Details for: POLQ

Gene ID: 10721

Symbol: POLQ

Ensembl ID: ENSG00000051341

Description: DNA polymerase theta

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 4.65
    Marker Score: 4,460
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 2.47
    Marker Score: 7,090
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169,373
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.41
    Marker Score: 2,665
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.38
    Marker Score: 2,858
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.09
    Marker Score: 2,213
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,817
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,041
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 503
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 458
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,736
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5,184
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.9
    Marker Score: 612
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.89
    Marker Score: 532
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,296
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.86
    Marker Score: 386
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.83
    Marker Score: 13,027
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.79
    Marker Score: 251
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.78
    Marker Score: 945
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.77
    Marker Score: 524
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,253
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 305
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.75
    Marker Score: 423
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 569
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.74
    Marker Score: 1,750
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.74
    Marker Score: 840
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.74
    Marker Score: 2,011
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.72
    Marker Score: 3,031
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.72
    Marker Score: 659
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.68
    Marker Score: 1,051
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.65
    Marker Score: 6,174
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.62
    Marker Score: 1,083
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.62
    Marker Score: 819
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.61
    Marker Score: 22,354
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.58
    Marker Score: 373
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.56
    Marker Score: 34,332
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5
    Marker Score: 1,481
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.5
    Marker Score: 160
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.5
    Marker Score: 363
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.48
    Marker Score: 4,089
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.48
    Marker Score: 357
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.47
    Marker Score: 387
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.45
    Marker Score: 330
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.44
    Marker Score: 1,521
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.43
    Marker Score: 1,669
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.43
    Marker Score: 205
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.42
    Marker Score: 583
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.41
    Marker Score: 397
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.41
    Marker Score: 128
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.38
    Marker Score: 157
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.37
    Marker Score: 103
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 376
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.37
    Marker Score: 390
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.37
    Marker Score: 1,545
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.36
    Marker Score: 96
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.36
    Marker Score: 334
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.35
    Marker Score: 252
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.35
    Marker Score: 111
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.35
    Marker Score: 3,018
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.34
    Marker Score: 220
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.33
    Marker Score: 242
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.33
    Marker Score: 288
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.33
    Marker Score: 206
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.32
    Marker Score: 3,024
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.32
    Marker Score: 114
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.32
    Marker Score: 82
  • Cell Name: pre-conventional dendritic cell (CL0002010)
    Fold Change: 0.31
    Marker Score: 93
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.31
    Marker Score: 139
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.31
    Marker Score: 152
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.3
    Marker Score: 515
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.3
    Marker Score: 123
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.3
    Marker Score: 426
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.29
    Marker Score: 187
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.29
    Marker Score: 466
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.29
    Marker Score: 300
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.28
    Marker Score: 143
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.28
    Marker Score: 138
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.27
    Marker Score: 95
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.27
    Marker Score: 131
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.25
    Marker Score: 4,497
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.25
    Marker Score: 115
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.25
    Marker Score: 280
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.25
    Marker Score: 141
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.24
    Marker Score: 102
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.24
    Marker Score: 254
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.24
    Marker Score: 916
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.24
    Marker Score: 4,699
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.23
    Marker Score: 960
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.23
    Marker Score: 961
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.23
    Marker Score: 196
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.23
    Marker Score: 135
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.22
    Marker Score: 315
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.22
    Marker Score: 276

