PDE10A | ENSG00000112541 | NCBI 10846

Details for: PDE10A

Gene ID: 10846

Symbol: PDE10A

Ensembl ID: ENSG00000112541

Description: phosphodiesterase 10A

Associated with

Cgmp effects
(R-HSA-418457)
G alpha (s) signalling events
(R-HSA-418555)
Gpcr downstream signalling
(R-HSA-388396)
Hemostasis
(R-HSA-109582)
Nitric oxide stimulates guanylate cyclase
(R-HSA-392154)
Platelet homeostasis
(R-HSA-418346)
Signaling by gpcr
(R-HSA-372790)
Signal transduction
(R-HSA-162582)
3',5'-cyclic-amp phosphodiesterase activity
(GO:0004115)
3',5'-cyclic-gmp phosphodiesterase activity
(GO:0047555)
3',5'-cyclic-nucleotide phosphodiesterase activity
(GO:0004114)
Camp-mediated signaling
(GO:0019933)
Camp binding
(GO:0030552)
Camp catabolic process
(GO:0006198)
Cgmp-stimulated cyclic-nucleotide phosphodiesterase activity
(GO:0004118)
Cgmp binding
(GO:0030553)
Cgmp catabolic process
(GO:0046069)
Cytosol
(GO:0005829)
Metal ion binding
(GO:0046872)
Negative regulation of cgmp-mediated signaling
(GO:0010754)

Other Information

Proteins

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
A0A1B1UZR0_HUMAN

Genular Protein ID: 78443436

Symbol: PDE10_HUMAN

Name: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

UniProtKB Accession Codes:

Q9Y233 A0A3F2YP58 Q6FHX1 Q9HCP9 Q9NTV4 Q9ULW9 Q9Y5T1

Database IDs:

Citations:

PubMed ID: 10441464

Title: Characterization and phosphorylation of PDE10A2, a novel alternative splice variant of human phosphodiesterase that hydrolyzes cAMP and cGMP.

PubMed ID: 10441464

DOI: 10.1006/bbrc.1999.1013

PubMed ID: 10373451

Title: Cloning and characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A).

PubMed ID: 10373451

DOI: 10.1074/jbc.274.26.18438

PubMed ID: 10393245

Title: Isolation and characterization of PDE10A, a novel human 3',5'-cyclic nucleotide phosphodiesterase.

PubMed ID: 10393245

DOI: 10.1016/s0378-1119(99)00171-7

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10998054

Title: The human phosphodiesterase PDE10A gene genomic organization and evolutionary relatedness with other PDEs containing GAF domains.

PubMed ID: 10998054

DOI: 10.1046/j.1432-1327.2000.01661.x

PubMed ID: 16330539

Title: cAMP is a ligand for the tandem GAF domain of human phosphodiesterase 10 and cGMP for the tandem GAF domain of phosphodiesterase 11.

PubMed ID: 16330539

DOI: 10.1074/jbc.m511468200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 27058446

Title: Biallelic mutations in PDE10A Lead to loss of striatal PDE10A and a hyperkinetic movement disorder with onset in infancy.

PubMed ID: 27058446

DOI: 10.1016/j.ajhg.2016.03.015

PubMed ID: 27058447

Title: De novo mutations in PDE10A cause childhood-onset chorea with bilateral striatal lesions.

PubMed ID: 27058447

DOI: 10.1016/j.ajhg.2016.02.015

PubMed ID: 17389385

Title: Structural insight into substrate specificity of phosphodiesterase 10.

PubMed ID: 17389385

DOI: 10.1073/pnas.0700279104

PubMed ID: 18477562

Title: Crystal structure of the GAF-B domain from human phosphodiesterase 10A complexed with its ligand, cAMP.

PubMed ID: 18477562

DOI: 10.1074/jbc.m800595200

Sequence Information:

Length: 1055
Mass: 114946
Checksum: 9FD62FD5851B001A
Sequence:

