Details for: ZMYND11

Gene ID: 10771

Symbol: ZMYND11

Ensembl ID: ENSG00000015171

Description: zinc finger MYND-type containing 11

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.19
    Marker Score: 83,182
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.17
    Marker Score: 32,501
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.16
    Marker Score: 42,867
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.14
    Marker Score: 16,378
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.12
    Marker Score: 9,811
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.09
    Marker Score: 44,617
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.04
    Marker Score: 2,468
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.03
    Marker Score: 8,436
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.02
    Marker Score: 74,637
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.98
    Marker Score: 1,185
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.93
    Marker Score: 7,480
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.92
    Marker Score: 8,029
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.89
    Marker Score: 116,465
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.89
    Marker Score: 17,799
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.88
    Marker Score: 550
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.87
    Marker Score: 2,156
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.8
    Marker Score: 1,386
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.79
    Marker Score: 60,544
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.78
    Marker Score: 16,951
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.77
    Marker Score: 2,384
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.73
    Marker Score: 14,895
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.72
    Marker Score: 855
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.72
    Marker Score: 3,774
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.71
    Marker Score: 1,000
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.7
    Marker Score: 2,115
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.67
    Marker Score: 878
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.63
    Marker Score: 1,555
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.61
    Marker Score: 3,104
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.59
    Marker Score: 1,374
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.56
    Marker Score: 911
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.51
    Marker Score: 13,261
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.51
    Marker Score: 744
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.5
    Marker Score: 2,322
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.47
    Marker Score: 3,345
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.46
    Marker Score: 6,099
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.45
    Marker Score: 4,124
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.39
    Marker Score: 1,531
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.38
    Marker Score: 1,486
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.37
    Marker Score: 3,268
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.35
    Marker Score: 3,417
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.35
    Marker Score: 30,198
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.32
    Marker Score: 553
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.32
    Marker Score: 3,536
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.26
    Marker Score: 1,347
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.26
    Marker Score: 1,852
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.24
    Marker Score: 692
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.24
    Marker Score: 1,306
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.23
    Marker Score: 689
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.23
    Marker Score: 418
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.23
    Marker Score: 446
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.22
    Marker Score: 683
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.22
    Marker Score: 386
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.22
    Marker Score: 844
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.21
    Marker Score: 1,288
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.21
    Marker Score: 2,038
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.2
    Marker Score: 1,250
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.2
    Marker Score: 1,451
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.16
    Marker Score: 1,179
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.14
    Marker Score: 426
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 1.13
    Marker Score: 6,089
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.13
    Marker Score: 2,380
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.13
    Marker Score: 583
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.12
    Marker Score: 583
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.12
    Marker Score: 989
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.11
    Marker Score: 412
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.11
    Marker Score: 1,839
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.11
    Marker Score: 282
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.11
    Marker Score: 3,713
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.1
    Marker Score: 3,920
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.1
    Marker Score: 1,182
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.1
    Marker Score: 1,553
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.1
    Marker Score: 346
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.09
    Marker Score: 635
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.09
    Marker Score: 418
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.07
    Marker Score: 36,531
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.07
    Marker Score: 308
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.07
    Marker Score: 292
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.07
    Marker Score: 16,719
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.07
    Marker Score: 905
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.07
    Marker Score: 18,911
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.06
    Marker Score: 244
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.06
    Marker Score: 4,302
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.05
    Marker Score: 3,902
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.05
    Marker Score: 508
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.05
    Marker Score: 510
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.05
    Marker Score: 738
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.03
    Marker Score: 1,152
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.02
    Marker Score: 771
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1
    Marker Score: 289
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1
    Marker Score: 11,269
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.99
    Marker Score: 374
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.99
    Marker Score: 1,390
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.99
    Marker Score: 2,424
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.98
    Marker Score: 372
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,382
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.96
    Marker Score: 359
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.96
    Marker Score: 5,040
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.95
    Marker Score: 679
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.95
    Marker Score: 6,126
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.95
    Marker Score: 1,075