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** POLQ is a member of the DNA polymerase theta family, characterized by its ability to process and repair damaged DNA. It is a hexameric enzyme composed of six subunits, each with distinct subunit-specific functions. POLQ exhibits high processivity, allowing it to synthesize long stretches of DNA in a single round of catalysis. This property enables POLQ to efficiently repair DNA double-strand breaks, which are often caused by errors during DNA replication or oxidative stress. **Pathways and Functions:** POLQ is involved in various DNA repair pathways, including: 1. **Homologous recombination (HR)**: POLQ plays a crucial role in the repair of double-strand breaks via HR, a process that relies on the presence of a homologous template. 2. **Non-homologous end joining (NHEJ)**: POLQ also participates in the repair of double-strand breaks via alternative non-homologous end joining (alt-NHEJ), a process that relies on the recruitment of DNA repair proteins. 3. **Base-excision repair**: POLQ has been implicated in the repair of oxidized bases, which are often caused by reactive oxygen species. 4. **Single-stranded DNA (ssDNA) processing**: POLQ is involved in the processing of ssDNA, which is a critical step in the repair of DNA double-strand breaks. POLQ's functions in DNA repair are closely linked to its role in maintaining genome stability. By repairing damaged DNA, POLQ helps to prevent mutations and maintain the integrity of the genome. **Clinical Significance:** Dysregulation of POLQ has been implicated in various diseases, including: 1. **Cancer**: Mutations in POLQ have been associated with an increased risk of cancer, particularly in the brain and retina. 2. **Neurodegenerative disorders**: POLQ has been implicated in the pathogenesis of neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Immunodeficiency**: POLQ plays a critical role in the repair of DNA damage in immune cells, and its dysregulation can lead to immunodeficiency. In conclusion, POLQ is a multifaceted enzyme with a critical role in DNA repair and immune function. Its dysregulation has been implicated in various diseases, highlighting the importance of maintaining POLQ expression and function in maintaining genome stability and immune homeostasis. **References:** * [Insert references to relevant studies and literature] Note: The references section should include a list of relevant studies and literature that support the discussion points outlined in the review article.

Genular Protein ID: 2187840672

Symbol: DPOLQ_HUMAN

Name: N/A

UniProtKB Accession Codes:

O75417 O95160 Q6VMB5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CPTAC 1 CTD 1 ChEBI 17 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EC 3 EMBL 5 EPD 1 Ensembl 1 GO 26 Gene3D 5 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MIM 3 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 21 PDBsum 11 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 7 SABIO-RK 1 SAM 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10395804

Title: Cloning and chromosomal mapping of the human DNA polymerase theta (POLQ), the eighth human DNA polymerase.

PubMed ID: 10395804

DOI: 10.1006/geno.1999.5843

PubMed ID: 14576298

Title: POLQ (Pol theta), a DNA polymerase and DNA-dependent ATPase in human cells.

PubMed ID: 14576298

DOI: 10.1093/nar/gkg814

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 18503084

Title: Low-fidelity DNA synthesis by human DNA polymerase theta.

PubMed ID: 18503084

DOI: 10.1093/nar/gkn310

PubMed ID: 19188258

Title: Human DNA polymerase theta possesses 5'-dRP lyase activity and functions in single-nucleotide base excision repair in vitro.

PubMed ID: 19188258

DOI: 10.1093/nar/gkp035

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20700469

Title: Overexpression of POLQ confers a poor prognosis in early breast cancer patients.

PubMed ID: 20700469

DOI: 10.18632/oncotarget.124

PubMed ID: 20624954

Title: DNA polymerase theta up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability.

PubMed ID: 20624954

DOI: 10.1073/pnas.0910759107

PubMed ID: 21050863

Title: Lesion bypass activity of DNA polymerase theta (POLQ) is an intrinsic property of the pol domain and depends on unique sequence inserts.

PubMed ID: 21050863

DOI: 10.1016/j.jmb.2010.10.041

PubMed ID: 22135286

Title: Promiscuous DNA synthesis by human DNA polymerase theta.

PubMed ID: 22135286

DOI: 10.1093/nar/gkr1102

PubMed ID: 25409685

Title: A DNA repair variant in POLQ (c.-1060A > G) is associated to hereditary breast cancer patients: a case-control study.

PubMed ID: 25409685

DOI: 10.1186/1471-2407-14-850

PubMed ID: 24648516

Title: A role for DNA polymerase theta in promoting replication through oxidative DNA lesion, thymine glycol, in human cells.

PubMed ID: 24648516

DOI: 10.1074/jbc.m114.556977

PubMed ID: 24989122

Title: A role for DNA polymerase theta in the timing of DNA replication.

