Details for: TCFL5

Gene ID: 10732

Symbol: TCFL5

Ensembl ID: ENSG00000101190

Description: transcription factor like 5

Associated with

  • Cell differentiation
    (GO:0030154)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Dna binding
    (GO:0003677)
  • Male germ cell nucleus
    (GO:0001673)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleus
    (GO:0005634)
  • Protein dimerization activity
    (GO:0046983)
  • Regulation of cell differentiation
    (GO:0045595)
  • Regulation of cell population proliferation
    (GO:0042127)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Spermatogenesis
    (GO:0007283)
  • Transcription by rna polymerase ii
    (GO:0006366)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 1.26
    Marker Score: 453
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.02
    Marker Score: 1,924
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,807
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,032
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 497
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.96
    Marker Score: 885
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 451
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,410
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.94
    Marker Score: 1,445
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,733
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5,174
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.89
    Marker Score: 54,656
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 316
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,278
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,250
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.76
    Marker Score: 11,866
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 386
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.74
    Marker Score: 491
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 566
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.73
    Marker Score: 670
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.73
    Marker Score: 2,837
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.72
    Marker Score: 1,469
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.72
    Marker Score: 1,254
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.71
    Marker Score: 10,563
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7
    Marker Score: 2,955
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.69
    Marker Score: 278
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.68
    Marker Score: 5,827
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.62
    Marker Score: 5,833
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.61
    Marker Score: 4,671
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.61
    Marker Score: 3,652
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.6
    Marker Score: 1,422
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.59
    Marker Score: 6,127
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.58
    Marker Score: 11,532
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.55
    Marker Score: 20,932
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.54
    Marker Score: 5,116
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.53
    Marker Score: 320
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.51
    Marker Score: 2,152
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.51
    Marker Score: 329
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.51
    Marker Score: 2,100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.49
    Marker Score: 10,377
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.48
    Marker Score: 156
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.47
    Marker Score: 490
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.47
    Marker Score: 1,895
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.47
    Marker Score: 222
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.46
    Marker Score: 270
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.46
    Marker Score: 16,907
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.45
    Marker Score: 142
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.45
    Marker Score: 143
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.44
    Marker Score: 1,060
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.42
    Marker Score: 124
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.37
    Marker Score: 389
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.36
    Marker Score: 245
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.35
    Marker Score: 155
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.35
    Marker Score: 347
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.35
    Marker Score: 120
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.35
    Marker Score: 421
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.34
    Marker Score: 144
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.33
    Marker Score: 734
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.32
    Marker Score: 473
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.32
    Marker Score: 531
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.32
    Marker Score: 351
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.31
    Marker Score: 240
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.31
    Marker Score: 266
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.3
    Marker Score: 343
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.29
    Marker Score: 424
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.29
    Marker Score: 93
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.29
    Marker Score: 732
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.29
    Marker Score: 361
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.28
    Marker Score: 165
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.28
    Marker Score: 143
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.28
    Marker Score: 129
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.27
    Marker Score: 259
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.27
    Marker Score: 170
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.27
    Marker Score: 180
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.26
    Marker Score: 284
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.26
    Marker Score: 352
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.26
    Marker Score: 316
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.26
    Marker Score: 67
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.26
    Marker Score: 135
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.26
    Marker Score: 125
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.25
    Marker Score: 2,551
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.25
    Marker Score: 66
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.25
    Marker Score: 72
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.25
    Marker Score: 523
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.25
    Marker Score: 65
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.24
    Marker Score: 84
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.24
    Marker Score: 235
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.24
    Marker Score: 295
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.24
    Marker Score: 114
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.24
    Marker Score: 536
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.23
    Marker Score: 181
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.23
    Marker Score: 173
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.23
    Marker Score: 294
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.23
    Marker Score: 642
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.22
    Marker Score: 263
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.22
    Marker Score: 237
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.22
    Marker Score: 378

