NEK6 | ENSG00000119408 | NCBI 10783

Details for: NEK6

Gene ID: 10783

Symbol: NEK6

Ensembl ID: ENSG00000119408

Description: NIMA related kinase 6

Associated with

Activation of nima kinases nek9, nek6, nek7
(R-HSA-2980767)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Eml4 and nudc in mitotic spindle formation
(R-HSA-9648025)
Mitotic prometaphase
(R-HSA-68877)
Mitotic prophase
(R-HSA-68875)
M phase
(R-HSA-68886)
Nuclear envelope breakdown
(R-HSA-2980766)
Nuclear pore complex (npc) disassembly
(R-HSA-3301854)
Apoptotic process
(GO:0006915)
Atp binding
(GO:0005524)
Cell division
(GO:0051301)
Centriolar satellite
(GO:0034451)
Centrosome
(GO:0005813)
Chromosome segregation
(GO:0007059)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dna-binding transcription factor binding
(GO:0140297)
Kinesin binding
(GO:0019894)
Magnesium ion binding
(GO:0000287)
Microtubule
(GO:0005874)
Mitotic nuclear membrane disassembly
(GO:0007077)
Mitotic spindle organization
(GO:0007052)
Nuclear speck
(GO:0016607)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Peptidyl-serine phosphorylation
(GO:0018105)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Protein-containing complex
(GO:0032991)
Protein autophosphorylation
(GO:0046777)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Regulation of cellular senescence
(GO:2000772)
Regulation of mitotic cell cycle
(GO:0007346)
Regulation of mitotic metaphase/anaphase transition
(GO:0030071)
Spindle assembly
(GO:0051225)
Spindle pole
(GO:0000922)
Transcription corepressor binding
(GO:0001222)
Ubiquitin protein ligase binding
(GO:0031625)

Other Information

Proteins

Never in mitosis A-related kinase 6

Genular Protein ID: 3695351977

Symbol: NEK6_HUMAN

Name: Never in mitosis A-related kinase 6

UniProtKB Accession Codes:

Q9HC98 B7Z2D9 Q5TBG3 Q5TBG9 Q6FG86 Q6IAR3 Q96E83 Q9ULX2

Database IDs:

Citations:

PubMed ID: 12054534

Title: Identification and characterization of Nek6 protein kinase, a potential human homolog of NIMA histone H3 kinase.

PubMed ID: 12054534

DOI: 10.1016/s0006-291x(02)00297-8

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11516946

Title: Identification of the NIMA family kinases NEK6/7 as regulators of the p70 ribosomal S6 kinase.

PubMed ID: 11516946

DOI: 10.1016/s0960-9822(01)00369-4

PubMed ID: 12840024

Title: A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases.

PubMed ID: 12840024

DOI: 10.1074/jbc.m303663200

PubMed ID: 14563848

Title: The serine/threonine kinase Nek6 is required for cell cycle progression through mitosis.

PubMed ID: 14563848

DOI: 10.1074/jbc.m308080200

PubMed ID: 16476580

Title: Interaction of Pin1 with Nek6 and characterization of their expression correlation in Chinese hepatocellular carcinoma patients.

PubMed ID: 16476580

DOI: 10.1016/j.bbrc.2005.12.228

PubMed ID: 17512906

Title: Human NIMA-related kinase 6 is one of the Fe65 WW domain binding proteins.

PubMed ID: 17512906

DOI: 10.1016/j.bbrc.2007.04.203

PubMed ID: 18728393

Title: Nek6 is involved in G2/M phase cell cycle arrest through DNA damage-induced phosphorylation.

PubMed ID: 18728393

DOI: 10.4161/cc.7.17.6551

PubMed ID: 19001501

Title: The NIMA-family kinase Nek6 phosphorylates the kinesin Eg5 at a novel site necessary for mitotic spindle formation.

PubMed ID: 19001501

DOI: 10.1242/jcs.035360

PubMed ID: 19941817

Title: An autoinhibitory tyrosine motif in the cell-cycle-regulated Nek7 kinase is released through binding of Nek9.

PubMed ID: 19941817

DOI: 10.1016/j.molcel.2009.09.038

PubMed ID: 19414596

Title: The Nek6 and Nek7 protein kinases are required for robust mitotic spindle formation and cytokinesis.

