Details for: YME1L1

Gene ID: 10730

Symbol: YME1L1

Ensembl ID: ENSG00000136758

Description: YME1 like 1 ATPase

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.55
    Marker Score: 4,450
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.39
    Marker Score: 2,034
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.34
    Marker Score: 79,698
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.13
    Marker Score: 5,985
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.05
    Marker Score: 883
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 2.01
    Marker Score: 1,526
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.01
    Marker Score: 4,415
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.97
    Marker Score: 8,227
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.95
    Marker Score: 22,692
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.91
    Marker Score: 953
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.9
    Marker Score: 766
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.85
    Marker Score: 1,948
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.83
    Marker Score: 1,955
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.81
    Marker Score: 62,745
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.81
    Marker Score: 561
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.81
    Marker Score: 20,346
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.8
    Marker Score: 1,270
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.79
    Marker Score: 1,222
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.79
    Marker Score: 428
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.79
    Marker Score: 31,708
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.78
    Marker Score: 67,736
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.78
    Marker Score: 7,231
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.77
    Marker Score: 2,608
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.77
    Marker Score: 17,937
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.75
    Marker Score: 1,377
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.74
    Marker Score: 7,447
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.73
    Marker Score: 3,949
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.73
    Marker Score: 426
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.72
    Marker Score: 703
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.69
    Marker Score: 1,230
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.69
    Marker Score: 683
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.68
    Marker Score: 25,141
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.68
    Marker Score: 6,220
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.68
    Marker Score: 103,203
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.67
    Marker Score: 12,818
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.67
    Marker Score: 33,233
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.66
    Marker Score: 1,134
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.65
    Marker Score: 2,130
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.65
    Marker Score: 686
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.65
    Marker Score: 2,188
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.64
    Marker Score: 1,783
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.63
    Marker Score: 6,292
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.62
    Marker Score: 1,013
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.62
    Marker Score: 59,814
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.62
    Marker Score: 15,400
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.62
    Marker Score: 1,897
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.61
    Marker Score: 13,788
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.6
    Marker Score: 84,756
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.6
    Marker Score: 557
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.6
    Marker Score: 396
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.6
    Marker Score: 933
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.59
    Marker Score: 2,200
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 1.59
    Marker Score: 668
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.58
    Marker Score: 14,852
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.57
    Marker Score: 1,440
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.57
    Marker Score: 1,047
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.56
    Marker Score: 1,040
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.56
    Marker Score: 15,712
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.56
    Marker Score: 1,654
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.55
    Marker Score: 4,230
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.55
    Marker Score: 10,108
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.55
    Marker Score: 357
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.55
    Marker Score: 1,266
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 1.54
    Marker Score: 406
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.54
    Marker Score: 2,179
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.54
    Marker Score: 746
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.53
    Marker Score: 1,479
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.53
    Marker Score: 15,807
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1.52
    Marker Score: 1,528
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.52
    Marker Score: 868
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.51
    Marker Score: 2,684
  • Cell Name: interneuron (CL0000099)
    Fold Change: 1.51
    Marker Score: 691
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 1.51
    Marker Score: 866
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 1.51
    Marker Score: 444
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.51
    Marker Score: 1,301
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.5
    Marker Score: 32,065
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 1.5
    Marker Score: 694
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.5
    Marker Score: 328
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.5
    Marker Score: 1,297
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.5
    Marker Score: 1,341
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.49
    Marker Score: 550
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.48
    Marker Score: 3,620
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.48
    Marker Score: 1,394
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.48
    Marker Score: 1,302
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.48
    Marker Score: 8,777
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 1.48
    Marker Score: 364
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 1.48
    Marker Score: 415
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.47
    Marker Score: 82,334
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.47
    Marker Score: 1,111
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.47
    Marker Score: 1,244
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.46
    Marker Score: 551
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 1.46
    Marker Score: 387
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.46
    Marker Score: 2,857
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 1.45
    Marker Score: 362
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.45
    Marker Score: 3,613
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.45
    Marker Score: 501
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.45
    Marker Score: 9,225
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.45
    Marker Score: 1,059
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.45
    Marker Score: 2,582
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.44
    Marker Score: 501

