Details for: ADCY2

Gene ID: 108

Symbol: ADCY2

Ensembl ID: ENSG00000078295

Description: adenylate cyclase 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: interneuron (CL0000099)
    Fold Change: 6.17
    Marker Score: 2,817
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 5.45
    Marker Score: 3,586
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 3.26
    Marker Score: 69,476
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.82
    Marker Score: 21,596
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.62
    Marker Score: 39,185
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.58
    Marker Score: 51,394
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.58
    Marker Score: 6,451
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.58
    Marker Score: 97,797
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 2.57
    Marker Score: 2,226
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.43
    Marker Score: 10,089
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.35
    Marker Score: 3,941
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.32
    Marker Score: 8,982
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 2.26
    Marker Score: 4,675
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.24
    Marker Score: 82,615
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.2
    Marker Score: 20,661
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.11
    Marker Score: 810
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.07
    Marker Score: 1,205
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.03
    Marker Score: 124,986
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.99
    Marker Score: 8,340
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.95
    Marker Score: 3,694
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.94
    Marker Score: 660
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.9
    Marker Score: 18,098
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.87
    Marker Score: 16,068
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.84
    Marker Score: 19,016
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.81
    Marker Score: 6,056
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 1.68
    Marker Score: 1,279
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.67
    Marker Score: 6,959
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.63
    Marker Score: 2,516
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.62
    Marker Score: 512
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1,163
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.56
    Marker Score: 1,932
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.52
    Marker Score: 1,249
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.49
    Marker Score: 387
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,557
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.47
    Marker Score: 2,981
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.35
    Marker Score: 2,973
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.34
    Marker Score: 1,882
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.18
    Marker Score: 2,790
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 1.15
    Marker Score: 382
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.15
    Marker Score: 293
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.13
    Marker Score: 3,230
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.12
    Marker Score: 841
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.04
    Marker Score: 434
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 791
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.03
    Marker Score: 1,182
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.02
    Marker Score: 15,887
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.01
    Marker Score: 296
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.01
    Marker Score: 564
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,807
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,032
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1
    Marker Score: 598
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 506
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,407
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.97
    Marker Score: 312
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.95
    Marker Score: 4,389
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 372
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,738
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5,173
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,284
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.87
    Marker Score: 5,208
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.83
    Marker Score: 1,029
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.82
    Marker Score: 3,455
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.8
    Marker Score: 3,244
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,269
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.76
    Marker Score: 503
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 686
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.73
    Marker Score: 296
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.7
    Marker Score: 846
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.7
    Marker Score: 486
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.69
    Marker Score: 180
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.69
    Marker Score: 216
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.69
    Marker Score: 198
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.68
    Marker Score: 328
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.68
    Marker Score: 325
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.67
    Marker Score: 1,288
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.59
    Marker Score: 379
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 0.58
    Marker Score: 166
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.57
    Marker Score: 555
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.56
    Marker Score: 203
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.54
    Marker Score: 268
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.54
    Marker Score: 219
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.54
    Marker Score: 301
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.53
    Marker Score: 231
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.52
    Marker Score: 1,800
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.52
    Marker Score: 803
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.52
    Marker Score: 215
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.52
    Marker Score: 346
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.52
    Marker Score: 137
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5
    Marker Score: 568
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.49
    Marker Score: 295
  • Cell Name: bipolar neuron (CL0000103)
    Fold Change: 0.49
    Marker Score: 164
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.49
    Marker Score: 133
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.47
    Marker Score: 855

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Expression pattern**: ADCY2 is predominantly expressed in interneurons, astrocytes, and skeletal muscle fibers, indicating its involvement in both the central nervous system and peripheral tissues. 2. **Enzymatic activity**: ADCY2 is an adenylate cyclase, an enzyme that catalyzes the conversion of ATP to cyclic AMP (cAMP), a key second messenger in cellular signaling. 3. **Signaling pathways**: ADCY2 is involved in various signaling pathways, including the activation of GABA receptors, the regulation of adenylate cyclase activity, and the production of anti-inflammatory cytokines. 4. **Cellular localization**: ADCY2 is primarily localized to the plasma membrane, where it can interact with G protein-coupled receptors and other signaling molecules. **Pathways and Functions** 1. **GABA receptor activation**: ADCY2 is involved in the activation of GABA receptors, which are a family of ligand-gated ion channels that regulate neurotransmission in the central nervous system. 2. **Adenylate cyclase-activating pathway**: ADCY2 is a key component of the adenylate cyclase-activating pathway, which regulates the production of cAMP in response to various stimuli, including neurotransmitters and hormones. 3. **Anti-inflammatory response**: ADCY2 is involved in the regulation of anti-inflammatory cytokine production, which is crucial for maintaining immune homeostasis and preventing excessive inflammation. 4. **Leishmania parasite infection**: ADCY2 has been implicated in the regulation of Leishmania parasite growth and survival, suggesting its potential role in the development of novel therapeutic strategies against this disease. 5. **Metabolic regulation**: ADCY2 is also involved in the regulation of energy metabolism, including the production of cAMP and the activation of glucagon signaling pathways. **Clinical Significance** 1. **Neurological disorders**: Dysregulation of ADCY2 has been implicated in various neurological disorders, including epilepsy, schizophrenia, and Parkinson's disease. 2. **Inflammatory diseases**: ADCY2 has been shown to play a role in the regulation of inflammatory responses, which is relevant to the development of inflammatory diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Leishmania infection**: Understanding the role of ADCY2 in Leishmania parasite infection may lead to the development of novel therapeutic strategies against this disease. 4. **Metabolic disorders**: Dysregulation of ADCY2 has been implicated in metabolic disorders, including obesity and diabetes, highlighting the potential for ADCY2 as a therapeutic target. In conclusion, the ADCY2 gene encodes for a crucial enzyme involved in the regulation of various cellular processes, including neurotransmission, inflammation, and metabolism. Further research is needed to fully understand the role of ADCY2 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 2995545697

Symbol: ADCY2_HUMAN

Name: Adenylate cyclase type 2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10470851

Title: Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10470851

DOI: 10.1093/dnares/6.3.197

PubMed ID: 1427768

Title: Different chromosomal localization of two adenylyl cyclase genes expressed in human brain.

