CGA | ENSG00000135346 | NCBI 1081

Details for: CGA

Gene ID: 1081

Symbol: CGA

Ensembl ID: ENSG00000135346

Description: glycoprotein hormones, alpha polypeptide

Associated with

Androgen biosynthesis
(R-HSA-193048)
Asparagine n-linked glycosylation
(R-HSA-446203)
Class a/1 (rhodopsin-like receptors)
(R-HSA-373076)
G alpha (s) signalling events
(R-HSA-418555)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Glycoprotein hormones
(R-HSA-209822)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Hormone ligand-binding receptors
(R-HSA-375281)
Metabolism
(R-HSA-1430728)
Metabolism of amine-derived hormones
(R-HSA-209776)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of lipids
(R-HSA-556833)
Metabolism of proteins
(R-HSA-392499)
Metabolism of steroid hormones
(R-HSA-196071)
Metabolism of steroids
(R-HSA-8957322)
Mineralocorticoid biosynthesis
(R-HSA-193993)
N-glycan antennae elongation in the medial/trans-golgi
(R-HSA-975576)
Peptide hormone biosynthesis
(R-HSA-209952)
Peptide hormone metabolism
(R-HSA-2980736)
Post-translational protein modification
(R-HSA-597592)
Reactions specific to the complex n-glycan synthesis pathway
(R-HSA-975578)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by gpcr
(R-HSA-372790)
Signal transduction
(R-HSA-162582)
Tfap2 (ap-2) family regulates transcription of growth factors and their receptors
(R-HSA-8866910)
Thyroxine biosynthesis
(R-HSA-209968)
Transcriptional regulation by the ap-2 (tfap2) family of transcription factors
(R-HSA-8864260)
Transport to the golgi and subsequent modification
(R-HSA-948021)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Follicle-stimulating hormone activity
(GO:0016913)
Follicle-stimulating hormone complex
(GO:0016914)
Follicle-stimulating hormone secretion
(GO:0046884)
Follicle-stimulating hormone signaling pathway
(GO:0042699)
Golgi lumen
(GO:0005796)
G protein-coupled receptor signaling pathway
(GO:0007186)
Hormone-mediated signaling pathway
(GO:0009755)
Hormone activity
(GO:0005179)
Luteinizing hormone secretion
(GO:0032275)
Negative regulation of organ growth
(GO:0046621)
Organ growth
(GO:0035265)
Pituitary gonadotropin complex
(GO:0061696)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of steroid biosynthetic process
(GO:0010893)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Regulation of signaling receptor activity
(GO:0010469)
Thyroid gland development
(GO:0030878)
Thyroid hormone generation
(GO:0006590)

Other Information

Proteins

Glycoprotein hormones alpha chain
A0A087WYZ4_HUMAN

Genular Protein ID: 3294534032

Symbol: GLHA_HUMAN

Name: Glycoprotein hormones alpha chain

UniProtKB Accession Codes:

P01215

Database IDs:

Citations:

PubMed ID: 481597

Title: Isolation, cloning and sequence analysis of the cDNA for the alpha-subunit of human chorionic gonadotropin.

PubMed ID: 481597

DOI: 10.1038/281351a0

PubMed ID: 8196184

Title: Structure and regulation of human thyroid-stimulating hormone (TSH) gene.

PubMed ID: 8196184

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6286817

Title: The gene encoding the common alpha subunit of the four human glycoprotein hormones.

PubMed ID: 6286817

PubMed ID: 7462224

Title: The amino acid sequences of the prepeptides contained in the alpha and beta subunits of human choriogonadotropin.

PubMed ID: 7462224

DOI: 10.1016/s0021-9258(19)69881-9

PubMed ID: 890569

Title: Human pituitary thyrotropin. The primary structure of the alpha and beta subunits.

PubMed ID: 890569

DOI: 10.1139/o77-108

PubMed ID: 5065401

Title: Human pituitary interstitial cell stimulating hormone: primary structure of the alpha-subunit.

PubMed ID: 5065401

DOI: 10.1016/0006-291x(72)90380-4

PubMed ID: 1158880

Title: Primary amino acid sequence of follicle-stimulating hormone from human pituitary glands. I. alpha subunit.

PubMed ID: 1158880

DOI: 10.1016/s0021-9258(19)40994-0

PubMed ID: 4835135

Title: Human follicle stimulating hormone (hFSH): first proposal for the amino acid sequence of the alpha-subunit (hFSHa) and first demonstration of its identity with the alpha-subunit of human luteinizing hormone (hLHa).

PubMed ID: 4835135

DOI: 10.1210/jcem-39-1-199

PubMed ID: 1150658

Title: The amino acid sequence of human chorionic gonadotropin. The alpha subunit and beta subunit.

PubMed ID: 1150658

DOI: 10.1016/s0021-9258(19)41303-3

PubMed ID: 4745444

Title: Human chorionic gonadotropin. Linear amino acid sequence of the alpha subunit.

