PLK4 | ENSG00000142731 | NCBI 10733

Details for: PLK4

Gene ID: 10733

Symbol: PLK4

Ensembl ID: ENSG00000142731

Description: polo like kinase 4

Associated with

Anchoring of the basal body to the plasma membrane
(R-HSA-5620912)
Aurka activation by tpx2
(R-HSA-8854518)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Centrosome maturation
(R-HSA-380287)
G2/m transition
(R-HSA-69275)
Loss of nlp from mitotic centrosomes
(R-HSA-380259)
Loss of proteins required for interphase microtubule organization from the centrosome
(R-HSA-380284)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mitotic prometaphase
(R-HSA-68877)
M phase
(R-HSA-68886)
Organelle biogenesis and maintenance
(R-HSA-1852241)
Recruitment of mitotic centrosome proteins and complexes
(R-HSA-380270)
Recruitment of numa to mitotic centrosomes
(R-HSA-380320)
Regulation of plk1 activity at g2/m transition
(R-HSA-2565942)
Atp binding
(GO:0005524)
Centriole
(GO:0005814)
Centriole replication
(GO:0007099)
Centrosome
(GO:0005813)
Cilium assembly
(GO:0060271)
Cleavage furrow
(GO:0032154)
Cytosol
(GO:0005829)
De novo centriole assembly involved in multi-ciliated epithelial cell differentiation
(GO:0098535)
Deuterosome
(GO:0098536)
Identical protein binding
(GO:0042802)
Nucleolus
(GO:0005730)
Positive regulation of centriole replication
(GO:0046601)
Procentriole
(GO:0120098)
Procentriole replication complex
(GO:0120099)
Protein binding
(GO:0005515)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Trophoblast giant cell differentiation
(GO:0060707)
Xy body
(GO:0001741)

Other Information

Proteins

Polo-like kinase 4

Genular Protein ID: 2918557232

Symbol: PLK4_HUMAN

Name: Polo-like kinase 4

UniProtKB Accession Codes:

O00444 B2RAL0 B7Z837 B7Z8G7 Q8IYF0 Q96Q95 Q9UD84 Q9UDE2

Database IDs:

Citations:

PubMed ID: 11489907

Title: Sak serine-threonine kinase acts as an effector of Tec tyrosine kinase.

PubMed ID: 11489907

DOI: 10.1074/jbc.m106249200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8260651

Title: Transmembrane signaling by the interleukin-2 receptor: progress and conundrums.

PubMed ID: 8260651

DOI: 10.1006/smim.1993.1041

PubMed ID: 1311287

Title: Analysis of tyrosine kinase mRNAs including four FGF receptor mRNAs expressed in MCF-7 breast-cancer cells.

PubMed ID: 1311287

DOI: 10.1002/ijc.2910500419

PubMed ID: 16326102

Title: SAK/PLK4 is required for centriole duplication and flagella development.

PubMed ID: 16326102

DOI: 10.1016/j.cub.2005.11.042

PubMed ID: 16244668

Title: The Polo kinase Plk4 functions in centriole duplication.

PubMed ID: 16244668

DOI: 10.1038/ncb1320

PubMed ID: 15967108

Title: SAK, a new polo-like kinase, is transcriptionally repressed by p53 and induces apoptosis upon RNAi silencing.

PubMed ID: 15967108

DOI: 10.1593/neo.04325

PubMed ID: 17681131

Title: Plk4-induced centriole biogenesis in human cells.

PubMed ID: 17681131

DOI: 10.1016/j.devcel.2007.07.002

PubMed ID: 18239451

Title: Human Plk4 phosphorylates Cdc25C.

PubMed ID: 18239451

DOI: 10.4161/cc.7.4.5387

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19164942

Title: Polo-like kinase 4 phosphorylates Chk2.

PubMed ID: 19164942

DOI: 10.4161/cc.8.2.7355

PubMed ID: 19454482

Title: Gamma-tubulin-containing abnormal centrioles are induced by insufficient Plk4 in human HCT116 colorectal cancer cells.

PubMed ID: 19454482

DOI: 10.1242/jcs.036715

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 21059844

Title: Cep152 acts as a scaffold for recruitment of Plk4 and CPAP to the centrosome.

PubMed ID: 21059844

DOI: 10.1083/jcb.201007107

PubMed ID: 20852615

Title: Asterless is a scaffold for the onset of centriole assembly.

PubMed ID: 20852615

DOI: 10.1038/nature09445

PubMed ID: 22020124

Title: The human microcephaly protein STIL interacts with CPAP and is required for procentriole formation.

PubMed ID: 22020124

DOI: 10.1038/emboj.2011.378

PubMed ID: 21725316

Title: The SCF-FBXW5 E3-ubiquitin ligase is regulated by PLK4 and targets HsSAS-6 to control centrosome duplication.

PubMed ID: 21725316

DOI: 10.1038/ncb2282

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25344692

Title: Mutations in PLK4, encoding a master regulator of centriole biogenesis, cause microcephaly, growth failure and retinopathy.

PubMed ID: 25344692

DOI: 10.1038/ng.3122

PubMed ID: 27246242

Title: Cep78 is a new centriolar protein involved in Plk4-induced centriole overduplication.

PubMed ID: 27246242

DOI: 10.1242/jcs.184093

PubMed ID: 27796307

Title: KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification.