PubMed ID: 24989122

DOI: 10.1038/ncomms5285

PubMed ID: 25642963

Title: Homologous-recombination-deficient tumours are dependent on Poltheta-mediated repair.

PubMed ID: 25642963

DOI: 10.1038/nature14184

PubMed ID: 25643323

Title: Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase theta.

PubMed ID: 25643323

DOI: 10.1038/nsmb.2961

PubMed ID: 27311885

Title: Polymerase theta is a robust terminal transferase that oscillates between three different mechanisms during end-joining.

PubMed ID: 27311885

DOI: 10.7554/elife.13740

PubMed ID: 27591252

Title: DNA polymerase theta specializes in incorporating synthetic expanded-size (xDNA) nucleotides.

PubMed ID: 27591252

DOI: 10.1093/nar/gkw721

PubMed ID: 28695890

Title: Dual loss of human POLQ and LIG4 abolishes random integration.

PubMed ID: 28695890

DOI: 10.1038/ncomms16112

PubMed ID: 30655289

Title: DNA polymerase theta (POLQ) is important for repair of DNA double-strand breaks caused by fork collapse.

PubMed ID: 30655289

DOI: 10.1074/jbc.ra118.005188

PubMed ID: 31562312

Title: Molecular basis of microhomology-mediated end-joining by purified full-length Poltheta.

PubMed ID: 31562312

DOI: 10.1038/s41467-019-12272-9

PubMed ID: 32234782

Title: Mechanistic basis for microhomology identification and genome scarring by polymerase theta.

PubMed ID: 32234782

DOI: 10.1073/pnas.1921791117

PubMed ID: 32873648

Title: POLQ suppresses interhomolog recombination and loss of heterozygosity at targeted DNA breaks.

PubMed ID: 32873648

DOI: 10.1073/pnas.2008073117

PubMed ID: 33577776

Title: Human DNA polymerase theta harbors DNA end-trimming activity critical for DNA repair.

PubMed ID: 33577776

DOI: 10.1016/j.molcel.2021.01.021

PubMed ID: 34179826

Title: A first-in-class Polymerase Theta Inhibitor selectively targets Homologous-Recombination-Deficient Tumors.

PubMed ID: 34179826

DOI: 10.1038/s43018-021-00203-x

PubMed ID: 34140467

Title: Poltheta inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance.

PubMed ID: 34140467

DOI: 10.1038/s41467-021-23463-8

PubMed ID: 36455556

Title: POLQ seals post-replicative ssDNA gaps to maintain genome stability in BRCA-deficient cancer cells.

PubMed ID: 36455556

DOI: 10.1016/j.molcel.2022.11.008

PubMed ID: 37674080

Title: Poltheta is phosphorylated by PLK1 to repair double-strand breaks in mitosis.

PubMed ID: 37674080

DOI: 10.1038/s41586-023-06506-6

PubMed ID: 37440612

Title: RHINO directs MMEJ to repair DNA breaks in mitosis.

PubMed ID: 37440612

DOI: 10.1126/science.adh3694

PubMed ID: 25775267

Title: Human DNA polymerase theta grasps the primer terminus to mediate DNA repair.

PubMed ID: 25775267

DOI: 10.1038/nsmb.2993

PubMed ID: 26636256

Title: Structure of the helicase domain of DNA polymerase theta reveals a possible role in the microhomology-mediated end-joining pathway.

PubMed ID: 26636256

DOI: 10.1016/j.str.2015.10.014

PubMed ID: 34117057

Title: Poltheta reverse transcribes RNA and promotes RNA-templated DNA repair.

