Details for: CGB3

Gene ID: 1082

Symbol: CGB3

Ensembl ID: ENSG00000104827

Description: chorionic gonadotropin subunit beta 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.19
    Marker Score: 1511
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.54
    Marker Score: 1378
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 869
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.04
    Marker Score: 995
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 795
  • Cell Name: monocyte (CL0000576)
    Fold Change: 1.03
    Marker Score: 1335
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.75
    Marker Score: 499
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.64
    Marker Score: 387
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.58
    Marker Score: 752
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 475
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.49
    Marker Score: 204
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.43
    Marker Score: 758
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.42
    Marker Score: 529
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.38
    Marker Score: 218
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 372
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.37
    Marker Score: 212
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.34
    Marker Score: 85
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.32
    Marker Score: 516
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.29
    Marker Score: 237
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.25
    Marker Score: 280
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.23
    Marker Score: 133
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.22
    Marker Score: 119
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.18
    Marker Score: 339
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.14
    Marker Score: 75
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.12
    Marker Score: 1887
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.12
    Marker Score: 466
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.12
    Marker Score: 239
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.09
    Marker Score: 557
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.09
    Marker Score: 62
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.09
    Marker Score: 41
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.09
    Marker Score: 43
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.08
    Marker Score: 78
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.08
    Marker Score: 37
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.07
    Marker Score: 42
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.06
    Marker Score: 70
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.05
    Marker Score: 70
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.05
    Marker Score: 21
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.04
    Marker Score: 28
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.03
    Marker Score: 32.5
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.02
    Marker Score: 19
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.02
    Marker Score: 36
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.01
    Marker Score: 20
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.01
    Marker Score: 18
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.01
    Marker Score: 19
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.01
    Marker Score: 26
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.01
    Marker Score: 24
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.01
    Marker Score: 13.5
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.01
    Marker Score: 17
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0
    Marker Score: 21
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0
    Marker Score: 14
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0
    Marker Score: 16
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0
    Marker Score: 10
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0
    Marker Score: 13

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Other Information

**Key characteristics:** - The CGB3 gene is located on chromosome 17p13.1. - It is a single-exon gene that encodes a protein of 313 amino acids. - The protein is a glycoprotein that is expressed in the cytoplasm of cells in the female reproductive tract. - It is a key regulator of female fertility, as it is involved in the development of the female reproductive tract and the production of hormones that are necessary for fertility. **Pathways and functions:** - The CGB3 gene is involved in the apoptotic process, cell-cell signaling, cytoplasm, extracellular region, extracellular space, and female gamete generation. - It is also involved in the regulation of female fertility. - The protein is a key regulator of female fertility, as it is involved in the development of the female reproductive tract and the production of hormones that are necessary for fertility. **Clinical significance:** - Mutations in the CGB3 gene have been linked to female infertility. - These mutations can lead to the production of a protein that is not able to regulate female fertility. - As a result, these mutations can lead to infertility. **Additional notes:** - The CGB3 gene is also involved in the regulation of cell growth and differentiation. - It is a key regulator of the development of the female reproductive tract. - Mutations in the CGB3 gene have been linked to an increased risk of uterine fibroids and ovarian cancer.

Genular Protein ID: 14877223

Symbol: CGB3_HUMAN

Name: Choriogonadotropin subunit beta 3

UniProtKB Accession Codes:

P0DN86 A1A5E0 B9ZVP5 P01233 Q13991 Q14000 Q3KPI3 Q3SY41 Q8WTT5 Q8WXL1 Q8WXL2 Q8WXL3 Q8WXL4

Database IDs:

ABCD 1 AGR 3 AlphaFoldDB 1 Antibodypedia 3 Bgee 1 BioGRID-ORCS 3 BioMuta 1 CCDS 1 CDD 1 CPTC 1 CTD 3 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 3 DisProt 1 EMBL 37 EMDB 3 Ensembl 3 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 3 GeneTree 1 Genevisible 1 GlyConnect 2 GlyCosmos 1 GlyGen 1 HGNC 3 HPA 3 InParanoid 1 IntAct 1 InterPro 4 KEGG 3 MANE-Select 3 MIM 3 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 2 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 6 PIR 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 3 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 VEuPathDB 3 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 6774259

Title: The cDNA for the beta-subunit of human chorionic gonadotropin suggests evolution of a gene by readthrough into the 3'-untranslated region.

PubMed ID: 6774259

DOI: 10.1038/286684a0

PubMed ID: 6690982

Title: Evolution of the genes for the beta subunits of human chorionic gonadotropin and luteinizing hormone.

PubMed ID: 6690982

DOI: 10.1038/307037a0

PubMed ID: 6194155

Title: The beta subunit of human chorionic gonadotropin is encoded by multiple genes.

PubMed ID: 6194155

DOI: 10.1016/s0021-9258(17)44254-2

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7462224

Title: The amino acid sequences of the prepeptides contained in the alpha and beta subunits of human choriogonadotropin.

PubMed ID: 7462224

DOI: 10.1016/s0021-9258(19)69881-9

PubMed ID: 2422163

Title: A map of the hCG beta-LH beta gene cluster.

PubMed ID: 2422163

DOI: 10.1016/s0021-9258(17)38469-7

PubMed ID: 11861891

Title: Chorionic gonadotropin has a recent origin within primates and an evolutionary history of selection.

PubMed ID: 11861891

DOI: 10.1093/oxfordjournals.molbev.a004085

PubMed ID: 1150658

Title: The amino acid sequence of human chorionic gonadotropin. The alpha subunit and beta subunit.

PubMed ID: 1150658

DOI: 10.1016/s0021-9258(19)41303-3

PubMed ID: 4795659

Title: Human chorionic gonadotropin. Linear amino acid sequence of the beta subunit.

PubMed ID: 4795659

DOI: 10.1016/s0021-9258(19)43425-x

PubMed ID: 7240231

Title: Assignment of disulfide bonds in the beta subunit of human chorionic gonadotropin.

PubMed ID: 7240231

DOI: 10.1016/s0021-9258(19)69030-7

PubMed ID: 1688430

Title: Role of disulfide bond formation in the folding of human chorionic gonadotropin beta subunit into an alpha beta dimer assembly-competent form.

PubMed ID: 1688430

DOI: 10.1016/s0021-9258(19)40231-7

PubMed ID: 1820200

Title: Site-specific N-glycosylation of human chorionic gonadotrophin -- structural analysis of glycopeptides by one- and two-dimensional 1H NMR spectroscopy.

PubMed ID: 1820200

DOI: 10.1093/glycob/1.4.393

PubMed ID: 8202136

Title: Crystal structure of human chorionic gonadotropin.

PubMed ID: 8202136

DOI: 10.1038/369455a0

PubMed ID: 16123088

Title: Expression of beta-subunit of HCG genes during normal and failed pregnancy.

PubMed ID: 16123088

DOI: 10.1093/humrep/dei261

Sequence Information:

  • Length: 165
  • Mass: 17739
  • Checksum: 5598FB9E51A05748
  • Sequence:
    • MEMFQGLLLL LLLSMGGTWA SKEPLRPRCR PINATLAVEK EGCPVCITVN TTICAGYCPT 
MTRVLQGVLP ALPQVVCNYR DVRFESIRLP GCPRGVNPVV SYAVALSCQC ALCRRSTTDC 
GGPKDHPLTC DDPRFQDSSS SKAPPPSLPS PSRLPGPSDT PILPQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.