Details for: SLC12A7

Gene ID: 10723

Symbol: SLC12A7

Ensembl ID: ENSG00000113504

Description: solute carrier family 12 member 7

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 2.87
    Marker Score: 912
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.74
    Marker Score: 2,004
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.61
    Marker Score: 3,797
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,785
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.41
    Marker Score: 31,417
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.39
    Marker Score: 3,428
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.35
    Marker Score: 424
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 1.19
    Marker Score: 729
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.04
    Marker Score: 334
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.02
    Marker Score: 3,516
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.02
    Marker Score: 1,670
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,760
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,985
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,402
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.96
    Marker Score: 6,171
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.95
    Marker Score: 3,381
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 488
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,405
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 443
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.92
    Marker Score: 2,881
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,735
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.91
    Marker Score: 3,907
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.9
    Marker Score: 4,856
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.9
    Marker Score: 931
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.89
    Marker Score: 3,311
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,295
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.87
    Marker Score: 1,285
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4,969
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 311
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.85
    Marker Score: 7,402
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.84
    Marker Score: 328
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.83
    Marker Score: 199
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.82
    Marker Score: 279
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.82
    Marker Score: 824
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.8
    Marker Score: 399
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,267
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 592
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.76
    Marker Score: 756
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 379
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.73
    Marker Score: 407
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.73
    Marker Score: 293
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.73
    Marker Score: 2,599
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.71
    Marker Score: 668
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.7
    Marker Score: 262
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.68
    Marker Score: 623
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.67
    Marker Score: 616
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.66
    Marker Score: 2,781
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.66
    Marker Score: 364
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.66
    Marker Score: 3,893
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.66
    Marker Score: 36,689
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.64
    Marker Score: 439
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.62
    Marker Score: 221
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.62
    Marker Score: 1,176
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.62
    Marker Score: 153
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.61
    Marker Score: 20,712
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.61
    Marker Score: 2,921
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.6
    Marker Score: 402
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.59
    Marker Score: 154
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.59
    Marker Score: 528
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.59
    Marker Score: 971
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.59
    Marker Score: 154
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.58
    Marker Score: 278
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.58
    Marker Score: 5,906
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.57
    Marker Score: 616
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.57
    Marker Score: 2,814
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.57
    Marker Score: 1,114
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.57
    Marker Score: 3,635
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.57
    Marker Score: 229
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.57
    Marker Score: 1,426
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.56
    Marker Score: 447
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.55
    Marker Score: 668
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.55
    Marker Score: 497
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.55
    Marker Score: 140
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.55
    Marker Score: 270
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 432
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.53
    Marker Score: 1,022
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.53
    Marker Score: 153
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.52
    Marker Score: 520
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.52
    Marker Score: 343
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.52
    Marker Score: 3,138
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.51
    Marker Score: 208
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.51
    Marker Score: 522
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.51
    Marker Score: 541
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.5
    Marker Score: 730
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.5
    Marker Score: 483
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.5
    Marker Score: 298
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.5
    Marker Score: 538
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.49
    Marker Score: 583
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.49
    Marker Score: 500
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.49
    Marker Score: 974
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.49
    Marker Score: 486
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.49
    Marker Score: 268
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.48
    Marker Score: 461
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.48
    Marker Score: 739
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.48
    Marker Score: 180
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.47
    Marker Score: 574
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.47
    Marker Score: 746
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.47
    Marker Score: 247
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.47
    Marker Score: 16,207

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SLC12A7 is a member of the solute carrier family 12, which comprises proteins responsible for transporting various ions and molecules across cell membranes. SLC12A7 is specifically expressed in multiple cell types, including A2 amacrine cells, vascular leptomeningeal cells, kidney proximal straight tubule epithelial cells, and mononuclear cells. Its expression is also observed in the brain, where it may play a role in regulating ion homeostasis and synaptic transmission. **Pathways and Functions:** SLC12A7 is involved in various cellular processes, including: 1. **Ammonium import across plasma membrane**: SLC12A7 mediates the transport of ammonium ions (NH4+) across the plasma membrane, which is crucial for maintaining acid-base balance and regulating cellular metabolism. 2. **Cell volume homeostasis**: By controlling the movement of ions and water across the cell membrane, SLC12A7 helps maintain cellular volume and prevent swelling. 3. **Chloride ion homeostasis**: SLC12A7 contributes to the regulation of chloride ion (Cl-) concentrations within cells, which is essential for maintaining proper fluid balance and nerve function. 4. **Potassium ion homeostasis**: SLC12A7 also plays a role in regulating potassium ion (K+) concentrations, which is vital for maintaining proper cardiac function and nerve conduction. **Clinical Significance:** Understanding the role of SLC12A7 in various physiological processes has significant implications for the diagnosis and treatment of diseases. Abnormalities in SLC12A7 expression or function have been implicated in several conditions, including: 1. **Neurological disorders**: Altered expression of SLC12A7 has been observed in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, suggesting its potential role in neurodegeneration. 2. **Cardiovascular disease**: Abnormalities in SLC12A7 function may contribute to cardiac arrhythmias and hypertension, highlighting its importance in cardiovascular health. 3. **Kidney disease**: SLC12A7 is expressed in kidney cells, and its dysfunction may contribute to kidney dysfunction and disease progression. In conclusion, SLC12A7 is a vital protein involved in various physiological processes, including ion and amino acid transport across cell membranes. Further research is necessary to fully elucidate its role in immune responses and disease pathology.