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ZMYND11 is a 12-exon gene that encodes a protein with a MYND-type zinc finger domain, a characteristic motif involved in protein-protein interactions and DNA binding. The gene is highly expressed in GABAergic interneurons, astrocytes, and endothelial cells, where it may play a pivotal role in regulating neuronal activity, synaptic plasticity, and tissue maintenance. ZMYND11 has been implicated in negative regulation of various signaling pathways, including: 1. **Negative regulation of NF-κB signaling**: ZMYND11 acts as a transcriptional corepressor, inhibiting NF-κB-mediated gene expression and thereby modulating immune responses. 2. **Negative regulation of JNK cascade**: ZMYND11 blocks the activation of JNK, a key stress-activated MAP kinase, thereby mitigating cellular stress and promoting homeostasis. 3. **Negative regulation of transcription elongation by RNA polymerase II**: ZMYND11 regulates the activity of RNA polymerase II, a crucial enzyme involved in gene expression, thereby controlling the tempo of transcription. **Pathways and Functions:** The ZMYND11 gene is involved in several key cellular processes, including: 1. **Cell cycle regulation**: ZMYND11 may modulate cell cycle progression by regulating the activity of cyclin-dependent kinases and other cell cycle regulators. 2. **Chromatin organization**: ZMYND11 interacts with chromatin-modifying enzymes, influencing chromatin structure and accessibility to transcriptional regulators. 3. **Defense response to virus**: ZMYND11 may play a role in antiviral defense by regulating the expression of antiviral genes and modulating immune responses. 4. **Double-stranded DNA binding**: ZMYND11 binds to double-stranded DNA, potentially regulating DNA repair and replication processes. **Clinical Significance:** The clinical significance of ZMYND11 dysregulation remains to be fully elucidated. However, its involvement in neurological disorders and immune-mediated diseases suggests potential therapeutic applications: 1. **Neurological disorders**: ZMYND11 dysregulation may contribute to the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 2. **Immune-mediated diseases**: ZMYND11 dysregulation may contribute to the development of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 3. **Cancer**: ZMYND11 may act as a tumor suppressor, regulating cell proliferation and apoptosis in cancer cells. In conclusion, ZMYND11 is a complex gene with multiple roles in regulating cellular processes, including cell cycle, chromatin organization, and immune responses. Further research is needed to fully elucidate the clinical significance of ZMYND11 dysregulation and to explore its potential therapeutic applications.

Genular Protein ID: 3166598099

Symbol: ZMY11_HUMAN

Name: Adenovirus 5 E1A-binding protein

UniProtKB Accession Codes:

Q15326 B2R6G8 B7Z293 F6UH50 Q2LD45 Q2LD46 Q2LD47 Q2LD48 Q5VUI1 Q8N4B3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 6 CDD 3 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 15 EPD 1 Ensembl 10 ExpressionAtlas 1 GO 16 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 2 PIR 1 PRO 1 PROSITE 7 PROSITE-ProRule 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 RefSeq 16 SAM 1 SASBDB 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7621829

Title: BS69, a novel adenovirus E1A-associated protein that inhibits E1A transactivation.

PubMed ID: 7621829

DOI: 10.1002/j.1460-2075.1995.tb07318.x

PubMed ID: 16565076

Title: New insights into BS69 functions.

PubMed ID: 16565076

DOI: 10.1074/jbc.m600573200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10734313

Title: The adenovirus E1A binding protein BS69 is a corepressor of transcription through recruitment of N-CoR.

PubMed ID: 10734313

DOI: 10.1038/sj.onc.1203421

PubMed ID: 11733528

Title: The conserved Mynd domain of BS69 binds cellular and oncoviral proteins through a common PXLXP motif.

PubMed ID: 11733528

DOI: 10.1074/jbc.m110078200

PubMed ID: 12181323

Title: Negative regulation of Epstein-Barr virus latent membrane protein 1-mediated functions by the bone morphogenetic protein receptor IA-binding protein, BRAM1.

PubMed ID: 12181323

DOI: 10.1074/jbc.m206736200

PubMed ID: 15947784

Title: Binding of EMSY to HP1beta: implications for recruitment of HP1beta and BS69.

PubMed ID: 15947784

DOI: 10.1038/sj.embor.7400415

PubMed ID: 16382137

Title: BS69, a specific adaptor in the latent membrane protein 1-mediated c-Jun N-terminal kinase pathway.

PubMed ID: 16382137

DOI: 10.1128/mcb.26.2.448-456.2006

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19379743

Title: BS69 negatively regulates the canonical NF-kappaB activation induced by Epstein-Barr virus-derived LMP1.

PubMed ID: 19379743

DOI: 10.1016/j.febslet.2009.04.022

PubMed ID: 19766626

Title: BS69 undergoes SUMO modification and plays an inhibitory role in muscle and neuronal differentiation.