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Mitochondrial localization:** YME1L1 is a mitochondrial protein that is involved in the degradation of mitochondrial proteins. 2. **ATP-dependent zinc metalloprotease activity:** YME1L1 possesses a unique ATP-dependent zinc metalloprotease activity, which is essential for its function in protein degradation. 3. **Protein quality control:** YME1L1 is involved in the quality control of proteins, particularly misfolded or incompletely synthesized proteins, which can be toxic to cells. 4. **Regulation of apoptosis:** YME1L1 has been shown to regulate the apoptotic process, which is essential for maintaining cellular homeostasis. **Pathways and Functions:** 1. **Mitochondrial protein degradation:** YME1L1 is involved in the degradation of mitochondrial proteins, which is essential for maintaining mitochondrial function and cellular homeostasis. 2. **Protein quality control for misfolded or incompletely synthesized proteins:** YME1L1 is involved in the quality control of proteins, particularly misfolded or incompletely synthesized proteins, which can be toxic to cells. 3. **Regulation of the apoptotic process:** YME1L1 has been shown to regulate the apoptotic process, which is essential for maintaining cellular homeostasis. 4. **Cellular responses to stimuli:** YME1L1 is involved in the regulation of cellular responses to stimuli, including oxidative stress and nutrient deprivation. 5. **Cellular responses to stress:** YME1L1 is involved in the regulation of cellular responses to stress, including mitochondrial stress and protein misfolding. **Clinical Significance:** 1. **Cancer:** Dysregulation of YME1L1 has been linked to various types of cancer, including breast, prostate, and lung cancer. 2. **Neurodegenerative disorders:** YME1L1 has been implicated in the pathogenesis of neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. 3. **Autoimmune diseases:** YME1L1 has been linked to autoimmune diseases, including multiple sclerosis and rheumatoid arthritis. 4. **Immunodeficiency:** YME1L1 is involved in the regulation of immune responses, and its dysregulation can lead to immunodeficiency. 5. **Mitochondrial disorders:** YME1L1 is involved in the regulation of mitochondrial function, and its dysregulation can lead to mitochondrial disorders. In conclusion, YME1L1 is a critical component of mitochondrial protein quality control and immune regulation. Its dysregulation has been linked to various diseases, including cancer, neurodegenerative disorders, autoimmune diseases, and immunodeficiency. Further research is needed to fully understand the role of YME1L1 in human disease and to develop therapeutic strategies to target its dysregulation.

Genular Protein ID: 1876029208

Symbol: YMEL1_HUMAN

Name: ATP-dependent zinc metalloprotease YME1L1

UniProtKB Accession Codes:

Q96TA2 B4DNM1 D3DRV8 D3DRV9 Q5T8D9 Q9H1Q0 Q9UMR9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 ChEBI 5 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 16 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 MANE-Select 1 MEROPS 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10843804

Title: Identification and characterization of YME1L1, a novel paraplegin-related gene.

PubMed ID: 10843804

DOI: 10.1006/geno.2000.6136

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18076378

Title: Metalloprotease-mediated OPA1 processing is modulated by the mitochondrial membrane potential.

PubMed ID: 18076378

DOI: 10.1042/bc20070110

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22262461

Title: YME1L controls the accumulation of respiratory chain subunits and is required for apoptotic resistance, cristae morphogenesis and cell proliferation.

PubMed ID: 22262461

DOI: 10.1091/mbc.e11-08-0674

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 26759378

Title: The mammalian homologue of yeast Afg1 ATPase (lactation elevated 1) mediates degradation of nuclear-encoded complex IV subunits.

PubMed ID: 26759378

DOI: 10.1042/bj20151029

PubMed ID: 26923599

Title: Reciprocal Degradation of YME1L and OMA1 Adapts Mitochondrial Proteolytic Activity during Stress.

PubMed ID: 26923599

DOI: 10.1016/j.celrep.2016.02.011

PubMed ID: 27786171

Title: Engineered AAA+ proteases reveal principles of proteolysis at the mitochondrial inner membrane.

PubMed ID: 27786171

DOI: 10.1038/ncomms13301

PubMed ID: 27495975

Title: Homozygous YME1L1 mutation causes mitochondriopathy with optic atrophy and mitochondrial network fragmentation.

PubMed ID: 27495975

DOI: 10.7554/elife.16078

Sequence Information:

  • Length: 773
  • Mass: 86455
  • Checksum: FB77990F4D7B3A58
  • Sequence:
    • MFSLSSTVQP QVTVPLSHLI NAFHTPKNTS VSLSGVSVSQ NQHRDVVPEH EAPSSECMFS 
DFLTKLNIVS IGKGKIFEGY RSMFMEPAKR MKKSLDTTDN WHIRPEPFSL SIPPSLNLRD 
LGLSELKIGQ IDQLVENLLP GFCKGKNISS HWHTSHVSAQ SFFENKYGNL DIFSTLRSSC 
LYRHHSRALQ SICSDLQYWP VFIQSRGFKT LKSRTRRLQS TSERLAETQN IAPSFVKGFL 
LRDRGSDVES LDKLMKTKNI PEAHQDAFKT GFAEGFLKAQ ALTQKTNDSL RRTRLILFVL 
LLFGIYGLLK NPFLSVRFRT TTGLDSAVDP VQMKNVTFEH VKGVEEAKQE LQEVVEFLKN 
PQKFTILGGK LPKGILLVGP PGTGKTLLAR AVAGEADVPF YYASGSEFDE MFVGVGASRI 
RNLFREAKAN APCVIFIDEL DSVGGKRIES PMHPYSRQTI NQLLAEMDGF KPNEGVIIIG 
ATNFPEALDN ALIRPGRFDM QVTVPRPDVK GRTEILKWYL NKIKFDQSVD PEIIARGTVG 
FSGAELENLV NQAALKAAVD GKEMVTMKEL EFSKDKILMG PERRSVEIDN KNKTITAYHE 
SGHAIIAYYT KDAMPINKAT IMPRGPTLGH VSLLPENDRW NETRAQLLAQ MDVSMGGRVA 
EELIFGTDHI TTGASSDFDN ATKIAKRMVT KFGMSEKLGV MTYSDTGKLS PETQSAIEQE 
IRILLRDSYE RAKHILKTHA KEHKNLAEAL LTYETLDAKE IQIVLEGKKL EVR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.