Details for: CEACAM3

Gene ID: 1084

Symbol: CEACAM3

Ensembl ID: ENSG00000170956

Description: CEA cell adhesion molecule 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 3.0911
    Cell Significance Index: -1.5900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.0582
    Cell Significance Index: 30.8400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.7648
    Cell Significance Index: 108.2000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5788
    Cell Significance Index: 110.1400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3972
    Cell Significance Index: 8.4600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3339
    Cell Significance Index: 33.0300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2831
    Cell Significance Index: 255.6600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2309
    Cell Significance Index: 25.1200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1716
    Cell Significance Index: 27.9200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1557
    Cell Significance Index: 2.2300
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.1552
    Cell Significance Index: 1.0300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1256
    Cell Significance Index: 8.6900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0904
    Cell Significance Index: 4.1000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0572
    Cell Significance Index: 0.8300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0432
    Cell Significance Index: 0.5900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0427
    Cell Significance Index: 0.7900
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0285
    Cell Significance Index: 0.4000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0232
    Cell Significance Index: 0.3900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0217
    Cell Significance Index: 0.4700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0139
    Cell Significance Index: 0.4500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0066
    Cell Significance Index: 0.1900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0023
    Cell Significance Index: 0.0800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.0019
    Cell Significance Index: 0.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0005
    Cell Significance Index: -0.9300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0006
    Cell Significance Index: -1.1300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0007
    Cell Significance Index: -1.0600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0008
    Cell Significance Index: -1.1300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0016
    Cell Significance Index: -0.0400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0016
    Cell Significance Index: -0.0400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0018
    Cell Significance Index: -0.9800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0020
    Cell Significance Index: -1.4900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0021
    Cell Significance Index: -0.2600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0023
    Cell Significance Index: -0.0900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0024
    Cell Significance Index: -1.5500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0032
    Cell Significance Index: -1.4600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0032
    Cell Significance Index: -1.1400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0044
    Cell Significance Index: -0.1100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0048
    Cell Significance Index: -0.8700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0050
    Cell Significance Index: -0.9900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0054
    Cell Significance Index: -1.0900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0055
    Cell Significance Index: -0.9400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0074
    Cell Significance Index: -0.3700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0077
    Cell Significance Index: -1.0600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0087
    Cell Significance Index: -0.1800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0100
    Cell Significance Index: -1.4600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0110
    Cell Significance Index: -1.2600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0111
    Cell Significance Index: -0.4800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0116
    Cell Significance Index: -1.1900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0117
    Cell Significance Index: -1.2200
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0141
    Cell Significance Index: -0.1500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0145
    Cell Significance Index: -0.4100
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0148
    Cell Significance Index: -0.1800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0162
    Cell Significance Index: -1.2400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0172
    Cell Significance Index: -0.4400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0193
    Cell Significance Index: -0.9000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0198
    Cell Significance Index: -1.2200
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0206
    Cell Significance Index: -0.2600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0216
    Cell Significance Index: -1.4500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0226
    Cell Significance Index: -0.3100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0243
    Cell Significance Index: -1.5700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0244
    Cell Significance Index: -0.4200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0269
    Cell Significance Index: -1.5100
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0273
    Cell Significance Index: -0.4000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0288
    Cell Significance Index: -0.9100
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0293
    Cell Significance Index: -0.4400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0303
    Cell Significance Index: -0.4900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0332
    Cell Significance Index: -1.4700
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0336
    Cell Significance Index: -0.4900
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0339
    Cell Significance Index: -0.4400
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0354
    Cell Significance Index: -0.4700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0359
    Cell Significance Index: -0.8700
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.0365
    Cell Significance Index: -0.3500
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0371
    Cell Significance Index: -0.4800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0371
    Cell Significance Index: -1.0100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0377
    Cell Significance Index: -1.3200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0379
    Cell Significance Index: -1.2400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0386
    Cell Significance Index: -1.2300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0386
    Cell Significance Index: -1.4600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0389
    Cell Significance Index: -0.7600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0391
    Cell Significance Index: -0.7800
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0428
    Cell Significance Index: -0.8700
  • Cell Name: urothelial cell (CL0000731)
    Fold Change: -0.0430
    Cell Significance Index: -0.3000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0433
    Cell Significance Index: -0.7400
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.0438
    Cell Significance Index: -0.3600
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0440
    Cell Significance Index: -0.4700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0444
    Cell Significance Index: -0.5000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0447
    Cell Significance Index: -1.1400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0456
    Cell Significance Index: -0.8900
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0458
    Cell Significance Index: -0.6100
  • Cell Name: immature neutrophil (CL0000776)
    Fold Change: -0.0459
    Cell Significance Index: -0.3500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0478
    Cell Significance Index: -1.2200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0489
    Cell Significance Index: -0.8300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0494
    Cell Significance Index: -1.3200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0506
    Cell Significance Index: -1.4900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0509
    Cell Significance Index: -1.2700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0511
    Cell Significance Index: -0.7700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0522
    Cell Significance Index: -1.4900
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0530
    Cell Significance Index: -0.6400
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0539
    Cell Significance Index: -0.6200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0561
    Cell Significance Index: -1.3700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CEACAM3 is a transmembrane glycoprotein with a molecular weight of approximately 40 kDa. It belongs to the immunoglobulin superfamily and is characterized by its ability to bind to various ligands, including proteins, lipids, and carbohydrates. CEACAM3 is expressed on the surface of various cell types, including epithelial cells, immune cells, and neurons. Its expression is tightly regulated, and its dysregulation has been linked to several diseases. **Pathways and Functions:** CEACAM3 is involved in multiple signaling pathways, including: 1. **Cell surface interactions**: CEACAM3 interacts with various ligands, including ICAM-1, VCAM-1, and CD14, to regulate cell adhesion, migration, and signaling. 2. **Hemostasis**: CEACAM3 plays a role in regulating platelet activation, aggregation, and adhesion, which are critical processes in hemostasis. 3. **Immune system regulation**: CEACAM3 is involved in the regulation of immune responses, including the activation of immune cells, such as neutrophils and macrophages. 4. **Neutrophil degranulation**: CEACAM3 is involved in the regulation of neutrophil degranulation, which is a critical process in the elimination of pathogens. 5. **Signal transduction**: CEACAM3 can act as a signaling molecule, transmitting signals from the cell surface to the cytoplasm and nucleus. **Clinical Significance:** Dysregulation of CEACAM3 has been implicated in various diseases, including: 1. **Cancer**: CEACAM3 is overexpressed in several types of cancer, including colon, breast, and lung cancer. 2. **Autoimmune disorders**: CEACAM3 is involved in the regulation of immune responses and has been implicated in autoimmune disorders, such as multiple sclerosis and rheumatoid arthritis. 3. **Neurological conditions**: CEACAM3 is expressed in the brain and has been implicated in neurological conditions, such as Alzheimer's disease and Parkinson's disease. 4. **Infectious diseases**: CEACAM3 is involved in the regulation of immune responses and has been implicated in infectious diseases, such as tuberculosis and malaria. In conclusion, CEACAM3 is a multifaceted gene that plays a critical role in the regulation of the immune system and cellular adhesion. Its dysregulation has been implicated in various diseases, and further research is needed to fully understand its role in human health and disease.

