Details for: POLQ
Associated with
Other Information
Genular Protein ID: 2187840672
Symbol: DPOLQ_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10395804
Title: Cloning and chromosomal mapping of the human DNA polymerase theta (POLQ), the eighth human DNA polymerase.
PubMed ID: 10395804
PubMed ID: 14576298
Title: POLQ (Pol theta), a DNA polymerase and DNA-dependent ATPase in human cells.
PubMed ID: 14576298
DOI: 10.1093/nar/gkg814
PubMed ID: 16641997
Title: The DNA sequence, annotation and analysis of human chromosome 3.
PubMed ID: 16641997
DOI: 10.1038/nature04728
PubMed ID: 18503084
Title: Low-fidelity DNA synthesis by human DNA polymerase theta.
PubMed ID: 18503084
DOI: 10.1093/nar/gkn310
PubMed ID: 19188258
Title: Human DNA polymerase theta possesses 5'-dRP lyase activity and functions in single-nucleotide base excision repair in vitro.
PubMed ID: 19188258
DOI: 10.1093/nar/gkp035
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20700469
Title: Overexpression of POLQ confers a poor prognosis in early breast cancer patients.
PubMed ID: 20700469
PubMed ID: 20624954
Title: DNA polymerase theta up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability.
PubMed ID: 20624954
PubMed ID: 21050863
Title: Lesion bypass activity of DNA polymerase theta (POLQ) is an intrinsic property of the pol domain and depends on unique sequence inserts.
PubMed ID: 21050863
PubMed ID: 22135286
Title: Promiscuous DNA synthesis by human DNA polymerase theta.
PubMed ID: 22135286
DOI: 10.1093/nar/gkr1102
PubMed ID: 25409685
Title: A DNA repair variant in POLQ (c.-1060A > G) is associated to hereditary breast cancer patients: a case-control study.
PubMed ID: 25409685
PubMed ID: 24648516
Title: A role for DNA polymerase theta in promoting replication through oxidative DNA lesion, thymine glycol, in human cells.
PubMed ID: 24648516
PubMed ID: 24989122
Title: A role for DNA polymerase theta in the timing of DNA replication.
PubMed ID: 24989122
DOI: 10.1038/ncomms5285
PubMed ID: 25642963
Title: Homologous-recombination-deficient tumours are dependent on Poltheta-mediated repair.
PubMed ID: 25642963
DOI: 10.1038/nature14184
PubMed ID: 25643323
Title: Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase theta.
PubMed ID: 25643323
DOI: 10.1038/nsmb.2961
PubMed ID: 27311885
Title: Polymerase theta is a robust terminal transferase that oscillates between three different mechanisms during end-joining.
PubMed ID: 27311885
DOI: 10.7554/elife.13740
PubMed ID: 27591252
Title: DNA polymerase theta specializes in incorporating synthetic expanded-size (xDNA) nucleotides.
PubMed ID: 27591252
DOI: 10.1093/nar/gkw721
PubMed ID: 28695890
Title: Dual loss of human POLQ and LIG4 abolishes random integration.
PubMed ID: 28695890
DOI: 10.1038/ncomms16112
PubMed ID: 30655289
Title: DNA polymerase theta (POLQ) is important for repair of DNA double-strand breaks caused by fork collapse.
PubMed ID: 30655289
PubMed ID: 31562312
Title: Molecular basis of microhomology-mediated end-joining by purified full-length Poltheta.
PubMed ID: 31562312
PubMed ID: 32234782
Title: Mechanistic basis for microhomology identification and genome scarring by polymerase theta.
PubMed ID: 32234782
PubMed ID: 32873648
Title: POLQ suppresses interhomolog recombination and loss of heterozygosity at targeted DNA breaks.
PubMed ID: 32873648
PubMed ID: 33577776
Title: Human DNA polymerase theta harbors DNA end-trimming activity critical for DNA repair.
PubMed ID: 33577776
PubMed ID: 34179826
Title: A first-in-class Polymerase Theta Inhibitor selectively targets Homologous-Recombination-Deficient Tumors.
PubMed ID: 34179826
PubMed ID: 34140467
Title: Poltheta inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance.
