MTHFD2 | ENSG00000065911 | NCBI 10797

Details for: MTHFD2

Gene ID: 10797

Symbol: MTHFD2

Ensembl ID: ENSG00000065911

Description: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase

Associated with

Metabolism
(R-HSA-1430728)
Metabolism of folate and pterines
(R-HSA-196757)
Metabolism of vitamins and cofactors
(R-HSA-196854)
Metabolism of water-soluble vitamins and cofactors
(R-HSA-196849)
Extracellular space
(GO:0005615)
Folic acid metabolic process
(GO:0046655)
Magnesium ion binding
(GO:0000287)
Methenyltetrahydrofolate cyclohydrolase activity
(GO:0004477)
Methylenetetrahydrofolate dehydrogenase (nad+) activity
(GO:0004487)
Methylenetetrahydrofolate dehydrogenase (nadp+) activity
(GO:0004488)
Mitochondrial matrix
(GO:0005759)
Mitochondrion
(GO:0005739)
Phosphate ion binding
(GO:0042301)
Protein binding
(GO:0005515)
Tetrahydrofolate interconversion
(GO:0035999)
Tetrahydrofolate metabolic process
(GO:0046653)

Other Information

Proteins

Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial

Genular Protein ID: 3059948152

Symbol: MTDC_HUMAN

Name: Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial

UniProtKB Accession Codes:

P13995 Q53G90 Q53GV5 Q53S36 Q7Z650

Database IDs:

Citations:

PubMed ID: 2587219

Title: Nucleotide sequence of the human NAD-dependent methylene tetrahydrofolate dehydrogenase-cyclohydrolase.

PubMed ID: 2587219

DOI: 10.1093/nar/17.21.8853

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8218174

Title: NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase is the mammalian homolog of the mitochondrial enzyme encoded by the yeast MIS1 gene.

PubMed ID: 8218174

DOI: 10.1021/bi00092a022

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 16100107

Title: Magnesium and phosphate ions enable NAD binding to methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase.

PubMed ID: 16100107

DOI: 10.1074/jbc.m505210200

PubMed ID: 27899380

Title: Crystal structure of the emerging cancer target MTHFD2 in complex with a substrate-based inhibitor.

PubMed ID: 27899380

DOI: 10.1158/0008-5472.can-16-1476

Sequence Information:

Length: 350
Mass: 37895
Checksum: 4DBD263CF7BE28F4
Sequence:

MAATSLMSAL AARLLQPAHS CSLRLRPFHL AAVRNEAVVI SGRKLAQQIK QEVRQEVEEW 
VASGNKRPHL SVILVGENPA SHSYVLNKTR AAAVVGINSE TIMKPASISE EELLNLINKL 
NNDDNVDGLL VQLPLPEHID ERRICNAVSP DKDVDGFHVI NVGRMCLDQY SMLPATPWGV 
WEIIKRTGIP TLGKNVVVAG RSKNVGMPIA MLLHTDGAHE RPGGDATVTI SHRYTPKEQL 
KKHTILADIV ISAAGIPNLI TADMIKEGAA VIDVGINRVH DPVTAKPKLV GDVDFEGVRQ 
KAGYITPVPG GVGPMTVAML MKNTIIAAKK VLRLEEREVL KSKELGVATN

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: MTHFD2

Associated with

Other Information

Nucleotide sequence of the human NAD-dependent methylene tetrahydrofolate dehydrogenase-cyclohydrolase. PubMed ID: 2587219

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase is the mammalian homolog of the mitochondrial enzyme encoded by the yeast MIS1 gene. PubMed ID: 8218174

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Magnesium and phosphate ions enable NAD binding to methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase. PubMed ID: 16100107

Crystal structure of the emerging cancer target MTHFD2 in complex with a substrate-based inhibitor. PubMed ID: 27899380