Genular Protein ID: 1130629216

Symbol: CEAM3_HUMAN

Name: Carcinoembryonic antigen-related cell adhesion molecule 3

UniProtKB Accession Codes:

P40198 G5E978 Q3KPH9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 4 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 3 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2050678

Title: Molecular cloning of nonspecific cross-reacting antigens in human granulocytes.

PubMed ID: 2050678

DOI: 10.1016/s0021-9258(18)99029-0

PubMed ID: 8508798

Title: Genomic organization, splice variants and expression of CGM1, a CD66-related member of the carcinoembryonic antigen gene family.

PubMed ID: 8508798

DOI: 10.1111/j.1432-1033.1993.tb17892.x

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1427854

Title: Identification of three new genes and estimation of the size of the carcinoembryonic antigen family.

PubMed ID: 1427854

DOI: 10.1016/s0888-7543(05)80230-7

PubMed ID: 11708798

Title: The microbial receptor CEACAM3 is linked to the calprotectin complex in granulocytes.

PubMed ID: 11708798

DOI: 10.1006/bbrc.2001.5955

PubMed ID: 12864848

Title: Immunoreceptor tyrosine-based activation motif phosphorylation during engulfment of Neisseria gonorrhoeae by the neutrophil-restricted CEACAM3 (CD66d) receptor.

PubMed ID: 12864848

DOI: 10.1046/j.1365-2958.2003.03591.x

PubMed ID: 14707113

Title: Granulocyte CEACAM3 is a phagocytic receptor of the innate immune system that mediates recognition and elimination of human-specific pathogens.

PubMed ID: 14707113

DOI: 10.1084/jem.20030204

Sequence Information:

  • Length: 252
  • Mass: 27091
  • Checksum: 179F0C51C6A062A1
  • Sequence:
    • MGPPSASPHR ECIPWQGLLL TASLLNFWNP PTTAKLTIES MPLSVAEGKE VLLLVHNLPQ 
HLFGYSWYKG ERVDGNSLIV GYVIGTQQAT PGAAYSGRET IYTNASLLIQ NVTQNDIGFY 
TLQVIKSDLV NEEATGQFHV YQENAPGLPV GAVAGIVTGV LVGVALVAAL VCFLLLAKTG 
RTSIQRDLKE QQPQALAPGR GPSHSSAFSM SPLSTAQAPL PNPRTAASIY EELLKHDTNI 
YCRMDHKAEV AS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.