Details for: CFL1

Gene ID: 1072

Symbol: CFL1

Ensembl ID: ENSG00000172757

Description: cofilin 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature T cell (CL0002419)
    Fold Change: 5.19
    Marker Score: 51400
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 5.08
    Marker Score: 14824
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 4.92
    Marker Score: 7577
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 4.72
    Marker Score: 14909
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 4.72
    Marker Score: 63443
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 4.51
    Marker Score: 11457
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.43
    Marker Score: 247665
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 4.35
    Marker Score: 1604
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 4.32
    Marker Score: 7406
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 4.32
    Marker Score: 3131
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 4.31
    Marker Score: 5609
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 4.28
    Marker Score: 11835
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 4.28
    Marker Score: 226398
  • Cell Name: blood cell (CL0000081)
    Fold Change: 4.27
    Marker Score: 49579
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 4.26
    Marker Score: 3803
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 4.24
    Marker Score: 4712
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 4.16
    Marker Score: 26559
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 4.11
    Marker Score: 2649
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 4.07
    Marker Score: 3929
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 4.06
    Marker Score: 11388
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 4.05
    Marker Score: 2374
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 4.05
    Marker Score: 2463
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.03
    Marker Score: 9832.5
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 3.99
    Marker Score: 17127
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 3.99
    Marker Score: 2050
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 3.97
    Marker Score: 5849
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 3.96
    Marker Score: 1709
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 3.93
    Marker Score: 5686
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.93
    Marker Score: 938
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.9
    Marker Score: 51424
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 3.87
    Marker Score: 3027
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 3.87
    Marker Score: 9427
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 3.86
    Marker Score: 3388
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 3.86
    Marker Score: 3026.5
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 3.83
    Marker Score: 3405
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 3.82
    Marker Score: 1721
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 3.82
    Marker Score: 3606.5
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.8
    Marker Score: 4591
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 3.77
    Marker Score: 3199
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 3.76
    Marker Score: 6724
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 3.7
    Marker Score: 3110
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 3.66
    Marker Score: 2997
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 3.65
    Marker Score: 3927
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 3.64
    Marker Score: 3422
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 3.61
    Marker Score: 1862
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 3.6
    Marker Score: 934
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 3.59
    Marker Score: 6559
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 3.59
    Marker Score: 2187
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 3.59
    Marker Score: 950
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 3.58
    Marker Score: 1627
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 3.57
    Marker Score: 3879
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 3.57
    Marker Score: 1533
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 3.56
    Marker Score: 1967
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 3.56
    Marker Score: 11185
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 3.56
    Marker Score: 7462
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 3.56
    Marker Score: 1897
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.55
    Marker Score: 3501
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.55
    Marker Score: 6678
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.55
    Marker Score: 4062.5
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.54
    Marker Score: 3785
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 3.54
    Marker Score: 3050
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 3.54
    Marker Score: 8542
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 3.54
    Marker Score: 2344
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 3.54
    Marker Score: 2675
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 3.52
    Marker Score: 1754
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 3.52
    Marker Score: 926
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.51
    Marker Score: 119524
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 3.49
    Marker Score: 2046
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 3.49
    Marker Score: 3128
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 3.47
    Marker Score: 1129
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 3.46
    Marker Score: 3054
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 3.46
    Marker Score: 1443
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 3.46
    Marker Score: 3316
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 3.46
    Marker Score: 2872
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 3.45
    Marker Score: 1545
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 3.43
    Marker Score: 5463
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 3.41
    Marker Score: 4024.5
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 3.4
    Marker Score: 1762
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 3.38
    Marker Score: 12014.5
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.37
    Marker Score: 2873
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 3.36
    Marker Score: 771
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 3.36
    Marker Score: 3361.5
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 3.36
    Marker Score: 16115
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.35
    Marker Score: 21799
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 3.34
    Marker Score: 4018
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 3.33
    Marker Score: 2241
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 3.32
    Marker Score: 2400
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 3.32
    Marker Score: 2184
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 3.31
    Marker Score: 3096
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 3.3
    Marker Score: 937
  • Cell Name: centroblast (CL0009112)
    Fold Change: 3.3
    Marker Score: 1624
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 3.29
    Marker Score: 4663
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 3.29
    Marker Score: 926
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 3.28
    Marker Score: 17262
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 3.28
    Marker Score: 3847.5
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 3.28
    Marker Score: 3422
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 3.28
    Marker Score: 4523.5
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 3.28
    Marker Score: 6384
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 3.27
    Marker Score: 2329
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 3.27
    Marker Score: 4038