PubMed ID: 19414596

DOI: 10.1128/mcb.01867-08

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 21099361

Title: Nek6 overexpression antagonizes p53-induced senescence in human cancer cells.

PubMed ID: 21099361

DOI: 10.4161/cc.9.23.14059

PubMed ID: 20873783

Title: Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome.

PubMed ID: 20873783

DOI: 10.1021/pr100562w

PubMed ID: 20407017

Title: Nek6 mediates human cancer cell transformation and is a potential cancer therapeutic target.

PubMed ID: 20407017

DOI: 10.1158/1541-7786.mcr-09-0291

PubMed ID: 28250205

Title: Retraction: Nek6 Mediates Human Cancer Cell Transformation and Is a Potential Cancer Therapeutic Target.

PubMed ID: 28250205

DOI: 10.1158/1541-7786.mcr-16-0440

PubMed ID: 16280549

Title: Caught Nek-ing: cilia and centrioles.

PubMed ID: 16280549

DOI: 10.1242/jcs.02681

PubMed ID: 21200151

Title: A role for Nek6 kinase activity in preventing senescence?

PubMed ID: 21200151

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 31409757

Title: Mitotic phosphorylation by NEK6 and NEK7 reduces the microtubule affinity of EML4 to promote chromosome congression.

PubMed ID: 31409757

DOI: 10.1126/scisignal.aaw2939

Sequence Information:

Length: 313
Mass: 35714
Checksum: B898DC57407A8C16
Sequence:

MAGQPGHMPH GGSSNNLCHT LGPVHPPDPQ RHPNTLSFRC SLADFQIEKK IGRGQFSEVY 
KATCLLDRKT VALKKVQIFE MMDAKARQDC VKEIGLLKQL NHPNIIKYLD SFIEDNELNI 
VLELADAGDL SQMIKYFKKQ KRLIPERTVW KYFVQLCSAV EHMHSRRVMH RDIKPANVFI 
TATGVVKLGD LGLGRFFSSE TTAAHSLVGT PYYMSPERIH ENGYNFKSDI WSLGCLLYEM 
AALQSPFYGD KMNLFSLCQK IEQCDYPPLP GEHYSEKLRE LVSMCICPDP HQRPDIGYVH 
QVAKQMHIWM SST

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: NEK6

Associated with

Other Information

Identification and characterization of Nek6 protein kinase, a potential human homolog of NIMA histone H3 kinase. PubMed ID: 12054534

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

DNA sequence and analysis of human chromosome 9. PubMed ID: 15164053

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of the NIMA family kinases NEK6/7 as regulators of the p70 ribosomal S6 kinase. PubMed ID: 11516946

A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases. PubMed ID: 12840024

The serine/threonine kinase Nek6 is required for cell cycle progression through mitosis. PubMed ID: 14563848

Interaction of Pin1 with Nek6 and characterization of their expression correlation in Chinese hepatocellular carcinoma patients. PubMed ID: 16476580

Human NIMA-related kinase 6 is one of the Fe65 WW domain binding proteins. PubMed ID: 17512906

Nek6 is involved in G2/M phase cell cycle arrest through DNA damage-induced phosphorylation. PubMed ID: 18728393

The NIMA-family kinase Nek6 phosphorylates the kinesin Eg5 at a novel site necessary for mitotic spindle formation. PubMed ID: 19001501

An autoinhibitory tyrosine motif in the cell-cycle-regulated Nek7 kinase is released through binding of Nek9. PubMed ID: 19941817

The Nek6 and Nek7 protein kinases are required for robust mitotic spindle formation and cytokinesis. PubMed ID: 19414596

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Nek6 overexpression antagonizes p53-induced senescence in human cancer cells. PubMed ID: 21099361

Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome. PubMed ID: 20873783

Nek6 mediates human cancer cell transformation and is a potential cancer therapeutic target. PubMed ID: 20407017

Retraction: Nek6 Mediates Human Cancer Cell Transformation and Is a Potential Cancer Therapeutic Target. PubMed ID: 28250205

Caught Nek-ing: cilia and centrioles. PubMed ID: 16280549

A role for Nek6 kinase activity in preventing senescence? PubMed ID: 21200151

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Mitotic phosphorylation by NEK6 and NEK7 reduces the microtubule affinity of EML4 to promote chromosome congression. PubMed ID: 31409757