AHCYL1 | ENSG00000168710 | NCBI 10768

Details for: AHCYL1

Gene ID: 10768

Symbol: AHCYL1

Ensembl ID: ENSG00000168710

Description: adenosylhomocysteinase like 1

Associated with

Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
C-type lectin receptors (clrs)
(R-HSA-5621481)
Cardiac conduction
(R-HSA-5576891)
Clec7a (dectin-1) induces nfat activation
(R-HSA-5607763)
Clec7a (dectin-1) signaling
(R-HSA-5607764)
Dag and ip3 signaling
(R-HSA-1489509)
Disease
(R-HSA-1643685)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
G-protein mediated events
(R-HSA-112040)
G alpha (i) signalling events
(R-HSA-418594)
Gpcr downstream signalling
(R-HSA-388396)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Integration of energy metabolism
(R-HSA-163685)
Intracellular signaling by second messengers
(R-HSA-9006925)
Ion homeostasis
(R-HSA-5578775)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Metabolism
(R-HSA-1430728)
Muscle contraction
(R-HSA-397014)
Opioid signalling
(R-HSA-111885)
Parasitic infection pathways
(R-HSA-9824443)
Plc beta mediated events
(R-HSA-112043)
Regulation of insulin secretion
(R-HSA-422356)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Signaling by gpcr
(R-HSA-372790)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Signaling by vegf
(R-HSA-194138)
Signal transduction
(R-HSA-162582)
Vegfa-vegfr2 pathway
(R-HSA-4420097)
Vegfr2 mediated cell proliferation
(R-HSA-5218921)
Adenosylhomocysteinase activity
(GO:0004013)
Angiotensin-activated signaling pathway
(GO:0038166)
Apical plasma membrane
(GO:0016324)
Apoptotic process
(GO:0006915)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Endoplasmic reticulum membrane
(GO:0005789)
Enzyme regulator activity
(GO:0030234)
Epithelial fluid transport
(GO:0042045)
Extracellular exosome
(GO:0070062)
Identical protein binding
(GO:0042802)
Mitochondria-associated endoplasmic reticulum membrane
(GO:0044233)
Mitochondrion-endoplasmic reticulum membrane tethering
(GO:1990456)
One-carbon metabolic process
(GO:0006730)
Positive regulation of sodium ion transport
(GO:0010765)
Protein binding
(GO:0005515)
Protein export from nucleus
(GO:0006611)
Regulation of monoatomic anion transport
(GO:0044070)
Regulation of monoatomic ion transmembrane transporter activity
(GO:0032412)
Regulation of mrna 3'-end processing
(GO:0031440)
Response to calcium ion
(GO:0051592)
Rna binding
(GO:0003723)
S-adenosylmethionine cycle
(GO:0033353)

Other Information

Proteins

DC-expressed AHCY-like molecule

Genular Protein ID: 3978817088

Symbol: SAHH2_HUMAN

Name: DC-expressed AHCY-like molecule

UniProtKB Accession Codes:

O43865 B4E168 Q2TAJ6 Q502W8 Q5VSM0 Q6P171 Q96PK4 Q9UG84

Database IDs:

Citations:

PubMed ID: 11904675

Title: Identification of an S-adenosylhomocysteine hydrolase-like transcript induced during dendritic cell differentiation.

PubMed ID: 11904675

DOI: 10.1007/s00251-001-0402-z

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12878157

Title: Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis.

PubMed ID: 12878157

DOI: 10.1016/s0014-4827(03)00130-7

PubMed ID: 7782076

Title: Characterization of a large population of mRNAs from human testis.

PubMed ID: 7782076

DOI: 10.1016/0888-7543(95)80096-5

PubMed ID: 16754674

Title: Suppression and overexpression of adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) influences zebrafish embryo development: a possible role for AHCYL1 in inositol phospholipid signaling.

PubMed ID: 16754674

DOI: 10.1074/jbc.m602520200

PubMed ID: 16793548

Title: IRBIT suppresses IP3 receptor activity by competing with IP3 for the common binding site on the IP3 receptor.

PubMed ID: 16793548

DOI: 10.1016/j.molcel.2006.05.017

PubMed ID: 16769890

Title: IRBIT, an inositol 1,4,5-trisphosphate receptor-binding protein, specifically binds to and activates pancreas-type Na+/HCO3-cotransporter 1 (pNBC1).

PubMed ID: 16769890

DOI: 10.1073/pnas.0602250103

PubMed ID: 18829453

Title: IRBIT, inositol 1,4,5-triphosphate (IP3) receptor-binding protein released with IP3, binds Na+/H+ exchanger NHE3 and activates NHE3 activity in response to calcium.

PubMed ID: 18829453

DOI: 10.1074/jbc.m805534200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19224921

Title: Inositol 1,4,5-triphosphate receptor-binding protein released with inositol 1,4,5-triphosphate (IRBIT) associates with components of the mRNA 3' processing machinery in a phosphorylation-dependent manner and inhibits polyadenylation.

PubMed ID: 19224921

DOI: 10.1074/jbc.m807136200

PubMed ID: 19220705

Title: An IRBIT homologue lacks binding activity to inositol 1,4,5-trisphosphate receptor due to the unique N-terminal appendage.

