Details for: NPM1P17

Gene ID: 10830

Symbol: NPM1P17

Ensembl ID: ENSG00000242070

Description: nucleophosmin 1 pseudogene 17

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location:** NPM1P17 is located on chromosome 1, a region that is also home to several other genes involved in immune regulation. 2. **Expression:** NPM1P17 is significantly expressed in neurons, monocytes, plasma cells, and stromal cells, suggesting its involvement in immune cell development and function. 3. **Pseudogenic status:** NPM1P17 is a pseudogene, meaning it does not encode a protein and does not have a known function. However, its expression in immune cells suggests that it may have a regulatory role. 4. **Sequence similarity:** NPM1P17 shares a high degree of sequence similarity with NPM1, the well-studied gene involved in cell cycle regulation and apoptosis. **Pathways and Functions:** The functional mechanisms underlying NPM1P17 are not yet fully understood. However, based on its expression in immune cells and its sequence similarity to NPM1, it is possible that NPM1P17 regulates immune cell development and function through the following pathways: 1. **Cell cycle regulation:** NPM1P17 may regulate the cell cycle in immune cells, influencing their proliferation and differentiation. 2. **Apoptosis:** NPM1P17 may also regulate apoptosis in immune cells, influencing their lifespan and function. 3. **Gene expression:** NPM1P17 may regulate the expression of genes involved in immune cell development and function, including genes involved in cytokine production and immune cell activation. 4. **Epigenetic regulation:** NPM1P17 may also regulate epigenetic marks on the genome, influencing the expression of genes involved in immune cell development and function. **Clinical Significance:** The discovery of NPM1P17 highlights the complexity of immune regulation and the importance of non-coding pseudogenes in immune cell development and function. Further investigation into the functions and pathways regulated by NPM1P17 is warranted to fully appreciate its significance in the immune system. Potential applications of NPM1P17 research include: 1. **Cancer immunotherapy:** Understanding the role of NPM1P17 in immune cell regulation may lead to the development of new cancer immunotherapies that target specific immune cell populations. 2. **Autoimmune disease:** NPM1P17 may play a role in the development of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, and understanding its function may lead to the development of new therapies. 3. **Immunodeficiency disorders:** NPM1P17 may also play a role in immunodeficiency disorders, such as severe combined immunodeficiency (SCID), and understanding its function may lead to the development of new treatments. In conclusion, the discovery of NPM1P17 highlights the complexity of immune regulation and the importance of non-coding pseudogenes in immune cell development and function. Further investigation into the functions and pathways regulated by NPM1P17 is warranted to fully appreciate its significance in the immune system and to explore its potential applications in cancer immunotherapy, autoimmune disease, and immunodeficiency disorders.

Database document:

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