Details for: ADCY2

Gene ID: 108

Symbol: ADCY2

Ensembl ID: ENSG00000078295

Description: adenylate cyclase 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: interneuron (CL0000099)
    Fold Change: 6.17
    Marker Score: 2817
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 5.45
    Marker Score: 3586
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 3.26
    Marker Score: 69475.5
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.82
    Marker Score: 21596
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.62
    Marker Score: 39185
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.58
    Marker Score: 51394
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.58
    Marker Score: 6451
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.58
    Marker Score: 97797
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 2.57
    Marker Score: 2226
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.43
    Marker Score: 10089
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.35
    Marker Score: 3941
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.32
    Marker Score: 8982
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 2.26
    Marker Score: 4674.5
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.24
    Marker Score: 82615
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.2
    Marker Score: 20661
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.11
    Marker Score: 810
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.07
    Marker Score: 1205
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.03
    Marker Score: 124986
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.99
    Marker Score: 8340
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.95
    Marker Score: 3694
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.94
    Marker Score: 659.5
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.9
    Marker Score: 18098
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.87
    Marker Score: 16068
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.84
    Marker Score: 19016
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.81
    Marker Score: 6056
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 1.68
    Marker Score: 1279
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.67
    Marker Score: 6959
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.63
    Marker Score: 2516
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.62
    Marker Score: 512
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1163
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.56
    Marker Score: 1932
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.52
    Marker Score: 1249
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.49
    Marker Score: 386.5
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168557
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.47
    Marker Score: 2981
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.35
    Marker Score: 2973
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.34
    Marker Score: 1882
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.18
    Marker Score: 2790
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 1.15
    Marker Score: 381.5
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.15
    Marker Score: 293
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.13
    Marker Score: 3230
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.12
    Marker Score: 841
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.04
    Marker Score: 434
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 791
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.03
    Marker Score: 1181.5
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.02
    Marker Score: 15887
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.01
    Marker Score: 296
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.01
    Marker Score: 564
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71807
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48032
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1
    Marker Score: 598
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 506
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.97
    Marker Score: 312
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.95
    Marker Score: 4389
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 372
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5173
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5284
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.87
    Marker Score: 5208
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.83
    Marker Score: 1029
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.82
    Marker Score: 3454.5
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.8
    Marker Score: 3244
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.76
    Marker Score: 503
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 686
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.73
    Marker Score: 296
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.7
    Marker Score: 845.5
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.7
    Marker Score: 486
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.69
    Marker Score: 180
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.69
    Marker Score: 216
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.69
    Marker Score: 198
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.68
    Marker Score: 328
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.68
    Marker Score: 325
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.67
    Marker Score: 1288
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.59
    Marker Score: 379
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 0.58
    Marker Score: 166
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.57
    Marker Score: 555
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.56
    Marker Score: 203
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.54
    Marker Score: 268
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.54
    Marker Score: 219
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.54
    Marker Score: 301
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.53
    Marker Score: 231
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.52
    Marker Score: 1800
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.52
    Marker Score: 803
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.52
    Marker Score: 215
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.52
    Marker Score: 346
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.52
    Marker Score: 137
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5
    Marker Score: 568
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.49
    Marker Score: 295
  • Cell Name: bipolar neuron (CL0000103)
    Fold Change: 0.49
    Marker Score: 164
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.49
    Marker Score: 133
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.47
    Marker Score: 854.5

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Other Information

## Summary The ADCY2 gene encodes a protein called ADCY2, which is an enzyme involved in the regulation of water and electrolyte homeostasis in the body. It is expressed in various cell types, including interneurons, astrocytes, skeletal muscle fibers, and vascular endothelial cells. ## Key characteristics * ADCY2 is a transmembrane protein with a molecular weight of approximately 135 kDa. * It is a member of the adenylate cyclase family of enzymes. * ADCY2 is expressed in high levels in the brain, particularly in the cerebral cortex. * It is involved in a variety of cellular processes, including water balance, electrolyte regulation, and signaling pathways. ## Pathways and functions * ADCY2 is involved in the aquaporin-mediated transport pathway of water and ions. * It is also involved in the Dag and ip3 signaling pathways, which are involved in regulating calcium and potassium ion concentrations. * In the disease state, ADCY2 is upregulated, which can lead to increased water and electrolyte efflux from cells and tissues, resulting in swelling and tissue damage. * ADCY2 also plays a role in the Gpcr downstream signaling pathway, which is involved in the regulation of lipid metabolism. * It also regulates the Hedgehog 'off' state and the integration of energy metabolism. ## Clinical significance * Mutations in the ADCY2 gene have been linked to a number of human diseases, including cerebral edema, stroke, and heart failure. * ADCY2 inhibitors are being investigated as potential treatments for these diseases. * By understanding the role of ADCY2 in water and electrolyte homeostasis, researchers hope to develop new treatments for a variety of diseases that are caused by abnormalities in ADCY2 function. ## Additional information * The ADCY2 gene is located on chromosome 15q21.1. * It is a highly conserved gene, with a similar gene found in other mammals. * ADCY2 is a well-characterized gene, with a wealth of literature available on its function and regulation.

Genular Protein ID: 2995545697

Symbol: ADCY2_HUMAN

Name: Adenylate cyclase type 2

UniProtKB Accession Codes:

Q08462 B7Z2C1 Q2NKL8 Q9UDB2 Q9UPU2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 17 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EC 1 EMBL 11 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 13 RefSeq 1 Rhea 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10470851

Title: Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10470851

DOI: 10.1093/dnares/6.3.197

PubMed ID: 1427768

Title: Different chromosomal localization of two adenylyl cyclase genes expressed in human brain.

