Details for: KDM5B
Associated with
Other Information
Genular Protein ID: 4222444990
Symbol: KDM5B_HUMAN
Name: Lysine-specific demethylase 5B
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10336460
Title: A novel gene (PLU-1) containing highly conserved putative DNA/chromatin binding motifs is specifically up-regulated in breast cancer.
PubMed ID: 10336460
PubMed ID: 10616211
Title: Deficiency of a novel retinoblastoma binding protein 2-homolog is a consistent feature of sporadic human melanoma skin cancer.
PubMed ID: 10616211
PubMed ID: 10878660
Title: Isolation and chromosomal localization of a new human retinoblastoma binding protein 2 homologue 1a (RBBP2H1A).
PubMed ID: 10878660
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 12237901
Title: PLU-1 nuclear protein, which is upregulated in breast cancer, shows restricted expression in normal human adult tissues: a new cancer/testis antigen?
PubMed ID: 12237901
DOI: 10.1002/ijc.10644
PubMed ID: 12657635
Title: Human PLU-1 has transcriptional repression properties and interacts with the developmental transcription factors BF-1 and PAX9.
PubMed ID: 12657635
PubMed ID: 15803180
Title: Retinoblastoma-binding protein 2-homolog 1: a retinoblastoma-binding protein downregulated in malignant melanomas.
PubMed ID: 15803180
PubMed ID: 16645588
Title: Re-expression of the retinoblastoma-binding protein 2-homolog 1 reveals tumor-suppressive functions in highly metastatic melanoma cells.
PubMed ID: 16645588
PubMed ID: 17320161
Title: RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3.
PubMed ID: 17320161
PubMed ID: 17311883
Title: The Trithorax group protein Lid is a trimethyl histone H3K4 demethylase required for dMyc-induced cell growth.
PubMed ID: 17311883
DOI: 10.1101/gad.1523007
PubMed ID: 17373667
Title: Breast cancer associated transcriptional repressor PLU-1/JARID1B interacts directly with histone deacetylases.
PubMed ID: 17373667
DOI: 10.1002/ijc.22673
PubMed ID: 17363312
Title: PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation.
PubMed ID: 17363312
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 25218447
Title: Uncovering global SUMOylation signaling networks in a site-specific manner.
PubMed ID: 25218447
DOI: 10.1038/nsmb.2890
PubMed ID: 25755297
Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.
PubMed ID: 25755297
PubMed ID: 26645689
Title: Characterization of a Linked Jumonji Domain of the KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases.
PubMed ID: 26645689
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 29276005
Title: Histone lysine methylases and demethylases in the landscape of human developmental disorders.
PubMed ID: 29276005
PubMed ID: 30409806
Title: Quantifying the contribution of recessive coding variation to developmental disorders.
PubMed ID: 30409806
PubMed ID: 24952722
Title: The PHD1 finger of KDM5B recognizes unmodified H3K4 during the demethylation of histone H3K4me2/3 by KDM5B.
PubMed ID: 24952722
PubMed ID: 26741168
Title: 8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors.
PubMed ID: 26741168
PubMed ID: 27214403
Title: Structural analysis of human KDM5B guides histone demethylase inhibitor development.
PubMed ID: 27214403
PubMed ID: 28262558
Title: Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells.
PubMed ID: 28262558
Sequence Information:
- Length: 1544
- Mass: 175658
- Checksum: 70A0738D9A709F61
- Sequence:
MEAATTLHPG PRPALPLGGP GPLGEFLPPP ECPVFEPSWE EFADPFAFIH KIRPIAEQTG ICKVRPPPDW QPPFACDVDK LHFTPRIQRL NELEAQTRVK LNFLDQIAKY WELQGSTLKI PHVERKILDL FQLNKLVAEE GGFAVVCKDR KWTKIATKMG FAPGKAVGSH IRGHYERILN PYNLFLSGDS LRCLQKPNLT TDTKDKEYKP HDIPQRQSVQ PSETCPPARR AKRMRAEAMN IKIEPEETTE ARTHNLRRRM GCPTPKCENE KEMKSSIKQE PIERKDYIVE NEKEKPKSRS KKATNAVDLY VCLLCGSGND EDRLLLCDGC DDSYHTFCLI PPLHDVPKGD WRCPKCLAQE CSKPQEAFGF EQAARDYTLR TFGEMADAFK SDYFNMPVHM VPTELVEKEF WRLVSTIEED VTVEYGADIA SKEFGSGFPV RDGKIKLSPE EEEYLDSGWN LNNMPVMEQS VLAHITADIC GMKLPWLYVG MCFSSFCWHI EDHWSYSINY LHWGEPKTWY GVPGYAAEQL ENVMKKLAPE LFVSQPDLLH QLVTIMNPNT LMTHEVPVYR TNQCAGEFVI TFPRAYHSGF NQGFNFAEAV NFCTVDWLPL GRQCVEHYRL LHRYCVFSHD EMICKMASKA DVLDVVVAST VQKDMAIMIE DEKALRETVR KLGVIDSERM DFELLPDDER QCVKCKTTCF MSAISCSCKP GLLVCLHHVK ELCSCPPYKY KLRYRYTLDD LYPMMNALKL RAESYNEWAL NVNEALEAKI NKKKSLVSFK ALIEESEMKK FPDNDLLRHL RLVTQDAEKC ASVAQQLLNG KRQTRYRSGG GKSQNQLTVN ELRQFVTQLY ALPCVLSQTP LLKDLLNRVE DFQQHSQKLL SEETPSAAEL QDLLDVSFEF DVELPQLAEM RIRLEQARWL EEVQQACLDP SSLTLDDMRR LIDLGVGLAP YSAVEKAMAR LQELLTVSEH WDDKAKSLLK ARPRHSLNSL ATAVKEIEEI PAYLPNGAAL KDSVQRARDW LQDVEGLQAG GRVPVLDTLI ELVTRGRSIP VHLNSLPRLE TLVAEVQAWK ECAVNTFLTE NSPYSLLEVL CPRCDIGLLG LKRKQRKLKE PLPNGKKKST KLESLSDLER ALTESKETAS AMATLGEARL REMEALQSLR LANEGKLLSP LQDVDIKICL CQKAPAAPMI QCELCRDAFH TSCVAVPSIS QGLRIWLCPH CRRSEKPPLE KILPLLASLQ RIRVRLPEGD ALRYMIERTV NWQHRAQQLL SSGNLKFVQD RVGSGLLYSR WQASAGQVSD TNKVSQPPGT TSFSLPDDWD NRTSYLHSPF STGRSCIPLH GVSPEVNELL MEAQLLQVSL PEIQELYQTL LAKPSPAQQT DRSSPVRPSS EKNDCCRGKR DGINSLERKL KRRLEREGLS SERWERVKKM RTPKKKKIKL SHPKDMNNFK LERERSYELV RSAETHSLPS DTSYSEQEDS EDEDAICPAV SCLQPEGDEV DWVQCDGSCN QWFHQVCVGV SPEMAEKEDY ICVRCTVKDA PSRK
Genular Protein ID: 3939173459
Symbol: A0A3B3ITA8_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
PubMed ID: 25218447
Title: Uncovering global SUMOylation signaling networks in a site-specific manner.
PubMed ID: 25218447
PubMed ID: 25755297
Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.
PubMed ID: 25755297
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
Sequence Information:
- Length: 1499
- Mass: 170426
- Checksum: 921292E99B1C1C23
- Sequence:
MEAATTLHPG PRPALPLGGP GPLGEFLPPP ECPVFEPSWE EFADPFAFIH KIRPIAEQTG ICKVRPPPDW QPPFACDVDK LHFTPRIQRL NELEAQTRVK LNFLDQIAKY WELQGSTLKI PHVERKILDL FQLNKLVAEE GGFAVVCKDR KWTKIATKMG FAPGKAVGSH IRGHYERILN PYNLFLSGDS LRAMNIKIEP EETTEARTHN LRRRMGCPTP KCENEKEMKS SIKQEPIERK DYIVENEKEK PKSRSKKATN AVDLYVCLLC GSGNDEDRLL LCDGCDDSYH TFCLIPPLHD VPKGDWRCPK CLAQECSKPQ EAFGFEQAAR DYTLRTFGEM ADAFKSDYFN MPVHMVPTEL VEKEFWRLVS TIEEDVTVEY GADIASKEFG SGFPVRDGKI KLSPEEEEYL DSGWNLNNMP VMEQSVLAHI TADICGMKLP WLYVGMCFSS FCWHIEDHWS YSINYLHWGE PKTWYGVPGY AAEQLENVMK KLAPELFVSQ PDLLHQLVTI MNPNTLMTHE VPVYRTNQCA GEFVITFPRA YHSGFNQGFN FAEAVNFCTV DWLPLGRQCV EHYRLLHRYC VFSHDEMICK MASKADVLDV VVASTVQKDM AIMIEDEKAL RETVRKLGVI DSERMDFELL PDDERQCVKC KTTCFMSAIS CSCKPGLLVC LHHVKELCSC PPYKYKLRYR YTLDDLYPMM NALKLRAESY NEWALNVNEA LEAKINKKKS LVSFKALIEE SEMKKFPDND LLRHLRLVTQ DAEKCASVAQ QLLNGKRQTR YRSGGGKSQN QLTVNELRQF VTQLYALPCV LSQTPLLKDL LNRVEDFQQH SQKLLSEETP SAAELQDLLD VSFEFDVELP QLAEMRIRLE QARWLEEVQQ ACLDPSSLTL DDMRRLIDLG VGLAPYSAVE KAMARLQELL TVSEHWDDKA KSLLKARPRH SLNSLATAVK EIEEIPAYLP NGAALKDSVQ RARDWLQDVE GLQAGGRVPV LDTLIELVTR GRSIPVHLNS LPRLETLVAE VQAWKECAVN TFLTENSPYS LLEVLCPRCD IGLLGLKRKQ RKLKEPLPNG KKKSTKLESL SDLERALTES KETASAMATL GEARLREMEA LQSLRLANEG KLLSPLQDVD IKICLCQKAP AAPMIQCELC RDAFHTSCVA VPSISQGLRI WLCPHCRRSE KPPLEKILPL LASLQRIRVR LPEGDALRYM IERTVNWQHR AQQLLSSGNL KFVQDRVGSG LLYSRWQASA GQVSDTNKVS QPPGTTSFSL PDDWDNRTSY LHSPFSTGRS CIPLHGVSPE VNELLMEAQL LQVSLPEIQE LYQTLLAKPS PAQQTDRSSP VRPSSEKNDC CRGKRDGINS LERKLKRRLE REGLSSERWE RVKKMRTPKK KKIKLSHPKD MNNFKLERER SYELVRSAET HSLPSDTSYS EQEDSEDEDA ICPAVSCLQP EGDEVDWVQC DGSCNQWFHQ VCVGVSPEMA EKEDYICVRC TVKDAPSRK
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.