Details for: NUDC

Gene ID: 10726

Symbol: NUDC

Ensembl ID: ENSG00000090273

Description: nuclear distribution C, dynein complex regulator

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 3.14
    Marker Score: 27,249
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 2.71
    Marker Score: 2,830
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.71
    Marker Score: 6,619
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.69
    Marker Score: 91,604
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.57
    Marker Score: 89,166
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.55
    Marker Score: 2,170
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.46
    Marker Score: 2,971
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.4
    Marker Score: 4,881
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.38
    Marker Score: 9,181
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.32
    Marker Score: 4,362
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 2.3
    Marker Score: 4,370
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.3
    Marker Score: 2,169
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.28
    Marker Score: 4,755
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.27
    Marker Score: 11,148
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 2.25
    Marker Score: 7,741
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.25
    Marker Score: 936
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.19
    Marker Score: 2,337
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.18
    Marker Score: 8,933
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.18
    Marker Score: 1,034
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.14
    Marker Score: 3,784
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.12
    Marker Score: 3,375
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.09
    Marker Score: 3,008
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.09
    Marker Score: 7,726
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.09
    Marker Score: 3,544
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 2.08
    Marker Score: 766
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.07
    Marker Score: 2,502
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.07
    Marker Score: 8,911
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.04
    Marker Score: 1,166
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.04
    Marker Score: 1,362
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.04
    Marker Score: 2,885
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.01
    Marker Score: 3,304
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2
    Marker Score: 7,879
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.99
    Marker Score: 2,110
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.99
    Marker Score: 4,536
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.98
    Marker Score: 1,997
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.98
    Marker Score: 5,395
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.97
    Marker Score: 3,427
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.96
    Marker Score: 2,891
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.95
    Marker Score: 21,920
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.93
    Marker Score: 719
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.92
    Marker Score: 681
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.91
    Marker Score: 2,241
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.9
    Marker Score: 455
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.9
    Marker Score: 978
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.89
    Marker Score: 19,016
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.88
    Marker Score: 1,273
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.87
    Marker Score: 1,759
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.87
    Marker Score: 753
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.85
    Marker Score: 12,052
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.83
    Marker Score: 1,939
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.82
    Marker Score: 4,963
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.82
    Marker Score: 18,398
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.81
    Marker Score: 523
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.81
    Marker Score: 1,934
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.81
    Marker Score: 11,539
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.81
    Marker Score: 23,855
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.8
    Marker Score: 4,096
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.8
    Marker Score: 1,418
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.8
    Marker Score: 447
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.79
    Marker Score: 2,005
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.78
    Marker Score: 447
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.78
    Marker Score: 17,589
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.78
    Marker Score: 1,168
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.77
    Marker Score: 2,935
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.77
    Marker Score: 1,117
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.77
    Marker Score: 916
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.76
    Marker Score: 3,513
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.75
    Marker Score: 1,814
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.72
    Marker Score: 1,744
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.72
    Marker Score: 2,151
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.71
    Marker Score: 2,276
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.7
    Marker Score: 4,461
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.7
    Marker Score: 1,068
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.7
    Marker Score: 3,999
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.7
    Marker Score: 1,237
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.7
    Marker Score: 4,687
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.7
    Marker Score: 976
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.69
    Marker Score: 505
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.69
    Marker Score: 658
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.69
    Marker Score: 417
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.69
    Marker Score: 2,710
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.69
    Marker Score: 2,853
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.68
    Marker Score: 4,241
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.68
    Marker Score: 9,962
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.68
    Marker Score: 884
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.68
    Marker Score: 578
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.67
    Marker Score: 3,977
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.67
    Marker Score: 413
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.67
    Marker Score: 1,796
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 1.66
    Marker Score: 763
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.66
    Marker Score: 580
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.66
    Marker Score: 1,749
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.66
    Marker Score: 1,303
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 1.66
    Marker Score: 757
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.65
    Marker Score: 2,542
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.65
    Marker Score: 14,196
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 1.65
    Marker Score: 738
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.64
    Marker Score: 1,026
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.64
    Marker Score: 1,122
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.63
    Marker Score: 795

