Details for: NEK6

Gene ID: 10783

Symbol: NEK6

Ensembl ID: ENSG00000119408

Description: NIMA related kinase 6

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.87
    Marker Score: 39,835
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.56
    Marker Score: 9,462
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,278
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.43
    Marker Score: 3,361
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.39
    Marker Score: 1,681
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.37
    Marker Score: 753
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.26
    Marker Score: 1,564
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.23
    Marker Score: 384
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.2
    Marker Score: 4,664
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.14
    Marker Score: 368
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.1
    Marker Score: 17,153
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.08
    Marker Score: 4,680
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.06
    Marker Score: 638
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.04
    Marker Score: 26,681
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1
    Marker Score: 6,443
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,754
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,979
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.99
    Marker Score: 60,625
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,400
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.97
    Marker Score: 280
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.97
    Marker Score: 475
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.97
    Marker Score: 2,870
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 491
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,404
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 445
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.94
    Marker Score: 12,597
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.94
    Marker Score: 943
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.92
    Marker Score: 4,923
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,716
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.9
    Marker Score: 3,542
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.88
    Marker Score: 359
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.88
    Marker Score: 5,269
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.88
    Marker Score: 824
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,295
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 314
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4,931
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.84
    Marker Score: 13,466
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.83
    Marker Score: 28,743
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.8
    Marker Score: 1,008
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.8
    Marker Score: 226
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.8
    Marker Score: 3,339
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.8
    Marker Score: 524
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.78
    Marker Score: 2,571
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.78
    Marker Score: 229
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 596
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,266
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.78
    Marker Score: 185
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.78
    Marker Score: 1,639
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.77
    Marker Score: 1,487
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.77
    Marker Score: 308
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.77
    Marker Score: 340
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.76
    Marker Score: 287
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.76
    Marker Score: 421
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.74
    Marker Score: 3,080
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 383
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.73
    Marker Score: 1,804
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.73
    Marker Score: 211
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.73
    Marker Score: 1,662
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.72
    Marker Score: 26,625
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.72
    Marker Score: 866
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.71
    Marker Score: 708
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.7
    Marker Score: 345
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.7
    Marker Score: 339
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.69
    Marker Score: 633
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.69
    Marker Score: 339
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.69
    Marker Score: 341
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.69
    Marker Score: 468
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.69
    Marker Score: 1,628
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.68
    Marker Score: 516
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.68
    Marker Score: 284
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2,856
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.68
    Marker Score: 253
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.67
    Marker Score: 2,898
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.67
    Marker Score: 403
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.67
    Marker Score: 761
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.66
    Marker Score: 1,176
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.66
    Marker Score: 1,651
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.65
    Marker Score: 888
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.64
    Marker Score: 984
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.63
    Marker Score: 547
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.62
    Marker Score: 1,616
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.62
    Marker Score: 416
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.61
    Marker Score: 2,562
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.61
    Marker Score: 214
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.61
    Marker Score: 158
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.61
    Marker Score: 652
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.6
    Marker Score: 352
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.6
    Marker Score: 220
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.6
    Marker Score: 691
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.6
    Marker Score: 1,088
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.59
    Marker Score: 215
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.59
    Marker Score: 151
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.58
    Marker Score: 338
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.58
    Marker Score: 2,146
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.58
    Marker Score: 1,516
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.58
    Marker Score: 542
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.57
    Marker Score: 3,639
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.57
    Marker Score: 312
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.56
    Marker Score: 31,582

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NEK6 is a serine/threonine kinase that belongs to the NIMA-related kinase family. It is characterized by its ability to activate other kinases, such as Nek9, Nek6, and Nek7, through protein-protein interactions and phosphorylation events. NEK6 is also known to bind to various proteins, including kinesin, magnesium ion, and transcription factors, which further underscores its regulatory role in cellular processes. **Pathways and Functions:** NEK6 is involved in several critical pathways, including: 1. **Mitotic Spindle Formation:** NEK6 regulates the assembly of the mitotic spindle by activating Nek9, Nek6, and Nek7, which in turn modulate the microtubule dynamics and chromosomal alignment. 2. **Apoptotic Process:** NEK6 is involved in the regulation of apoptosis by activating pro-apoptotic proteins and inhibiting anti-apoptotic proteins. 3. **Cell Cycle Regulation:** NEK6 regulates the cell cycle by modulating the activity of cyclin-dependent kinases and the expression of cell cycle regulatory genes. 4. **Cellular Senescence:** NEK6 is involved in the regulation of cellular senescence by modulating the activity of telomerase and the expression of senescence-associated genes. 5. **Protein Phosphorylation:** NEK6 phosphorylates various proteins, including transcription factors, kinases, and proteins involved in the regulation of cellular processes. **Clinical Significance:** Dysregulation of NEK6 has been implicated in various diseases, including: 1. **Cancer:** NEK6 overexpression has been observed in various types of cancer, including breast, lung, and colon cancer, suggesting its potential role as a tumor suppressor. 2. **Neurological Disorders:** NEK6 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, and its dysregulation has been observed in patients with these conditions. 3. **Cardiovascular Disease:** NEK6 has been shown to play a role in the regulation of cardiac function and its dysregulation has been implicated in the pathogenesis of cardiovascular disease. In conclusion, NEK6 is a multifunctional protein that plays a critical role in regulating various cellular processes, including mitosis, apoptosis, and cellular homeostasis. Its dysregulation has been implicated in various diseases, making it a potential therapeutic target for the treatment of these conditions. Further studies are needed to fully elucidate the mechanisms of NEK6 and its role in human disease.

