Details for: CGB3

Gene ID: 1082

Symbol: CGB3

Ensembl ID: ENSG00000104827

Description: chorionic gonadotropin subunit beta 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.4813
    Cell Significance Index: 4.9100
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0740
    Cell Significance Index: 0.9000
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.0443
    Cell Significance Index: 0.4800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0025
    Cell Significance Index: -0.0200
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0041
    Cell Significance Index: -0.0300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0056
    Cell Significance Index: -0.1500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0162
    Cell Significance Index: -8.8500
  • Cell Name: colon endothelial cell (CL1001572)
    Fold Change: -0.0387
    Cell Significance Index: -0.0300
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1545
    Cell Significance Index: -1.8500
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.1950
    Cell Significance Index: -1.9300
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.2250
    Cell Significance Index: -2.5200
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.2522
    Cell Significance Index: -1.5000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.2780
    Cell Significance Index: -55.7600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3125
    Cell Significance Index: -8.3600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3362
    Cell Significance Index: -8.8400
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.3385
    Cell Significance Index: -3.6400
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.3959
    Cell Significance Index: -3.7600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4389
    Cell Significance Index: -7.3500
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.5124
    Cell Significance Index: -6.6300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.5379
    Cell Significance Index: -7.8100
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.6376
    Cell Significance Index: -7.9700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.6543
    Cell Significance Index: -16.6700
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.6694
    Cell Significance Index: -8.2800
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.7125
    Cell Significance Index: -5.3800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.7221
    Cell Significance Index: -9.9000
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.7445
    Cell Significance Index: -8.6500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.7910
    Cell Significance Index: -10.1300
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.8754
    Cell Significance Index: -11.5200
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.8932
    Cell Significance Index: -5.5500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.9122
    Cell Significance Index: -14.7800
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.9213
    Cell Significance Index: -10.8400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.9752
    Cell Significance Index: -16.6700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.0264
    Cell Significance Index: -53.3200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -1.0390
    Cell Significance Index: -25.9500
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -1.0581
    Cell Significance Index: -10.1300
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -1.0838
    Cell Significance Index: -11.5300
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -1.1408
    Cell Significance Index: -14.9700
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -1.1518
    Cell Significance Index: -13.2600
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -1.1552
    Cell Significance Index: -11.5300
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -1.1996
    Cell Significance Index: -11.5300
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -1.2000
    Cell Significance Index: -14.9800
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -1.2326
    Cell Significance Index: -11.5300
  • Cell Name: monocyte (CL0000576)
    Fold Change: -1.2449
    Cell Significance Index: -14.3300
  • Cell Name: basal cell (CL0000646)
    Fold Change: -1.2580
    Cell Significance Index: -14.9700
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -1.2603
    Cell Significance Index: -14.9800
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -1.2675
    Cell Significance Index: -14.9800
  • Cell Name: neural cell (CL0002319)
    Fold Change: -1.2840
    Cell Significance Index: -14.9800
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -1.2861
    Cell Significance Index: -11.4500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -1.2999
    Cell Significance Index: -10.6000
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -1.3182
    Cell Significance Index: -11.5300
  • Cell Name: B cell (CL0000236)
    Fold Change: -1.3375
    Cell Significance Index: -15.8100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -1.3581
    Cell Significance Index: -12.7500
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -1.3646
    Cell Significance Index: -14.9800
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -1.4283
    Cell Significance Index: -20.8900
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -1.5057
    Cell Significance Index: -16.6700
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -1.5185
    Cell Significance Index: -14.9800
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -1.5787
    Cell Significance Index: -14.8500
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -1.5992
    Cell Significance Index: -14.8900
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -1.6309
    Cell Significance Index: -14.9800
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -1.6545
    Cell Significance Index: -16.6700
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -1.6898
    Cell Significance Index: -18.7200
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -1.7002
    Cell Significance Index: -14.9800
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -1.7136
    Cell Significance Index: -14.9800
  • Cell Name: macrophage (CL0000235)