PubMed ID: 19220705

DOI: 10.1111/j.1471-4159.2009.05979.x

PubMed ID: 20584908

Title: Activation of Na+/H+ exchanger NHE3 by angiotensin II is mediated by inositol 1,4,5-triphosphate (IP3) receptor-binding protein released with IP3 (IRBIT) and Ca2+/calmodulin-dependent protein kinase II.

PubMed ID: 20584908

DOI: 10.1074/jbc.m110.133066

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 27995898

Title: IRBIT controls apoptosis by interacting with the Bcl-2 homolog, Bcl2l10, and by promoting ER-mitochondria contact.

PubMed ID: 27995898

DOI: 10.7554/elife.19896

PubMed ID: 31799605

Title: The human methyltransferase ZCCHC4 catalyses N6-methyladenosine modification of 28S ribosomal RNA.

PubMed ID: 31799605

DOI: 10.1093/nar/gkz1147

PubMed ID: 28647132

Title: Mutations in S-adenosylhomocysteine hydrolase (AHCY) affect its nucleocytoplasmic distribution and capability to interact with S-adenosylhomocysteine hydrolase-like 1 protein.

PubMed ID: 28647132

DOI: 10.1016/j.ejcb.2017.05.002

PubMed ID: 25237103

Title: Enzyme regulation. IRBIT is a novel regulator of ribonucleotide reductase in higher eukaryotes.

PubMed ID: 25237103

DOI: 10.1126/science.1251550

Sequence Information:

Length: 530
Mass: 58951
Checksum: 974D23361A245D04
Sequence:

MSMPDAMPLP GVGEELKQAK EIEDAEKYSF MATVTKAPKK QIQFADDMQE FTKFPTKTGR 
RSLSRSISQS STDSYSSAAS YTDSSDDEVS PREKQQTNSK GSSNFCVKNI KQAEFGRREI 
EIAEQDMSAL ISLRKRAQGE KPLAGAKIVG CTHITAQTAV LIETLCALGA QCRWSACNIY 
STQNEVAAAL AEAGVAVFAW KGESEDDFWW CIDRCVNMDG WQANMILDDG GDLTHWVYKK 
YPNVFKKIRG IVEESVTGVH RLYQLSKAGK LCVPAMNVND SVTKQKFDNL YCCRESILDG 
LKRTTDVMFG GKQVVVCGYG EVGKGCCAAL KALGAIVYIT EIDPICALQA CMDGFRVVKL 
NEVIRQVDVV ITCTGNKNVV TREHLDRMKN SCIVCNMGHS NTEIDVTSLR TPELTWERVR 
SQVDHVIWPD GKRVVLLAEG RLLNLSCSTV PTFVLSITAT TQALALIELY NAPEGRYKQD 
VYLLPKKMDE YVASLHLPSF DAHLTELTDD QAKYLGLNKN GPFKPNYYRY

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: AHCYL1

Associated with

Other Information

Identification of an S-adenosylhomocysteine hydrolase-like transcript induced during dendritic cell differentiation. PubMed ID: 11904675

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis. PubMed ID: 12878157

Characterization of a large population of mRNAs from human testis. PubMed ID: 7782076

Suppression and overexpression of adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) influences zebrafish embryo development: a possible role for AHCYL1 in inositol phospholipid signaling. PubMed ID: 16754674

IRBIT suppresses IP3 receptor activity by competing with IP3 for the common binding site on the IP3 receptor. PubMed ID: 16793548

IRBIT, an inositol 1,4,5-trisphosphate receptor-binding protein, specifically binds to and activates pancreas-type Na+/HCO3-cotransporter 1 (pNBC1). PubMed ID: 16769890

IRBIT, inositol 1,4,5-triphosphate (IP3) receptor-binding protein released with IP3, binds Na+/H+ exchanger NHE3 and activates NHE3 activity in response to calcium. PubMed ID: 18829453

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Inositol 1,4,5-triphosphate receptor-binding protein released with inositol 1,4,5-triphosphate (IRBIT) associates with components of the mRNA 3' processing machinery in a phosphorylation-dependent manner and inhibits polyadenylation. PubMed ID: 19224921

An IRBIT homologue lacks binding activity to inositol 1,4,5-trisphosphate receptor due to the unique N-terminal appendage. PubMed ID: 19220705

Activation of Na+/H+ exchanger NHE3 by angiotensin II is mediated by inositol 1,4,5-triphosphate (IP3) receptor-binding protein released with IP3 (IRBIT) and Ca2+/calmodulin-dependent protein kinase II. PubMed ID: 20584908

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

IRBIT controls apoptosis by interacting with the Bcl-2 homolog, Bcl2l10, and by promoting ER-mitochondria contact. PubMed ID: 27995898

The human methyltransferase ZCCHC4 catalyses N6-methyladenosine modification of 28S ribosomal RNA. PubMed ID: 31799605

Mutations in S-adenosylhomocysteine hydrolase (AHCY) affect its nucleocytoplasmic distribution and capability to interact with S-adenosylhomocysteine hydrolase-like 1 protein. PubMed ID: 28647132

Enzyme regulation. IRBIT is a novel regulator of ribonucleotide reductase in higher eukaryotes. PubMed ID: 25237103