Genular Protein ID: 3695351977

Symbol: NEK6_HUMAN

Name: Never in mitosis A-related kinase 6

UniProtKB Accession Codes:

Q9HC98 B7Z2D9 Q5TBG3 Q5TBG9 Q6FG86 Q6IAR3 Q96E83 Q9ULX2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CTD 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 2 EMBL 14 EPD 1 Ensembl 8 ExpressionAtlas 1 GO 31 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 3 RefSeq 10 Rhea 6 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12054534

Title: Identification and characterization of Nek6 protein kinase, a potential human homolog of NIMA histone H3 kinase.

PubMed ID: 12054534

DOI: 10.1016/s0006-291x(02)00297-8

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11516946

Title: Identification of the NIMA family kinases NEK6/7 as regulators of the p70 ribosomal S6 kinase.

PubMed ID: 11516946

DOI: 10.1016/s0960-9822(01)00369-4

PubMed ID: 12840024

Title: A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases.

PubMed ID: 12840024

DOI: 10.1074/jbc.m303663200

PubMed ID: 14563848

Title: The serine/threonine kinase Nek6 is required for cell cycle progression through mitosis.

PubMed ID: 14563848

DOI: 10.1074/jbc.m308080200

PubMed ID: 16476580

Title: Interaction of Pin1 with Nek6 and characterization of their expression correlation in Chinese hepatocellular carcinoma patients.

PubMed ID: 16476580

DOI: 10.1016/j.bbrc.2005.12.228

PubMed ID: 17512906

Title: Human NIMA-related kinase 6 is one of the Fe65 WW domain binding proteins.

PubMed ID: 17512906

DOI: 10.1016/j.bbrc.2007.04.203

PubMed ID: 18728393

Title: Nek6 is involved in G2/M phase cell cycle arrest through DNA damage-induced phosphorylation.

PubMed ID: 18728393

DOI: 10.4161/cc.7.17.6551

PubMed ID: 19001501

Title: The NIMA-family kinase Nek6 phosphorylates the kinesin Eg5 at a novel site necessary for mitotic spindle formation.

PubMed ID: 19001501

DOI: 10.1242/jcs.035360

PubMed ID: 19941817

Title: An autoinhibitory tyrosine motif in the cell-cycle-regulated Nek7 kinase is released through binding of Nek9.

PubMed ID: 19941817

DOI: 10.1016/j.molcel.2009.09.038

PubMed ID: 19414596

Title: The Nek6 and Nek7 protein kinases are required for robust mitotic spindle formation and cytokinesis.

PubMed ID: 19414596

DOI: 10.1128/mcb.01867-08

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 21099361

Title: Nek6 overexpression antagonizes p53-induced senescence in human cancer cells.

PubMed ID: 21099361

DOI: 10.4161/cc.9.23.14059

PubMed ID: 20873783

Title: Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome.

PubMed ID: 20873783

DOI: 10.1021/pr100562w

PubMed ID: 20407017

Title: Nek6 mediates human cancer cell transformation and is a potential cancer therapeutic target.

PubMed ID: 20407017

DOI: 10.1158/1541-7786.mcr-09-0291

PubMed ID: 28250205

Title: Retraction: Nek6 Mediates Human Cancer Cell Transformation and Is a Potential Cancer Therapeutic Target.

PubMed ID: 28250205

DOI: 10.1158/1541-7786.mcr-16-0440

PubMed ID: 16280549

Title: Caught Nek-ing: cilia and centrioles.

PubMed ID: 16280549

DOI: 10.1242/jcs.02681

PubMed ID: 21200151

Title: A role for Nek6 kinase activity in preventing senescence?

PubMed ID: 21200151

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 31409757

Title: Mitotic phosphorylation by NEK6 and NEK7 reduces the microtubule affinity of EML4 to promote chromosome congression.

PubMed ID: 31409757

DOI: 10.1126/scisignal.aaw2939

Sequence Information:

  • Length: 313
  • Mass: 35714
  • Checksum: B898DC57407A8C16
  • Sequence:
    • MAGQPGHMPH GGSSNNLCHT LGPVHPPDPQ RHPNTLSFRC SLADFQIEKK IGRGQFSEVY 
KATCLLDRKT VALKKVQIFE MMDAKARQDC VKEIGLLKQL NHPNIIKYLD SFIEDNELNI 
VLELADAGDL SQMIKYFKKQ KRLIPERTVW KYFVQLCSAV EHMHSRRVMH RDIKPANVFI 
TATGVVKLGD LGLGRFFSSE TTAAHSLVGT PYYMSPERIH ENGYNFKSDI WSLGCLLYEM 
AALQSPFYGD KMNLFSLCQK IEQCDYPPLP GEHYSEKLRE LVSMCICPDP HQRPDIGYVH 
QVAKQMHIWM SST

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.