Details for: NEU3

Gene ID: 10825

Symbol: NEU3

Ensembl ID: ENSG00000162139

Description: neuraminidase 3

Associated with

Other Information

Genular Protein ID: 2302048401

Symbol: NEUR3_HUMAN

Name: Sialidase-3

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10405317

Title: Cloning, expression, and chromosomal mapping of a human ganglioside sialidase.

PubMed ID: 10405317

DOI: 10.1006/bbrc.1999.0973

PubMed ID: 10861246

Title: Identification and expression of NEU3, a novel human sialidase associated to the plasma membrane.

PubMed ID: 10861246

DOI: 10.1042/0264-6021:3490343

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11298736

Title: Site-directed mutagenesis of human membrane-associated ganglioside sialidase: identification of amino-acid residues contributing to substrate specificity.

PubMed ID: 11298736

DOI: 10.1046/j.1432-1327.2001.02069.x

PubMed ID: 12011038

Title: A close association of the ganglioside-specific sialidase Neu3 with caveolin in membrane microdomains.

PubMed ID: 12011038

DOI: 10.1074/jbc.m110515200

PubMed ID: 15847605

Title: Evidence for mitochondrial localization of a novel human sialidase (NEU4).

PubMed ID: 15847605

DOI: 10.1042/bj20050017

PubMed ID: 17708748

Title: Sialidase NEU3 is a peripheral membrane protein localized on the cell surface and in endosomal structures.

PubMed ID: 17708748

DOI: 10.1042/bj20070503

PubMed ID: 17334392

Title: A crucial role of plasma membrane-associated sialidase in the survival of human cancer cells.

PubMed ID: 17334392

DOI: 10.1038/sj.onc.1210341

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 20511247

Title: Insight into substrate recognition and catalysis by the human neuraminidase 3 (NEU3) through molecular modeling and site-directed mutagenesis.

PubMed ID: 20511247

DOI: 10.1093/glycob/cwq077

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 26251452

Title: Role of plasma-membrane-bound sialidase NEU3 in clathrin-mediated endocytosis.

PubMed ID: 26251452

DOI: 10.1042/bj20141550

PubMed ID: 25922362

Title: NEU3 activity enhances EGFR activation without affecting EGFR expression and acts on its sialylation levels.

PubMed ID: 25922362

DOI: 10.1093/glycob/cwv026

PubMed ID: 28646141

Title: Human Sialidase Neu3 is S-Acylated and Behaves Like an Integral Membrane Protein.

PubMed ID: 28646141

DOI: 10.1038/s41598-017-04488-w

Sequence Information:

  • Length: 428
  • Mass: 48252
  • Checksum: 35D1DD9359A78C98
  • Sequence:
  • MEEVTTCSFN SPLFRQEDDR GITYRIPALL YIPPTHTFLA FAEKRSTRRD EDALHLVLRR 
    GLRIGQLVQW GPLKPLMEAT LPGHRTMNPC PVWEQKSGCV FLFFICVRGH VTERQQIVSG 
    RNAARLCFIY SQDAGCSWSE VRDLTEEVIG SELKHWATFA VGPGHGIQLQ SGRLVIPAYT 
    YYIPSWFFCF QLPCKTRPHS LMIYSDDLGV TWHHGRLIRP MVTVECEVAE VTGRAGHPVL 
    YCSARTPNRC RAEALSTDHG EGFQRLALSR QLCEPPHGCQ GSVVSFRPLE IPHRCQDSSS 
    KDAPTIQQSS PGSSLRLEEE AGTPSESWLL YSHPTSRKQR VDLGIYLNQT PLEAACWSRP 
    WILHCGPCGY SDLAALEEEG LFGCLFECGT KQECEQIAFR LFTHREILSH LQGDCTSPGR 
    NPSQFKSN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.