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Other Information

**Key characteristics:** - Cofilin 1 is a large protein with a molecular weight of approximately 140 kDa. - It is a cytoskeletal protein that is involved in the maintenance of cell structure and signaling. - It is a key regulator of cell migration, adhesion, and signaling in immune cells. **Pathways and functions:** - Cofilin 1 is involved in the regulation of axon guidance, cytokine signaling in the immune system, and development. - It is a key regulator of platelet activation, degranulation, and aggregation. - It plays a role in the regulation of inflammation and immune responses. - It is involved in the regulation of the actin cytoskeleton, which is essential for cell migration and signaling. **Clinical significance:** - Mutations in the CFL1 gene have been linked to several human diseases, including cancer, autoimmune disorders, and vascular diseases. - Targeting CFL1 has been explored as a therapeutic strategy for these diseases. - Studies on animal models have shown that blocking CFL1 can inhibit tumor growth and metastasis. **Additional notes:** - CFL1 is a highly conserved protein that is found in all vertebrate species. - It is a key regulator of cell migration, adhesion, and signaling in a variety of cell types. - It is a promising target for cancer immunotherapy.

Genular Protein ID: 3225620032

Symbol: COF1_HUMAN

Name: Cofilin-1

UniProtKB Accession Codes:

P23528 B3KUQ1 Q53Y87 Q9UCA2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 CarbonylDB 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DOSAC-COBS-2DPAGE 1 DisGeNET 1 DrugBank 3 EMBL 10 EMDB 5 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 29 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 10 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 6 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCD-2DPAGE 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2263493

Title: Coding sequence of human placenta cofilin cDNA.

PubMed ID: 2263493

DOI: 10.1093/nar/18.23.7169

PubMed ID: 7552146

Title: A provisional transcript map of the spinal muscular atrophy (SMA) critical region.

PubMed ID: 7552146

DOI: 10.1159/000472281

PubMed ID: 8800436

Title: Mapping of human non-muscle type cofilin (CFL1) to chromosome 11q13 and muscle-type cofilin (CFL2) to chromosome 14.

PubMed ID: 8800436

DOI: 10.1111/j.1469-1809.1996.tb00423.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 8037689

Title: Dephosphorylation of cofilin in stimulated platelets: roles for a GTP-binding protein and Ca2+.

PubMed ID: 8037689

DOI: 10.1042/bj3010041

PubMed ID: 11812157

Title: Determining the differences in actin binding by human ADF and cofilin.

PubMed ID: 11812157

DOI: 10.1006/jmbi.2001.5280

PubMed ID: 12837278

Title: Cofilin phosphorylation and actin polymerization by NRK/NESK, a member of the germinal center kinase family.

PubMed ID: 12837278

DOI: 10.1016/s0014-4827(03)00136-8

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 15580268

Title: Chronophin, a novel HAD-type serine protein phosphatase, regulates cofilin-dependent actin dynamics.

PubMed ID: 15580268

DOI: 10.1038/ncb1201

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16548883

Title: Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection.

PubMed ID: 16548883

DOI: 10.1111/j.1462-5822.2005.00644.x

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21834987

Title: Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration.

PubMed ID: 21834987

DOI: 10.1186/1741-7007-9-54

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23633677

Title: Beta-arrestin-dependent activation of the cofilin pathway is required for the scavenging activity of the atypical chemokine receptor D6.

PubMed ID: 23633677

DOI: 10.1126/scisignal.2003627

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 25556234

Title: New host factors important for respiratory syncytial virus (RSV) replication revealed by a novel microfluidics screen for interactors of matrix (M) protein.

PubMed ID: 25556234

DOI: 10.1074/mcp.m114.044107

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 30550596

Title: A quantitative proteomic analysis of cofilin phosphorylation in myeloid cells and its modulation using the LIM kinase inhibitor Pyr1.

PubMed ID: 30550596

DOI: 10.1371/journal.pone.0208979

PubMed ID: 14627701

Title: Solution structure of human cofilin: actin binding, pH sensitivity, and relationship to actin-depolymerizing factor.

PubMed ID: 14627701

DOI: 10.1074/jbc.m310148200

Sequence Information:

  • Length: 166
  • Mass: 18502
  • Checksum: 589EF8FC1EC13719
  • Sequence:
    • MASGVAVSDG VIKVFNDMKV RKSSTPEEVK KRKKAVLFCL SEDKKNIILE EGKEILVGDV 
GQTVDDPYAT FVKMLPDKDC RYALYDATYE TKESKKEDLV FIFWAPESAP LKSKMIYASS 
KDAIKKKLTG IKHELQANCY EEVKDRCTLA EKLGGSAVIS LEGKPL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.