FRS2 | ENSG00000166225 | NCBI 10818

Details for: FRS2

Gene ID: 10818

Symbol: FRS2

Ensembl ID: ENSG00000166225

Description: fibroblast growth factor receptor substrate 2

Associated with

Activated ntrk2 signals through frs2 and frs3
(R-HSA-9028731)
Axon guidance
(R-HSA-422475)
Constitutive signaling by aberrant pi3k in cancer
(R-HSA-2219530)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Downstream signaling of activated fgfr1
(R-HSA-5654687)
Downstream signaling of activated fgfr2
(R-HSA-5654696)
Downstream signaling of activated fgfr3
(R-HSA-5654708)
Downstream signaling of activated fgfr4
(R-HSA-5654716)
Frs-mediated fgfr1 signaling
(R-HSA-5654693)
Frs-mediated fgfr2 signaling
(R-HSA-5654700)
Frs-mediated fgfr3 signaling
(R-HSA-5654706)
Frs-mediated fgfr4 signaling
(R-HSA-5654712)
Frs2-mediated activation
(R-HSA-170968)
Igf1r signaling cascade
(R-HSA-2428924)
Insulin receptor signalling cascade
(R-HSA-74751)
Intracellular signaling by second messengers
(R-HSA-9006925)
Irs-mediated signalling
(R-HSA-112399)
Irs-related events triggered by igf1r
(R-HSA-2428928)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Negative regulation of fgfr1 signaling
(R-HSA-5654726)
Negative regulation of fgfr2 signaling
(R-HSA-5654727)
Negative regulation of fgfr3 signaling
(R-HSA-5654732)
Negative regulation of fgfr4 signaling
(R-HSA-5654733)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Nervous system development
(R-HSA-9675108)
Pi-3k cascade:fgfr1
(R-HSA-5654689)
Pi-3k cascade:fgfr2
(R-HSA-5654695)
Pi-3k cascade:fgfr3
(R-HSA-5654710)
Pi-3k cascade:fgfr4
(R-HSA-5654720)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pi3k cascade
(R-HSA-109704)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pip3 activates akt signaling
(R-HSA-1257604)
Prolonged erk activation events
(R-HSA-169893)
Raf/map kinase cascade
(R-HSA-5673001)
Ret signaling
(R-HSA-8853659)
Rho gtpase cycle
(R-HSA-9012999)
Rnd1 gtpase cycle
(R-HSA-9696273)
Rnd2 gtpase cycle
(R-HSA-9696270)
Signaling by alk
(R-HSA-201556)
Signaling by alk fusions and activated point mutants
(R-HSA-9725370)
Signaling by alk in cancer
(R-HSA-9700206)
Signaling by fgfr
(R-HSA-190236)
Signaling by fgfr1
(R-HSA-5654736)
Signaling by fgfr1 in disease
(R-HSA-5655302)
Signaling by fgfr2
(R-HSA-5654738)
Signaling by fgfr2 in disease
(R-HSA-5655253)
Signaling by fgfr3
(R-HSA-5654741)
Signaling by fgfr3 in disease
(R-HSA-5655332)
Signaling by fgfr4
(R-HSA-5654743)
Signaling by fgfr4 in disease
(R-HSA-5655291)
Signaling by fgfr in disease
(R-HSA-1226099)
Signaling by insulin receptor
(R-HSA-74752)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrk2 (trkb)
(R-HSA-9006115)
Signaling by ntrks
(R-HSA-166520)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
(R-HSA-2404192)
Signalling to erks
(R-HSA-187687)
Signal transduction
(R-HSA-162582)
Adherens junction
(GO:0005912)
Anterior/posterior axis specification, embryo
(GO:0008595)
Cell-cell junction
(GO:0005911)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Endomembrane system
(GO:0012505)
Fibroblast growth factor receptor binding
(GO:0005104)
Fibroblast growth factor receptor signaling pathway
(GO:0008543)
Forebrain development
(GO:0030900)
Gastrulation with mouth forming second
(GO:0001702)
G protein-coupled receptor signaling pathway
(GO:0007186)
Lens fiber cell development
(GO:0070307)
Lens placode formation involved in camera-type eye formation
(GO:0046619)
Membrane
(GO:0016020)
Negative regulation of cardiac muscle cell differentiation
(GO:2000726)
Neuroblast proliferation
(GO:0007405)
Neurotrophin trka receptor binding
(GO:0005168)
Organ induction
(GO:0001759)
Phosphatase activator activity
(GO:0019211)
Plasma membrane
(GO:0005886)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of vascular associated smooth muscle cell proliferation
(GO:1904707)
Prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
(GO:0060527)
Protein binding
(GO:0005515)
Regulation of apoptotic process
(GO:0042981)
Regulation of epithelial cell proliferation
(GO:0050678)
Regulation of erk1 and erk2 cascade
(GO:0070372)
Transmembrane receptor protein tyrosine kinase adaptor activity
(GO:0005068)
Transmembrane receptor protein tyrosine phosphatase signaling pathway
(GO:0007185)
Ventricular septum development
(GO:0003281)

