CLPX | ENSG00000166855 | NCBI 10845

Details for: CLPX

Gene ID: 10845

Symbol: CLPX

Ensembl ID: ENSG00000166855

Description: caseinolytic mitochondrial matrix peptidase chaperone subunit X

Associated with

Metabolism of proteins
(R-HSA-392499)
Mitochondrial protein degradation
(R-HSA-9837999)
Atp-dependent peptidase activity
(GO:0004176)
Atp-dependent protein folding chaperone
(GO:0140662)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Atp metabolic process
(GO:0046034)
Cytosol
(GO:0005829)
Endopeptidase clp complex
(GO:0009368)
Mitochondrial endopeptidase clp complex
(GO:0009841)
Mitochondrial inner membrane
(GO:0005743)
Mitochondrial matrix
(GO:0005759)
Mitochondrial nucleoid
(GO:0042645)
Mitochondrion
(GO:0005739)
Nucleoplasm
(GO:0005654)
Peptidase activator activity
(GO:0016504)
Protein binding
(GO:0005515)
Protein dimerization activity
(GO:0046983)
Protein folding
(GO:0006457)
Proteolysis
(GO:0006508)
Proteolysis involved in protein catabolic process
(GO:0051603)
Unfolded protein binding
(GO:0051082)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial

Genular Protein ID: 2366398277

Symbol: CLPX_HUMAN

Name: ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial

UniProtKB Accession Codes:

O76031 A1L428 A8K8F1 B9EGI8 Q9H4D9

Database IDs:

Citations:

PubMed ID: 11003706

Title: Human and mouse mitochondrial orthologs of bacterial ClpX.

PubMed ID: 11003706

DOI: 10.1007/s003350010173

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11923310

Title: Functional proteolytic complexes of the human mitochondrial ATP-dependent protease, hClpXP.

PubMed ID: 11923310

DOI: 10.1074/jbc.m201642200

PubMed ID: 15522782

Title: Crystallography and mutagenesis point to an essential role for the N-terminus of human mitochondrial ClpP.

PubMed ID: 15522782

DOI: 10.1016/j.jsb.2004.07.004

PubMed ID: 16115876

Title: Human mitochondrial ClpP is a stable heptamer that assembles into a tetradecamer in the presence of ClpX.

PubMed ID: 16115876

DOI: 10.1074/jbc.m507240200

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22841477

Title: Maintenance of mitochondrial genome distribution by mitochondrial AAA+ protein ClpX.

PubMed ID: 22841477

DOI: 10.1016/j.yexcr.2012.07.012

PubMed ID: 22710082

Title: Substrate recognition and processing by a Walker B mutant of the human mitochondrial AAA+ protein CLPX.

PubMed ID: 22710082

DOI: 10.1016/j.jsb.2012.06.001

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25957689

Title: Mitochondrial ClpX activates a key enzyme for heme biosynthesis and erythropoiesis.

PubMed ID: 25957689

DOI: 10.1016/j.cell.2015.04.017

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28874591

Title: Mutation in human CLPX elevates levels of delta-aminolevulinate synthase and protoporphyrin IX to promote erythropoietic protoporphyria.

PubMed ID: 28874591

DOI: 10.1073/pnas.1700632114

Sequence Information:

Length: 633
Mass: 69224
Checksum: CF46A6DC0DDBF022
Sequence:

MPSCGACTCG AAAVRLITSS LASAQRGISG GRIHMSVLGR LGTFETQILQ RAPLRSFTET 
PAYFASKDGI SKDGSGDGNK KSASEGSSKK SGSGNSGKGG NQLRCPKCGD LCTHVETFVS 
STRFVKCEKC HHFFVVLSEA DSKKSIIKEP ESAAEAVKLA FQQKPPPPPK KIYNYLDKYV 
VGQSFAKKVL SVAVYNHYKR IYNNIPANLR QQAEVEKQTS LTPRELEIRR REDEYRFTKL 
LQIAGISPHG NALGASMQQQ VNQQIPQEKR GGEVLDSSHD DIKLEKSNIL LLGPTGSGKT 
LLAQTLAKCL DVPFAICDCT TLTQAGYVGE DIESVIAKLL QDANYNVEKA QQGIVFLDEV 
DKIGSVPGIH QLRDVGGEGV QQGLLKLLEG TIVNVPEKNS RKLRGETVQV DTTNILFVAS 
GAFNGLDRII SRRKNEKYLG FGTPSNLGKG RRAAAAADLA NRSGESNTHQ DIEEKDRLLR 
HVEARDLIEF GMIPEFVGRL PVVVPLHSLD EKTLVQILTE PRNAVIPQYQ ALFSMDKCEL 
NVTEDALKAI ARLALERKTG ARGLRSIMEK LLLEPMFEVP NSDIVCVEVD KEVVEGKKEP 
GYIRAPTKES SEEEYDSGVE EEGWPRQADA ANS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CLPX

Associated with

Other Information

Human and mouse mitochondrial orthologs of bacterial ClpX. PubMed ID: 11003706

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Functional proteolytic complexes of the human mitochondrial ATP-dependent protease, hClpXP. PubMed ID: 11923310

Crystallography and mutagenesis point to an essential role for the N-terminus of human mitochondrial ClpP. PubMed ID: 15522782

Human mitochondrial ClpP is a stable heptamer that assembles into a tetradecamer in the presence of ClpX. PubMed ID: 16115876

A probability-based approach for high-throughput protein phosphorylation analysis and site localization. PubMed ID: 16964243

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

Maintenance of mitochondrial genome distribution by mitochondrial AAA+ protein ClpX. PubMed ID: 22841477

Substrate recognition and processing by a Walker B mutant of the human mitochondrial AAA+ protein CLPX. PubMed ID: 22710082

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Mitochondrial ClpX activates a key enzyme for heme biosynthesis and erythropoiesis. PubMed ID: 25957689

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Mutation in human CLPX elevates levels of delta-aminolevulinate synthase and protoporphyrin IX to promote erythropoietic protoporphyria. PubMed ID: 28874591