PubMed ID: 34117057

DOI: 10.1126/sciadv.abf1771

Sequence Information:

  • Length: 2590
  • Mass: 289619
  • Checksum: F5550BED2DAD8013
  • Sequence:
    • MNLLRRSGKR RRSESGSDSF SGSGGDSSAS PQFLSGSVLS PPPGLGRCLK AAAAGECKPT 
VPDYERDKLL LANWGLPKAV LEKYHSFGVK KMFEWQAECL LLGQVLEGKN LVYSAPTSAG 
KTLVAELLIL KRVLEMRKKA LFILPFVSVA KEKKYYLQSL FQEVGIKVDG YMGSTSPSRH 
FSSLDIAVCT IERANGLINR LIEENKMDLL GMVVVDELHM LGDSHRGYLL ELLLTKICYI 
TRKSASCQAD LASSLSNAVQ IVGMSATLPN LELVASWLNA ELYHTDFRPV PLLESVKVGN 
SIYDSSMKLV REFEPMLQVK GDEDHVVSLC YETICDNHSV LLFCPSKKWC EKLADIIARE 
FYNLHHQAEG LVKPSECPPV ILEQKELLEV MDQLRRLPSG LDSVLQKTVP WGVAFHHAGL 
TFEERDIIEG AFRQGLIRVL AATSTLSSGV NLPARRVIIR TPIFGGRPLD ILTYKQMVGR 
AGRKGVDTVG ESILICKNSE KSKGIALLQG SLKPVRSCLQ RREGEEVTGS MIRAILEIIV 
GGVASTSQDM HTYAACTFLA ASMKEGKQGI QRNQESVQLG AIEACVMWLL ENEFIQSTEA 
SDGTEGKVYH PTHLGSATLS SSLSPADTLD IFADLQRAMK GFVLENDLHI LYLVTPMFED 
WTTIDWYRFF CLWEKLPTSM KRVAELVGVE EGFLARCVKG KVVARTERQH RQMAIHKRFF 
TSLVLLDLIS EVPLREINQK YGCNRGQIQS LQQSAAVYAG MITVFSNRLG WHNMELLLSQ 
FQKRLTFGIQ RELCDLVRVS LLNAQRARVL YASGFHTVAD LARANIVEVE VILKNAVPFK 
SARKAVDEEE EAVEERRNMR TIWVTGRKGL TEREAAALIV EEARMILQQD LVEMGVQWNP 
CALLHSSTCS LTHSESEVKE HTFISQTKSS YKKLTSKNKS NTIFSDSYIK HSPNIVQDLN 
KSREHTSSFN CNFQNGNQEH QTCSIFRARK RASLDINKEK PGASQNEGKT SDKKVVQTFS 
QKTKKAPLNF NSEKMSRSFR SWKRRKHLKR SRDSSPLKDS GACRIHLQGQ TLSNPSLCED 
PFTLDEKKTE FRNSGPFAKN VSLSGKEKDN KTSFPLQIKQ NCSWNITLTN DNFVEHIVTG 
SQSKNVTCQA TSVVSEKGRG VAVEAEKINE VLIQNGSKNQ NVYMKHHDIH PINQYLRKQS 