MASLEEPLAP RPQGPLPAAG DEPGCGPGKL RPEPRLSAAG GGSAAGPGPA PEWPGRGRAE 
RAAPPRPPLS SAGRPSPAGG PGALSARGGG CGWVAARAPL ALAFSSRVPS SSPSFFYFWP 
PPPPPPPSFL PSSSAFHLPV RLPGREGAAA AAAAGGGGDA GGGGGGGQEA APLSVPTSSS 
HRGGGGSGGG RRRLFLSPAL QGLLLPARAG PRPPPPPRLP LGQAARRAGS PGFPGAGPGG 
GGQTPRRPQG ASFALAAAAA LLFGSDMEDG PSNNASCFRR LTECFLSPSL TDEKVKAYLS 
LHPQVLDEFV SESVSAETVE KWLKRKNNKS EDESAPKEVS RYQDTNMQGV VYELNSYIEQ 
RLDTGGDNQL LLYELSSIIK IATKADGFAL YFLGECNNSL CIFTPPGIKE GKPRLIPAGP 
ITQGTTVSAY VAKSRKTLLV EDILGDERFP RGTGLESGTR IQSVLCLPIV TAIGDLIGIL 
ELYRHWGKEA FCLSHQEVAT ANLAWASVAI HQVQVCRGLA KQTELNDFLL DVSKTYFDNI 
VAIDSLLEHI MIYAKNLVNA DRCALFQVDH KNKELYSDLF DIGEEKEGKP VFKKTKEIRF 
SIEKGIAGQV ARTGEVLNIP DAYADPRFNR EVDLYTGYTT RNILCMPIVS RGSVIGVVQM 
VNKISGSAFS KTDENNFKMF AVFCALALHC ANMYHRIRHS ECIYRVTMEK LSYHSICTSE 
EWQGLMQFTL PVRLCKEIEL FHFDIGPFEN MWPGIFVYMV HRSCGTSCFE LEKLCRFIMS 
VKKNYRRVPY HNWKHAVTVA HCMYAILQNN HTLFTDLERK GLLIACLCHD LDHRGFSNSY 
LQKFDHPLAA LYSTSTMEQH HFSQTVSILQ LEGHNIFSTL SSSEYEQVLE IIRKAIIATD 
LALYFGNRKQ LEEMYQTGSL NLNNQSHRDR VIGLMMTACD LCSVTKLWPV TKLTANDIYA 
EFWAEGDEMK KLGIQPIPMM DRDKKDEVPQ GQLGFYNAVA IPCYTTLTQI LPPTEPLLKA 
CRDNLSQWEK VIRGEETATW ISSPSVAQKA AASED

Genular Protein ID: 790908767

Symbol: A0A1B1UZR0_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A1B1UZR0

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

Length: 779
Mass: 88412
Checksum: C5651BBB524A32B7
Sequence:

MRIEERKSQH LTGLTDEKVK AYLSLHPQVL DEFVSESVSA ETVEKWLKRK NNKSEDESAP 
KEVSRYQDTN MQGVVYELNS YIEQRLDTGG DNQLLLYELS SIIKIATKAD GFALYFLGEC 
NNSLCIFTPP GIKEGKPRLI PAGPITQGTT VSAYVAKSRK TLLVEDILGD ERFPRGTGLE 
SGTRIQSVLC LPIVTAIGDL IGILELYRHW GKEAFCLSHQ EVATANLAWA SVAIHQVQVC 
RGLAKQTELN DFLLDVSKTY FDNIVAIDSL LEHIMIYAKN LVNADRCALF QVDHKNKELY 
SDLFDIGEEK EGKPVFKKTK EIRFSIEKGI AGQVARTGEV LNIPDAYADP RFNREVDLYT 
GYTTRNILCM PIVSRGSVIG VVQMVNKISG SAFSKTDENN FKMFAVFCAL ALHCANMYHR 
IRHSECIYRV TMEKLSYHSI CTSEEWQGLM QFTLPVRLCK EIELFHFDIG PFENMWPGIF 
VYMVHRSCGT SCFELEKLCR FIMSVKKNYR RVPYHNWKHA VTVAHCMYAI LQNNHTLFTD 
LERKGLLIAC LCHDLDHRGF SNSYLQKFDH PLAALYSTST MEQHHFSQTV SILQLEGHNI 
FSTLSSSEYE QVLEIIRKAI IATDLALYFG NRKQLEEMYQ TGSLNLNNQS HRDRVIGLMM 
TACDLCSVTK LWPVTKLTAN DIYAEFWAEG DEMKKLGIQP IPMMDRDKKD EVPQGQLGFY 
NAVAIPCYTT LTQILPPTEP LLKACRDNLS QWEKVIRGEE TATWISSPSV AQKAAASED

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PDE10A

Associated with

Other Information

Characterization and phosphorylation of PDE10A2, a novel alternative splice variant of human phosphodiesterase that hydrolyzes cAMP and cGMP. PubMed ID: 10441464

Cloning and characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A). PubMed ID: 10373451

Isolation and characterization of PDE10A, a novel human 3',5'-cyclic nucleotide phosphodiesterase. PubMed ID: 10393245

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The human phosphodiesterase PDE10A gene genomic organization and evolutionary relatedness with other PDEs containing GAF domains. PubMed ID: 10998054

cAMP is a ligand for the tandem GAF domain of human phosphodiesterase 10 and cGMP for the tandem GAF domain of phosphodiesterase 11. PubMed ID: 16330539

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Biallelic mutations in PDE10A Lead to loss of striatal PDE10A and a hyperkinetic movement disorder with onset in infancy. PubMed ID: 27058446

De novo mutations in PDE10A cause childhood-onset chorea with bilateral striatal lesions. PubMed ID: 27058447

Structural insight into substrate specificity of phosphodiesterase 10. PubMed ID: 17389385

Crystal structure of the GAF-B domain from human phosphodiesterase 10A complexed with its ligand, cAMP. PubMed ID: 18477562

The sequence of the human genome. PubMed ID: 11181995