PubMed ID: 1427768

DOI: 10.1007/bf00210755

PubMed ID: 8476432

Title: A novel adenylyl cyclase sequence cloned from the human erythroleukemia cell line.

PubMed ID: 8476432

DOI: 10.1006/bbrc.1993.1415

PubMed ID: 11549699

Title: Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland.

PubMed ID: 11549699

DOI: 10.1210/jcem.86.9.7837

PubMed ID: 15385642

Title: Raf kinase activation of adenylyl cyclases: isoform-selective regulation.

PubMed ID: 15385642

DOI: 10.1124/mol.66.4.921

PubMed ID: 21228062

Title: Human bronchial smooth muscle cells express adenylyl cyclase isoforms 2, 4, and 6 in distinct membrane microdomains.

PubMed ID: 21228062

DOI: 10.1124/jpet.110.177923

Sequence Information:

  • Length: 1091
  • Mass: 123603
  • Checksum: 41FD8BC607C075D1
  • Sequence:
  • MWQEAMRRRR YLRDRSEEAA GGGDGLPRSR DWLYESYYCM SQQHPLIVFL LLIVMGSCLA 
    LLAVFFALGL EVEDHVAFLI TVPTALAIFF AIFILVCIES VFKKLLRLFS LVIWICLVAM 
    GYLFMCFGGT VSPWDQVSFF LFIIFVVYTM LPFNMRDAII ASVLTSSSHT IVLSVCLSAT 
    PGGKEHLVWQ ILANVIIFIC GNLAGAYHKH LMELALQQTY QDTCNCIKSR IKLEFEKRQQ 
    ERLLLSLLPA HIAMEMKAEI IQRLQGPKAG QMENTNNFHN LYVKRHTNVS ILYADIVGFT 
    RLASDCSPGE LVHMLNELFG KFDQIAKENE CMRIKILGDC YYCVSGLPIS LPNHAKNCVK 
    MGLDMCEAIK KVRDATGVDI NMRVGVHSGN VLCGVIGLQK WQYDVWSHDV TLANHMEAGG 
    VPGRVHISSV TLEHLNGAYK VEEGDGDIRD PYLKQHLVKT YFVINPKGER RSPQHLFRPR 
    HTLDGAKMRA SVRMTRYLES WGAAKPFAHL HHRDSMTTEN GKISTTDVPM GQHNFQNRTL 
    RTKSQKKRFE EELNERMIQA IDGINAQKQW LKSEDIQRIS LLFYNKVLEK EYRATALPAF 
    KYYVTCACLI FFCIFIVQIL VLPKTSVLGI SFGAAFLLLA FILFVCFAGQ LLQCSKKASP 
    LLMWLLKSSG IIANRPWPRI SLTIITTAII LMMAVFNMFF LSDSEETIPP TANTTNTSFS 
    ASNNQVAILR AQNLFFLPYF IYSCILGLIS CSVFLRVNYE LKMLIMMVAL VGYNTILLHT 
    HAHVLGDYSQ VLFERPGIWK DLKTMGSVSL SIFFITLLVL GRQNEYYCRL DFLWKNKFKK 
    EREEIETMEN LNRVLLENVL PAHVAEHFLA RSLKNEELYH QSYDCVCVMF ASIPDFKEFY 
    TESDVNKEGL ECLRLLNEII ADFDDLLSKP KFSGVEKIKT IGSTYMAATG LSAVPSQEHS 
    QEPERQYMHI GTMVEFAFAL VGKLDAINKH SFNDFKLRVG INHGPVIAGV IGAQKPQYDI 
    WGNTVNVASR MDSTGVLDKI QVTEETSLVL QTLGYTCTCR GIINVKGKGD LKTYFVNTEM 
    SRSLSQSNVA S

Genular Protein ID: 971448224

Symbol: Q71UM8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8619474

Title: A "double adaptor" method for improved shotgun library construction.

PubMed ID: 8619474

DOI: 10.1006/abio.1996.0138

PubMed ID: 9110174

Title: Large-scale concatenation cDNA sequencing.

PubMed ID: 9110174

Sequence Information:

  • Length: 367
  • Mass: 41622
  • Checksum: A4D44988A2679601
  • Sequence:
  • QVAILRAQNL FFLPYFIYSC ILGLISCSVF LRVNYELKML IMMVALVGYN TILLHTHAHV 
    LGDYSQVLFE RPGIWKDLKT MGSVSLSIFF ITLLVLGRQN EYYCRLDFLW KNKFKKEREE 
    IETMENLNRV LLENVLPAHV AEHFLARSLK NEELYHQSYD CVCVMFASIP DFKEFYTESD 
    VNKEGLECLR LLNEIIADFD DLLSKPKFSG VEKIKTIGST YMAATGLSAV PSQEHSQEPE 
    RQYMHIGTMV EFAFALVGKL DAINKHSFND FKLRVGINHG PVIAGVIGAQ KPQYDIWGNT 
    VNVASRMDST GVLDKIQVTE ETSLVLQTLG YTCTCRGIIN VKGKGDLKTY FVNTEMSRSL 
    SQSNVAS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.