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NUDC is a nuclear protein that belongs to the NudC family of proteins, which are known to regulate the dynamics of microtubules and the dynein complex. The NUDC protein is characterized by its ability to regulate the amplification of signal from kinetochores, which are the protein complexes that attach to chromosomes during mitosis. NUDC also interacts with various signaling pathways, including the Rho GTPase cycle, which is involved in the regulation of cytoskeletal dynamics and cell migration. **Pathways and Functions:** NUDC is involved in several key pathways that regulate cell cycle and mitotic spindle formation, including: 1. **Amplification of signal from kinetochores**: NUDC regulates the amplification of signal from kinetochores, which is essential for the proper alignment and separation of chromosomes during mitosis. 2. **Cadherin binding**: NUDC interacts with cadherins, which are adhesion molecules that regulate cell-cell interactions and tissue structure. 3. **Cell cycle checkpoints**: NUDC is involved in the regulation of cell cycle checkpoints, which are mechanisms that prevent cells from entering mitosis with damaged DNA. 4. **Microtubule organization**: NUDC regulates the organization of microtubules, which are essential for the formation of the mitotic spindle. 5. **Protein binding**: NUDC interacts with various proteins, including those involved in signaling pathways and protein folding. **Clinical Significance:** Dysregulation of NUDC has been implicated in various diseases, including: 1. **Cancer**: NUDC dysfunction has been linked to various types of cancer, including breast cancer and prostate cancer. 2. **Developmental disorders**: NUDC dysfunction has been implicated in developmental disorders, including Down syndrome and other chromosomal abnormalities. 3. **Neurological disorders**: NUDC dysfunction has been linked to neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, NUDC is a critical regulator of cell cycle and mitotic spindle formation, and its dysfunction has been implicated in various diseases. Further research is needed to fully understand the role of NUDC in maintaining chromosomal integrity and its implications for human health.

Genular Protein ID: 2857680593

Symbol: NUDC_HUMAN

Name: Nuclear migration protein nudC

UniProtKB Accession Codes:

Q9Y266 Q5QP31 Q5QP35 Q9H0N2 Q9Y2B6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 13 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 7 RefSeq 1 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10210332

Title: A homolog of the fungal nuclear migration gene nudC is involved in normal and malignant human hematopoiesis.

PubMed ID: 10210332

DOI: 10.1016/s0301-472x(98)00074-5

PubMed ID: 10453739

Title: Molecular cloning and characterization of the human NUDC gene.

PubMed ID: 10453739

DOI: 10.1007/s004390050994

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12852857

Title: A role for Plk1 phosphorylation of NudC in cytokinesis.

PubMed ID: 12852857

DOI: 10.1016/s1534-5807(03)00186-2

PubMed ID: 12679384

Title: Role for NudC, a dynein-associated nuclear movement protein, in mitosis and cytokinesis.

PubMed ID: 12679384

DOI: 10.1242/jcs.00412

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22159412

Title: Linking cytoplasmic dynein and transport of Rab8 vesicles to the midbody during cytokinesis by the doublecortin domain-containing 5 protein.

PubMed ID: 22159412

DOI: 10.1242/jcs.085407

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25789526

Title: EML4 promotes the loading of NUDC to the spindle for mitotic progression.

PubMed ID: 25789526

DOI: 10.1080/15384101.2015.1026514

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 331
  • Mass: 38243
  • Checksum: 34F591170F7594AF
  • Sequence:
    • MGGEQEEERF DGMLLAMAQQ HEGGVQELVN TFFSFLRRKT DFFIGGEEGM AEKLITQTFS 
HHNQLAQKTR REKRARQEAE RREKAERAAR LAKEAKSETS GPQIKELTDE EAERLQLEID 
QKKDAENHEA QLKNGSLDSP GKQDTEEDEE EDEKDKGKLK PNLGNGADLP NYRWTQTLSE 
LDLAVPFCVN FRLKGKDMVV DIQRRHLRVG LKGQPAIIDG ELYNEVKVEE SSWLIEDGKV 
VTVHLEKINK MEWWSRLVSS DPEINTKKIN PENSKLSDLD SETRSMVEKM MYDQRQKSMG 
LPTSDEQKKQ EILKKFMDQH PEMDFSKAKF N

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.