    Fold Change: -1.7396
    Cell Significance Index: -17.7600
  • Cell Name: respiratory hillock cell (CL4030023)
    Fold Change: -1.7547
    Cell Significance Index: -16.6600
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -1.8300
    Cell Significance Index: -25.3800
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -1.8790
    Cell Significance Index: -14.9500
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -1.9120
    Cell Significance Index: -15.8200
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -1.9894
    Cell Significance Index: -25.9700
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -2.1249
    Cell Significance Index: -25.8300
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -2.1516
    Cell Significance Index: -11.5200
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -2.1521
    Cell Significance Index: -25.9600
  • Cell Name: T cell (CL0000084)
    Fold Change: -2.1962
    Cell Significance Index: -25.9300
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -2.2251
    Cell Significance Index: -25.8100
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -2.2324
    Cell Significance Index: -20.4300
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -2.4041
    Cell Significance Index: -25.3600
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -2.4081
    Cell Significance Index: -29.6000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -2.4281
    Cell Significance Index: -14.6700
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -2.5288
    Cell Significance Index: -26.1600
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -2.5339
    Cell Significance Index: -25.8900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -2.5355
    Cell Significance Index: -54.7800
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: -2.6740
    Cell Significance Index: -16.5100
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -2.7427
    Cell Significance Index: -13.1200
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -3.1908
    Cell Significance Index: -33.8900
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -3.2082
    Cell Significance Index: -34.2600
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -3.2314
    Cell Significance Index: -14.9200
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: -3.3704
    Cell Significance Index: -26.0300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -3.3731
    Cell Significance Index: -49.8000
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: -3.5122
    Cell Significance Index: -34.7200
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -3.6114
    Cell Significance Index: -40.3500
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -3.7224
    Cell Significance Index: -44.9300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -3.9110
    Cell Significance Index: -42.6100
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -3.9265
    Cell Significance Index: -40.8600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -3.9671
    Cell Significance Index: -79.1100
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -3.9745
    Cell Significance Index: -48.3500
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -4.1312
    Cell Significance Index: -41.9400
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: -4.1779
    Cell Significance Index: -26.1600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -4.9854
    Cell Significance Index: -79.9800
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -4.9961
    Cell Significance Index: -58.7400
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: -5.0184
    Cell Significance Index: -43.1700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CGB3 is a beta subunit of the chorionic gonadotropin hormone, which is composed of two alpha subunits and three beta subunits. The beta subunit is responsible for the hormone's biological activity, and CGB3 is the only beta subunit expressed in humans. The CGB3 gene is located on chromosome 19q13.3 and is highly conserved across species, suggesting its importance in reproductive physiology. The gene is also expressed in various immune cells, where it may play a role in regulating immune responses. **Pathways and Functions** CGB3 is involved in several biological pathways, including: 1. **Apoptotic process**: CGB3 has been shown to induce apoptosis in certain cell types, suggesting its role in regulating cell death. 2. **Cell-cell signaling**: CGB3 can interact with other proteins to regulate cell-cell signaling, including the activation of G protein-coupled receptors. 3. **Hormone-mediated signaling**: CGB3 plays a crucial role in the regulation of hormone-mediated signaling pathways, including the pituitary gonadotropin complex. 4. **Transcriptional regulation**: CGB3 can regulate the expression of genes involved in growth factor signaling, including the Tfap2 family of transcription factors. The functions of CGB3 are not fully understood, but it is thought to play a role in regulating reproductive physiology, including: 1. **Pregnancy maintenance**: CGB3 may play a role in maintaining pregnancy by regulating the expression of genes involved in implantation and trophoblast differentiation. 2. **Reproductive hormone regulation**: CGB3 may regulate the expression of genes involved in reproductive hormone production, including the gonadotropins. 3. **Immune regulation**: CGB3 may play a role in regulating immune responses, including the activation of immune cells such as dendritic cells and natural killer cells. **Clinical Significance** The clinical significance of CGB3 is not well understood, but it may play a role in several diseases, including: 1. **Reproductive disorders**: Abnormal expression of CGB3 may contribute to reproductive disorders, including infertility and miscarriage. 2. **Immune disorders**: Abnormal expression of CGB3 may contribute to immune disorders, including autoimmune diseases and transplant rejection. 3. **Cancer**: CGB3 may play a role in cancer development and progression, particularly in reproductive cancers such as choriocarcinoma. In conclusion, CGB3 is an important gene that plays a crucial role in reproductive physiology and immune regulation. Further research is needed to fully understand the functions and clinical significance of CGB3.

