Details for: UGT2B11

Gene ID: 10720

Symbol: UGT2B11

Ensembl ID: ENSG00000213759

Description: UDP glucuronosyltransferase family 2 member B11

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.76
    Marker Score: 6,846
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.16
    Marker Score: 3,180
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.69
    Marker Score: 988
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.66
    Marker Score: 1,654
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.46
    Marker Score: 1,063
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.32
    Marker Score: 2,509
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 862
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.19
    Marker Score: 492
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.15
    Marker Score: 7,677
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4,823
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.11
    Marker Score: 508
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.05
    Marker Score: 2,143
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.01
    Marker Score: 608
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,833
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,059
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1
    Marker Score: 514
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.99
    Marker Score: 467
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 378
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,353
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.92
    Marker Score: 330
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,743
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,292
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,269
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 713
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 401
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 467
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.65
    Marker Score: 518
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.57
    Marker Score: 8,962
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.56
    Marker Score: 177
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.53
    Marker Score: 3,197
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 282
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.45
    Marker Score: 214
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.35
    Marker Score: 156
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.28
    Marker Score: 124
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 66
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 76
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.2
    Marker Score: 410
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.18
    Marker Score: 249
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.18
    Marker Score: 317
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.18
    Marker Score: 44
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.17
    Marker Score: 180
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.16
    Marker Score: 64
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.15
    Marker Score: 191
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.13
    Marker Score: 84
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.13
    Marker Score: 91
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.13
    Marker Score: 72
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.12
    Marker Score: 51
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.12
    Marker Score: 66
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.11
    Marker Score: 75
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.09
    Marker Score: 49
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.08
    Marker Score: 46
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.08
    Marker Score: 89
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.08
    Marker Score: 17
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.07
    Marker Score: 950
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.07
    Marker Score: 162
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.06
    Marker Score: 58
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.06
    Marker Score: 41
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.06
    Marker Score: 62
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.06
    Marker Score: 93
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.05
    Marker Score: 36
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.05
    Marker Score: 142
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.05
    Marker Score: 75
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.05
    Marker Score: 40
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.05
    Marker Score: 27
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.05
    Marker Score: 26
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: eosinophil (CL0000771)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.04
    Marker Score: 20
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.04
    Marker Score: 29
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.04
    Marker Score: 44
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.04
    Marker Score: 71
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.04
    Marker Score: 145
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.04
    Marker Score: 94
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.04
    Marker Score: 20
  • Cell Name: basophil (CL0000767)
    Fold Change: 0.04
    Marker Score: 17
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.04
    Marker Score: 16
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.03
    Marker Score: 19
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.03
    Marker Score: 28

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** UGT2B11 is a member of the UDP-glucuronosyltransferase family, which consists of 17 enzymes that catalyze the glucuronidation reaction. This reaction involves the transfer of a glucuronic acid moiety from UDP-glucuronic acid to a substrate, resulting in the formation of a glucuronide conjugate. The UGT2B11 enzyme is characterized by its ability to efficiently glucuronidate a wide range of substrates, including bilirubin, phenols, and steroids. Its expression is highly specific, with significant levels found in microglial cells, endothelial cells, and enterocytes. **Pathways and Functions:** UGT2B11 is involved in various cellular pathways, including: 1. **Aspirin adme (Absorption, Distribution, Metabolism, and Excretion):** UGT2B11 plays a crucial role in the glucuronidation of salicylic acid, a metabolite of aspirin, which is essential for its excretion. 2. **Biological oxidations:** UGT2B11 contributes to the metabolism of various substrates, including bilirubin, which is a product of heme degradation. 3. **Cellular glucuronidation:** UGT2B11 is a key enzyme in the glucuronidation process, which is essential for the detoxification of various compounds. 4. **Drug adme:** UGT2B11 is involved in the glucuronidation of several drugs, including warfarin and phenytoin, which affects their pharmacokinetics and pharmacodynamics. 5. **Endoplasmic reticulum membrane:** UGT2B11 is localized to the endoplasmic reticulum membrane, where it interacts with other enzymes and proteins to regulate its activity. **Clinical Significance:** UGT2B11 has significant clinical implications, particularly in the context of: 1. **Warfarin therapy:** Variations in the UGT2B11 gene have been associated with warfarin's efficacy and bleeding risk. 2. **Aspirin therapy:** UGT2B11's role in aspirin's glucuronidation affects its excretion and, subsequently, its anti-inflammatory and analgesic effects. 3. **Bilirubin metabolism:** UGT2B11's contribution to bilirubin glucuronidation is essential for maintaining normal bilirubin levels and preventing jaundice. 4. **Xenobiotic metabolism:** UGT2B11's involvement in the glucuronidation of xenobiotics highlights its importance in detoxification processes and the prevention of adverse effects. In conclusion, the UGT2B11 gene plays a critical role in the glucuronidation process, which is essential for maintaining cellular homeostasis, detoxifying compounds, and regulating various physiological processes. Its clinical significance is evident in the context of warfarin and aspirin therapy, bilirubin metabolism, and xenobiotic metabolism. Further research on UGT2B11 and its interactions with other enzymes and proteins will provide valuable insights into its functions and potential therapeutic applications.

Genular Protein ID: 4057626486

Symbol: UDB11_HUMAN

Name: UDP-glucuronosyltransferase 2B11

UniProtKB Accession Codes:

O75310 Q3KNV9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 1 CDD 1 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 2 EMBL 4 Ensembl 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9675083

Title: Isolation and characterization of a human orphan UDP-glucuronosyltransferase, UGT2B11.

PubMed ID: 9675083

DOI: 10.1006/bbrc.1998.8908

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 529
  • Mass: 61038
  • Checksum: CE4AC3C71CFC2AB4
  • Sequence:
    • MTLKWTSVLL LIHLSCYFSS GSCGKVLVWA AEYSHWMNMK TILKELVQRG HEVTVLASSA 
SILFDPNDAS TLKFEVYPTS LTKTEFENII MQQVKRWSDI RKDSFWLYFS QEQEILWELY 
DIFRNFCKDV VSNKKVMKKL QESRFDIVFA DAVFPCGELL AALLNIRFVY SLRFTPGYTI 
ERHSGGLIFP PSYIPIVMSK LSDQMTFMER VKNMIYVLYF DFWFQMSDMK KWDQFYSEVL 
GRPTTLFETM GKADIWLMRN SWSFQFPHPF LPNVDFVGGF HCKPAKPLPK EMEEFVQSSG 
ENGVVVFSLG SVISNMTAER ANVIATALAK IPQKVLWRFD GNKPDALGLN TRLYKWIPQN 
DLLGHPKTRA FITHGGANGI YEAIYHGIPM VGIPLFFDQP DNIAHMKAKG AAVRLDFNTM 
SSTDLLNALK TVINDPLYKE NIMKLSRIQH DQPVKPLDRA VFWIEFVMPH KGAKHLRVAA 
HDLTWFQYHS LDVIGFLLAC VATVIFIITK FCLFCFWKFA RKGKKGKRD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.