Details for: CEACAM3

Gene ID: 1084

Symbol: CEACAM3

Ensembl ID: ENSG00000170956

Description: CEA cell adhesion molecule 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1173.5
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 858.5
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 490
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7682
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4818.5
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 1.02
    Marker Score: 473
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71831
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48056
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 512
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 465
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.98
    Marker Score: 1352
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.94
    Marker Score: 1915
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 376
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5351
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 328
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.82
    Marker Score: 629.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 465
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.65
    Marker Score: 394
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 459
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.57
    Marker Score: 399
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 175
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.54
    Marker Score: 175
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.51
    Marker Score: 962
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.48
    Marker Score: 200
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 280
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.42
    Marker Score: 405
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.37
    Marker Score: 216.5
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.37
    Marker Score: 720
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.37
    Marker Score: 213
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.37
    Marker Score: 105
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.36
    Marker Score: 5710
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.34
    Marker Score: 834.5
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.33
    Marker Score: 192
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.33
    Marker Score: 332
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.33
    Marker Score: 142
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.32
    Marker Score: 193
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.3
    Marker Score: 201
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.3
    Marker Score: 715
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.25
    Marker Score: 92
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.24
    Marker Score: 152
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.24
    Marker Score: 124.5
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.23
    Marker Score: 129
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.22
    Marker Score: 110
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.2
    Marker Score: 204
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.19
    Marker Score: 200
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.19
    Marker Score: 56
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.19
    Marker Score: 484
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.18
    Marker Score: 764
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.16
    Marker Score: 337
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.16
    Marker Score: 74
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.15
    Marker Score: 37
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.13
    Marker Score: 130
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.13
    Marker Score: 204
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.12
    Marker Score: 115
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.12
    Marker Score: 80
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.12
    Marker Score: 62
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.11
    Marker Score: 50
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.11
    Marker Score: 57
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1
    Marker Score: 5702
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.09
    Marker Score: 61
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.09
    Marker Score: 32
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.09
    Marker Score: 80
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.09
    Marker Score: 40
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.09
    Marker Score: 1004
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.09
    Marker Score: 52
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.09
    Marker Score: 147
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.08
    Marker Score: 54
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.08
    Marker Score: 86
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.08
    Marker Score: 73
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.07
    Marker Score: 92
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.07
    Marker Score: 199.5
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.07
    Marker Score: 39
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.07
    Marker Score: 1795
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.07
    Marker Score: 98
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.07
    Marker Score: 68
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.07
    Marker Score: 30
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: colon macrophage (CL0009038)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.06
    Marker Score: 68
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.06
    Marker Score: 60
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.06
    Marker Score: 24
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.06
    Marker Score: 65

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Other Information

**Key characteristics:** * CEACAM3 is a transmembrane protein with a molecular weight of approximately 120 kDa. * It is expressed on a variety of cell types, including epithelial cells, endothelial cells, and immune cells. * It is a member of the cadherin family of cell adhesion molecules. * It is involved in cell-cell adhesion, cell migration, and angiogenesis. **Pathways and functions:** * CEACAM3 is involved in cell-cell adhesion by binding to cadherins on neighboring cells. * It is also involved in cell migration by binding to extracellular matrix proteins and guiding cells along the extracellular matrix. * It is involved in angiogenesis by promoting the migration of endothelial cells and the formation of new blood vessels. * It is also involved in immune responses, where it helps to regulate the migration and adhesion of immune cells to the vascular wall. **Clinical significance:** * Mutations in CEACAM3 have been linked to several human diseases, including colorectal cancer, inflammatory bowel disease, and vascular diseases. * By understanding the role of CEACAM3 in cancer and inflammation, it may be possible to develop new therapies to treat these diseases. **Additional information:** * CEACAM3 is a relatively new protein, with the first sequence being identified in 2001. * It is a highly conserved protein, with similar sequences found in animals. * It is expressed in high levels in normal colon and small intestine, but its expression is often increased in cancer cells.

Genular Protein ID: 1130629216

Symbol: CEAM3_HUMAN

Name: Carcinoembryonic antigen-related cell adhesion molecule 3

UniProtKB Accession Codes:

P40198 G5E978 Q3KPH9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 4 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 4 PIR 3 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 2 RefSeq 2 SAM 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2050678

Title: Molecular cloning of nonspecific cross-reacting antigens in human granulocytes.

PubMed ID: 2050678

DOI: 10.1016/s0021-9258(18)99029-0

PubMed ID: 8508798

Title: Genomic organization, splice variants and expression of CGM1, a CD66-related member of the carcinoembryonic antigen gene family.

PubMed ID: 8508798

DOI: 10.1111/j.1432-1033.1993.tb17892.x

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1427854

Title: Identification of three new genes and estimation of the size of the carcinoembryonic antigen family.

PubMed ID: 1427854

DOI: 10.1016/s0888-7543(05)80230-7

PubMed ID: 11708798

Title: The microbial receptor CEACAM3 is linked to the calprotectin complex in granulocytes.

PubMed ID: 11708798

DOI: 10.1006/bbrc.2001.5955

PubMed ID: 12864848

Title: Immunoreceptor tyrosine-based activation motif phosphorylation during engulfment of Neisseria gonorrhoeae by the neutrophil-restricted CEACAM3 (CD66d) receptor.

PubMed ID: 12864848

DOI: 10.1046/j.1365-2958.2003.03591.x

PubMed ID: 14707113

Title: Granulocyte CEACAM3 is a phagocytic receptor of the innate immune system that mediates recognition and elimination of human-specific pathogens.

PubMed ID: 14707113

DOI: 10.1084/jem.20030204

Sequence Information:

  • Length: 252
  • Mass: 27091
  • Checksum: 179F0C51C6A062A1
  • Sequence:
    • MGPPSASPHR ECIPWQGLLL TASLLNFWNP PTTAKLTIES MPLSVAEGKE VLLLVHNLPQ 
HLFGYSWYKG ERVDGNSLIV GYVIGTQQAT PGAAYSGRET IYTNASLLIQ NVTQNDIGFY 
TLQVIKSDLV NEEATGQFHV YQENAPGLPV GAVAGIVTGV LVGVALVAAL VCFLLLAKTG 
RTSIQRDLKE QQPQALAPGR GPSHSSAFSM SPLSTAQAPL PNPRTAASIY EELLKHDTNI 
YCRMDHKAEV AS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.