PubMed ID: 34140467
PubMed ID: 36455556
Title: POLQ seals post-replicative ssDNA gaps to maintain genome stability in BRCA-deficient cancer cells.
PubMed ID: 36455556
PubMed ID: 37674080
Title: Poltheta is phosphorylated by PLK1 to repair double-strand breaks in mitosis.
PubMed ID: 37674080
PubMed ID: 37440612
Title: RHINO directs MMEJ to repair DNA breaks in mitosis.
PubMed ID: 37440612
PubMed ID: 25775267
Title: Human DNA polymerase theta grasps the primer terminus to mediate DNA repair.
PubMed ID: 25775267
DOI: 10.1038/nsmb.2993
PubMed ID: 26636256
Title: Structure of the helicase domain of DNA polymerase theta reveals a possible role in the microhomology-mediated end-joining pathway.
PubMed ID: 26636256
PubMed ID: 34117057
Title: Poltheta reverse transcribes RNA and promotes RNA-templated DNA repair.
PubMed ID: 34117057
Sequence Information:
- Length: 2590
- Mass: 289619
- Checksum: F5550BED2DAD8013
- Sequence:
MNLLRRSGKR RRSESGSDSF SGSGGDSSAS PQFLSGSVLS PPPGLGRCLK AAAAGECKPT VPDYERDKLL LANWGLPKAV LEKYHSFGVK KMFEWQAECL LLGQVLEGKN LVYSAPTSAG KTLVAELLIL KRVLEMRKKA LFILPFVSVA KEKKYYLQSL FQEVGIKVDG YMGSTSPSRH FSSLDIAVCT IERANGLINR LIEENKMDLL GMVVVDELHM LGDSHRGYLL ELLLTKICYI TRKSASCQAD LASSLSNAVQ IVGMSATLPN LELVASWLNA ELYHTDFRPV PLLESVKVGN SIYDSSMKLV REFEPMLQVK GDEDHVVSLC YETICDNHSV LLFCPSKKWC EKLADIIARE FYNLHHQAEG LVKPSECPPV ILEQKELLEV MDQLRRLPSG LDSVLQKTVP WGVAFHHAGL TFEERDIIEG AFRQGLIRVL AATSTLSSGV NLPARRVIIR TPIFGGRPLD ILTYKQMVGR AGRKGVDTVG ESILICKNSE KSKGIALLQG SLKPVRSCLQ RREGEEVTGS MIRAILEIIV GGVASTSQDM HTYAACTFLA ASMKEGKQGI QRNQESVQLG AIEACVMWLL ENEFIQSTEA SDGTEGKVYH PTHLGSATLS SSLSPADTLD IFADLQRAMK GFVLENDLHI LYLVTPMFED WTTIDWYRFF CLWEKLPTSM KRVAELVGVE EGFLARCVKG KVVARTERQH RQMAIHKRFF TSLVLLDLIS EVPLREINQK YGCNRGQIQS LQQSAAVYAG MITVFSNRLG WHNMELLLSQ FQKRLTFGIQ RELCDLVRVS LLNAQRARVL YASGFHTVAD LARANIVEVE VILKNAVPFK SARKAVDEEE EAVEERRNMR TIWVTGRKGL TEREAAALIV EEARMILQQD LVEMGVQWNP CALLHSSTCS LTHSESEVKE HTFISQTKSS YKKLTSKNKS NTIFSDSYIK HSPNIVQDLN KSREHTSSFN CNFQNGNQEH QTCSIFRARK RASLDINKEK PGASQNEGKT SDKKVVQTFS QKTKKAPLNF NSEKMSRSFR SWKRRKHLKR SRDSSPLKDS GACRIHLQGQ TLSNPSLCED PFTLDEKKTE FRNSGPFAKN