Other Information

Proteins

Fibroblast growth factor receptor substrate 2

Genular Protein ID: 1488068848

Symbol: FRS2_HUMAN

Name: Fibroblast growth factor receptor substrate 2

UniProtKB Accession Codes:

Q8WU20 B0LPF2 B2R684 O43558 Q7LDQ6

Database IDs:

Citations:

PubMed ID: 9660748

Title: Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins.

PubMed ID: 9660748

DOI: 10.1074/jbc.273.29.17987

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10092678

Title: The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation.

PubMed ID: 10092678

DOI: 10.1074/jbc.274.14.9861

PubMed ID: 12974390

Title: EGFR and FGFR signaling through FRS2 is subject to negative feedback control by ERK1/2.

PubMed ID: 12974390

DOI: 10.1515/bc.2003.134

PubMed ID: 15488758

Title: TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma.

PubMed ID: 15488758

DOI: 10.1016/j.ccr.2004.09.011

PubMed ID: 17274988

Title: ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation.

PubMed ID: 17274988

DOI: 10.1016/j.febslet.2007.01.039

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21765395

Title: Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function.

PubMed ID: 21765395

DOI: 10.1038/emboj.2011.234

PubMed ID: 18452557

Title: Regulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins.

PubMed ID: 18452557

DOI: 10.1111/j.1349-7006.2008.00840.x

PubMed ID: 20094046

Title: Fibroblast growth factor signalling: from development to cancer.

PubMed ID: 20094046

DOI: 10.1038/nrc2780

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 11090629

Title: Structural basis of SNT PTB domain interactions with distinct neurotrophic receptors.

PubMed ID: 11090629

DOI: 10.1016/s1097-2765(05)00087-0

Sequence Information:

Length: 508
Mass: 57029
Checksum: 833714EE12097C75
Sequence:

MGSCCSCPDK DTVPDNHRNK FKVINVDDDG NELGSGIMEL TDTELILYTR KRDSVKWHYL 
CLRRYGYDSN LFSFESGRRC QTGQGIFAFK CARAEELFNM LQEIMQNNSI NVVEEPVVER 
NNHQTELEVP RTPRTPTTPG FAAQNLPNGY PRYPSFGDAS SHPSSRHPSV GSARLPSVGE 
ESTHPLLVAE EQVHTYVNTT GVQEERKNRT SVHVPLEARV SNAESSTPKE EPSSIEDRDP 
QILLEPEGVK FVLGPTPVQK QLMEKEKLEQ LGRDQVSGSG ANNTEWDTGY DSDERRDAPS 
VNKLVYENIN GLSIPSASGV RRGRLTSTST SDTQNINNSA QRRTALLNYE NLPSLPPVWE 
ARKLSRDEDD NLGPKTPSLN GYHNNLDPMH NYVNTENVTV PASAHKIEYS RRRDCTPTVF 
NFDIRRPSLE HRQLNYIQVD LEGGSDSDNP QTPKTPTTPL PQTPTRRTEL YAVIDIERTA 
AMSNLQKALP RDDGTSRKTR HNSTDLPM

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: FRS2

Associated with

Other Information

Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins. PubMed ID: 9660748

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The finished DNA sequence of human chromosome 12. PubMed ID: 16541075

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation. PubMed ID: 10092678

EGFR and FGFR signaling through FRS2 is subject to negative feedback control by ERK1/2. PubMed ID: 12974390

TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma. PubMed ID: 15488758

ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation. PubMed ID: 17274988

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function. PubMed ID: 21765395

Regulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins. PubMed ID: 18452557

Fibroblast growth factor signalling: from development to cancer. PubMed ID: 20094046

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Structural basis of SNT PTB domain interactions with distinct neurotrophic receptors. PubMed ID: 11090629