Details for: CFL2

Gene ID: 1073

Symbol: CFL2

Ensembl ID: ENSG00000165410

Description: cofilin 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 266.9963
    Cell Significance Index: -41.5300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 164.5026
    Cell Significance Index: -41.7300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 85.8240
    Cell Significance Index: -35.3600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 82.0549
    Cell Significance Index: -38.7400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 75.2971
    Cell Significance Index: -30.5900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 34.2997
    Cell Significance Index: -42.2900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 32.3228
    Cell Significance Index: -30.8600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.0956
    Cell Significance Index: -37.7600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.8615
    Cell Significance Index: -42.8600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.8662
    Cell Significance Index: -10.6500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 3.3157
    Cell Significance Index: 80.9000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 3.2075
    Cell Significance Index: 34.8700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.1404
    Cell Significance Index: 58.2600
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 2.0756
    Cell Significance Index: 33.4900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.3535
    Cell Significance Index: 28.3300
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.3132
    Cell Significance Index: 6.9100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 1.2724
    Cell Significance Index: 18.7900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.0894
    Cell Significance Index: 57.2000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0766
    Cell Significance Index: 106.5000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.9380
    Cell Significance Index: 128.8100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9172
    Cell Significance Index: 828.1500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.7556
    Cell Significance Index: 47.6200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.6137
    Cell Significance Index: 79.2900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5818
    Cell Significance Index: 74.5800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5227
    Cell Significance Index: 85.0100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4788
    Cell Significance Index: 12.8300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4730
    Cell Significance Index: 36.3000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4123
    Cell Significance Index: 44.8500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4087
    Cell Significance Index: 14.2000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3606
    Cell Significance Index: 71.5600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2978
    Cell Significance Index: 7.8300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2790
    Cell Significance Index: 152.3800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2540
    Cell Significance Index: 50.9500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2437
    Cell Significance Index: 18.1600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2019
    Cell Significance Index: 4.3000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1636
    Cell Significance Index: 7.6900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1569
    Cell Significance Index: 1.8700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1546
    Cell Significance Index: 55.4600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1465
    Cell Significance Index: 6.8300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1303
    Cell Significance Index: 9.0100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1094
    Cell Significance Index: 6.5700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0920
    Cell Significance Index: 4.7900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0893
    Cell Significance Index: 39.4800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.0651
    Cell Significance Index: 0.5200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0576
    Cell Significance Index: 1.6500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0423
    Cell Significance Index: 8.0500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0287
    Cell Significance Index: 3.5400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0285
    Cell Significance Index: 4.8600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0223
    Cell Significance Index: 41.9800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0204
    Cell Significance Index: 3.6700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0009
    Cell Significance Index: 0.0200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0107
    Cell Significance Index: -6.6600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0128
    Cell Significance Index: -9.4700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0199
    Cell Significance Index: -15.0500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0209
    Cell Significance Index: -15.3600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0222
    Cell Significance Index: -0.6400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0230
    Cell Significance Index: -35.3900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0230
    Cell Significance Index: -31.2200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0242
    Cell Significance Index: -16.7100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0249
    Cell Significance Index: -0.5400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0257
    Cell Significance Index: -47.3300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0281
    Cell Significance Index: -17.8200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0286
    Cell Significance Index: -12.9900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0378
    Cell Significance Index: -1.0100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0382
    Cell Significance Index: -21.5500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0428
    Cell Significance Index: -1.0700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0571
    Cell Significance Index: -0.4800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0663
    Cell Significance Index: -6.7700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0768
    Cell Significance Index: -9.0600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0941
    Cell Significance Index: -19.8200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0985
    Cell Significance Index: -28.3400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1178
    Cell Significance Index: -13.7300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1228
    Cell Significance Index: -14.0700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1253
    Cell Significance Index: -6.5100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1568
    Cell Significance Index: -4.0300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1740
    Cell Significance Index: -19.8600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1813
    Cell Significance Index: -26.3500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2423
    Cell Significance Index: -17.1400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2588
    Cell Significance Index: -2.9400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2626
    Cell Significance Index: -4.5000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2884
    Cell Significance Index: -13.0700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2954
    Cell Significance Index: -10.3800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3255
    Cell Significance Index: -19.9600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3456
    Cell Significance Index: -35.9900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3537
    Cell Significance Index: -28.0100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3663
    Cell Significance Index: -23.6300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3796
    Cell Significance Index: -6.4000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3882
    Cell Significance Index: -10.8500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.4068
    Cell Significance Index: -5.7800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4117
    Cell Significance Index: -27.6800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4143
    Cell Significance Index: -23.2500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.4966
    Cell Significance Index: -8.7800
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.5345
    Cell Significance Index: -5.5800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5741
    Cell Significance Index: -35.2900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6435
    Cell Significance Index: -20.6100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.6753
    Cell Significance Index: -5.2100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.7175
    Cell Significance Index: -29.4000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.7324
    Cell Significance Index: -37.0100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.7368
    Cell Significance Index: -14.3800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7473
    Cell Significance Index: -22.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Actin-binding protein:** Cofilin 2 is a member of the actin-binding protein family, which regulates actin filament dynamics. 2. **Depolymerization and fragmentation:** Cofilin 2 is involved in the depolymerization and fragmentation of actin filaments, which is essential for cellular processes such as muscle contraction and cellular migration. 3. **Cellular localization:** Cofilin 2 is expressed in various cell types, including smooth muscle cells, cardiomyocytes, and immune cells. 4. **Regulatory function:** Cofilin 2 regulates the activity of actin depolymerizing factor (ADF) and actin-severing protein (ASAP), which are essential for actin filament dynamics. **Pathways and Functions:** 1. **Actin cytoskeleton regulation:** Cofilin 2 regulates the dynamics of actin filaments, which is essential for maintaining cellular homeostasis and function. 2. **Muscle cell homeostasis:** Cofilin 2 is involved in the regulation of muscle cell contraction and relaxation, which is essential for maintaining muscle homeostasis. 3. **Cellular migration and invasion:** Cofilin 2 regulates the dynamics of actin filaments, which is essential for cellular migration and invasion. 4. **Cell signaling:** Cofilin 2 regulates the activity of various signaling pathways, including the PI3K/Akt pathway, which is essential for cell survival and proliferation. **Clinical Significance:** Dysregulation of CFL2 has been implicated in various diseases, including: 1. **Muscular dystrophy:** Mutations in CFL2 have been associated with muscular dystrophy, a group of genetic disorders characterized by progressive muscle weakness and degeneration. 2. **Cardiovascular disease:** Dysregulation of CFL2 has been implicated in cardiovascular disease, including hypertension and atherosclerosis. 3. **Cancer:** Cofilin 2 has been shown to regulate the dynamics of actin filaments in cancer cells, which is essential for cancer cell migration and invasion. 4. **Neurological disorders:** Dysregulation of CFL2 has been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, the CFL2 gene plays a critical role in regulating actin dynamics and maintaining cellular homeostasis. Dysregulation of CFL2 has been implicated in various diseases, highlighting the importance of this gene in maintaining human health. Further research is necessary to fully understand the mechanisms by which CFL2 regulates actin dynamics and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 3534162100

