Details for: NFAT5
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 5.84
Marker Score: 4,793 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: 4.87
Marker Score: 20,319 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 4.8
Marker Score: 85,218 - Cell Name: taste receptor cell (CL0000209)
Fold Change: 4.42
Marker Score: 3,815 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 4.14
Marker Score: 3,673 - Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 3.9
Marker Score: 7,509 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 3.7
Marker Score: 4,976 - Cell Name: mature astrocyte (CL0002627)
Fold Change: 3.42
Marker Score: 2,251 - Cell Name: renal principal cell (CL0005009)
Fold Change: 3.37
Marker Score: 2,597 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 3.36
Marker Score: 4,062 - Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 3.35
Marker Score: 13,952 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 3.32
Marker Score: 3,757 - Cell Name: hepatoblast (CL0005026)
Fold Change: 3.28
Marker Score: 10,750 - Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 3.21
Marker Score: 2,228 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 3.13
Marker Score: 6,874 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 3.09
Marker Score: 66,006 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 3.08
Marker Score: 12,905 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 2.95
Marker Score: 65,911 - Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 2.93
Marker Score: 1,546 - Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 2.92
Marker Score: 2,788 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 2.92
Marker Score: 7,316 - Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 2.92
Marker Score: 3,358 - Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 2.81
Marker Score: 1,563 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 2.76
Marker Score: 93,120 - Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 2.74
Marker Score: 2,956 - Cell Name: lung goblet cell (CL1000143)
Fold Change: 2.65
Marker Score: 764 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 2.58
Marker Score: 11,949 - Cell Name: stellate neuron (CL0000122)
Fold Change: 2.56
Marker Score: 13,772 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 2.55
Marker Score: 1,487 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 2.52
Marker Score: 737 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 2.52
Marker Score: 796 - Cell Name: contractile cell (CL0000183)
Fold Change: 2.52
Marker Score: 1,364 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 2.49
Marker Score: 1,488 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 2.49
Marker Score: 37,215 - Cell Name: lactocyte (CL0002325)
Fold Change: 2.48
Marker Score: 39,868 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.47
Marker Score: 2,605 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 2.46
Marker Score: 18,881 - Cell Name: mesangial cell (CL0000650)
Fold Change: 2.43
Marker Score: 2,936 - Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 2.42
Marker Score: 92,010 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 2.42
Marker Score: 1,194 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 2.41
Marker Score: 47,898 - Cell Name: cardiac neuron (CL0010022)
Fold Change: 2.38
Marker Score: 2,970 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 2.38
Marker Score: 1,394 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 2.33
Marker Score: 9,639 - Cell Name: oligodendrocyte (CL0000128)
Fold Change: 2.31
Marker Score: 5,535 - Cell Name: fat cell (CL0000136)
Fold Change: 2.28
Marker Score: 1,272 - Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 2.27
Marker Score: 825 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 2.25
Marker Score: 1,479 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 2.23
Marker Score: 82,237 - Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 2.19
Marker Score: 1,462 - Cell Name: astrocyte (CL0000127)
Fold Change: 2.19
Marker Score: 1,894 - Cell Name: podocyte (CL0000653)
Fold Change: 2.18
Marker Score: 806 - Cell Name: neuronal brush cell (CL0000555)
Fold Change: 2.15
Marker Score: 7,206 - Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 2.14
Marker Score: 3,113 - Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.12
Marker Score: 8,208 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 2.07
Marker Score: 2,287 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 2.06
Marker Score: 19,397 - Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 2.03
Marker Score: 5,801 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.02
Marker Score: 124,154 - Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 2.01
Marker Score: 512 - Cell Name: macroglial cell (CL0000126)
Fold Change: 2.01
Marker Score: 4,612 - Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 1.99
Marker Score: 2,019 - Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 1.99
Marker Score: 832 - Cell Name: granule cell (CL0000120)
Fold Change: 1.98
