WASF3 | ENSG00000132970 | NCBI 10810

Details for: WASF3

Gene ID: 10810

Symbol: WASF3

Ensembl ID: ENSG00000132970

Description: WASP family member 3

Associated with

Disease
(R-HSA-1643685)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Rac1 gtpase cycle
(R-HSA-9013149)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Rho gtpase cycle
(R-HSA-9012999)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate wasps and waves
(R-HSA-5663213)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by vegf
(R-HSA-194138)
Signal transduction
(R-HSA-162582)
Vegfa-vegfr2 pathway
(R-HSA-4420097)
Actin binding
(GO:0003779)
Actin cytoskeleton organization
(GO:0030036)
Actin filament polymerization
(GO:0030041)
Arp2/3 complex binding
(GO:0071933)
Cytoskeleton
(GO:0005856)
Cytoskeleton organization
(GO:0007010)
Extracellular exosome
(GO:0070062)
Glial cell projection
(GO:0097386)
Glutamatergic synapse
(GO:0098978)
Lamellipodium
(GO:0030027)
Lamellipodium assembly
(GO:0030032)
Modification of postsynaptic actin cytoskeleton
(GO:0098885)
Oligodendrocyte development
(GO:0014003)
Positive regulation of arp2/3 complex-mediated actin nucleation
(GO:2000601)
Positive regulation of myelination
(GO:0031643)
Postsynapse
(GO:0098794)
Protein-containing complex assembly
(GO:0065003)
Protein kinase a regulatory subunit binding
(GO:0034237)
Regulation of cell shape
(GO:0008360)
Scar complex
(GO:0031209)

Other Information

Proteins

Protein WAVE-3

Genular Protein ID: 981512741

Symbol: WASF3_HUMAN

Name: Protein WAVE-3

UniProtKB Accession Codes:

Q9UPY6 O94974 Q86VQ2

Database IDs:

Citations:

PubMed ID: 10381382

Title: Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex.

PubMed ID: 10381382

DOI: 10.1006/bbrc.1999.0894

PubMed ID: 12856283

Title: Genomic organization and expression profile of the human and mouse WAVE gene family.

PubMed ID: 12856283

DOI: 10.1007/s00335-002-2247-7

PubMed ID: 10048485

Title: Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10048485

DOI: 10.1093/dnares/5.6.355

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17623672

Title: c-Abl-mediated phosphorylation of WAVE3 is required for lamellipodia formation and cell migration.

PubMed ID: 17623672

DOI: 10.1074/jbc.m701484200

PubMed ID: 21834987

Title: Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration.

PubMed ID: 21834987

DOI: 10.1186/1741-7007-9-54

Sequence Information:

Length: 502
Mass: 55293
Checksum: C0655CE181BD3C57
Sequence:

MPLVKRNIEP RHLCRGALPE GITSELECVT NSTLAAIIRQ LSSLSKHAED IFGELFNEAN 
NFYIRANSLQ DRIDRLAVKV TQLDSTVEEV SLQDINMKKA FKSSTVQDQQ VVSKNSIPNP 
VADIYNQSDK PPPLNILTPY RDDKKDGLKF YTDPSYFFDL WKEKMLQDTE DKRKEKRRQK 
EQKRIDGTTR EVKKVRKARN RRQEWNMMAY DKELRPDNRL SQSVYHGASS EGSLSPDTRS 
HASDVTDYSY PATPNHSLHP QPVTPSYAAG DVPPHGPASQ AAEHEYRPPS ASARHMALNR 
PQQPPPPPPP QAPEGSQASA PMAPADYGML PAQIIEYYNP SGPPPPPPPP VIPSAQTAFV 
SPLQMPMQPP FPASASSTHA APPHPPSTGL LVTAPPPPGP PPPPPGPPGP GSSLSSSPMH 
GPPVAEAKRQ EPAQPPISDA RSDLLAAIRM GIQLKKVQEQ REQEAKREPV GNDVATILSR 
RIAVEYSDSD DDSEFDENDW SD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: WASF3

Associated with

Other Information

Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex. PubMed ID: 10381382

Genomic organization and expression profile of the human and mouse WAVE gene family. PubMed ID: 12856283

Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. PubMed ID: 10048485

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. PubMed ID: 12168954

The DNA sequence and analysis of human chromosome 13. PubMed ID: 15057823

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

c-Abl-mediated phosphorylation of WAVE3 is required for lamellipodia formation and cell migration. PubMed ID: 17623672

Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration. PubMed ID: 21834987