Symbol: COF2_HUMAN

Name: Cofilin-2

UniProtKB Accession Codes:

Q9Y281 G3V5P4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 7 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 4 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11422377

Title: Characterization of human muscle type cofilin (CFL2) in normal and regenerating muscle.

PubMed ID: 11422377

DOI: 10.1046/j.1432-1327.2001.02247.x

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19752190

Title: Muscle LIM protein interacts with cofilin 2 and regulates F-actin dynamics in cardiac and skeletal muscle.

PubMed ID: 19752190

DOI: 10.1128/mcb.00654-09

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 17160903

Title: Nemaline myopathy with minicores caused by mutation of the CFL2 gene encoding the skeletal muscle actin-binding protein, cofilin-2.

PubMed ID: 17160903

DOI: 10.1086/510402

PubMed ID: 22560515

Title: Congenital myopathy caused by a novel missense mutation in the CFL2 gene.

PubMed ID: 22560515

DOI: 10.1016/j.nmd.2012.03.008

Sequence Information:

  • Length: 166
  • Mass: 18737
  • Checksum: 48B6CDCCAE9FE1CC
  • Sequence:
    • MASGVTVNDE VIKVFNDMKV RKSSTQEEIK KRKKAVLFCL SDDKRQIIVE EAKQILVGDI 
GDTVEDPYTS FVKLLPLNDC RYALYDATYE TKESKKEDLV FIFWAPESAP LKSKMIYASS 
KDAIKKKFTG IKHEWQVNGL DDIKDRSTLG EKLGGNVVVS LEGKPL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.