Marker Score: 14,950 - Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 1.98
Marker Score: 4,863 - Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 1.97
Marker Score: 981 - Cell Name: mature microglial cell (CL0002629)
Fold Change: 1.95
Marker Score: 705 - Cell Name: acinar cell (CL0000622)
Fold Change: 1.95
Marker Score: 1,375 - Cell Name: germ cell (CL0000586)
Fold Change: 1.94
Marker Score: 3,391 - Cell Name: endocrine cell (CL0000163)
Fold Change: 1.91
Marker Score: 990 - Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 1.9
Marker Score: 2,696 - Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 1.9
Marker Score: 2,031 - Cell Name: lymphocyte (CL0000542)
Fold Change: 1.89
Marker Score: 957 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.89
Marker Score: 19,489 - Cell Name: skin fibroblast (CL0002620)
Fold Change: 1.89
Marker Score: 489 - Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 1.88
Marker Score: 6,672 - Cell Name: subcutaneous fat cell (CL0002521)
Fold Change: 1.87
Marker Score: 684 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.87
Marker Score: 17,775 - Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 1.87
Marker Score: 9,800 - Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 1.86
Marker Score: 904 - Cell Name: neuron (CL0000540)
Fold Change: 1.85
Marker Score: 7,545 - Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 1.85
Marker Score: 2,287 - Cell Name: pyramidal neuron (CL0000598)
Fold Change: 1.85
Marker Score: 3,100 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.83
Marker Score: 15,703 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 1.82
Marker Score: 6,467 - Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 1.82
Marker Score: 4,581 - Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 1.81
Marker Score: 3,614 - Cell Name: sympathetic neuron (CL0011103)
Fold Change: 1.8
Marker Score: 594 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.8
Marker Score: 61,111 - Cell Name: cholangiocyte (CL1000488)
Fold Change: 1.79
Marker Score: 671 - Cell Name: chromaffin cell (CL0000166)
Fold Change: 1.79
Marker Score: 2,524 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 1.76
Marker Score: 600 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.74
Marker Score: 2,557 - Cell Name: photoreceptor cell (CL0000210)
Fold Change: 1.73
Marker Score: 1,306 - Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 1.7
Marker Score: 1,825 - Cell Name: basal cell (CL0000646)
Fold Change: 1.67
Marker Score: 2,159 - Cell Name: club cell (CL0000158)
Fold Change: 1.64
Marker Score: 1,919 - Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 1.6
Marker Score: 11,901 - Cell Name: papillary tips cell (CL1000597)
Fold Change: 1.59
Marker Score: 320 - Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 1.58
Marker Score: 502
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 577988347
Symbol: NFAT5_HUMAN
Name: Nuclear factor of activated T-cells 5
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10051678
Title: Tonicity-responsive enhancer binding protein, a rel-like protein that stimulates transcription in response to hypertonicity.
PubMed ID: 10051678
PubMed ID: 10377394
Title: NFAT5, a constitutively nuclear NFAT protein that does not cooperate with Fos and Jun.
PubMed ID: 10377394
PubMed ID: 11528118
Title: Genomic organization of the human NFAT5 gene: exon-intron structure of the 14-kb transcript and CpG-island analysis of the promoter region.
PubMed ID: 11528118
DOI: 10.1159/000056990
PubMed ID: 10048485
Title: Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
PubMed ID: 10048485
PubMed ID: 15616553
Title: The sequence and analysis of duplication-rich human chromosome 16.
PubMed ID: 15616553
DOI: 10.1038/nature03187
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11233530
Title: NFAT5: the NF-AT family of transcription factors expands in a new direction.
PubMed ID: 11233530
PubMed ID: 10565538
Title: Isolation and characterization of novel CAG repeat containing genes expressed in human brain.
PubMed ID: 10565538
PubMed ID: 11934689
Title: Mouse TonEBP-NFAT5: expression in early development and alternative splicing.
PubMed ID: 11934689
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 21209322
Title: High NaCl-induced activation of CDK5 increases phosphorylation of the osmoprotective transcription factor TonEBP/OREBP at threonine 135, which contributes to its rapid nuclear localization.
PubMed ID: 21209322
PubMed ID: 22266867
Title: Dual role of the ddx5/ddx17 RNA helicases in the control of the pro-migratory NFAT5 transcription factor.
PubMed ID: 22266867
DOI: 10.1038/onc.2011.618
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25218447
Title: Uncovering global SUMOylation signaling networks in a site-specific manner.
PubMed ID: 25218447
DOI: 10.1038/nsmb.2890
PubMed ID: 25114211
Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.
PubMed ID: 25114211
PubMed ID: 25772364
Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.
PubMed ID: 25772364
PubMed ID: 25755297
Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.
