Details for: RBBP9

Gene ID: 10741

Symbol: RBBP9

Ensembl ID: ENSG00000089050

Description: RB binding protein 9, serine hydrolase

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,786
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,011
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,404
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 488
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 442
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,725
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5,084
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.89
    Marker Score: 357
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,267
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 310
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.83
    Marker Score: 553
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,265
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.75
    Marker Score: 1,308
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.73
    Marker Score: 212
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 379
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.71
    Marker Score: 569
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.71
    Marker Score: 541
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2,889
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.68
    Marker Score: 624
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 169
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.55
    Marker Score: 270
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.55
    Marker Score: 1,878
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 430
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.51
    Marker Score: 1,870
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5
    Marker Score: 317
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.48
    Marker Score: 3,605
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.46
    Marker Score: 217
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.45
    Marker Score: 565
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.44
    Marker Score: 6,887
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.43
    Marker Score: 396
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.43
    Marker Score: 304
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.42
    Marker Score: 434
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.39
    Marker Score: 122
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.38
    Marker Score: 473
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.38
    Marker Score: 260
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.38
    Marker Score: 699
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.38
    Marker Score: 183
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.38
    Marker Score: 2,467
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.38
    Marker Score: 860
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.38
    Marker Score: 712
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.37
    Marker Score: 1,308
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.36
    Marker Score: 526
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.35
    Marker Score: 721
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.35
    Marker Score: 388
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.35
    Marker Score: 145
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.35
    Marker Score: 235
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.34
    Marker Score: 1,411
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.34
    Marker Score: 263
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.34
    Marker Score: 900
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.33
    Marker Score: 2,907
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.33
    Marker Score: 331
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.33
    Marker Score: 3,115
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.33
    Marker Score: 370
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.33
    Marker Score: 826
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.33
    Marker Score: 535
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.33
    Marker Score: 215
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.32
    Marker Score: 85
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.32
    Marker Score: 3,290
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.32
    Marker Score: 337
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.31
    Marker Score: 1,216
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.31
    Marker Score: 73
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.31
    Marker Score: 750
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.3
    Marker Score: 11,454
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.3
    Marker Score: 318
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.3
    Marker Score: 301
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.3
    Marker Score: 291
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.3
    Marker Score: 94
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.29
    Marker Score: 614
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.29
    Marker Score: 261
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.29
    Marker Score: 1,167
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.28
    Marker Score: 90
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.28
    Marker Score: 10,462
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.28
    Marker Score: 72
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.28
    Marker Score: 1,154
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.28
    Marker Score: 16,967
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.28
    Marker Score: 468
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.28
    Marker Score: 1,446
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.27
    Marker Score: 437
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.27
    Marker Score: 634
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.27
    Marker Score: 313
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.27
    Marker Score: 60
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.27
    Marker Score: 146
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.26
    Marker Score: 176
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.26
    Marker Score: 262
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.26
    Marker Score: 368
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.26
    Marker Score: 993
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.26
    Marker Score: 104
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.25
    Marker Score: 95
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.25
    Marker Score: 268
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.25
    Marker Score: 2,414
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.25
    Marker Score: 271
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.25
    Marker Score: 131
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.25
    Marker Score: 573
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.25
    Marker Score: 88
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.25
    Marker Score: 1,927
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.25
    Marker Score: 2,513
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.25
    Marker Score: 442
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.25
    Marker Score: 62
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.25
    Marker Score: 103

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RBBP9 is a serine hydrolase, a class of enzymes that catalyze the hydrolysis of ester bonds. Its primary function is to regulate gene expression by modulating the activity of various transcription factors and chromatin remodeling complexes. This gene is characterized by its ability to bind to retinoblastoma-binding proteins (RBP), which are crucial for the regulation of cell cycle progression and apoptosis. The unique expression profile of RBBP9 in specific cell types highlights its specialized role in maintaining tissue homeostasis. **Pathways and Functions:** The RBBP9 gene is involved in several key signaling pathways, including: 1. **Hydrolase activity:** RBBP9 catalyzes the hydrolysis of ester bonds, a crucial step in the regulation of gene expression. 2. **Positive regulation of gene expression:** RBBP9 acts as a co-activator for various transcription factors, promoting the expression of genes involved in cellular differentiation and homeostasis. 3. **Protein binding:** RBBP9 interacts with a range of proteins, including RBP, histones, and chromatin remodeling complexes, to regulate gene expression and chromatin structure. 4. **Response to nematode:** RBBP9 is involved in the response to nematode infections, highlighting its role in the innate immune response. 5. **Type II pneumocyte differentiation:** RBBP9 is essential for the differentiation of type II pneumocytes, a crucial step in lung development and repair. **Clinical Significance:** The RBBP9 gene has significant implications for various diseases, including: 1. **Neurological disorders:** Alterations in RBBP9 expression have been linked to neurological disorders, such as schizophrenia and autism spectrum disorder. 2. **Cancer:** RBBP9 is frequently overexpressed in various types of cancer, including colon, breast, and lung cancers, suggesting its role as an oncogene. 3. **Gastrointestinal disorders:** RBBP9 expression is altered in gastrointestinal disorders, such as inflammatory bowel disease and colon cancer. 4. **Neuropathic pain:** RBBP9 is involved in the regulation of pain signaling pathways, highlighting its potential as a therapeutic target for neuropathic pain. In conclusion, the RBBP9 gene is a complex and multifaceted regulator of gene expression and cellular differentiation. Its involvement in various signaling pathways and diseases underscores its significance in maintaining tissue homeostasis and responding to external stimuli. Further research is necessary to fully elucidate the functional and clinical significance of RBBP9, with potential implications for the development of novel therapeutic strategies.

Genular Protein ID: 1221679734

Symbol: RBBP9_HUMAN

Name: Retinoblastoma-binding protein 10

UniProtKB Accession Codes:

O75884 D3DW31 Q5JPH9 Q9H1D8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugCentral 1 EMBL 8 EPD 1 ESTHER 1 Ensembl 1 EvolutionaryTrace 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9697699

Title: A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability.

PubMed ID: 9697699

DOI: 10.1038/1258

PubMed ID: 12296629

Title: Cloning and expression of a novel retinoblastoma binding protein cDNA, RBBP10.

PubMed ID: 12296629

DOI: 10.1023/a:1019886918029

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19329999

Title: Identification of selective inhibitors of uncharacterized enzymes by high-throughput screening with fluorescent activity-based probes.

PubMed ID: 19329999

DOI: 10.1038/nbt.1531

PubMed ID: 20080647

Title: RBBP9: a tumor-associated serine hydrolase activity required for pancreatic neoplasia.

PubMed ID: 20080647

DOI: 10.1073/pnas.0911646107

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21689726

Title: Retinoblastoma-binding proteins 4 and 9 are important for human pluripotent stem cell maintenance.

PubMed ID: 21689726

DOI: 10.1016/j.exphem.2011.05.008

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 19004028

Title: Crystal structure of human retinoblastoma binding protein 9.

PubMed ID: 19004028

DOI: 10.1002/prot.22278

Sequence Information:

  • Length: 186
  • Mass: 21000
  • Checksum: F645E159DCB759BF
  • Sequence:
    • MASPSKAVIV PGNGGGDVTT HGWYGWVKKE LEKIPGFQCL AKNMPDPITA RESIWLPFME 
TELHCDEKTI IIGHSSGAIA AMRYAETHRV YAIVLVSAYT SDLGDENERA SGYFTRPWQW 
EKIKANCPYI VQFGSTDDPF LPWKEQQEVA DRLETKLHKF TDCGHFQNTE FHELITVVKS 
LLKVPA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.