Details for: CCL27

Gene ID: 10850

Symbol: CCL27

Ensembl ID: ENSG00000213927

Description: C-C motif chemokine ligand 27

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.85
    Marker Score: 966
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 2.83
    Marker Score: 5,856
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.01
    Marker Score: 2,004
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 1.89
    Marker Score: 1,902
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4,828
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.07
    Marker Score: 778
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.02
    Marker Score: 1,278
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,842
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,067
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1
    Marker Score: 513
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.99
    Marker Score: 466
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 377
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.93
    Marker Score: 774
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 329
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.9
    Marker Score: 897
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.85
    Marker Score: 13,364
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.85
    Marker Score: 576
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.84
    Marker Score: 443
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.83
    Marker Score: 345
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.81
    Marker Score: 1,530
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.78
    Marker Score: 358
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 400
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.69
    Marker Score: 220
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.68
    Marker Score: 1,388
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.62
    Marker Score: 1,449
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.56
    Marker Score: 432
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.53
    Marker Score: 253
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.52
    Marker Score: 166
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5
    Marker Score: 320
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 280
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.42
    Marker Score: 108
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.4
    Marker Score: 242
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.37
    Marker Score: 165
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.35
    Marker Score: 111
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.25
    Marker Score: 90
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.23
    Marker Score: 130
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.22
    Marker Score: 110
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.22
    Marker Score: 354
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.17
    Marker Score: 74
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.15
    Marker Score: 374
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.14
    Marker Score: 90
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.1
    Marker Score: 93
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.1
    Marker Score: 37
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.09
    Marker Score: 134
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.08
    Marker Score: 163
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.07
    Marker Score: 69
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.07
    Marker Score: 82
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.07
    Marker Score: 97
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.07
    Marker Score: 84
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.07
    Marker Score: 28
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.07
    Marker Score: 59
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.07
    Marker Score: 24
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.06
    Marker Score: 23
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.06
    Marker Score: 34
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.06
    Marker Score: 69
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.06
    Marker Score: 81
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.05
    Marker Score: 122
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 0.05
    Marker Score: 166
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.05
    Marker Score: 24
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.05
    Marker Score: 25
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.05
    Marker Score: 22
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.05
    Marker Score: 19
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.04
    Marker Score: 45
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.04
    Marker Score: 30
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.04
    Marker Score: 24
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.04
    Marker Score: 65
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.04
    Marker Score: 60
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.04
    Marker Score: 37
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.04
    Marker Score: 9
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.04
    Marker Score: 22
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.04
    Marker Score: 20
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.04
    Marker Score: 9
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.04
    Marker Score: 24
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.03
    Marker Score: 19
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.03
    Marker Score: 37
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.03
    Marker Score: 23
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.03
    Marker Score: 48
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.03
    Marker Score: 8
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.03
    Marker Score: 89
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.03
    Marker Score: 32
  • Cell Name: epithelial fate stem cell (CL0000036)
    Fold Change: 0.03
    Marker Score: 8
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.03
    Marker Score: 58
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.03
    Marker Score: 26
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.03
    Marker Score: 7
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.03
    Marker Score: 106
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.03
    Marker Score: 45
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.03
    Marker Score: 25
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.02
    Marker Score: 26
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.02
    Marker Score: 7
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.02
    Marker Score: 16

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CCL27 is a 10-amino acid chemokine that binds to the CCR7 receptor, a G-protein coupled receptor. This interaction triggers a signaling cascade that regulates various cellular processes, including chemotaxis, cell proliferation, and survival. CCL27 is primarily produced by epithelial cells, endothelial cells, and immune cells, such as dendritic cells and T cells. Its expression is tightly regulated by transcription factors, such as CREB and NF-κB, which respond to inflammatory signals and developmental cues. **Pathways and Functions:** CCL27's signaling pathways involve the activation of G-protein coupled receptors, leading to the modulation of downstream signaling events, including: 1. **Chemotaxis**: CCL27 induces chemotaxis in target cells, facilitating the migration of immune cells, such as T cells and dendritic cells, towards chemokine gradients. 2. **Cell proliferation**: CCL27 promotes cell proliferation by activating signaling pathways that regulate cell cycle progression and apoptosis. 3. **Survival**: CCL27 protects cells from apoptosis by activating anti-apoptotic signaling pathways. 4. **Tissue homeostasis**: CCL27 maintains tissue homeostasis by regulating the differentiation and migration of stem cells and progenitor cells. **Clinical Significance:** CCL27's dysregulation has been implicated in various diseases, including: 1. **Autoimmune diseases**: CCL27 is involved in the pathogenesis of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, where it regulates the migration and differentiation of immune cells. 2. **Cancer**: CCL27 has been shown to promote tumor growth and metastasis by inducing chemotaxis and angiogenesis in cancer cells. 3. **Neurological disorders**: CCL27 is involved in the regulation of neuroinflammation and neurodegeneration, as seen in diseases such as Alzheimer's and Parkinson's. 4. **Infectious diseases**: CCL27 plays a role in the immune response to infections, such as tuberculosis and HIV, by regulating the migration and activation of immune cells. In conclusion, CCL27 is a key player in the regulation of immune responses, cell migration, and tissue homeostasis. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in human health and disease. Further research is needed to fully elucidate the mechanisms by which CCL27 regulates immune responses and to identify potential therapeutic targets for the treatment of diseases associated with CCL27 dysregulation.

Genular Protein ID: 2597570232

Symbol: CCL27_HUMAN

Name: C-C motif chemokine 27

UniProtKB Accession Codes:

Q9Y4X3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10556532

Title: Molecular cloning of a novel CC chemokine, interleukin-11 receptor alpha-locus chemokine (ILC), which is located on chromosome 9p13 and a potential homologue of a CC chemokine encoded by molluscum contagiosum virus.

PubMed ID: 10556532

DOI: 10.1016/s0014-5793(99)01406-4

PubMed ID: 10588729

Title: CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells.

PubMed ID: 10588729

DOI: 10.1073/pnas.96.25.14470

PubMed ID: 10725697

Title: The orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC).

PubMed ID: 10725697

DOI: 10.4049/jimmunol.164.7.3465

PubMed ID: 27044744

Title: The Anti-inflammatory Protein TSG-6 Regulates Chemokine Function by Inhibiting Chemokine/Glycosaminoglycan Interactions.

PubMed ID: 27044744

DOI: 10.1074/jbc.m116.720953

PubMed ID: 20200157

Title: NMR analysis of the structure, dynamics, and unique oligomerization properties of the chemokine CCL27.

PubMed ID: 20200157

DOI: 10.1074/jbc.m109.091108

Sequence Information:

  • Length: 112
  • Mass: 12618
  • Checksum: 7B5940E147ABF820
  • Sequence:
    • MKGPPTFCSL LLLSLLLSPD PTAAFLLPPS TACCTQLYRK PLSDKLLRKV IQVELQEADG 
DCHLQAFVLH LAQRSICIHP QNPSLSQWFE HQERKLHGTL PKLNFGMLRK MG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.