TRAF3IP2 | ENSG00000056972 | NCBI 10758

Details for: TRAF3IP2

Gene ID: 10758

Symbol: TRAF3IP2

Ensembl ID: ENSG00000056972

Description: TRAF3 interacting protein 2

Associated with

B cell affinity maturation
(GO:0002344)
B cell apoptotic process
(GO:0001783)
B cell homeostasis
(GO:0001782)
Cd40 signaling pathway
(GO:0023035)
Cellular_component
(GO:0005575)
Cytoplasmic vesicle
(GO:0031410)
Eosinophil homeostasis
(GO:1990959)
Eosinophil mediated immunity
(GO:0002447)
Establishment of t cell polarity
(GO:0001768)
Extrinsic component of cytoplasmic side of plasma membrane
(GO:0031234)
Heart development
(GO:0007507)
Humoral immune response
(GO:0006959)
Inflammatory response
(GO:0006954)
Interleukin-17-mediated signaling pathway
(GO:0097400)
Interleukin-17a-mediated signaling pathway
(GO:0038173)
Intracellular signal transduction
(GO:0035556)
Kidney development
(GO:0001822)
Leukocyte activation involved in inflammatory response
(GO:0002269)
Lymph node development
(GO:0048535)
Mrna stabilization
(GO:0048255)
Mucus secretion
(GO:0070254)
Neutrophil activation
(GO:0042119)
Nucleus
(GO:0005634)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of defense response to virus by host
(GO:0002230)
Protein binding
(GO:0005515)
Protein import into nucleus
(GO:0006606)
Protein k63-linked ubiquitination
(GO:0070534)
Protein localization to p-body
(GO:0110012)
Response to xenobiotic stimulus
(GO:0009410)
Signaling receptor binding
(GO:0005102)
Signal transduction involved in regulation of gene expression
(GO:0023019)
Skin development
(GO:0043588)
Spleen development
(GO:0048536)
T-helper 17 type immune response
(GO:0072538)
T cell differentiation
(GO:0030217)
Transitional two stage b cell differentiation
(GO:0002334)
Tumor necrosis factor-mediated signaling pathway
(GO:0033209)
Type 2 immune response
(GO:0042092)
Ubiquitin protein ligase activity
(GO:0061630)

Other Information

Proteins

Adapter protein CIKS

Genular Protein ID: 2743285562

Symbol: CIKS_HUMAN

Name: Adapter protein CIKS

UniProtKB Accession Codes:

O43734 B2RAY9 E1P555 Q5R3A3 Q7Z6Q1 Q7Z6Q2 Q7Z6Q3 Q9H5W2 Q9H6Y3 Q9NS14 Q9UG72

Database IDs:

Citations:

PubMed ID: 10903453

Title: Cloning and characterization of two overlapping genes in a subregion at 6q21 involved in replicative senescence and schizophrenia.

PubMed ID: 10903453

DOI: 10.1016/s0378-1119(00)00231-6

PubMed ID: 10962024

Title: Act1, an NF-kappa B-activating protein.

PubMed ID: 10962024

DOI: 10.1073/pnas.160265197

PubMed ID: 10962033

Title: CIKS, a connection to Ikappa B kinase and stress-activated protein kinase.

PubMed ID: 10962033

DOI: 10.1073/pnas.190245697

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12459498

Title: NF-kappaB activator Act1 associates with IL-1/Toll pathway adapter molecule TRAF6.

PubMed ID: 12459498

DOI: 10.1016/s0014-5793(02)03688-8

PubMed ID: 19825828

Title: Act1, a U-box E3 ubiquitin ligase for IL-17 signaling.

PubMed ID: 19825828

DOI: 10.1126/scisignal.2000382

PubMed ID: 33723527

Title: Title: ORF8 contributes to cytokine storm during SARS-CoV-2 infection by activating IL-17 pathway.

PubMed ID: 33723527

DOI: 10.1016/j.isci.2021.102293

PubMed ID: 20953186

Title: Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis.

PubMed ID: 20953186

DOI: 10.1038/ng.688

PubMed ID: 20953188

Title: Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2.

PubMed ID: 20953188

DOI: 10.1038/ng.689

PubMed ID: 24120361

Title: An ACT1 mutation selectively abolishes interleukin-17 responses in humans with chronic mucocutaneous candidiasis.

PubMed ID: 24120361

DOI: 10.1016/j.immuni.2013.09.002

Sequence Information:

Length: 574
Mass: 64666
Checksum: 4985795466D71422
Sequence:

MPPQLQETRM NRSIPVEVDE SEPYPSQLLK PIPEYSPEEE SEPPAPNIRN MAPNSLSAPT 
MLHNSSGDFS QAHSTLKLAN HQRPVSRQVT CLRTQVLEDS EDSFCRRHPG LGKAFPSGCS 
AVSEPASESV VGALPAEHQF SFMEKRNQWL VSQLSAASPD TGHDSDKSDQ SLPNASADSL 
GGSQEMVQRP QPHRNRAGLD LPTIDTGYDS QPQDVLGIRQ LERPLPLTSV CYPQDLPRPL 
RSREFPQFEP QRYPACAQML PPNLSPHAPW NYHYHCPGSP DHQVPYGHDY PRAAYQQVIQ 
PALPGQPLPG ASVRGLHPVQ KVILNYPSPW DHEERPAQRD CSFPGLPRHQ DQPHHQPPNR 
AGAPGESLEC PAELRPQVPQ PPSPAAVPRP PSNPPARGTL KTSNLPEELR KVFITYSMDT 
AMEVVKFVNF LLVNGFQTAI DIFEDRIRGI DIIKWMERYL RDKTVMIIVA ISPKYKQDVE 
GAESQLDEDE HGLHTKYIHR MMQIEFIKQG SMNFRFIPVL FPNAKKEHVP TWLQNTHVYS 
WPKNKKNILL RLLREEEYVA PPRGPLPTLQ VVPL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: TRAF3IP2

Associated with

Other Information

Cloning and characterization of two overlapping genes in a subregion at 6q21 involved in replicative senescence and schizophrenia. PubMed ID: 10903453

Act1, an NF-kappa B-activating protein. PubMed ID: 10962024

CIKS, a connection to Ikappa B kinase and stress-activated protein kinase. PubMed ID: 10962033

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

NF-kappaB activator Act1 associates with IL-1/Toll pathway adapter molecule TRAF6. PubMed ID: 12459498

Act1, a U-box E3 ubiquitin ligase for IL-17 signaling. PubMed ID: 19825828

Title: ORF8 contributes to cytokine storm during SARS-CoV-2 infection by activating IL-17 pathway. PubMed ID: 33723527

Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis. PubMed ID: 20953186

Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2. PubMed ID: 20953188

An ACT1 mutation selectively abolishes interleukin-17 responses in humans with chronic mucocutaneous candidiasis. PubMed ID: 24120361