CFL2 | ENSG00000165410 | NCBI 1073

Details for: CFL2

Gene ID: 1073

Symbol: CFL2

Ensembl ID: ENSG00000165410

Description: cofilin 2

Associated with

Actin cytoskeleton
(GO:0015629)
Actin filament binding
(GO:0051015)
Actin filament depolymerization
(GO:0030042)
Actin filament fragmentation
(GO:0030043)
Actin filament severing
(GO:0051014)
Cytoplasm
(GO:0005737)
Extracellular exosome
(GO:0070062)
Extracellular space
(GO:0005615)
I band
(GO:0031674)
Muscle cell cellular homeostasis
(GO:0046716)
Nuclear matrix
(GO:0016363)
Positive regulation of actin filament depolymerization
(GO:0030836)
Protein binding
(GO:0005515)
Sarcomere organization
(GO:0045214)
Skeletal muscle tissue development
(GO:0007519)
Z disc
(GO:0030018)

Other Information

Proteins

Cofilin-2

Genular Protein ID: 3534162100

Symbol: COF2_HUMAN

Name: Cofilin-2

UniProtKB Accession Codes:

Q9Y281 G3V5P4

Database IDs:

Citations:

PubMed ID: 11422377

Title: Characterization of human muscle type cofilin (CFL2) in normal and regenerating muscle.

PubMed ID: 11422377

DOI: 10.1046/j.1432-1327.2001.02247.x

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19752190

Title: Muscle LIM protein interacts with cofilin 2 and regulates F-actin dynamics in cardiac and skeletal muscle.

PubMed ID: 19752190

DOI: 10.1128/mcb.00654-09

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 17160903

Title: Nemaline myopathy with minicores caused by mutation of the CFL2 gene encoding the skeletal muscle actin-binding protein, cofilin-2.

PubMed ID: 17160903

DOI: 10.1086/510402

PubMed ID: 22560515

Title: Congenital myopathy caused by a novel missense mutation in the CFL2 gene.

PubMed ID: 22560515

DOI: 10.1016/j.nmd.2012.03.008

Sequence Information:

Length: 166
Mass: 18737
Checksum: 48B6CDCCAE9FE1CC
Sequence:

MASGVTVNDE VIKVFNDMKV RKSSTQEEIK KRKKAVLFCL SDDKRQIIVE EAKQILVGDI 
GDTVEDPYTS FVKLLPLNDC RYALYDATYE TKESKKEDLV FIFWAPESAP LKSKMIYASS 
KDAIKKKFTG IKHEWQVNGL DDIKDRSTLG EKLGGNVVVS LEGKPL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CFL2

Associated with

Other Information

Characterization of human muscle type cofilin (CFL2) in normal and regenerating muscle. PubMed ID: 11422377

The DNA sequence and analysis of human chromosome 14. PubMed ID: 12508121

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Muscle LIM protein interacts with cofilin 2 and regulates F-actin dynamics in cardiac and skeletal muscle. PubMed ID: 19752190

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

The consensus coding sequences of human breast and colorectal cancers. PubMed ID: 16959974

Nemaline myopathy with minicores caused by mutation of the CFL2 gene encoding the skeletal muscle actin-binding protein, cofilin-2. PubMed ID: 17160903

Congenital myopathy caused by a novel missense mutation in the CFL2 gene. PubMed ID: 22560515