HEQTSTITKQ KNIIERQMPC EAVSSYINRD SNVTINCERI KLNTEENKPS HFQALGDDIS 
RTVIPSEVLP SAGAFSKSEG QHENFLNISR LQEKTGTYTT NKTKNNHVSD LGLVLCDFED 
SFYLDTQSEK IIQQMATENA KLGAKDTNLA AGIMQKSLVQ QNSMNSFQKE CHIPFPAEQH 
PLGATKIDHL DLKTVGTMKQ SSDSHGVDIL TPESPIFHSP ILLEENGLFL KKNEVSVTDS 
QLNSFLQGYQ TQETVKPVIL LIPQKRTPTG VEGECLPVPE TSLNMSDSLL FDSFSDDYLV 
KEQLPDMQMK EPLPSEVTSN HFSDSLCLQE DLIKKSNVNE NQDTHQQLTC SNDESIIFSE 
MDSVQMVEAL DNVDIFPVQE KNHTVVSPRA LELSDPVLDE HHQGDQDGGD QDERAEKSKL 
TGTRQNHSFI WSGASFDLSP GLQRILDKVS SPLENEKLKS MTINFSSLNR KNTELNEEQE 
VISNLETKQV QGISFSSNNE VKSKIEMLEN NANHDETSSL LPRKESNIVD DNGLIPPTPI 
PTSASKLTFP GILETPVNPW KTNNVLQPGE SYLFGSPSDI KNHDLSPGSR NGFKDNSPIS 
DTSFSLQLSQ DGLQLTPASS SSESLSIIDV ASDQNLFQTF IKEWRCKKRF SISLACEKIR 
SLTSSKTATI GSRFKQASSP QEIPIRDDGF PIKGCDDTLV VGLAVCWGGR DAYYFSLQKE 
QKHSEISASL VPPSLDPSLT LKDRMWYLQS CLRKESDKEC SVVIYDFIQS YKILLLSCGI 
SLEQSYEDPK VACWLLDPDS QEPTLHSIVT SFLPHELPLL EGMETSQGIQ SLGLNAGSEH 
SGRYRASVES ILIFNSMNQL NSLLQKENLQ DVFRKVEMPS QYCLALLELN GIGFSTAECE 
SQKHIMQAKL DAIETQAYQL AGHSFSFTSS DDIAEVLFLE LKLPPNREMK NQGSKKTLGS 
TRRGIDNGRK LRLGRQFSTS KDVLNKLKAL HPLPGLILEW RRITNAITKV VFPLQREKCL 
NPFLGMERIY PVSQSHTATG RITFTEPNIQ NVPRDFEIKM PTLVGESPPS QAVGKGLLPM 
GRGKYKKGFS VNPRCQAQME ERAADRGMPF SISMRHAFVP FPGGSILAAD YSQLELRILA 
HLSHDRRLIQ VLNTGADVFR SIAAEWKMIE PESVGDDLRQ QAKQICYGII YGMGAKSLGE 
QMGIKENDAA CYIDSFKSRY TGINQFMTET VKNCKRDGFV QTILGRRRYL PGIKDNNPYR 
KAHAERQAIN TIVQGSAADI VKIATVNIQK QLETFHSTFK SHGHREGMLQ SDQTGLSRKR 
KLQGMFCPIR GGFFILQLHD ELLYEVAEED VVQVAQIVKN EMESAVKLSV KLKVKVKIGA 
SWGELKDFDV

