Details for: ADCY2

Gene ID: 108

Symbol: ADCY2

Ensembl ID: ENSG00000078295

Description: adenylate cyclase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 301.9701
    Cell Significance Index: -46.9700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 188.6507
    Cell Significance Index: -47.8500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 43.2472
    Cell Significance Index: -41.2900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 38.1684
    Cell Significance Index: -47.0600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.1286
    Cell Significance Index: -47.8600
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 9.3553
    Cell Significance Index: 130.8200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.3472
    Cell Significance Index: -16.0800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 6.1600
    Cell Significance Index: 158.3400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 6.0145
    Cell Significance Index: 146.7500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 4.2712
    Cell Significance Index: 1532.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 3.0455
    Cell Significance Index: 610.9200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 2.8318
    Cell Significance Index: 80.8100
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 2.7084
    Cell Significance Index: 43.7000
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 2.6403
    Cell Significance Index: 34.2400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.5492
    Cell Significance Index: 1071.4600
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.2455
    Cell Significance Index: 13.8400
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 1.1931
    Cell Significance Index: 15.9200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.1095
    Cell Significance Index: 74.6000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.1038
    Cell Significance Index: 23.6000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.9855
    Cell Significance Index: 24.6400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.8917
    Cell Significance Index: 54.8100
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: 0.7480
    Cell Significance Index: 6.0400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.4691
    Cell Significance Index: 8.1100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.4131
    Cell Significance Index: 777.7800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.2935
    Cell Significance Index: 7.0400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2379
    Cell Significance Index: 214.7700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1936
    Cell Significance Index: 5.4100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1841
    Cell Significance Index: 35.0400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1292
    Cell Significance Index: 82.0500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.1068
    Cell Significance Index: 1.6100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1013
    Cell Significance Index: 2.9200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.0915
    Cell Significance Index: 0.6200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0588
    Cell Significance Index: 26.7100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0054
    Cell Significance Index: 3.3500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0002
    Cell Significance Index: -0.0300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0097
    Cell Significance Index: -17.8100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0196
    Cell Significance Index: -30.1100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0212
    Cell Significance Index: -0.4200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0217
    Cell Significance Index: -29.4600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0241
    Cell Significance Index: -17.8500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0443
    Cell Significance Index: -0.9400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0451
    Cell Significance Index: -4.4700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0508
    Cell Significance Index: -1.0200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0522
    Cell Significance Index: -1.8400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0573
    Cell Significance Index: -32.3300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0580
    Cell Significance Index: -9.4300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0681
    Cell Significance Index: -51.5600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0724
    Cell Significance Index: -32.0200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0730
    Cell Significance Index: -13.1600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0830
    Cell Significance Index: -45.3500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0838
    Cell Significance Index: -1.0400
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.0897
    Cell Significance Index: -0.9900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1068
    Cell Significance Index: -1.5300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.1218
    Cell Significance Index: -13.2500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1249
    Cell Significance Index: -7.0100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1368
    Cell Significance Index: -8.3900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1401
    Cell Significance Index: -3.0400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1405
    Cell Significance Index: -14.6300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1412
    Cell Significance Index: -40.6300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1472
    Cell Significance Index: -29.2100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1539
    Cell Significance Index: -32.4200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1887
    Cell Significance Index: -32.2300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2117
    Cell Significance Index: -6.9300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2301
    Cell Significance Index: -10.4300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.2579
