Details for: PLK2

Gene ID: 10769

Symbol: PLK2

Ensembl ID: ENSG00000145632

Description: polo like kinase 2

Associated with

Other Information

Genular Protein ID: 738984227

Symbol: PLK2_HUMAN

Name: Serine/threonine-protein kinase PLK2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11696980

Title: Identification of the human homologue of the early-growth response gene Snk, encoding a serum-inducible kinase.

PubMed ID: 11696980

DOI: 10.3109/10425170109041337

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11716500

Title: Radiation-inducible hSNK gene is transcriptionally regulated by p53 binding homology element in human thyroid cells.

PubMed ID: 11716500

DOI: 10.1006/bbrc.2001.5993

PubMed ID: 15242618

Title: Polo-like kinase-2 is required for centriole duplication in mammalian cells.

PubMed ID: 15242618

DOI: 10.1016/j.cub.2004.06.059

PubMed ID: 16160013

Title: Transcriptional silencing of Polo-like kinase 2 (SNK/PLK2) is a frequent event in B-cell malignancies.

PubMed ID: 16160013

DOI: 10.1182/blood-2005-03-1194

PubMed ID: 19001868

Title: Plk2 regulated centriole duplication is dependent on its localization to the centrioles and a functional polo-box domain.

PubMed ID: 19001868

DOI: 10.4161/cc.7.22.7071

PubMed ID: 18832181

Title: Distinct microRNA expression profiles in acute myeloid leukemia with common translocations.

PubMed ID: 18832181

DOI: 10.1073/pnas.0808266105

PubMed ID: 20531387

Title: PLK2 phosphorylation is critical for CPAP function in procentriole formation during the centrosome cycle.

PubMed ID: 20531387

DOI: 10.1038/emboj.2010.118

PubMed ID: 20352051

Title: Polo-like kinase 2-dependent phosphorylation of NPM/B23 on serine 4 triggers centriole duplication.

PubMed ID: 20352051

DOI: 10.1371/journal.pone.0009849

PubMed ID: 21340720

Title: Polo-like kinase 2 (SNK/PLK2) is a novel epigenetically regulated gene in acute myeloid leukemia and myelodysplastic syndromes: genetic and epigenetic interactions.

PubMed ID: 21340720

DOI: 10.1007/s00277-011-1193-4

PubMed ID: 20671765

Title: Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy.

PubMed ID: 20671765

DOI: 10.1038/nrd3184

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 685
  • Mass: 78237
  • Checksum: 6429F6EFD830B333
  • Sequence:
  • MELLRTITYQ PAASTKMCEQ ALGKGCGADS KKKRPPQPPE ESQPPQSQAQ VPPAAPHHHH 
    HHSHSGPEIS RIIVDPTTGK RYCRGKVLGK GGFAKCYEMT DLTNNKVYAA KIIPHSRVAK 
    PHQREKIDKE IELHRILHHK HVVQFYHYFE DKENIYILLE YCSRRSMAHI LKARKVLTEP 
    EVRYYLRQIV SGLKYLHEQE ILHRDLKLGN FFINEAMELK VGDFGLAARL EPLEHRRRTI 
    CGTPNYLSPE VLNKQGHGCE SDIWALGCVM YTMLLGRPPF ETTNLKETYR CIREARYTMP 
    SSLLAPAKHL IASMLSKNPE DRPSLDDIIR HDFFLQGFTP DRLSSSCCHT VPDFHLSSPA 
    KNFFKKAAAA LFGGKKDKAR YIDTHNRVSK EDEDIYKLRH DLKKTSITQQ PSKHRTDEEL 
    QPPTTTVARS GTPAVENKQQ IGDAIRMIVR GTLGSCSSSS ECLEDSTMGS VADTVARVLR 
    GCLENMPEAD CIPKEQLSTS FQWVTKWVDY SNKYGFGYQL SDHTVGVLFN NGAHMSLLPD 
    KKTVHYYAEL GQCSVFPATD APEQFISQVT VLKYFSHYME ENLMDGGDLP SVTDIRRPRL 
    YLLQWLKSDK ALMMLFNDGT FQVNFYHDHT KIIICSQNEE YLLTYINEDR ISTTFRLTTL 
    LMSGCSSELK NRMEYALNML LQRCN

Genular Protein ID: 3656486340

Symbol: A0A087WUH9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

Sequence Information:

  • Length: 671
  • Mass: 76651
  • Checksum: 0472EA69A9A626E7
  • Sequence:
  • MELLRTITYQ PAASTKMCEQ ALGKGCGADS KKKRPPQPPE ESQPPQSQAQ VPPAISRIIV 
    DPTTGKRYCR GKVLGKGGFA KCYEMTDLTN NKVYAAKIIP HSRVAKPHQR EKIDKEIELH 
    RILHHKHVVQ FYHYFEDKEN IYILLEYCSR RSMAHILKAR KVLTEPEVRY YLRQIVSGLK 
    YLHEQEILHR DLKLGNFFIN EAMELKVGDF GLAARLEPLE HRRRTICGTP NYLSPEVLNK 
    QGHGCESDIW ALGCVMYTML LGRPPFETTN LKETYRCIRE ARYTMPSSLL APAKHLIASM 
    LSKNPEDRPS LDDIIRHDFF LQGFTPDRLS SSCCHTVPDF HLSSPAKNFF KKAAAALFGG 
    KKDKARYIDT HNRVSKEDED IYKLRHDLKK TSITQQPSKH RTDEELQPPT TTVARSGTPA 
    VENKQQIGDA IRMIVRGTLG SCSSSSECLE DSTMGSVADT VARVLRGCLE NMPEADCIPK 
    EQLSTSFQWV TKWVDYSNKY GFGYQLSDHT VGVLFNNGAH MSLLPDKKTV HYYAELGQCS 
    VFPATDAPEQ FISQVTVLKY FSHYMEENLM DGGDLPSVTD IRRPRLYLLQ WLKSDKALMM 
    LFNDGTFQVN FYHDHTKIII CSQNEEYLLT YINEDRISTT FRLTTLLMSG CSSELKNRME 
    YALNMLLQRC N

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.