Genular Protein ID: 3653588783

Symbol: Q59EE4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59EE4

Database IDs:

ARBA 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 3 DNASU 1 EC 1 EMBL 2 GO 5 Gene3D 5 Genevisible 1 GenomeRNAi 1 InterPro 10 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 4 PharmGKB 1 RefSeq 1 Rhea 3 SAM 2 SMART 2 SUPFAM 4

Sequence Information:

  • Length: 2214
  • Mass: 247978
  • Checksum: 327C2D6AC85F7753
  • Sequence:
    • MPTSNSGQKE LLEVMDQLRR LPSGLDSVLQ KTVPWGVAFH HAGLTFEERD IIEGAFRQGL 
IRVLAATSTL SSGVNLPARR VIIRTPIFGG RPLDILTYKQ MVGRAGRKGV DTVGESILIC 
KNSEKSKGIA LLQGSLKPVR SCLQRREGEE VTGSMIRAIL EIIVGGVAST SQDMHTYAAC 
TFLAASMKEG KQGIQRNQES VQLGAIEACV MWLLENEFIQ STEASDGTEG KVYHPTHLGS 
ATLSSSLSPA DTLDIFADLQ RAMKGFVLEN DLHILYLVTP MFEDWTTIDW YRFFCLWEKL 
PTSMKRVAEL VGVEEGFLAR CVKGKVVART ERQHRQMAIH KRFFTSLVLL DLISEVPLRE 
INQKYGCNRG QIQSLQQSAA VYAGMITVFS NRLGWHNMEL LLSQFQKRLT FGIQRELCDL 
VRVSLLNAQR ARVLYASGFH TVADLARANI VEVEVILKNA VPFKSARKAV DEEEEAVEER 
RNMRTIWVTG RKGLTEREAA ALIVEEARMI LQQDLVEMGV QWNPCALLHS STCSLTHSES 
EVKEHTFISQ TKSSYKKLTS KNKSNTIFSD SYIKHSPNIV QDLNKSREHT SSFNCNFQNG 
NQEHQRCSIF RARKRASLDI NKEKPGASQN EGKTSDKKVV QTFSQKTKKA PLNFNSEKMS 
RSFRSWKRRK HLKRSRDSSP LKDSGACRIH LQGQTLSNPS LCEDPFTLDE KKTEFRNSGP 
FAKNVSLSGK EKDNKTSFPL QIKQNCSWNI TLTNDNFVEH IVTGSQSKNV TCQATSVVSE 
KGRGVAVEAE KINEVLIQNG SKNQNVYMKH HDIHPINQYL RKQSHEQTST ITKQKNIIER 
QMPCEAVSSY INRDSNVTIN CERIKLNTEE NKPSHFQALG DDISRTVIPS EVLPSAGAFS 
KSEGQHENFL NISRLQEKTG TYTTNKTKNN HVSDLGLVLC DFEDSFYLDT QSEKIIQQMA 
TENAKLGAKD TNLAAGIMQK SLVQQNSMNS FQKECHIPFP AEQHPLGATK IDHLDLKTVG 
TMKQSSDSHG VDILTPESPI FHSPILLEEN GLFLKKNEVS VTDSQLNSFL QGYQTQETVK 
PVILLIPQKR TPTGVEGECL PVPETSLNMS DSLLFDSFSD DYLVKEQLPD MQMKEPLPSE 
VTSNHFSDSL CLQEDLIKKS NVNENQDTHQ QLTCSNDESI IFSEMDSVQM VEALDNVDIF 
PVQEKNHTVV SPRALELSDP VLDEHHQGDQ DGGDQDERAE KSKLTGTRQN HSFIWSGASF 
DLSPGLQRIL DKVSSPLENE KLKSMTINFS SLNRKNTELN EEQEVISNLE TKQVQGISFS 
SNNEVKSKIE MLENNANHDE TSSLLPRKES NIVDDNGLIP PTPIPTSASK LTFPGILETP 
VNPWKTNNVL QPGESYLFGS PSDIKNHDLS PGSRNGFKDN SPISDTSFSL QLSQDGLQLT 
PASSSSESLS IIDVASDQNL FQTFIKEWRC KKRFSISLAC EKIRSLTSSK TATIGSRFKQ 
ASSPQEIPIR DDGFPIKGCD DTLVVGLAVC WGGRDAYYFS LQKEQKHSEI SASLVPPSLD 
PSLTLKDRMW YLQSCLRKES DKECSVVIYD FIQSYKILLL SCGISLEQSY EDPKVACWLL 
DPDSQEPTLH SIVTSFLPHE LPLLEGMETS QGIQSLGLNA GSEHSGRYRA SVESILIFNS 
MNQLNSLLQK ENLQDVFRKV EMPSQYCLAL LELNGIGFST AECESQKHIM QAKLDAIETQ 
AYQLAGHSFS FTSSDDIAEV LFLELKLPPN REMKNQGSKK TLGSTRRGID NGRKLRLGRQ 
FSTSKDVLNK LKALHPLPGL ILEWRRITNA ITKVVFPLQR EKCLNPFLGM ERIYPVSQSH 
TATGRITFTE PNIQNVPRDF EIKMPTLVGE SPPSQAVGKG LLPMGRGKYK KGFSVNPRCQ 
AQMEERAADR GMPFSISMRH AFVPFPGGSI LAADYSQLEL RILAHLSHDR RLIQVLNTGA 
DVFRSIAAEW KMIEPESVGD DLRQQAKQIC YGIIYGMGAK SLGEQMGIKE NDAACYIDSF 
KSRYTGINQF MTETVKNCKR DGFVQTILGR RRYLPGIKDN NPYRKAHAER QAINTIVQGS 
AADIVKIATV NIQKQLETFH STFKSHGHRE GMLQSDRTGL SRKRKLQGMF CPIRGGFFIL 
QLHDELLYEV AEEDVVQVAQ IVKNEMESAV KLSVKLKVKV KIGASWGELK DFDV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.