CPLX1 | ENSG00000168993 | NCBI 10815

Details for: CPLX1

Gene ID: 10815

Symbol: CPLX1

Ensembl ID: ENSG00000168993

Description: complexin 1

Associated with

Acetylcholine neurotransmitter release cycle
(R-HSA-264642)
Dopamine neurotransmitter release cycle
(R-HSA-212676)
Gaba synthesis, release, reuptake and degradation
(R-HSA-888590)
Glutamate neurotransmitter release cycle
(R-HSA-210500)
Neuronal system
(R-HSA-112316)
Neurotransmitter release cycle
(R-HSA-112310)
Norepinephrine neurotransmitter release cycle
(R-HSA-181430)
Serotonin neurotransmitter release cycle
(R-HSA-181429)
Transmission across chemical synapses
(R-HSA-112315)
Calyx of held
(GO:0044305)
Chemical synaptic transmission
(GO:0007268)
Cytosol
(GO:0005829)
Exocytosis
(GO:0006887)
Glutamatergic synapse
(GO:0098978)
Insulin secretion
(GO:0030073)
Neurotransmitter transmembrane transporter activity
(GO:0005326)
Perikaryon
(GO:0043204)
Postsynapse
(GO:0098794)
Protein binding
(GO:0005515)
Regulation of exocytic insertion of neurotransmitter receptor to postsynaptic membrane
(GO:0099145)
Regulation of exocytosis
(GO:0017157)
Regulation of neurotransmitter secretion
(GO:0046928)
Regulation of synaptic vesicle fusion to presynaptic active zone membrane
(GO:0031630)
Schaffer collateral - ca1 synapse
(GO:0098685)
Snare binding
(GO:0000149)
Snare complex
(GO:0031201)
Synaptic vesicle exocytosis
(GO:0016079)
Synaptobrevin 2-snap-25-syntaxin-3-complexin complex
(GO:0070554)
Syntaxin binding
(GO:0019905)
Terminal bouton
(GO:0043195)

Other Information

Proteins

Complexin-1

Genular Protein ID: 3779919991

Symbol: CPLX1_HUMAN

Name: Complexin-1

UniProtKB Accession Codes:

O14810 A6NI80 B2R4R5 D3DVN3 F1T0G1

Database IDs:

Citations:

PubMed ID: 7553862

Title: Complexins: cytosolic proteins that regulate SNAP receptor function.

PubMed ID: 7553862

DOI: 10.1016/0092-8674(95)90239-2

PubMed ID: 24722188

Title: Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.

PubMed ID: 24722188

DOI: 10.1038/ncomms4650

PubMed ID: 21697133

Title: Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method.

PubMed ID: 21697133

DOI: 10.1167/iovs.11-7479

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9853440

Title: Preferential involvement of excitatory neurons in medial temporal lobe in schizophrenia.

PubMed ID: 9853440

DOI: 10.1016/s0140-6736(98)03341-8

PubMed ID: 11483314

Title: Cerebellar synaptic protein expression in schizophrenia.

PubMed ID: 11483314

DOI: 10.1016/s0306-4522(01)00141-5

PubMed ID: 15526345

Title: Proteome analysis of human substantia nigra in Parkinson's disease.

PubMed ID: 15526345

DOI: 10.1002/pmic.200400848

PubMed ID: 26539891

Title: Genes that affect brain structure and function identified by rare variant analyses of mendelian neurologic disease.

PubMed ID: 26539891

DOI: 10.1016/j.neuron.2015.09.048

PubMed ID: 28422131

Title: Variants in CPLX1 in two families with autosomal-recessive severe infantile myoclonic epilepsy and ID.

PubMed ID: 28422131

DOI: 10.1038/ejhg.2017.52

PubMed ID: 21785414

Title: Complexin cross-links prefusion SNAREs into a zigzag array.

PubMed ID: 21785414

DOI: 10.1038/nsmb.2101

Sequence Information:

Length: 134
Mass: 15030
Checksum: A7A52F17F10D28A4
Sequence:

MEFVMKQALG GATKDMGKML GGDEEKDPDA AKKEEERQEA LRQAEEERKA KYAKMEAERE 
AVRQGIRDKY GIKKKEEREA EAQAAMEANS EGSLTRPKKA IPPGCGDEVE EEDESILDTV 
IKYLPGPLQD MLKK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CPLX1

Associated with

Other Information

Complexins: cytosolic proteins that regulate SNAP receptor function. PubMed ID: 7553862

Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. PubMed ID: 24722188

Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. PubMed ID: 21697133

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Preferential involvement of excitatory neurons in medial temporal lobe in schizophrenia. PubMed ID: 9853440

Cerebellar synaptic protein expression in schizophrenia. PubMed ID: 11483314

Proteome analysis of human substantia nigra in Parkinson's disease. PubMed ID: 15526345

Genes that affect brain structure and function identified by rare variant analyses of mendelian neurologic disease. PubMed ID: 26539891

Variants in CPLX1 in two families with autosomal-recessive severe infantile myoclonic epilepsy and ID. PubMed ID: 28422131

Complexin cross-links prefusion SNAREs into a zigzag array. PubMed ID: 21785414