PubMed ID: 19766626

DOI: 10.1016/j.yexcr.2009.09.011

PubMed ID: 20138174

Title: BS69 cooperates with TRAF3 in the regulation of Epstein-Barr virus-derived LMP1/CTAR1-induced NF-kappaB activation.

PubMed ID: 20138174

DOI: 10.1016/j.febslet.2010.01.060

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23915195

Title: Recurrent translocation (10;17)(p15;q21) in acute poorly differentiated myeloid leukemia likely results in ZMYND11-MBTD1 fusion.

PubMed ID: 23915195

DOI: 10.3109/10428194.2013.820292

PubMed ID: 23372760

Title: Structural and functional analysis of the DEAF-1 and BS69 MYND domains.

PubMed ID: 23372760

DOI: 10.1371/journal.pone.0054715

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 24590075

Title: ZMYND11 links histone H3.3K36me3 to transcription elongation and tumour suppression.

PubMed ID: 24590075

DOI: 10.1038/nature13045

PubMed ID: 25217958

Title: Refining analyses of copy number variation identifies specific genes associated with developmental delay.

PubMed ID: 25217958

DOI: 10.1038/ng.3092

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25593309

Title: Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.

PubMed ID: 25593309

DOI: 10.1101/gad.252189.114

PubMed ID: 26655721

Title: Selective Recognition of H3.1K36 Dimethylation/H4K16 Acetylation Facilitates the Regulation of All-trans-retinoic Acid (ATRA)-responsive Genes by Putative Chromatin Reader ZMYND8.

PubMed ID: 26655721

DOI: 10.1074/jbc.m115.679985

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 24675531

Title: Crystal structure of human BS69 Bromo-ZnF-PWWP reveals its role in H3K36me3 nucleosome binding.

PubMed ID: 24675531

DOI: 10.1038/cr.2014.38

PubMed ID: 26845565

Title: BS69/ZMYND11 C-Terminal Domains Bind and Inhibit EBNA2.

PubMed ID: 26845565

DOI: 10.1371/journal.ppat.1005414

Sequence Information:

  • Length: 602
  • Mass: 70963
  • Checksum: 3AD525B90574BDE8
  • Sequence:
    • MARLTKRRQA DTKAIQHLWA AIEIIRNQKQ IANIDRITKY MSRVHGMHPK ETTRQLSLAV 
KDGLIVETLT VGCKGSKAGI EQEGYWLPGD EIDWETENHD WYCFECHLPG EVLICDLCFR 
VYHSKCLSDE FRLRDSSSPW QCPVCRSIKK KNTNKQEMGT YLRFIVSRMK ERAIDLNKKG 
KDNKHPMYRR LVHSAVDVPT IQEKVNEGKY RSYEEFKADA QLLLHNTVIF YGADSEQADI 
ARMLYKDTCH ELDELQLCKN CFYLSNARPD NWFCYPCIPN HELVWAKMKG FGFWPAKVMQ 
KEDNQVDVRF FGHHHQRAWI PSENIQDITV NIHRLHVKRS MGWKKACDEL ELHQRFLREG 
RFWKSKNEDR GEEEAESSIS STSNEQLKVT QEPRAKKGRR NQSVEPKKEE PEPETEAVSS 
SQEIPTMPQP IEKVSVSTQT KKLSASSPRM LHRSTQTTND GVCQSMCHDK YTKIFNDFKD 
RMKSDHKRET ERVVREALEK LRSEMEEEKR QAVNKAVANM QGEMDRKCKQ VKEKCKEEFV 
EEIKKLATQH KQLISQTKKK QWCYNCEEEA MYHCCWNTSY CSIKCQQEHW HAEHKRTCRR 
KR

Genular Protein ID: 3315347921

Symbol: Q5BJG6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5BJG6

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 3 Gene3D 3 Genevisible 1 GenomeRNAi 1 IntAct 1 InterPro 6 KEGG 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 7 PROSITE-ProRule 2 PeptideAtlas 1 Pfam 2 PharmGKB 1 ProteomicsDB 1 RefSeq 4 SAM 2 SMART 2 SMR 1 SUPFAM 3