VSLSGKEKDN KTSFPLQIKQ NCSWNITLTN DNFVEHIVTG SQSKNVTCQA TSVVSEKGRG VAVEAEKINE VLIQNGSKNQ NVYMKHHDIH PINQYLRKQS HEQTSTITKQ KNIIERQMPC EAVSSYINRD SNVTINCERI KLNTEENKPS HFQALGDDIS RTVIPSEVLP SAGAFSKSEG QHENFLNISR LQEKTGTYTT NKTKNNHVSD LGLVLCDFED SFYLDTQSEK IIQQMATENA KLGAKDTNLA AGIMQKSLVQ QNSMNSFQKE CHIPFPAEQH PLGATKIDHL DLKTVGTMKQ SSDSHGVDIL TPESPIFHSP ILLEENGLFL KKNEVSVTDS QLNSFLQGYQ TQETVKPVIL LIPQKRTPTG VEGECLPVPE TSLNMSDSLL FDSFSDDYLV KEQLPDMQMK EPLPSEVTSN HFSDSLCLQE DLIKKSNVNE NQDTHQQLTC SNDESIIFSE MDSVQMVEAL DNVDIFPVQE KNHTVVSPRA LELSDPVLDE HHQGDQDGGD QDERAEKSKL TGTRQNHSFI WSGASFDLSP GLQRILDKVS SPLENEKLKS MTINFSSLNR KNTELNEEQE VISNLETKQV QGISFSSNNE VKSKIEMLEN NANHDETSSL LPRKESNIVD DNGLIPPTPI PTSASKLTFP GILETPVNPW KTNNVLQPGE SYLFGSPSDI KNHDLSPGSR NGFKDNSPIS DTSFSLQLSQ DGLQLTPASS SSESLSIIDV ASDQNLFQTF IKEWRCKKRF SISLACEKIR SLTSSKTATI GSRFKQASSP QEIPIRDDGF PIKGCDDTLV VGLAVCWGGR DAYYFSLQKE QKHSEISASL VPPSLDPSLT LKDRMWYLQS CLRKESDKEC SVVIYDFIQS YKILLLSCGI SLEQSYEDPK VACWLLDPDS QEPTLHSIVT SFLPHELPLL EGMETSQGIQ SLGLNAGSEH SGRYRASVES ILIFNSMNQL NSLLQKENLQ DVFRKVEMPS QYCLALLELN GIGFSTAECE SQKHIMQAKL DAIETQAYQL AGHSFSFTSS DDIAEVLFLE LKLPPNREMK NQGSKKTLGS TRRGIDNGRK LRLGRQFSTS KDVLNKLKAL HPLPGLILEW RRITNAITKV VFPLQREKCL NPFLGMERIY PVSQSHTATG RITFTEPNIQ NVPRDFEIKM PTLVGESPPS QAVGKGLLPM GRGKYKKGFS VNPRCQAQME ERAADRGMPF SISMRHAFVP FPGGSILAAD YSQLELRILA HLSHDRRLIQ VLNTGADVFR SIAAEWKMIE PESVGDDLRQ QAKQICYGII YGMGAKSLGE QMGIKENDAA CYIDSFKSRY TGINQFMTET VKNCKRDGFV QTILGRRRYL PGIKDNNPYR KAHAERQAIN TIVQGSAADI VKIATVNIQK QLETFHSTFK SHGHREGMLQ SDQTGLSRKR KLQGMFCPIR GGFFILQLHD ELLYEVAEED VVQVAQIVKN EMESAVKLSV KLKVKVKIGA SWGELKDFDV
Genular Protein ID: 3653588783
Symbol: Q59EE4_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 2214
- Mass: 247978
- Checksum: 327C2D6AC85F7753
- Sequence:
MPTSNSGQKE LLEVMDQLRR LPSGLDSVLQ KTVPWGVAFH HAGLTFEERD IIEGAFRQGL IRVLAATSTL SSGVNLPARR VIIRTPIFGG RPLDILTYKQ MVGRAGRKGV DTVGESILIC KNSEKSKGIA LLQGSLKPVR SCLQRREGEE VTGSMIRAIL EIIVGGVAST SQDMHTYAAC TFLAASMKEG KQGIQRNQES VQLGAIEACV MWLLENEFIQ STEASDGTEG KVYHPTHLGS ATLSSSLSPA DTLDIFADLQ RAMKGFVLEN DLHILYLVTP MFEDWTTIDW YRFFCLWEKL PTSMKRVAEL VGVEEGFLAR