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TCFL5 is a member of the transcription factor-like family, characterized by its ability to bind to DNA and regulate gene expression. Its protein product shares structural homology with well-known transcription factors, such as TCF4 and LEF1. Notably, TCFL5 exhibits a unique combination of transcriptional activation and repression activities, suggesting a complex regulatory role in gene expression. The gene is highly conserved across species, with orthologs present in mammals and other vertebrates, underscoring its evolutionary significance. **Pathways and Functions:** TCFL5 is implicated in various cellular processes, including: 1. **Cell Differentiation**: TCFL5 regulates the expression of genes involved in the differentiation of cells, particularly in the development of the nervous system and intestinal epithelium. 2. **Chromatin Remodeling**: The gene is involved in chromatin remodeling, a process essential for the regulation of gene expression and the transmission of epigenetic marks. 3. **Transcriptional Regulation**: TCFL5 modulates the activity of RNA polymerase II, a key enzyme responsible for the transcription of protein-coding genes. 4. **Cell Proliferation**: The gene is involved in regulating cell proliferation, particularly in the intestinal crypt stem cell niche. 5. **Spermatogenesis**: TCFL5 is expressed in male germ cells and is thought to play a role in the regulation of spermatogenesis. **Clinical Significance:** Dysregulation of TCFL5 has been implicated in various diseases, including: 1. **Cancer**: Alterations in TCFL5 expression have been observed in several types of cancer, including colorectal and breast cancer. 2. **Neurological Disorders**: TCFL5 has been linked to neurological disorders, such as autism spectrum disorder and schizophrenia. 3. **Cardiovascular Disease**: The gene is involved in the regulation of cardiovascular development and function, making it a potential target for the treatment of cardiovascular disease. In conclusion, TCFL5 is a multifunctional gene that plays a critical role in regulating cell differentiation, proliferation, and transcription. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms underlying its function and the development of therapeutic strategies to modulate its activity.

Genular Protein ID: 3129002383

Symbol: TCFL5_HUMAN

Name: Transcription factor-like 5 protein

UniProtKB Accession Codes:

Q9UL49 O94771 Q9BYW0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11306602

Title: Dominant T- and B-cell epitopes in an autoantigen linked to Chagas' disease.

PubMed ID: 11306602

DOI: 10.1172/jci10734

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 9763657

Title: Cloning of TCFL5 encoding a novel human basic helix-loop-helix motif protein that is specifically expressed in primary spermatocytes at the pachytene stage.

PubMed ID: 9763657

DOI: 10.1159/000015061

Sequence Information:

  • Length: 500
  • Mass: 52697
  • Checksum: 39918DCA21A94E7B
  • Sequence:
    • MSGPGPREPP PEAGAAGGEA AVEGAGGGDA ALGEPGLSFT TTDLSLVEMT EVEYTQLQHI 
LCSHMEAAAD GELETRLNSA LLAAAGPGAG AGGFAAGGQG GAAPVYPVLC PSALAADAPC 
LGHIDFQELR MMLLSEAGAA EKTSGGGDGA RARADGAAKE GAGAAAAAAG PDGAPEARAK 
PAVRVRLEDR FNSIPAEPPP APRGPEPPEP GGALNNLVTL IRHPSELMNV PLQQQNKCTA 
LVKNKTAATT TALQFTYPLF TTNACSTSGN SNLSQTQSSS NSCSVLEAAK HQDIGLPRAF 
SFCYQQEIES TKQTLGSRNK VLPEQVWIKV GEAALCKQAL KRNRSRMRQL DTNVERRALG 
EIQNVGEGAT ATQGAWQSSE SSQANLGEQA QSGPQGGRSQ RRERHNRMER DRRRRIRICC 
DELNLLVPFC NAETDKATTL QWTTAFLKYI QERHGDSLKK EFESVFCGKT GRRLKLTRPD 
SLVTCPAQGS LQSSPSMEIK

Genular Protein ID: 300787290

Symbol: Q86TP4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q86TP4

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 6 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 2 SAM 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 483
  • Mass: 52265
  • Checksum: 9DB370986A5157DE
  • Sequence:
    • MTEVEYTQLQ HILCSHMEAA ADGELETRLN SALLAAAGPG AGAGGFAAGG QGGAAPVYPV 
LCPSALAADA PCLGHIDFQE LRMMLLSEAG AAEKTSGGGD GARARADGAA KEGAGAAAAA 
AGPDGAPEAR AKPAVRVRLE DRFNSIPAEP PPAPRGPEPP EPGGALNNLV TLIRHPSELM 
NVPLQQQNKC TALVKNKTAA TTTALQFTYP LFTTNACSTS GNSDLSQTQS SSNSCSVLEA 
AKHQDIGLPR AFSFCYQQEI ESTKQTLGSR NKVLPEQVWI KVGEAALCKQ ALKRNRSRMR 
QLDTNVERRA LGEIQNVGEG ATATQGAWQS SESSQANLGE QAQSGPQGGR SQRRERHNRM 
ERDRRRRIRI CCDELNLLVP FCNAETDKAT TLQWTTAFLK YIQERHGDSL KKVLSTNSRY 
VMLWTCFLKM KSAVDGKNPQ HAYRTANHKW LCLHEARSFA FEVSIWAHFQ LFRVRIPEGF 
LSI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.