Details for: SIX2

Gene ID: 10736

Symbol: SIX2

Ensembl ID: ENSG00000170577

Description: SIX homeobox 2

Associated with

  • Developmental biology
    (R-HSA-1266738)
  • Formation of the ureteric bud
    (R-HSA-9830674)
  • Anatomical structure morphogenesis
    (GO:0009653)
  • Anterior/posterior axis specification
    (GO:0009948)
  • Cell migration
    (GO:0016477)
  • Cell population proliferation
    (GO:0008283)
  • Chondrocyte differentiation
    (GO:0002062)
  • Chromatin
    (GO:0000785)
  • Condensed mesenchymal cell proliferation
    (GO:0072137)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Embryonic cranial skeleton morphogenesis
    (GO:0048701)
  • Embryonic digestive tract morphogenesis
    (GO:0048557)
  • Kidney development
    (GO:0001822)
  • Mesenchymal cell differentiation involved in kidney development
    (GO:0072161)
  • Mesenchymal stem cell maintenance involved in nephron morphogenesis
    (GO:0072038)
  • Mesenchymal stem cell proliferation
    (GO:0097168)
  • Mesenchymal to epithelial transition involved in metanephros morphogenesis
    (GO:0003337)
  • Mesodermal cell fate specification
    (GO:0007501)
  • Middle ear morphogenesis
    (GO:0042474)
  • Negative regulation of epithelial cell differentiation
    (GO:0030857)
  • Nephron development
    (GO:0072006)
  • Nephron morphogenesis
    (GO:0072028)
  • Nucleus
    (GO:0005634)
  • Positive regulation of chondrocyte proliferation
    (GO:1902732)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein-containing complex binding
    (GO:0044877)
  • Protein binding
    (GO:0005515)
  • Protein import into nucleus
    (GO:0006606)
  • Regulation of branching involved in ureteric bud morphogenesis
    (GO:0090189)
  • Regulation of chondrocyte differentiation
    (GO:0032330)
  • Regulation of ossification
    (GO:0030278)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Transcription regulator complex
    (GO:0005667)

Other Information

Genular Protein ID: 1390573057

Symbol: SIX2_HUMAN

Name: Homeobox protein SIX2

UniProtKB Accession Codes:

Q9NPC8 Q9BXH7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EPD 1 Ensembl 1 GO 33 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10677303

Title: Familial syndromic esophageal atresia maps to 2p23-p24.

PubMed ID: 10677303

DOI: 10.1086/302779

PubMed ID: 10773454

Title: Structure, mapping and expression of the human gene encoding the homeodomain protein, SIX2.

PubMed ID: 10773454

DOI: 10.1016/s0378-1119(00)00105-0

PubMed ID: 20515681

Title: Inactivation of Six2 in mouse identifies a novel genetic mechanism controlling development and growth of the cranial base.

PubMed ID: 20515681

DOI: 10.1016/j.ydbio.2010.05.509

PubMed ID: 22703800

Title: SIX2 and CITED1, markers of nephronic progenitor self-renewal, remain active in primitive elements of Wilms' tumor.

PubMed ID: 22703800

DOI: 10.1016/j.jpedsurg.2012.03.034

PubMed ID: 22995329

Title: The pluripotent renal stem cell regulator SIX2 is activated in renal neoplasms and influences cellular proliferation and migration.

PubMed ID: 22995329

DOI: 10.1016/j.humpath.2012.05.021

PubMed ID: 18305125

Title: SIX2 and BMP4 mutations associate with anomalous kidney development.

PubMed ID: 18305125

DOI: 10.1681/asn.2006111282

Sequence Information:

  • Length: 291
  • Mass: 32286
  • Checksum: 8388C3C331575BDD
  • Sequence:
    • MSMLPTFGFT QEQVACVCEV LQQGGNIERL GRFLWSLPAC EHLHKNESVL KAKAVVAFHR 
GNFRELYKIL ESHQFSPHNH AKLQQLWLKA HYIEAEKLRG RPLGAVGKYR VRRKFPLPRS 
IWDGEETSYC FKEKSRSVLR EWYAHNPYPS PREKRELAEA TGLTTTQVSN WFKNRRQRDR 
AAEAKERENN ENSNSNSHNP LNGSGKSVLG SSEDEKTPSG TPDHSSSSPA LLLSPPPPGL 
PSLHSLGHPP GPSAVPVPVP GGGGADPLQH HHGLQDSILN PMSANLVDLG S

Genular Protein ID: 1468880772

Symbol: Q8TBA2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8TBA2

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 2 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 SAM 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 291
  • Mass: 32316
  • Checksum: C288C3D3305B2AC1
  • Sequence:
    • MSMLPTFGFT QEQVACVCEV LQQGGNIERL GRFLWSLPAC EHLHKNESVL KAKAVVAFHR 
GNFRELYKIL ESHQFSPHNH AKLQQLWLKA HYIEAEKLRG RPLGAVGKYR VRRKFPLPRS 
IWDGEETSYC FKEKSRSVLR EWYAHNPYPS PREKRELTEA TGLTTTQVSN WFKNRRQRDR 
AAEAKERENN ENSNSNSHNP LNGSGKSVLG SSEDEKTPSG TPDHSSSSPA LLLSPPPPGL 
PSLHSLGHPP GPSAVPVPVP GGGGADPLQH HHGLQDSILN PMSANLVDLG S

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.