    Cell Significance Index: -15.4800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2647
    Cell Significance Index: -36.3500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2912
    Cell Significance Index: -35.8100
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: -0.3038
    Cell Significance Index: -2.3300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3295
    Cell Significance Index: -3.5900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.3439
    Cell Significance Index: -44.0800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3512
    Cell Significance Index: -45.3700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3515
    Cell Significance Index: -40.2700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.3682
    Cell Significance Index: -25.4700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3865
    Cell Significance Index: -9.6400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3908
    Cell Significance Index: -12.4500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3990
    Cell Significance Index: -46.5000
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.4131
    Cell Significance Index: -5.7900
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.4194
    Cell Significance Index: -4.8000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4245
    Cell Significance Index: -48.4600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4392
    Cell Significance Index: -9.4900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.4407
    Cell Significance Index: -45.0200
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.4437
    Cell Significance Index: -6.7500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5455
    Cell Significance Index: -41.8600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.5943
    Cell Significance Index: -44.2900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.6832
    Cell Significance Index: -7.9700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.6838
    Cell Significance Index: -35.5200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.6911
    Cell Significance Index: -30.0500
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.7235
    Cell Significance Index: -8.7700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7249
    Cell Significance Index: -38.0600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.7277
    Cell Significance Index: -46.9500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7483
    Cell Significance Index: -47.1600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7610
    Cell Significance Index: -26.6600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.7963
    Cell Significance Index: -41.4800
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.8503
    Cell Significance Index: -10.7300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.8521
    Cell Significance Index: -16.6300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.8850
    Cell Significance Index: -18.4700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.9006
    Cell Significance Index: -28.8500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.9147
    Cell Significance Index: -42.9900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.9272
    Cell Significance Index: -43.2300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.9842
    Cell Significance Index: -37.2700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Expression pattern**: ADCY2 is predominantly expressed in interneurons, astrocytes, and skeletal muscle fibers, indicating its involvement in both the central nervous system and peripheral tissues. 2. **Enzymatic activity**: ADCY2 is an adenylate cyclase, an enzyme that catalyzes the conversion of ATP to cyclic AMP (cAMP), a key second messenger in cellular signaling. 3. **Signaling pathways**: ADCY2 is involved in various signaling pathways, including the activation of GABA receptors, the regulation of adenylate cyclase activity, and the production of anti-inflammatory cytokines. 4. **Cellular localization**: ADCY2 is primarily localized to the plasma membrane, where it can interact with G protein-coupled receptors and other signaling molecules. **Pathways and Functions** 1. **GABA receptor activation**: ADCY2 is involved in the activation of GABA receptors, which are a family of ligand-gated ion channels that regulate neurotransmission in the central nervous system. 2. **Adenylate cyclase-activating pathway**: ADCY2 is a key component of the adenylate cyclase-activating pathway, which regulates the production of cAMP in response to various stimuli, including neurotransmitters and hormones. 3. **Anti-inflammatory response**: ADCY2 is involved in the regulation of anti-inflammatory cytokine production, which is crucial for maintaining immune homeostasis and preventing excessive inflammation. 4. **Leishmania parasite infection**: ADCY2 has been implicated in the regulation of Leishmania parasite growth and survival, suggesting its potential role in the development of novel therapeutic strategies against this disease. 5. **Metabolic regulation**: ADCY2 is also involved in the regulation of energy metabolism, including the production of cAMP and the activation of glucagon signaling pathways. **Clinical Significance** 1. **Neurological disorders**: Dysregulation of ADCY2 has been implicated in various neurological disorders, including epilepsy, schizophrenia, and Parkinson's disease. 2. **Inflammatory diseases**: ADCY2 has been shown to play a role in the regulation of inflammatory responses, which is relevant to the development of inflammatory diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Leishmania infection**: Understanding the role of ADCY2 in Leishmania parasite infection may lead to the development of novel therapeutic strategies against this disease. 4. **Metabolic disorders**: Dysregulation of ADCY2 has been implicated in metabolic disorders, including obesity and diabetes, highlighting the potential for ADCY2 as a therapeutic target. In conclusion, the ADCY2 gene encodes for a crucial enzyme involved in the regulation of various cellular processes, including neurotransmission, inflammation, and metabolism. Further research is needed to fully understand the role of ADCY2 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 2995545697