PubMed ID: 4745444

DOI: 10.1016/s0021-9258(19)43424-8

PubMed ID: 6774759

Title: Studies on the disulfide bonds in human pituitary follicle-stimulating hormone.

PubMed ID: 6774759

DOI: 10.1016/0005-2795(80)90084-7

PubMed ID: 7410374

Title: Assignment of disulfide bonds in the alpha subunit of human chorionic gonadotropin.

PubMed ID: 7410374

DOI: 10.1016/s0021-9258(18)43527-2

PubMed ID: 1991473

Title: NMR investigations of the N-linked oligosaccharides at individual glycosylation sites of human lutropin.

PubMed ID: 1991473

DOI: 10.1111/j.1432-1033.1991.tb15702.x

PubMed ID: 2494176

Title: Expression of biologically active human follitropin in Chinese hamster ovary cells.

PubMed ID: 2494176

DOI: 10.1016/s0021-9258(18)83656-0

PubMed ID: 8202136

Title: Crystal structure of human chorionic gonadotropin.

PubMed ID: 8202136

DOI: 10.1038/369455a0

PubMed ID: 8898911

Title: NMR studies of the free alpha subunit of human chorionic gonadotropin. Structural influences of N-glycosylation and the beta subunit on the conformation of the alpha subunit.

PubMed ID: 8898911

DOI: 10.1111/j.1432-1033.1996.0229t.x

PubMed ID: 15662415

Title: Structure of human follicle-stimulating hormone in complex with its receptor.

PubMed ID: 15662415

DOI: 10.1038/nature03206

PubMed ID: 24692546

Title: Evidence for follicle-stimulating hormone receptor as a functional trimer.

PubMed ID: 24692546

DOI: 10.1074/jbc.m114.549592

Sequence Information:

Length: 116
Mass: 13075
Checksum: F0623CD8CC90CFCD
Sequence:

MDYYRKYAAI FLVTLSVFLH VLHSAPDVQD CPECTLQENP FFSQPGAPIL QCMGCCFSRA 
YPTPLRSKKT MLVQKNVTSE STCCVAKSYN RVTVMGGFKV ENHTACHCST CYYHKS

Genular Protein ID: 2593547026

Symbol: A0A087WYZ4_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087WYZ4

Database IDs:

Citations:

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

Sequence Information:

Length: 147
Mass: 16306
Checksum: AEE3CD031FEF95AE
Sequence:

MDYYRKYAAI FLVTLSVFLH VLHSAPDVQE TGFHHVAQAA LKLLSSSNPP TKASQSARIT 
DCPECTLQEN PFFSQPGAPI LQCMGCCFSR AYPTPLRSKK TMLVQKNVTS ESTCCVAKSY 
NRVTVMGGFK VENHTACHCS TCYYHKS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CGA

Associated with

Other Information

Isolation, cloning and sequence analysis of the cDNA for the alpha-subunit of human chorionic gonadotropin. PubMed ID: 481597

Structure and regulation of human thyroid-stimulating hormone (TSH) gene. PubMed ID: 8196184

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The gene encoding the common alpha subunit of the four human glycoprotein hormones. PubMed ID: 6286817

The amino acid sequences of the prepeptides contained in the alpha and beta subunits of human choriogonadotropin. PubMed ID: 7462224

Human pituitary thyrotropin. The primary structure of the alpha and beta subunits. PubMed ID: 890569

Human pituitary interstitial cell stimulating hormone: primary structure of the alpha-subunit. PubMed ID: 5065401

Primary amino acid sequence of follicle-stimulating hormone from human pituitary glands. I. alpha subunit. PubMed ID: 1158880

Human follicle stimulating hormone (hFSH): first proposal for the amino acid sequence of the alpha-subunit (hFSHa) and first demonstration of its identity with the alpha-subunit of human luteinizing hormone (hLHa). PubMed ID: 4835135

The amino acid sequence of human chorionic gonadotropin. The alpha subunit and beta subunit. PubMed ID: 1150658

Human chorionic gonadotropin. Linear amino acid sequence of the alpha subunit. PubMed ID: 4745444

Studies on the disulfide bonds in human pituitary follicle-stimulating hormone. PubMed ID: 6774759

Assignment of disulfide bonds in the alpha subunit of human chorionic gonadotropin. PubMed ID: 7410374

NMR investigations of the N-linked oligosaccharides at individual glycosylation sites of human lutropin. PubMed ID: 1991473

Expression of biologically active human follitropin in Chinese hamster ovary cells. PubMed ID: 2494176

Crystal structure of human chorionic gonadotropin. PubMed ID: 8202136

NMR studies of the free alpha subunit of human chorionic gonadotropin. Structural influences of N-glycosylation and the beta subunit on the conformation of the alpha subunit. PubMed ID: 8898911

Structure of human follicle-stimulating hormone in complex with its receptor. PubMed ID: 15662415

Evidence for follicle-stimulating hormone receptor as a functional trimer. PubMed ID: 24692546

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404