PubMed ID: 25755297
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 34049076
Title: PARP1-mediated PARylation of TonEBP prevents R-loop-associated DNA damage.
PubMed ID: 34049076
PubMed ID: 11780147
Title: Structure of a TonEBP-DNA complex reveals DNA encircled by a transcription factor.
PubMed ID: 11780147
DOI: 10.1038/nsb749
Sequence Information:
- Length: 1531
- Mass: 165763
- Checksum: A68C68088DABF69E
- Sequence:
MPSDFISLLS ADLDLESPKS LYSRESVYDL LPKELQLPPS RETSVASMSQ TSGGEAGSPP PAVVAADASS APSSSSMGGA CSSFTTSSSP TIYSTSVTDS KAMQVESCSS AVGVSNRGVS EKQLTSNTVQ QHPSTPKRHT VLYISPPPED LLDNSRMSCQ DEGCGLESEQ SCSMWMEDSP SNFSNMSTSS YNDNTEVPRK SRKRNPKQRP GVKRRDCEES NMDIFDADSA KAPHYVLSQL TTDNKGNSKA GNGTLENQKG TGVKKSPMLC GQYPVKSEGK ELKIVVQPET QHRARYLTEG SRGSVKDRTQ QGFPTVKLEG HNEPVVLQVF VGNDSGRVKP HGFYQACRVT GRNTTPCKEV DIEGTTVIEV GLDPSNNMTL AVDCVGILKL RNADVEARIG IAGSKKKSTR ARLVFRVNIM RKDGSTLTLQ TPSSPILCTQ PAGVPEILKK SLHSCSVKGE EEVFLIGKNF LKGTKVIFQE NVSDENSWKS EAEIDMELFH QNHLIVKVPP YHDQHITLPV SVGIYVVTNA GRSHDVQPFT YTPDPAAAGA LNVNVKKEIS SPARPCSFEE AMKAMKTTGC NLDKVNIIPN ALMTPLIPSS MIKSEDVTPM EVTAEKRSST IFKTTKSVGS TQQTLENISN IAGNGSFSSP SSSHLPSENE KQQQIQPKAY NPETLTTIQT QDISQPGTFP AVSASSQLPN SDALLQQATQ FQTRETQSRE ILQSDGTVVN LSQLTEASQQ QQQSPLQEQA QTLQQQISSN IFPSPNSVSQ LQNTIQQLQA GSFTGSTASG SSGSVDLVQQ VLEAQQQLSS VLFSAPDGNE NVQEQLSADI FQQVSQIQSG VSPGMFSSTE PTVHTRPDNL LPGRAESVHP QSENTLSNQQ QQQQQQQQVM ESSAAMVMEM QQSICQAAAQ IQSELFPSTA SANGNLQQSP VYQQTSHMMS ALSTNEDMQM QCELFSSPPA VSGNETSTTT TQQVATPGTT MFQTSSSGDG EETGTQAKQI QNSVFQTMVQ MQHSGDNQPQ VNLFSSTKSM MSVQNSGTQQ QGNGLFQQGN EMMSLQSGNF LQQSSHSQAQ LFHPQNPIAD AQNLSQETQG SLFHSPNPIV HSQTSTTSSE QMQPPMFHSQ STIAVLQGSS VPQDQQSTNI FLSQSPMNNL QTNTVAQEAF FAAPNSISPL QSTSNSEQQA AFQQQAPISH IQTPMLSQEQ AQPPQQGLFQ PQVALGSLPP NPMPQSQQGT MFQSQHSIVA MQSNSPSQEQ QQQQQQQQQQ QQQQQQSILF SNQNTMATMA SPKQPPPNMI FNPNQNPMAN QEQQNQSIFH QQSNMAPMNQ EQQPMQFQSQ STVSSLQNPG PTQSESSQTP LFHSSPQIQL VQGSPSSQEQ QVTLFLSPAS MSALQTSINQ QDMQQSPLYS PQNNMPGIQG ATSSPQPQAT LFHNTAGGTM NQLQNSPGSS QQTSGMFLFG IQNNCSQLLT SGPATLPDQL MAISQPGQPQ NEGQPPVTTL LSQQMPENSP LASSINTNQN IEKIDLLVSL QNQGNNLTGS F
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.