Symbol: ADCY2_HUMAN

Name: Adenylate cyclase type 2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10470851

Title: Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10470851

DOI: 10.1093/dnares/6.3.197

PubMed ID: 1427768

Title: Different chromosomal localization of two adenylyl cyclase genes expressed in human brain.

PubMed ID: 1427768

DOI: 10.1007/bf00210755

PubMed ID: 8476432

Title: A novel adenylyl cyclase sequence cloned from the human erythroleukemia cell line.

PubMed ID: 8476432

DOI: 10.1006/bbrc.1993.1415

PubMed ID: 11549699

Title: Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland.

PubMed ID: 11549699

DOI: 10.1210/jcem.86.9.7837

PubMed ID: 15385642

Title: Raf kinase activation of adenylyl cyclases: isoform-selective regulation.

PubMed ID: 15385642

DOI: 10.1124/mol.66.4.921

PubMed ID: 21228062

Title: Human bronchial smooth muscle cells express adenylyl cyclase isoforms 2, 4, and 6 in distinct membrane microdomains.

PubMed ID: 21228062

DOI: 10.1124/jpet.110.177923

Sequence Information:

  • Length: 1091
  • Mass: 123603
  • Checksum: 41FD8BC607C075D1
  • Sequence:
  • MWQEAMRRRR YLRDRSEEAA GGGDGLPRSR DWLYESYYCM SQQHPLIVFL LLIVMGSCLA 
    LLAVFFALGL EVEDHVAFLI TVPTALAIFF AIFILVCIES VFKKLLRLFS LVIWICLVAM 
    GYLFMCFGGT VSPWDQVSFF LFIIFVVYTM LPFNMRDAII ASVLTSSSHT IVLSVCLSAT 
    PGGKEHLVWQ ILANVIIFIC GNLAGAYHKH LMELALQQTY QDTCNCIKSR IKLEFEKRQQ 
    ERLLLSLLPA HIAMEMKAEI IQRLQGPKAG QMENTNNFHN LYVKRHTNVS ILYADIVGFT 
    RLASDCSPGE LVHMLNELFG KFDQIAKENE CMRIKILGDC YYCVSGLPIS LPNHAKNCVK 
    MGLDMCEAIK KVRDATGVDI NMRVGVHSGN VLCGVIGLQK WQYDVWSHDV TLANHMEAGG 
    VPGRVHISSV TLEHLNGAYK VEEGDGDIRD PYLKQHLVKT YFVINPKGER RSPQHLFRPR 
    HTLDGAKMRA SVRMTRYLES WGAAKPFAHL HHRDSMTTEN GKISTTDVPM GQHNFQNRTL 
    RTKSQKKRFE EELNERMIQA IDGINAQKQW LKSEDIQRIS LLFYNKVLEK EYRATALPAF 
    KYYVTCACLI FFCIFIVQIL VLPKTSVLGI SFGAAFLLLA FILFVCFAGQ LLQCSKKASP 
    LLMWLLKSSG IIANRPWPRI SLTIITTAII LMMAVFNMFF LSDSEETIPP TANTTNTSFS 
    ASNNQVAILR AQNLFFLPYF IYSCILGLIS CSVFLRVNYE LKMLIMMVAL VGYNTILLHT 
    HAHVLGDYSQ VLFERPGIWK DLKTMGSVSL SIFFITLLVL GRQNEYYCRL DFLWKNKFKK 
    EREEIETMEN LNRVLLENVL PAHVAEHFLA RSLKNEELYH QSYDCVCVMF ASIPDFKEFY 
    TESDVNKEGL ECLRLLNEII ADFDDLLSKP KFSGVEKIKT IGSTYMAATG LSAVPSQEHS 
    QEPERQYMHI GTMVEFAFAL VGKLDAINKH SFNDFKLRVG INHGPVIAGV IGAQKPQYDI 
    WGNTVNVASR MDSTGVLDKI QVTEETSLVL QTLGYTCTCR GIINVKGKGD LKTYFVNTEM 
    SRSLSQSNVA S

Genular Protein ID: 971448224

Symbol: Q71UM8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8619474

Title: A "double adaptor" method for improved shotgun library construction.

PubMed ID: 8619474

DOI: 10.1006/abio.1996.0138

PubMed ID: 9110174

Title: Large-scale concatenation cDNA sequencing.

PubMed ID: 9110174

Sequence Information:

  • Length: 367
  • Mass: 41622
  • Checksum: A4D44988A2679601
  • Sequence:
  • QVAILRAQNL FFLPYFIYSC ILGLISCSVF LRVNYELKML IMMVALVGYN TILLHTHAHV 
    LGDYSQVLFE RPGIWKDLKT MGSVSLSIFF ITLLVLGRQN EYYCRLDFLW KNKFKKEREE 
    IETMENLNRV LLENVLPAHV AEHFLARSLK NEELYHQSYD CVCVMFASIP DFKEFYTESD 
    VNKEGLECLR LLNEIIADFD DLLSKPKFSG VEKIKTIGST YMAATGLSAV PSQEHSQEPE 
    RQYMHIGTMV EFAFALVGKL DAINKHSFND FKLRVGINHG PVIAGVIGAQ KPQYDIWGNT 
    VNVASRMDST GVLDKIQVTE ETSLVLQTLG YTCTCRGIIN VKGKGDLKTY FVNTEMSRSL 
    SQSNVAS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.