Details for: VAMP5

Gene ID: 10791

Symbol: VAMP5

Ensembl ID: ENSG00000168899

Description: vesicle associated membrane protein 5

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 4.12
    Marker Score: 10,474
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 3.48
    Marker Score: 5,036
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 3.02
    Marker Score: 2,595
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.89
    Marker Score: 5,765
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.47
    Marker Score: 4,819
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.37
    Marker Score: 2,373
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.37
    Marker Score: 3,444
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 2.32
    Marker Score: 540
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.29
    Marker Score: 26,592
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 2.24
    Marker Score: 5,406
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.19
    Marker Score: 122,363
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.18
    Marker Score: 5,711
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 2.1
    Marker Score: 1,980
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.04
    Marker Score: 13,018
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.02
    Marker Score: 2,175
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.96
    Marker Score: 476
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.95
    Marker Score: 8,422
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 1.95
    Marker Score: 1,958
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.91
    Marker Score: 430
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.91
    Marker Score: 406
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.82
    Marker Score: 2,506
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.82
    Marker Score: 759
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.8
    Marker Score: 17,812
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.77
    Marker Score: 1,586
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.77
    Marker Score: 2,992
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.77
    Marker Score: 387
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 1.73
    Marker Score: 439
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.73
    Marker Score: 1,843
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.69
    Marker Score: 1,223
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.65
    Marker Score: 379
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.63
    Marker Score: 5,143
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.57
    Marker Score: 17,660
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.54
    Marker Score: 1,310
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 1.52
    Marker Score: 629
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.51
    Marker Score: 427
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.48
    Marker Score: 574
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.45
    Marker Score: 1,812
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.45
    Marker Score: 166,352
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.4
    Marker Score: 336
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 1.39
    Marker Score: 748
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.36
    Marker Score: 781
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.36
    Marker Score: 1,310
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.35
    Marker Score: 2,847
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.33
    Marker Score: 1,165
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.33
    Marker Score: 1,280
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 1.32
    Marker Score: 682
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.32
    Marker Score: 960
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.31
    Marker Score: 2,345
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.31
    Marker Score: 324
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.31
    Marker Score: 1,104
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.29
    Marker Score: 681
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 1.29
    Marker Score: 342
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.29
    Marker Score: 2,528
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.28
    Marker Score: 1,159
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 1.28
    Marker Score: 298
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.26
    Marker Score: 358
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.26
    Marker Score: 1,175
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 1.25
    Marker Score: 276
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.25
    Marker Score: 2,350
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.25
    Marker Score: 5,113
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.25
    Marker Score: 1,835
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.24
    Marker Score: 620
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.23
    Marker Score: 314
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.23
    Marker Score: 3,455
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 1.22
    Marker Score: 764
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.22
    Marker Score: 41,667
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.22
    Marker Score: 1,227
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.2
    Marker Score: 703
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 1.2
    Marker Score: 1,064
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.19
    Marker Score: 3,479
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 1.19
    Marker Score: 304
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.19
    Marker Score: 1,747
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.18
    Marker Score: 2,876
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.17
    Marker Score: 834
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 1.17
    Marker Score: 283
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.17
    Marker Score: 2,138
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.17
    Marker Score: 427
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 1.16
    Marker Score: 1,288
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.16
    Marker Score: 361
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.14
    Marker Score: 1,616
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.14
    Marker Score: 5,979
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.13
    Marker Score: 327
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.13
    Marker Score: 4,693
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.13
    Marker Score: 4,840
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.12
    Marker Score: 740
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.12
    Marker Score: 480
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.11
    Marker Score: 1,375
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 1.11
    Marker Score: 1,233
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 1.1
    Marker Score: 741
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.09
    Marker Score: 57,785
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.09
    Marker Score: 744
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.09
    Marker Score: 2,056
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 1.08
    Marker Score: 356
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 1.07
    Marker Score: 246
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.05
    Marker Score: 665
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.04
    Marker Score: 696
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.03
    Marker Score: 430
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 1.02
    Marker Score: 221
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 1.01
    Marker Score: 463
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 1.01
    Marker Score: 269

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** VAMP5 is a small, membrane-associated protein that belongs to the VAMP family of synaptic vesicle proteins. It is characterized by its ability to bind to specific receptors and interact with other proteins to regulate exocytosis. VAMP5 is predominantly expressed in endothelial cells, which line blood vessels and lymphatic vessels, and in immune cells such as monocytes and macrophages. Its expression is also detected in other cell types, including alveolar capillary type 1 endothelial cells and pulmonary artery endothelial cells. **Pathways and Functions:** VAMP5 is involved in various cellular processes, including: 1. **Exocytosis**: VAMP5 regulates the fusion of vesicles with the plasma membrane, releasing signaling molecules and proteins that modulate immune responses. 2. **Cell differentiation**: VAMP5 plays a crucial role in the differentiation of endothelial cells and immune cells, influencing their development and function. 3. **Immune regulation**: VAMP5 modulates the activity of immune cells, including monocytes and macrophages, and influences their ability to produce cytokines and chemokines. 4. **Cell signaling**: VAMP5 interacts with other proteins to regulate cell signaling pathways, including those involved in cell growth, survival, and migration. **Clinical Significance:** Dysregulation of VAMP5 has been implicated in various diseases, including: 1. **Inflammatory disorders**: Altered expression of VAMP5 has been linked to inflammatory conditions, such as atherosclerosis and rheumatoid arthritis. 2. **Immunodeficiency disorders**: Mutations in the VAMP5 gene have been associated with immunodeficiency disorders, including primary immunodeficiency diseases. 3. **Cancer**: VAMP5 has been implicated in the progression of various cancers, including lung and breast cancer, where it regulates cell growth and invasion. 4. **Neurological disorders**: VAMP5 has been linked to neurological disorders, including Alzheimer's disease and Parkinson's disease, where it regulates synaptic function and plasticity. In conclusion, VAMP5 is a critical component of the exocytotic machinery involved in immune response and cellular regulation. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into its role in human health and disease.

Genular Protein ID: 3351487985

Symbol: VAMP5_HUMAN

Name: Vesicle-associated membrane protein 5

UniProtKB Accession Codes:

O95183 Q9P0T2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9725904

Title: A novel synaptobrevin/VAMP homologous protein (VAMP5) is increased during in vitro myogenesis and present in the plasma membrane.

PubMed ID: 9725904

DOI: 10.1091/mbc.9.9.2423

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 28770820

Title: Identification and characterization of a novel botulinum neurotoxin.

PubMed ID: 28770820

DOI: 10.1038/ncomms14130

Sequence Information:

  • Length: 116
  • Mass: 12805
  • Checksum: 32A1F3B808A6016C
  • Sequence:
    • MAGIELERCQ QQANEVTEIM RNNFGKVLER GVKLAELQQR SDQLLDMSST FNKTTQNLAQ 
KKCWENIRYR ICVGLVVVGV LLIILIVLLV VFLPQSSDSS SAPRTQDAGI ASGPGN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.