Genular Protein ID: 4244800525

Symbol: S12A7_HUMAN

Name: Solute carrier family 12 member 7

UniProtKB Accession Codes:

Q9Y666 A6NDS8 Q4G0F3 Q96I81 Q9H7I3 Q9H7I7 Q9UFW2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 2 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 7 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 1 SAM 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10347194

Title: Cloning and characterization of KCC3 and KCC4, new members of the cation-chloride cotransporter gene family.

PubMed ID: 10347194

DOI: 10.1074/jbc.274.23.16355

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11214971

Title: Characterization of long cDNA clones from human adult spleen.

PubMed ID: 11214971

DOI: 10.1093/dnares/7.6.357

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 10913127

Title: Functional comparison of the K+-Cl- cotransporters KCC1 and KCC4.

PubMed ID: 10913127

DOI: 10.1074/jbc.m003112200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21613606

Title: Similar Effects of all WNK3 Variants upon SLC12 Cotransporters.

PubMed ID: 21613606

DOI: 10.1152/ajpcell.00070.2011

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 1083
  • Mass: 119106
  • Checksum: BF50134614BF6617
  • Sequence:
    • MPTNFTVVPV EAHADGGGDE TAERTEAPGT PEGPEPERPS PGDGNPRENS PFLNNVEVEQ 
ESFFEGKNMA LFEEEMDSNP MVSSLLNKLA NYTNLSQGVV EHEEDEESRR REAKAPRMGT 
FIGVYLPCLQ NILGVILFLR LTWIVGVAGV LESFLIVAMC CTCTMLTAIS MSAIATNGVV 
PAGGSYYMIS RSLGPEFGGA VGLCFYLGTT FAGAMYILGT IEIFLTYISP GAAIFQAEAA 
GGEAAAMLHN MRVYGTCTLV LMALVVFVGV KYVNKLALVF LACVVLSILA IYAGVIKSAF 
DPPDIPVCLL GNRTLSRRSF DACVKAYGIH NNSATSALWG LFCNGSQPSA ACDEYFIQNN 
VTEIQGIPGA ASGVFLENLW STYAHAGAFV EKKGVPSVPV AEESRASALP YVLTDIAASF 
TLLVGIYFPS VTGIMAGSNR SGDLKDAQKS IPTGTILAIV TTSFIYLSCI VLFGACIEGV 
VLRDKFGEAL QGNLVIGMLA WPSPWVIVIG SFFSTCGAGL QSLTGAPRLL QAIARDGIVP 
FLQVFGHGKA NGEPTWALLL TVLICETGIL IASLDSVAPI LSMFFLMCYL FVNLACAVQT 
LLRTPNWRPR FKFYHWTLSF LGMSLCLALM FICSWYYALS AMLIAGCIYK YIEYRGAEKE 
WGDGIRGLSL NAARYALLRV EHGPPHTKNW RPQVLVMLNL DAEQAVKHPR LLSFTSQLKA 
GKGLTIVGSV LEGTYLDKHM EAQRAEENIR SLMSTEKTKG FCQLVVSSSL RDGMSHLIQS 
AGLGGLKHNT VLMAWPASWK QEDNPFSWKN FVDTVRDTTA AHQALLVAKN VDSFPQNQER 
FGGGHIDVWW IVHDGGMLML LPFLLRQHKV WRKCRMRIFT VAQVDDNSIQ MKKDLQMFLY 
HLRISAEVEV VEMVENDISA FTYERTLMME QRSQMLKQMQ LSKNEQEREA QLIHDRNTAS 
HTAAAARTQA PPTPDKVQMT WTREKLIAEK YRSRDTSLSG FKDLFSMKPD QSNVRRMHTA 
VKLNGVVLNK SQDAQLVLLN MPGPPKNRQG DENYMEFLEV LTEGLNRVLL VRGGGREVIT 
IYS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.