Details for: PTTG2

Gene ID: 10744

Symbol: PTTG2

Ensembl ID: ENSG00000250254

Description: pituitary tumor-transforming 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.15
    Marker Score: 2166
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.47
    Marker Score: 2783
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.26
    Marker Score: 2561
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.18
    Marker Score: 18461
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7692
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.06
    Marker Score: 2704
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71842
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48066
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5352
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.89
    Marker Score: 426
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.85
    Marker Score: 512
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 713
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 402
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.65
    Marker Score: 515
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.64
    Marker Score: 370
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.64
    Marker Score: 3823
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.45
    Marker Score: 1741
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.39
    Marker Score: 769
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.35
    Marker Score: 155
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.3
    Marker Score: 318
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.26
    Marker Score: 1073.5
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.18
    Marker Score: 118
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.13
    Marker Score: 142
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.12
    Marker Score: 53
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.11
    Marker Score: 71
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.1
    Marker Score: 99
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.1
    Marker Score: 85
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.08
    Marker Score: 47
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.08
    Marker Score: 141
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.07
    Marker Score: 110
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.07
    Marker Score: 42
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.07
    Marker Score: 121
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.07
    Marker Score: 113
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.06
    Marker Score: 553
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.06
    Marker Score: 246
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.05
    Marker Score: 48
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.05
    Marker Score: 38
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.05
    Marker Score: 33
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.05
    Marker Score: 35
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.05
    Marker Score: 20
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.05
    Marker Score: 23
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.05
    Marker Score: 48.5
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.05
    Marker Score: 31
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.04
    Marker Score: 49
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.04
    Marker Score: 45
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.04
    Marker Score: 60
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.04
    Marker Score: 38
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.04
    Marker Score: 2419
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.04
    Marker Score: 22
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.04
    Marker Score: 9
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.04
    Marker Score: 9
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.03
    Marker Score: 332
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.03
    Marker Score: 56
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.03
    Marker Score: 43
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.03
    Marker Score: 23
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.03
    Marker Score: 8
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.03
    Marker Score: 21
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.03
    Marker Score: 8
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.03
    Marker Score: 65
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.03
    Marker Score: 273
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.03
    Marker Score: 8
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.03
    Marker Score: 110
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.03
    Marker Score: 7
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.03
    Marker Score: 8
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.03
    Marker Score: 40
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.03
    Marker Score: 7
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.03
    Marker Score: 7
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.03
    Marker Score: 9
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.03
    Marker Score: 8
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.03
    Marker Score: 8
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.02
    Marker Score: 24
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.02
    Marker Score: 7
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.02
    Marker Score: 8
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.02
    Marker Score: 25
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.02
    Marker Score: 21
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.02
    Marker Score: 9
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.02
    Marker Score: 19
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.02
    Marker Score: 9
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.02
    Marker Score: 763

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Other Information

**Key Characteristics:** PTTG2 is a 60-kDa protein that belongs to the securin family, which is characterized by its ability to bind and inhibit the activity of the anaphase-promoting complex (APC). The APC is a crucial regulator of the cell cycle, and its inactivation allows cells to enter the anaphase stage, leading to cell division. PTTG2 is highly expressed in various tissues, including the pituitary gland, brain, and cardiovascular system. Its expression is often associated with cell proliferation, differentiation, and survival. **Pathways and Functions:** PTTG2 is involved in multiple signaling pathways that regulate cell cycle progression, apoptosis, and cellular differentiation. These pathways include: 1. **Cell Cycle Regulation:** PTTG2 inhibits the activity of the APC, which in turn regulates the G2/M phase transition. This ensures that cells only enter the anaphase stage when necessary, preventing excessive cell proliferation. 2. **Apoptosis:** PTTG2 has been shown to regulate apoptosis by modulating the activity of pro-apoptotic and anti-apoptotic proteins. 3. **Cell Differentiation:** PTTG2 is involved in the regulation of cellular differentiation, particularly in the development of the nervous system and cardiovascular system. 4. **Stem Cell Maintenance:** PTTG2 is expressed in stem cells and is required for the maintenance of their self-renewal capacity. **Clinical Significance:** Dysregulation of PTTG2 has been implicated in various human diseases, including: 1. **Cancer:** Overexpression of PTTG2 has been observed in various types of cancer, including pituitary tumors, brain tumors, and cardiovascular diseases. 2. **Neurodegenerative Diseases:** PTTG2 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Cardiovascular Disease:** PTTG2 has been shown to play a role in the development of cardiovascular disease, particularly in the context of atherosclerosis and cardiac hypertrophy. In conclusion, PTTG2 is a multifunctional protein that plays a critical role in regulating cell cycle progression, apoptosis, cellular differentiation, and stem cell maintenance. Its dysregulation has been implicated in various human diseases, highlighting the need for further research into the molecular mechanisms underlying PTTG2's functions and its potential as a therapeutic target.

Genular Protein ID: 2855862672

Symbol: PTTG2_HUMAN

Name: Securin-2

UniProtKB Accession Codes:

Q9NZH5 O95355 Q6NTC9 Q9UNJ6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EPD 1 Ensembl 1 GO 5 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 1 SAM 1 SIGNOR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10084610

Title: An intronless homolog of human proto-oncogene hPTTG is expressed in pituitary tumors: evidence for hPTTG family.

PubMed ID: 10084610

DOI: 10.1210/jcem.84.3.5658

PubMed ID: 10806349

Title: Identification of the human pituitary tumor transforming gene (hPTTG) family: molecular structure, expression, and chromosomal localization.

PubMed ID: 10806349

DOI: 10.1016/s0378-1119(00)00096-2

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 202
  • Mass: 22302
  • Checksum: 3CBE738EC7817263
  • Sequence:
    • MATLIYVDKE IGEPGTRVAA KDVLKLESRP SIKALDGISQ VLTRRFGKTY DAPSALPKAT 
RKALGTVNRA TEKSVKTNGP RKQKQPSFSA KKMTEKTVKT KSSVPASDDA YPEIEKFFPF 
NLLDFESFDL PEERQIAHLP LSGVPLMILD EEGELEKLFQ LGPPSPVKMP SPPWECNLLQ 
SPSSILSTLD VELPAVCYDI DI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.