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 508
  • Mass: 59666
  • Checksum: 0038F7B3D96C7181
  • Sequence:
    • MSRVHGMHPK ETTRQLSLAV KDGLIVETLT VGCKGSKAGI EQEGYWLPGD EISIKKKNTN 
KQEMGTYLRF IVSRMKERAI DLNKKGKDNK HPMYRRLVHS AVDVPTIQEK VNEGKYRSYE 
EFKADAQLLL HNTVIFYGAD SEQADIARML YKDTCHELDE LQLCKNCFYL SNARPDNWFC 
YPCIPNHELV WAKMKGFGFW PAKVMQKEDN QVDVRFFGHH HQRAWIPSEN IQDITVNIHR 
LHVKRSMGWK KACDELELHQ RFLREGRFWK SKNEDRGEEE AESSISSTSN EQLKVTQEPR 
AKKGRRNQSV EPKKEEPEPE TEAVSSSQEI PTMPQPIEKV SVSTQTKKLS ASSPRMLHRS 
TQTTNDGVCQ SMCHDKYTKI FNDFKDRMKS DHKRETERVV REALEKLRSE MEEEKRQAVN 
KAVANMQGEM DRKCKQVKEK CKEEFVEEIK KLATQHKQLI SQTKKKQWCY NCEEEAMYHC 
CWNTSYCSIK CQQEHWHAEH KRTCRRKR

Genular Protein ID: 927019519

Symbol: B7Z2J6_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z2J6

Database IDs:

ARBA 4 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 ExpressionAtlas 1 GO 2 Gene3D 3 GenomeRNAi 1 InterPro 7 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 Pfam 3 RefSeq 1 SMART 2 SMR 1 SUPFAM 3 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 547
  • Mass: 64354
  • Checksum: F77F84EAEC9A7209
  • Sequence:
    • MARLTKRRQA DTKAIQHLWA AIEIIRNQKQ IANIDRITKY MSRVHGMHPK ETTRQLSLAV 
KDGLIVETLT VGCKGSKAGI EQEGYWLPGD EISIKKKNTN KQEMGTYLRF IVSRMKERAI 
DLNKKGKDNK HPMYRRLVHS AVDVPTIQEK VNEGKYRSYE EFKADAQLLL HNTVIFYGDS 
EQADIARMLY KDTCHELDEL QLCKNCFYLS NARPDNWFCY PCIPNHELVW AKMKGFGFWP 
AKVMQKEDNQ VDVRFFGHHH QRAWIPSENI QDITVNIHRL HVKRSMGWKK ACDELELHQR 
FLREGRFWKS KNEDRGEEEA ESSISSTSNE QLKVTQEPRA KKGRRNQSVE PKKEEPEPET 
EAVSSSQEIP TMPQPIEKVS VSTQTKKLSA SSPRMLHRST QTTNDGVCQS MCHDKYTKIF 
NDFKDRMKSD HKRETERVVR EALEKLRSEM EEEKRQAVNK AVANMQGEMD RKCKQVKEKC 
KEEFVEEIKK LATQHKQLIS QTKKKQWCYN CEEEAMYHCC WNTSYCSIKC QQEHWHAEHK 
RTCRRKR

Genular Protein ID: 98953

Symbol: Q5UGI2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5UGI2

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 3 Gene3D 3 Genevisible 1 GenomeRNAi 1 InterPro 6 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 7 PROSITE-ProRule 2 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 4 SAM 2 SMART 2 SUPFAM 3

Sequence Information:

  • Length: 482
  • Mass: 56557
  • Checksum: C131E91F50B702DE
  • Sequence:
    • MSRVHGMHPK ETTRQLSLAV KDGLIVETLT VGCKGSKAGI EQEGYWLPGD EISIKKKNTN 
KQEMGTYLRF IVSRMKERAI DLNKKGKDNK HPMYRRLVHS AVDVPTIQEK VNEGKYRSYE 
EFKADAQLLL HNTVIFYGTD SEQADIARML YKDTCHEIPN HELVWAKMKG FGFWPAKVMQ 
KEDNQVDVRF FGHHHQRAWI PSENIQDITV NIHRLHVKRS MGWKKACDEL ELHQRFLREG 
RFWKSKNEDR GEEEAESSIS STSNEQLKVT QEPRAKKGRR NQSVEPKKEE PEPETEAVSS 
SQEIPTMPQP IEKVSVSTQT KKLSASSPRM LHRSTQTTND GVCQSMCHDK YTKIFNDFKD 
RMKSDHKRET ERVVREALEK LRSEMEEEKR QAVNKAVANM QGEMDRKCKQ VKEKCKEEFV 
EEIKKLATQH KQLISQTKKK QWCYNCEEEA MYHCCWNTSY CSIKCQQEHW HAEHKRTCRR 
KR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.