HBS1L | ENSG00000112339 | NCBI 10767

Details for: HBS1L

Gene ID: 10767

Symbol: HBS1L

Ensembl ID: ENSG00000112339

Description: HBS1 like translational GTPase

Associated with

Deadenylation-dependent mrna decay
(R-HSA-429914)
Metabolism of rna
(R-HSA-8953854)
Mrna decay by 3' to 5' exoribonuclease
(R-HSA-429958)
Cytosol
(GO:0005829)
Cytosolic ribosome
(GO:0022626)
Dom34-hbs1 complex
(GO:1990533)
Extracellular exosome
(GO:0070062)
Gtpase activity
(GO:0003924)
Gtp binding
(GO:0005525)
Membrane
(GO:0016020)
Nuclear-transcribed mrna catabolic process, no-go decay
(GO:0070966)
Protein binding
(GO:0005515)
Regulation of translation
(GO:0006417)
Rescue of stalled ribosome
(GO:0072344)
Ribosome disassembly
(GO:0032790)
Signal transduction
(GO:0007165)
Translation
(GO:0006412)
Translation elongation factor activity
(GO:0003746)

Other Information

Proteins

ERFS

Genular Protein ID: 3146902896

Symbol: HBS1L_HUMAN

Name: ERFS

UniProtKB Accession Codes:

Q9Y450 B7Z365 Q4VX89 Q4VX90 Q5T7G3 Q8NDW9 Q9UPW3

Database IDs:

Citations:

PubMed ID: 9872408

Title: The product of the mammalian orthologue of the Saccharomyces cerevisiae HBS1 gene is phylogenetically related to eukaryotic release factor 3 (eRF3) but does not carry eRF3-like activity.

PubMed ID: 9872408

DOI: 10.1016/s0014-5793(98)01492-6

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10470851

Title: Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10470851

DOI: 10.1093/dnares/6.3.197

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21448132

Title: Dissociation by Pelota, Hbs1 and ABCE1 of mammalian vacant 80S ribosomes and stalled elongation complexes.

PubMed ID: 21448132

DOI: 10.1038/emboj.2011.93

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 24288412

Title: Rare complete loss of function provides insight into a pleiotropic genome-wide association study locus.

PubMed ID: 24288412

DOI: 10.1182/blood-2013-09-528315

PubMed ID: 23667253

Title: The Hbs1-Dom34 protein complex functions in non-stop mRNA decay in mammalian cells.

PubMed ID: 23667253

DOI: 10.1074/jbc.m112.448977

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28204585

Title: A short splicing isoform of HBS1L links the cytoplasmic exosome and SKI complexes in humans.

PubMed ID: 28204585

DOI: 10.1093/nar/gkw862

PubMed ID: 32006463

Title: Extraction of mRNA from stalled ribosomes by the Ski complex.

PubMed ID: 32006463

DOI: 10.1016/j.molcel.2020.01.011

PubMed ID: 30707697

Title: Mammalian Hbs1L deficiency causes congenital anomalies and developmental delay associated with Pelota depletion and 80S monosome accumulation.

PubMed ID: 30707697

DOI: 10.1371/journal.pgen.1007917

PubMed ID: 27863242

Title: Decoding mammalian ribosome-mRNA states by translational GTPase complexes.

PubMed ID: 27863242

DOI: 10.1016/j.cell.2016.10.046

Sequence Information:

Length: 684
Mass: 75473
Checksum: D457ACA3941C4B4B
Sequence:

MARHRNVRGY NYDEDFEDDD LYGQSVEDDY CISPSTAAQF IYSRRDKPSV EPVEEYDYED 
LKESSNSVSN HQLSGFDQAR LYSCLDHMRE VLGDAVPDEI LIEAVLKNKF DVQKALSGVL 
EQDRVQSLKD KNEATVSTGK IAKGKPVDSQ TSRSESEIVP KVAKMTVSGK KQTMGFEVPG 
VSSEENGHSF HTPQKGPPIE DAIASSDVLE TASKSANPPH TIQASEEQSS TPAPVKKSGK 
LRQQIDVKAE LEKRQGGKQL LNLVVIGHVD AGKSTLMGHM LYLLGNINKR TMHKYEQESK 
KAGKASFAYA WVLDETGEER ERGVTMDVGM TKFETTTKVI TLMDAPGHKD FIPNMITGAA 
QADVAVLVVD ASRGEFEAGF ETGGQTREHG LLVRSLGVTQ LAVAVNKMDQ VNWQQERFQE 
ITGKLGHFLK QAGFKESDVG FIPTSGLSGE NLITRSQSSE LTKWYKGLCL LEQIDSFKPP 
QRSIDKPFRL CVSDVFKDQG SGFCITGKIE AGYIQTGDRL LAMPPNETCT VKGITLHDEP 
VDWAAAGDHV SLTLVGMDII KINVGCIFCG PKVPIKACTR FRARILIFNI EIPITKGFPV 
LLHYQTVSEP AVIKRLISVL NKSTGEVTKK KPKFLTKGQN ALVELQTQRP IALELYKDFK 
ELGRFMLRYG GSTIAAGVVT EIKE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: HBS1L

Associated with

Other Information

The product of the mammalian orthologue of the Saccharomyces cerevisiae HBS1 gene is phylogenetically related to eukaryotic release factor 3 (eRF3) but does not carry eRF3-like activity. PubMed ID: 9872408

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. PubMed ID: 10470851

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

Dissociation by Pelota, Hbs1 and ABCE1 of mammalian vacant 80S ribosomes and stalled elongation complexes. PubMed ID: 21448132

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Rare complete loss of function provides insight into a pleiotropic genome-wide association study locus. PubMed ID: 24288412

The Hbs1-Dom34 protein complex functions in non-stop mRNA decay in mammalian cells. PubMed ID: 23667253

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

A short splicing isoform of HBS1L links the cytoplasmic exosome and SKI complexes in humans. PubMed ID: 28204585

Extraction of mRNA from stalled ribosomes by the Ski complex. PubMed ID: 32006463

Mammalian Hbs1L deficiency causes congenital anomalies and developmental delay associated with Pelota depletion and 80S monosome accumulation. PubMed ID: 30707697

Decoding mammalian ribosome-mRNA states by translational GTPase complexes. PubMed ID: 27863242