance Index: -199.7300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -4.5769
    Cell Significance Index: -130.6100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -5.0655
    Cell Significance Index: -185.9500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -5.3452
    Cell Significance Index: -202.4100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -5.3531
    Cell Significance Index: -137.6000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -5.8005
    Cell Significance Index: -189.9100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -5.8694
    Cell Significance Index: -205.6200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -5.8940
    Cell Significance Index: -70.2600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -6.1255
    Cell Significance Index: -164.1400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Actin filament severing**: CFL1 is a potent actin filament severing enzyme, responsible for regulating actin dynamics and cytoskeleton organization. 2. **Immune cell expression**: CFL1 is significantly expressed in immune cells, including mature T cells, NKp46-positive innate lymphoid cells, and classical monocytes. 3. **Cytoskeleton organization**: CFL1 plays a crucial role in regulating cytoskeleton organization, which is essential for cell migration, differentiation, and phagocytosis. 4. **Protein binding**: CFL1 interacts with various proteins, including actin-binding proteins, Rho GTPases, and microtubule-associated proteins. **Pathways and Functions:** CFL1 is involved in several key pathways, including: 1. **Actin cytoskeleton organization**: CFL1 regulates actin filament organization, severing, and depolymerization, which is essential for cell migration, differentiation, and phagocytosis. 2. **Immune system signaling**: CFL1 is involved in immune system signaling, including cytokine signaling, Rho GTPase-mediated signaling, and interleukin-12 family signaling. 3. **Cell migration and differentiation**: CFL1 regulates cell migration and differentiation by controlling actin filament organization and cytoskeleton dynamics. 4. **Phagocytosis**: CFL1 is involved in phagocytosis, a critical process for immune cell function, by regulating actin filament organization and cytoskeleton dynamics. **Clinical Significance:** CFL1's involvement in actin dynamics and immune function makes it a potential biomarker for various diseases, including: 1. **Cancer**: CFL1's role in actin dynamics and cytoskeleton organization suggests its potential as a biomarker for cancer diagnosis and treatment. 2. **Neurological disorders**: CFL1's involvement in actin dynamics and cytoskeleton organization may contribute to the development of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Immune system disorders**: CFL1's role in immune system signaling and regulation of immune cell function makes it a potential target for the treatment of immune system disorders, such as autoimmune diseases and immunodeficiency disorders. In conclusion, CFL1 is a critical protein involved in actin dynamics, cytoskeleton organization, and immune function. Its significance in various cellular processes and diseases highlights the need for further research into the role of CFL1 in human health and disease.

Genular Protein ID: 3225620032

Symbol: COF1_HUMAN

Name: Cofilin-1

UniProtKB Accession Codes:

P23528 B3KUQ1 Q53Y87 Q9UCA2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 CarbonylDB 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 10 EMDB 5 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 29 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 10 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 6 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2263493

Title: Coding sequence of human placenta cofilin cDNA.

PubMed ID: 2263493

DOI: 10.1093/nar/18.23.7169

PubMed ID: 7552146

Title: A provisional transcript map of the spinal muscular atrophy (SMA) critical region.

PubMed ID: 7552146

DOI: 10.1159/000472281

PubMed ID: 8800436

Title: Mapping of human non-muscle type cofilin (CFL1) to chromosome 11q13 and muscle-type cofilin (CFL2) to chromosome 14.

PubMed ID: 8800436

DOI: 10.1111/j.1469-1809.1996.tb00423.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 8037689

Title: Dephosphorylation of cofilin in stimulated platelets: roles for a GTP-binding protein and Ca2+.

PubMed ID: 8037689

DOI: 10.1042/bj3010041

PubMed ID: 11812157

Title: Determining the differences in actin binding by human ADF and cofilin.

PubMed ID: 11812157

DOI: 10.1006/jmbi.2001.5280

PubMed ID: 12837278

Title: Cofilin phosphorylation and actin polymerization by NRK/NESK, a member of the germinal center kinase family.

PubMed ID: 12837278

DOI: 10.1016/s0014-4827(03)00136-8

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 15580268

Title: Chronophin, a novel HAD-type serine protein phosphatase, regulates cofilin-dependent actin dynamics.

PubMed ID: 15580268

DOI: 10.1038/ncb1201

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16548883

Title: Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection.

PubMed ID: 16548883

DOI: 10.1111/j.1462-5822.2005.00644.x

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21834987

Title: Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration.

PubMed ID: 21834987

DOI: 10.1186/1741-7007-9-54

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23633677

Title: Beta-arrestin-dependent activation of the cofilin pathway is required for the scavenging activity of the atypical chemokine receptor D6.

PubMed ID: 23633677

DOI: 10.1126/scisignal.2003627

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 25556234

Title: New host factors important for respiratory syncytial virus (RSV) replication revealed by a novel microfluidics screen for interactors of matrix (M) protein.

PubMed ID: 25556234

DOI: 10.1074/mcp.m114.044107

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 30550596

Title: A quantitative proteomic analysis of cofilin phosphorylation in myeloid cells and its modulation using the LIM kinase inhibitor Pyr1.

PubMed ID: 30550596

DOI: 10.1371/journal.pone.0208979

PubMed ID: 14627701

Title: Solution structure of human cofilin: actin binding, pH sensitivity, and relationship to actin-depolymerizing factor.

PubMed ID: 14627701

DOI: 10.1074/jbc.m310148200

Sequence Information:

  • Length: 166
  • Mass: 18502
  • Checksum: 589EF8FC1EC13719
  • Sequence:
    • MASGVAVSDG VIKVFNDMKV RKSSTPEEVK KRKKAVLFCL SEDKKNIILE EGKEILVGDV 
GQTVDDPYAT FVKMLPDKDC RYALYDATYE TKESKKEDLV FIFWAPESAP LKSKMIYASS 
KDAIKKKLTG IKHELQANCY EEVKDRCTLA EKLGGSAVIS LEGKPL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.