Genular Protein ID: 14877223

Symbol: CGB3_HUMAN

Name: Choriogonadotropin subunit beta 3

UniProtKB Accession Codes:

P0DN86 A1A5E0 B9ZVP5 P01233 Q13991 Q14000 Q3KPI3 Q3SY41 Q8WTT5 Q8WXL1 Q8WXL2 Q8WXL3 Q8WXL4

Database IDs:

ABCD 1 AGR 3 AlphaFoldDB 1 Antibodypedia 3 Bgee 1 BioGRID-ORCS 3 BioMuta 1 CCDS 1 CDD 1 CPTC 1 CTD 3 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 3 DisProt 1 EMBL 37 EMDB 3 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 3 GeneTree 1 GlyConnect 2 GlyCosmos 1 GlyGen 1 HGNC 3 HPA 3 InParanoid 1 IntAct 1 InterPro 4 KEGG 3 MANE-Select 3 MIM 3 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 2 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 3 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 VEuPathDB 3 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 6774259

Title: The cDNA for the beta-subunit of human chorionic gonadotropin suggests evolution of a gene by readthrough into the 3'-untranslated region.

PubMed ID: 6774259

DOI: 10.1038/286684a0

PubMed ID: 6690982

Title: Evolution of the genes for the beta subunits of human chorionic gonadotropin and luteinizing hormone.

PubMed ID: 6690982

DOI: 10.1038/307037a0

PubMed ID: 6194155

Title: The beta subunit of human chorionic gonadotropin is encoded by multiple genes.

PubMed ID: 6194155

DOI: 10.1016/s0021-9258(17)44254-2

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7462224

Title: The amino acid sequences of the prepeptides contained in the alpha and beta subunits of human choriogonadotropin.

PubMed ID: 7462224

DOI: 10.1016/s0021-9258(19)69881-9

PubMed ID: 2422163

Title: A map of the hCG beta-LH beta gene cluster.

PubMed ID: 2422163

DOI: 10.1016/s0021-9258(17)38469-7

PubMed ID: 11861891

Title: Chorionic gonadotropin has a recent origin within primates and an evolutionary history of selection.

PubMed ID: 11861891

DOI: 10.1093/oxfordjournals.molbev.a004085

PubMed ID: 1150658

Title: The amino acid sequence of human chorionic gonadotropin. The alpha subunit and beta subunit.

PubMed ID: 1150658

DOI: 10.1016/s0021-9258(19)41303-3

PubMed ID: 4795659

Title: Human chorionic gonadotropin. Linear amino acid sequence of the beta subunit.

PubMed ID: 4795659

DOI: 10.1016/s0021-9258(19)43425-x

PubMed ID: 7240231

Title: Assignment of disulfide bonds in the beta subunit of human chorionic gonadotropin.

PubMed ID: 7240231

DOI: 10.1016/s0021-9258(19)69030-7

PubMed ID: 1688430

Title: Role of disulfide bond formation in the folding of human chorionic gonadotropin beta subunit into an alpha beta dimer assembly-competent form.

PubMed ID: 1688430

DOI: 10.1016/s0021-9258(19)40231-7

PubMed ID: 1820200

Title: Site-specific N-glycosylation of human chorionic gonadotrophin -- structural analysis of glycopeptides by one- and two-dimensional 1H NMR spectroscopy.

PubMed ID: 1820200

DOI: 10.1093/glycob/1.4.393

PubMed ID: 8202136

Title: Crystal structure of human chorionic gonadotropin.

PubMed ID: 8202136

DOI: 10.1038/369455a0

PubMed ID: 16123088

Title: Expression of beta-subunit of HCG genes during normal and failed pregnancy.

PubMed ID: 16123088

DOI: 10.1093/humrep/dei261

Sequence Information:

  • Length: 165
  • Mass: 17739
  • Checksum: 5598FB9E51A05748
  • Sequence:
    • MEMFQGLLLL LLLSMGGTWA SKEPLRPRCR PINATLAVEK EGCPVCITVN TTICAGYCPT 
MTRVLQGVLP ALPQVVCNYR DVRFESIRLP GCPRGVNPVV SYAVALSCQC ALCRRSTTDC 
GGPKDHPLTC DDPRFQDSSS SKAPPPSLPS PSRLPGPSDT PILPQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.