Details for: DIAPH2 AS1

Gene ID: 10824

Symbol: DIAPH2 AS1

Ensembl ID: ENSG00000236256

Description: DIAPH2 antisense RNA 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 4.4
    Marker Score: 58,477
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 4.17
    Marker Score: 25,069
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 4.06
    Marker Score: 3,894
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 3.44
    Marker Score: 29,065
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1,169
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.57
    Marker Score: 919
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169,804
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.41
    Marker Score: 508
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.39
    Marker Score: 2,643
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.37
    Marker Score: 768
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 870
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.34
    Marker Score: 678
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 855
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 489
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4,808
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.12
    Marker Score: 7,417
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1
    Marker Score: 505
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.09
    Marker Score: 1,345
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 797
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.02
    Marker Score: 6,212
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,813
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,037
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 511
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.99
    Marker Score: 2,013
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.99
    Marker Score: 1,527
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 464
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.95
    Marker Score: 1,044
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 376
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.93
    Marker Score: 295
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,292
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 328
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.89
    Marker Score: 422
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.88
    Marker Score: 1,928
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.87
    Marker Score: 3,102
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.83
    Marker Score: 262
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.82
    Marker Score: 18,414
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.82
    Marker Score: 1,490
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.81
    Marker Score: 3,410
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,262
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.78
    Marker Score: 467
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.73
    Marker Score: 362
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 464
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 181
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.71
    Marker Score: 343
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.69
    Marker Score: 199
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.69
    Marker Score: 289
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.68
    Marker Score: 10,692
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.67
    Marker Score: 372
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.67
    Marker Score: 441
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.65
    Marker Score: 189
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.64
    Marker Score: 259
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.62
    Marker Score: 657
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.61
    Marker Score: 1,550
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.59
    Marker Score: 470
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.58
    Marker Score: 395
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.58
    Marker Score: 924
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 235
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.56
    Marker Score: 176
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.53
    Marker Score: 255
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.52
    Marker Score: 633
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.51
    Marker Score: 441
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.5
    Marker Score: 237
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 477
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.48
    Marker Score: 128
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.48
    Marker Score: 122
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.47
    Marker Score: 129
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.44
    Marker Score: 27,165
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.43
    Marker Score: 738
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.42
    Marker Score: 1,132
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.41
    Marker Score: 414
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.41
    Marker Score: 550
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.4
    Marker Score: 363
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.4
    Marker Score: 498
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4
    Marker Score: 398
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.4
    Marker Score: 764
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.38
    Marker Score: 249
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 374
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.36
    Marker Score: 126
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.36
    Marker Score: 106
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.36
    Marker Score: 327
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.34
    Marker Score: 143
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.34
    Marker Score: 564
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.33
    Marker Score: 360
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.33
    Marker Score: 1,180
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.33
    Marker Score: 124
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.32
    Marker Score: 65
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.32
    Marker Score: 185
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.31
    Marker Score: 109
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.31
    Marker Score: 114
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.3
    Marker Score: 87
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.29
    Marker Score: 128
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.29
    Marker Score: 171
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.28
    Marker Score: 315
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.28
    Marker Score: 394
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.27
    Marker Score: 262

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DIAPH2 AS1 is a 3' untranslated region (UTR) antisense RNA transcript that is significantly expressed in various cell types, including cardiac muscle cells, fibroblasts, and immune cells. Its expression is tissue-specific, with notable presence in tissues involved in immune regulation, such as the retina and colon. Unlike its parent gene, DIAPH2, which is primarily involved in actin cytoskeleton regulation, DIAPH2 AS1 lacks a coding potential and does not share any known functional domains. This suggests that DIAPH2 AS1 may play a distinct role in regulating gene expression and cellular behavior. **Pathways and Functions:** The pathways and functions of DIAPH2 AS1 are not yet fully elucidated, but several lines of evidence suggest that it plays a crucial role in regulating cellular signaling and immune responses. Studies have shown that DIAPH2 AS1 is involved in the regulation of signal transduction pathways, including those involved in cell proliferation, differentiation, and survival. In the context of immune regulation, DIAPH2 AS1 has been implicated in the modulation of immune cell function, including the regulation of T cell activation and cytokine production. Furthermore, its expression in retinal cells suggests a role in regulating photoreceptor function and visual processing. **Clinical Significance:** While the clinical significance of DIAPH2 AS1 is still largely unknown, its expression in various tissues and its involvement in immune regulation and cellular signaling suggest that it may play a role in the pathogenesis of certain diseases. For example, its dysregulation has been implicated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, where immune cell dysfunction is a hallmark of the disease. Additionally, its expression in cardiac tissue suggests a potential role in heart disease, where dysregulation of cardiac cell function is a major contributor to morbidity and mortality. In conclusion, DIAPH2 AS1 is a non-coding RNA transcript that plays a crucial role in regulating cellular signaling and immune responses. Its tissue-specific expression and involvement in various cellular processes suggest that it may have significant clinical implications in human health and disease. Further research is needed to fully elucidate the functions and clinical significance of DIAPH2 AS1, but its discovery highlights the importance of non-coding RNAs in regulating cellular behavior and disease. **Future Directions:** Future studies should focus on elucidating the molecular mechanisms underlying the functions of DIAPH2 AS1, including its role in regulating signal transduction pathways and immune cell function. Additionally, its clinical significance should be further investigated, including its potential role in autoimmune diseases, heart disease, and other conditions where immune regulation and cellular signaling are dysregulated.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.