PubMed ID: 27796307

DOI: 10.1038/ncomms13227

PubMed ID: 30804208

Title: Polo-like kinase 4 maintains centriolar satellite integrity by phosphorylation of centrosomal protein 131 (CEP131).

PubMed ID: 30804208

DOI: 10.1074/jbc.ra118.004867

PubMed ID: 32107292

Title: Direct interaction between CEP85 and STIL mediates PLK4-driven directed cell migration.

PubMed ID: 32107292

DOI: 10.1242/jcs.238352

PubMed ID: 32433990

Title: Structural and Functional Analyses of the FAM46C/Plk4 Complex.

PubMed ID: 32433990

DOI: 10.1016/j.str.2020.04.023

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

Length: 970
Mass: 108972
Checksum: 4D56F5FD983211A6
Sequence:

MATCIGEKIE DFKVGNLLGK GSFAGVYRAE SIHTGLEVAI KMIDKKAMYK AGMVQRVQNE 
VKIHCQLKHP SILELYNYFE DSNYVYLVLE MCHNGEMNRY LKNRVKPFSE NEARHFMHQI 
ITGMLYLHSH GILHRDLTLS NLLLTRNMNI KIADFGLATQ LKMPHEKHYT LCGTPNYISP 
EIATRSAHGL ESDVWSLGCM FYTLLIGRPP FDTDTVKNTL NKVVLADYEM PSFLSIEAKD 
LIHQLLRRNP ADRLSLSSVL DHPFMSRNSS TKSKDLGTVE DSIDSGHATI STAITASSST 
SISGSLFDKR RLLIGQPLPN KMTVFPKNKS STDFSSSGDG NSFYTQWGNQ ETSNSGRGRV 
IQDAEERPHS RYLRRAYSSD RSGTSNSQSQ AKTYTMERCH SAEMLSVSKR SGGGENEERY 
SPTDNNANIF NFFKEKTSSS SGSFERPDNN QALSNHLCPG KTPFPFADPT PQTETVQQWF 
GNLQINAHLR KTTEYDSISP NRDFQGHPDL QKDTSKNAWT DTKVKKNSDA SDNAHSVKQQ 
NTMKYMTALH SKPEIIQQEC VFGSDPLSEQ SKTRGMEPPW GYQNRTLRSI TSPLVAHRLK 
PIRQKTKKAV VSILDSEEVC VELVKEYASQ EYVKEVLQIS SDGNTITIYY PNGGRGFPLA 
DRPPSPTDNI SRYSFDNLPE KYWRKYQYAS RFVQLVRSKS PKITYFTRYA KCILMENSPG 
ADFEVWFYDG VKIHKTEDFI QVIEKTGKSY TLKSESEVNS LKEEIKMYMD HANEGHRICL 
ALESIISEEE RKTRSAPFFP IIIGRKPGST SSPKALSPPP SVDSNYPTRE RASFNRMVMH 
SAASPTQAPI LNPSMVTNEG LGLTTTASGT DISSNSLKDC LPKSAQLLKS VFVKNVGWAT 
QLTSGAVWVQ FNDGSQLVVQ AGVSSISYTS PNGQTTRYGE NEKLPDYIKQ KLQCLSSILL 
MFSNPTPNFH

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PLK4

Associated with

Other Information

Sak serine-threonine kinase acts as an effector of Tec tyrosine kinase. PubMed ID: 11489907

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Transmembrane signaling by the interleukin-2 receptor: progress and conundrums. PubMed ID: 8260651

Analysis of tyrosine kinase mRNAs including four FGF receptor mRNAs expressed in MCF-7 breast-cancer cells. PubMed ID: 1311287

SAK/PLK4 is required for centriole duplication and flagella development. PubMed ID: 16326102

The Polo kinase Plk4 functions in centriole duplication. PubMed ID: 16244668

SAK, a new polo-like kinase, is transcriptionally repressed by p53 and induces apoptosis upon RNAi silencing. PubMed ID: 15967108

Plk4-induced centriole biogenesis in human cells. PubMed ID: 17681131

Human Plk4 phosphorylates Cdc25C. PubMed ID: 18239451

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Polo-like kinase 4 phosphorylates Chk2. PubMed ID: 19164942

Gamma-tubulin-containing abnormal centrioles are induced by insufficient Plk4 in human HCT116 colorectal cancer cells. PubMed ID: 19454482

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Cep152 acts as a scaffold for recruitment of Plk4 and CPAP to the centrosome. PubMed ID: 21059844

Asterless is a scaffold for the onset of centriole assembly. PubMed ID: 20852615

The human microcephaly protein STIL interacts with CPAP and is required for procentriole formation. PubMed ID: 22020124

The SCF-FBXW5 E3-ubiquitin ligase is regulated by PLK4 and targets HsSAS-6 to control centrosome duplication. PubMed ID: 21725316

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Mutations in PLK4, encoding a master regulator of centriole biogenesis, cause microcephaly, growth failure and retinopathy. PubMed ID: 25344692

Cep78 is a new centriolar protein involved in Plk4-induced centriole overduplication. PubMed ID: 27246242

KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification. PubMed ID: 27796307

Polo-like kinase 4 maintains centriolar satellite integrity by phosphorylation of centrosomal protein 131 (CEP131). PubMed ID: 30804208

Direct interaction between CEP85 and STIL mediates PLK4-driven directed cell migration. PubMed ID: 32107292

Structural and Functional Analyses of the FAM46C/Plk4 Complex. PubMed ID: 32433990

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846