CVKGKVVART ERQHRQMAIH KRFFTSLVLL DLISEVPLRE INQKYGCNRG QIQSLQQSAA VYAGMITVFS NRLGWHNMEL LLSQFQKRLT FGIQRELCDL VRVSLLNAQR ARVLYASGFH TVADLARANI VEVEVILKNA VPFKSARKAV DEEEEAVEER RNMRTIWVTG RKGLTEREAA ALIVEEARMI LQQDLVEMGV QWNPCALLHS STCSLTHSES EVKEHTFISQ TKSSYKKLTS KNKSNTIFSD SYIKHSPNIV QDLNKSREHT SSFNCNFQNG NQEHQRCSIF RARKRASLDI NKEKPGASQN EGKTSDKKVV QTFSQKTKKA PLNFNSEKMS RSFRSWKRRK HLKRSRDSSP LKDSGACRIH LQGQTLSNPS LCEDPFTLDE KKTEFRNSGP FAKNVSLSGK EKDNKTSFPL QIKQNCSWNI TLTNDNFVEH IVTGSQSKNV TCQATSVVSE KGRGVAVEAE KINEVLIQNG SKNQNVYMKH HDIHPINQYL RKQSHEQTST ITKQKNIIER QMPCEAVSSY INRDSNVTIN CERIKLNTEE NKPSHFQALG DDISRTVIPS EVLPSAGAFS KSEGQHENFL NISRLQEKTG TYTTNKTKNN HVSDLGLVLC DFEDSFYLDT QSEKIIQQMA TENAKLGAKD TNLAAGIMQK SLVQQNSMNS FQKECHIPFP AEQHPLGATK IDHLDLKTVG TMKQSSDSHG VDILTPESPI FHSPILLEEN GLFLKKNEVS VTDSQLNSFL QGYQTQETVK PVILLIPQKR TPTGVEGECL PVPETSLNMS DSLLFDSFSD DYLVKEQLPD MQMKEPLPSE VTSNHFSDSL CLQEDLIKKS NVNENQDTHQ QLTCSNDESI IFSEMDSVQM VEALDNVDIF PVQEKNHTVV SPRALELSDP VLDEHHQGDQ DGGDQDERAE KSKLTGTRQN HSFIWSGASF DLSPGLQRIL DKVSSPLENE KLKSMTINFS SLNRKNTELN EEQEVISNLE TKQVQGISFS SNNEVKSKIE MLENNANHDE TSSLLPRKES NIVDDNGLIP PTPIPTSASK LTFPGILETP VNPWKTNNVL QPGESYLFGS PSDIKNHDLS PGSRNGFKDN SPISDTSFSL QLSQDGLQLT PASSSSESLS IIDVASDQNL FQTFIKEWRC KKRFSISLAC EKIRSLTSSK TATIGSRFKQ ASSPQEIPIR DDGFPIKGCD DTLVVGLAVC WGGRDAYYFS LQKEQKHSEI SASLVPPSLD PSLTLKDRMW YLQSCLRKES DKECSVVIYD FIQSYKILLL SCGISLEQSY EDPKVACWLL DPDSQEPTLH SIVTSFLPHE LPLLEGMETS QGIQSLGLNA GSEHSGRYRA SVESILIFNS MNQLNSLLQK ENLQDVFRKV EMPSQYCLAL LELNGIGFST AECESQKHIM QAKLDAIETQ AYQLAGHSFS FTSSDDIAEV LFLELKLPPN REMKNQGSKK TLGSTRRGID NGRKLRLGRQ FSTSKDVLNK LKALHPLPGL ILEWRRITNA ITKVVFPLQR EKCLNPFLGM ERIYPVSQSH TATGRITFTE PNIQNVPRDF EIKMPTLVGE SPPSQAVGKG LLPMGRGKYK KGFSVNPRCQ AQMEERAADR GMPFSISMRH AFVPFPGGSI LAADYSQLEL RILAHLSHDR RLIQVLNTGA DVFRSIAAEW KMIEPESVGD DLRQQAKQIC YGIIYGMGAK SLGEQMGIKE NDAACYIDSF KSRYTGINQF MTETVKNCKR DGFVQTILGR RRYLPGIKDN NPYRKAHAER QAINTIVQGS AADIVKIATV NIQKQLETFH STFKSHGHRE GMLQSDRTGL SRKRKLQGMF CPIRGGFFIL QLHDELLYEV AEEDVVQVAQ IVKNEMESAV KLSVKLKVKV KIGASWGELK DFDV
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.