PubMed ID: 1427768

DOI: 10.1007/bf00210755

PubMed ID: 8476432

Title: A novel adenylyl cyclase sequence cloned from the human erythroleukemia cell line.

PubMed ID: 8476432

DOI: 10.1006/bbrc.1993.1415

PubMed ID: 11549699

Title: Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland.

PubMed ID: 11549699

DOI: 10.1210/jcem.86.9.7837

PubMed ID: 15385642

Title: Raf kinase activation of adenylyl cyclases: isoform-selective regulation.

PubMed ID: 15385642

DOI: 10.1124/mol.66.4.921

PubMed ID: 21228062

Title: Human bronchial smooth muscle cells express adenylyl cyclase isoforms 2, 4, and 6 in distinct membrane microdomains.

PubMed ID: 21228062

DOI: 10.1124/jpet.110.177923

Sequence Information:

  • Length: 1091
  • Mass: 123603
  • Checksum: 41FD8BC607C075D1
  • Sequence:
    • MWQEAMRRRR YLRDRSEEAA GGGDGLPRSR DWLYESYYCM SQQHPLIVFL LLIVMGSCLA 
LLAVFFALGL EVEDHVAFLI TVPTALAIFF AIFILVCIES VFKKLLRLFS LVIWICLVAM 
GYLFMCFGGT VSPWDQVSFF LFIIFVVYTM LPFNMRDAII ASVLTSSSHT IVLSVCLSAT 
PGGKEHLVWQ ILANVIIFIC GNLAGAYHKH LMELALQQTY QDTCNCIKSR IKLEFEKRQQ 
ERLLLSLLPA HIAMEMKAEI IQRLQGPKAG QMENTNNFHN LYVKRHTNVS ILYADIVGFT 
RLASDCSPGE LVHMLNELFG KFDQIAKENE CMRIKILGDC YYCVSGLPIS LPNHAKNCVK 
MGLDMCEAIK KVRDATGVDI NMRVGVHSGN VLCGVIGLQK WQYDVWSHDV TLANHMEAGG 
VPGRVHISSV TLEHLNGAYK VEEGDGDIRD PYLKQHLVKT YFVINPKGER RSPQHLFRPR 
HTLDGAKMRA SVRMTRYLES WGAAKPFAHL HHRDSMTTEN GKISTTDVPM GQHNFQNRTL 
RTKSQKKRFE EELNERMIQA IDGINAQKQW LKSEDIQRIS LLFYNKVLEK EYRATALPAF 
KYYVTCACLI FFCIFIVQIL VLPKTSVLGI SFGAAFLLLA FILFVCFAGQ LLQCSKKASP 
LLMWLLKSSG IIANRPWPRI SLTIITTAII LMMAVFNMFF LSDSEETIPP TANTTNTSFS 
ASNNQVAILR AQNLFFLPYF IYSCILGLIS CSVFLRVNYE LKMLIMMVAL VGYNTILLHT 
HAHVLGDYSQ VLFERPGIWK DLKTMGSVSL SIFFITLLVL GRQNEYYCRL DFLWKNKFKK 
EREEIETMEN LNRVLLENVL PAHVAEHFLA RSLKNEELYH QSYDCVCVMF ASIPDFKEFY 
TESDVNKEGL ECLRLLNEII ADFDDLLSKP KFSGVEKIKT IGSTYMAATG LSAVPSQEHS 
QEPERQYMHI GTMVEFAFAL VGKLDAINKH SFNDFKLRVG INHGPVIAGV IGAQKPQYDI 
WGNTVNVASR MDSTGVLDKI QVTEETSLVL QTLGYTCTCR GIINVKGKGD LKTYFVNTEM 
SRSLSQSNVA S

Genular Protein ID: 971448224

Symbol: Q71UM8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q71UM8

Database IDs:

ARBA 10 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 5 DNASU 1 EC 1 EMBL 2 GO 4 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 Rhea 1 RuleBase 1 SAM 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 8619474

Title: A "double adaptor" method for improved shotgun library construction.

PubMed ID: 8619474

DOI: 10.1006/abio.1996.0138

PubMed ID: 9110174

Title: Large-scale concatenation cDNA sequencing.

PubMed ID: 9110174

Sequence Information:

  • Length: 367
  • Mass: 41622
  • Checksum: A4D44988A2679601
  • Sequence:
    • QVAILRAQNL FFLPYFIYSC ILGLISCSVF LRVNYELKML IMMVALVGYN TILLHTHAHV 
LGDYSQVLFE RPGIWKDLKT MGSVSLSIFF ITLLVLGRQN EYYCRLDFLW KNKFKKEREE 
IETMENLNRV LLENVLPAHV AEHFLARSLK NEELYHQSYD CVCVMFASIP DFKEFYTESD 
VNKEGLECLR LLNEIIADFD DLLSKPKFSG VEKIKTIGST YMAATGLSAV PSQEHSQEPE 
RQYMHIGTMV EFAFALVGKL DAINKHSFND FKLRVGINHG PVIAGVIGAQ KPQYDIWGNT 
VNVASRMDST GVLDKIQVTE ETSLVLQTLG YTCTCRGIIN VKGKGDLKTY FVNTEMSRSL 
SQSNVAS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.